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1. 发明授权

US08535691B2 Perflurochemical treatment process and apparatus 有权
标题翻译：全氟化学处理工艺及设备
公开(公告)号：US08535691B2
公开(公告)日：2013-09-17
申请号：US11276180
申请日：2006-02-16
申请人： Thomas H. Shaffer , Robert G. Stern , Marla R. Wolfson
发明人： Thomas H. Shaffer , Robert G. Stern , Marla R. Wolfson
IPC分类号： A61K9/00
CPC分类号： A61G10/023
摘要： A subject is confined in a closed environment at an elevated pressure through which perfluorochemical fluid containing dissolved oxygen is circulated to treat disease or injury.
摘要翻译：受试者被限制在高压下的封闭环境中，通过该压力使含有溶解氧的全氟化合物循环以治疗疾病或损伤。

2. 发明授权

US08375952B2 Device and method for unilateral lung ventilation 有权
公开(公告)号：US08375952B2
公开(公告)日：2013-02-19
申请号：US12228019
申请日：2008-08-08
申请人： Thomas L. Miller , Thomas H. Shaffer , Mary Theroux , John Bernardi
发明人： Thomas L. Miller , Thomas H. Shaffer , Mary Theroux , John Bernardi
IPC分类号： A61M16/00 , A62B7/00 , A62B9/06
CPC分类号： A61M16/04 , A61M16/0404 , A61M16/0459 , A61M16/0486 , A61M2202/0275
摘要： A system for unilateral lung ventilation includes an endotracheal tube and a blocking device for blocking the bronchus of a non-ventilated lung to prevent a ventilation medium from entering the lung. The blocking device includes an inflatable member supported by a catheter having an inflation lumen for inflating the inflatable member. The catheter includes at least one lung treatment lumen for delivering a therapeutic agent to the non-ventilated lung. An inner channel within the main channel and a side branch provide a guideway for the blocking device within the tube. A valve may be included to close the side branch when the blocking device is removed from the inner channel for parallel flow of ventilating gas in the main and inner channels. A method of using the system provides for ventilation/perfusion (V/Q) matching by respectively delivering cooled air and nitric oxide to the non-ventilated and ventilated lungs.

3. 发明授权

US08034011B2 Thoracic stabilizer 有权
标题翻译：胸部稳定剂
公开(公告)号：US08034011B2
公开(公告)日：2011-10-11
申请号：US12083253
申请日：2006-10-18
申请人： Thomas H. Shaffer , Marla R. Wolfson
发明人： Thomas H. Shaffer , Marla R. Wolfson
IPC分类号： A61F5/00 , A61F5/24 , A61F5/28 , A61B5/103 , A61B5/117 , A47C20/00
CPC分类号： A61H31/006 , A61H31/008 , A61H2201/018 , A61H2201/5007 , A61H2201/5061
摘要： A thoracic stabilizer for limiting anterior chest wall collapse includes a platform supporting a patient and a pair of lateral supports contacting opposite sides of the patient's chest wall and applying force to limit collapse of the chest wall. The force applied by the lateral supports is varied depending on the force applied to the platform by the patient. The stabilizer includes a retractometer measuring the collapse of the chest wall. According to one embodiment, the stabilizer includes a controller that varies the force applied to the chest wall in closed-loop fashion based on the chest wall collapse measured by the retractometer using an algorithm of the controller. According to one embodiment, the stabilizer includes motors moving the lateral supports. According to another embodiment, the stabilizer includes a hydraulic system and the lateral supports include expandable fluid-filled members.
摘要翻译：用于限制前胸壁塌陷的胸部稳定器包括支撑患者的平台和与患者胸壁的相对侧接触的一对侧向支撑件，并施加力以限制胸壁的塌陷。由侧向支撑施加的力根据患者施加到平台的力而变化。稳定器包括测量胸壁塌陷的收缩计。根据一个实施例，所述稳定器包括控制器，所述控制器使用所述控制器的算法，以闭环方式改变施加到所述胸壁的力，所述控制器基于由所述收缩计测量的所述胸壁塌陷。根据一个实施例，稳定器包括移动横向支撑件的马达。根据另一个实施例，稳定器包括液压系统，并且侧向支撑件包括可膨胀流体填充构件。

4. 发明申请

US20110162646A1 PROCESS FOR TRANSIENT AND STEADY STATE DELIVERY OF BIOLOGICAL AGENTS TO THE LUNG VIA BREATHABLE LIQUIDS 有权
标题翻译：过敏和稳定状态通过可呼吸液体向肺部递送生物代谢
公开(公告)号：US20110162646A1
公开(公告)日：2011-07-07
申请号：US13050027
申请日：2011-03-17
申请人： Thomas H. Shaffer , Marla R. Wolfson
发明人： Thomas H. Shaffer , Marla R. Wolfson
IPC分类号： A61M16/14
CPC分类号： A61M16/0054 , A61M16/22 , A61M2202/0476
摘要： The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.
摘要翻译：本发明包括将透气液体中的生物剂递送到患者的肺的瞬时方法。本发明包括将透气液体中的生物剂递送到患者的肺的稳态方法。瞬时输送方式和稳态输送方法两者的步骤可以由伺服控制装置控制。可以在递送生物剂的瞬时方法和递送生物制剂的稳态方法两者中进行补充生物剂递送步骤。

5. 发明授权

US07909031B2 Process for transient and steady state delivery of biological agents to the lung via breathable liquids 有权
标题翻译：通过透气液体暂时和稳态地将生物制剂递送到肺的过程
公开(公告)号：US07909031B2
公开(公告)日：2011-03-22
申请号：US11149114
申请日：2005-06-09
申请人： Thomas H. Shaffer , Marla R. Wolfson
发明人： Thomas H. Shaffer , Marla R. Wolfson
IPC分类号： A61M16/00 , A61M16/10 , A61M15/00 , A61M11/00
CPC分类号： A61M16/0054 , A61M16/22 , A61M2202/0476
摘要： The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.
摘要翻译：本发明包括将透气液体中的生物剂递送到患者的肺的瞬时方法。本发明包括将透气液体中的生物剂递送到患者的肺的稳态方法。瞬时输送方式和稳态输送方法两者的步骤可以由伺服控制装置控制。可以在递送生物剂的瞬时方法和递送生物制剂的稳态方法两者中进行补充生物剂递送步骤。

6. 发明申请

US20100084066A1 PERFLUOROCARBON GAS INSUFFLATION 有权
标题翻译：全氟化碳消毒
公开(公告)号：US20100084066A1
公开(公告)日：2010-04-08
申请号：US12613625
申请日：2009-11-06
申请人： Thomas H. Shaffer , Robert G. Stern , Marla R. Wolfson
发明人： Thomas H. Shaffer , Robert G. Stern , Marla R. Wolfson
IPC分类号： B60C5/00 , B65B31/00 , B60S5/04
CPC分类号： B01F13/1055 , B60C5/001 , Y10T152/10495
摘要： Vehicle tires are filled with perfluorocarbon gas to extend tire life.
摘要翻译：汽车轮胎充满全氟化碳气体，延长轮胎寿命。

7. 发明申请

US20100012122A1 OPEN-CIRCUIT LIQUID VENTILATOR 有权
标题翻译：开路液体通风机
公开(公告)号：US20100012122A1
公开(公告)日：2010-01-21
申请号：US12449331
申请日：2008-01-25
申请人： Thomas H. Shaffer , Marla R. Wolfson
发明人： Thomas H. Shaffer , Marla R. Wolfson
IPC分类号： A61M16/00
CPC分类号： A61M16/0054 , A61M2016/0027 , A61M2016/0033 , A61M2205/583 , A61M2230/205 , A61M2230/432
摘要： An open-circuit liquid ventilation system includes a reservoir containing a breathable liquid, a patient interface receiving breathable liquid from the reservoir, a pump directing breathable liquid from the reservoir to the patient, a controller for the pump, and a tank for storing used breathable liquid. The system may be passive regarding expired liquid. Alternatively, the system may be active and include a bypass line connected to the pump such that used breathable liquid is drawn from the patient. The patient interface may be adapted to interface a gas ventilation system to facilitate a rapid conversion from gas to liquid ventilation. The system may include sensors monitoring pressure and volume parameters and may include an output displaying information including schematics and real time tracings regarding a ventilation procedure.
摘要翻译：一种开放式液体通气系统，包括一个容纳透气液体的储存器，一个患者接口，从该储存器接收透气液体，一个泵将来自储存器的透气液体引导到病人身上，一个用于泵的控制器，液体。对于过期液体，系统可能是被动的。或者，系统可以是有效的，并且包括连接到泵的旁路管线，使得从患者抽出使用的透气液体。患者接口可适于接合气体通气系统，以便于从气体到液体通气的快速转换。该系统可以包括监测压力和体积参数的传感器，并且可以包括显示包括关于通气程序的原理图和实时跟踪的信息的输出。

8. 发明授权

US6166092A Fluorocarbon compositions for pulmonary therapy 失效
标题翻译：用于肺部治疗的氟碳组合物
公开(公告)号：US6166092A
公开(公告)日：2000-12-26
申请号：US479615
申请日：1995-06-07
申请人： K. Michael Sekins , Thomas H. Shaffer , Marla R. Wolfson
发明人： K. Michael Sekins , Thomas H. Shaffer , Marla R. Wolfson
IPC分类号： A61B17/22 , A61B18/00 , A61F7/00 , A61F7/12 , A61K9/00 , A61M16/04 , A61N7/02 , B06B1/06 , A61K47/00 , A01N25/00
CPC分类号： A61K9/0026 , A61B2017/22054 , A61B2018/00011 , A61F7/123 , A61F2007/0054 , A61M16/0404 , A61M16/0454 , A61M16/0459 , A61M16/0463 , A61M16/0479 , A61M16/0486 , A61M2202/0468 , A61M2202/0476 , A61M2205/3368 , A61N7/022 , B06B1/0633 , Y10S128/913 , Y10S514/937 , Y10T137/87652
摘要： Biocompatible fluorocarbon compositions are provided which may be used for the delivery of bioactive agents to the pulmonary air passages of a patient. Preferred compositions comprise a fluorocarbon liquid carrier having a bioactive agent in a solid or immiscible liquid form distributed therein. The disclosed compositions allow for the selective delivery of bioactive agents in conjunction with liquid lavage and liquid ventilation for the treatment of ARDS and other pulmonary disorders.
摘要翻译：提供生物相容性碳氟组合物，其可用于将生物活性剂递送至患者的肺空气通道。优选的组合物包含具有分布在其中的固体或不混溶液体形式的生物活性剂的氟碳液体载体。所公开的组合物允许生物活性剂与液体灌洗和液体通气结合选择性递送用于治疗ARDS和其它肺部疾病。

9. 发明授权

US5590651A Breathable liquid elimination analysis 失效
标题翻译：透气液体消除分析
公开(公告)号：US5590651A
公开(公告)日：1997-01-07
申请号：US373662
申请日：1995-01-17
申请人： Thomas H. Shaffer , Marla R. Wolfson , Thomas F. Miller , Raymond Foust, III
发明人： Thomas H. Shaffer , Marla R. Wolfson , Thomas F. Miller , Raymond Foust, III
IPC分类号： G01N25/18 , A61B5/08 , A61B5/083 , A61B5/087 , A61M16/00 , F16K17/38 , G01N33/00 , G01N33/497 , A61B5/097
CPC分类号： G01N33/497 , A61M16/0054 , A61M16/00 , A61M2202/0476 , G01N33/0049 , Y10S128/913
摘要： The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration is detected by measuring the amount of saturation of the expiratory gas by vapors or the breathable liquid. Instantaneous saturation values are employed to gauge the amount of interaction in the lungs between the breathable liquid and respiratory gas flowing therein and to control selected feedback operations to maintain the maximum possible amount of interaction therebetween. The saturation level of expiratory gas is also employed to optimize operating parameters or a system for recovering the breathable liquid from the expiratory gas, directly from the patient, or from a gas or liquid ventilator. The saturation level or expiratory gas is also employed to perform functional residual capacity studies and to correct for errors in conventional functional residual capacity measurements performed while a patient undergoes partial liquid ventilation. When breathable liquid is employed as a blood substitute, the quantification or the loss of the breathable liquid from volatilization and transpiration helps to determine when to replenish the breathable liquid in the bloodstream. Vapors of one form of breathable liquid, perfluorocarbon, are employed to determine the functional residual capacity of a mammal's lung.
摘要翻译：通过用蒸气或透气液体测量呼气气体的饱和度来检测从哺乳动物通过肺中挥发和/或通过皮肤蒸腾而消除的透气液体的量。使用瞬时饱和值来测量在其中流动的透气液体和呼吸气体之间的肺中的相互作用的量，并且控制所选择的反馈操作以保持其间的最大可能的相互作用量。呼吸气体的饱和水平也用于优化操作参数或用于从呼气气体直接从患者或从气体或液体通气机回收呼吸气体的系统。还使用饱和水平或呼气气体进行功能性残留能力研究并纠正在患者进行部分液体通气时执行的常规功能残余容量测量中的误差。当采用透气液体作为血液替代品时，透泡液体的挥发和蒸腾的定量或损失有助于确定何时补充血液中的透气液体。使用一种透气性液体全氟化碳的蒸气来确定哺乳动物肺的功能残留能力。

10. 发明授权

US5562608A Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation 失效
标题翻译：用于同时进行液体灌洗和通气的肺部递送药物的装置
公开(公告)号：US5562608A
公开(公告)日：1996-10-08
申请号：US424577
申请日：1995-04-13
申请人： K. Michael Sekins , Thomas H. Shaffer , Marla R. Wolfson
发明人： K. Michael Sekins , Thomas H. Shaffer , Marla R. Wolfson
IPC分类号： A61B17/22 , A61B18/00 , A61F7/00 , A61F7/12 , A61K9/00 , A61M16/04 , A61N7/02 , B06B1/06 , A61N1/30
CPC分类号： A61K9/0026 , A61F7/123 , A61M16/0404 , A61M16/0463 , A61M16/0479 , A61N7/022 , B06B1/0633 , A61B2017/22054 , A61B2018/00011 , A61F2007/0054 , A61M2202/0468 , A61M2202/0476 , A61M2205/3368 , Y10S128/913 , Y10S514/937 , Y10T137/87652
摘要： An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
摘要翻译：一种用于在连续液体输送阶段内均匀分散的含药相的制备装置。

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