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1. 发明专利

CA2865430A1 SYSTEMS AND METHODS FOR DETERMINING CONTAINER CONTENTS, LOCATIONS, AND SURROUNDINGS 未知
公开(公告)号：CA2865430A1
公开(公告)日：2013-08-29
申请号：CA2865430
申请日：2013-02-25
申请人： ADHERETECH INC , TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE B
发明人： STEIN JOSHUA , LANGHAUSER JOHN , MORENA MICHAEL , JOVANOV EMIL
IPC分类号： A61J1/03 , A61J7/04 , G16H10/60
摘要： Systems and methods are provided for determining whether and/or when a patient is taking his or her medication and, when appropriate, providing reminders and/or alerts to the patient to improve adherence to a medication regimen. In some embodiments, a medication container is provided that includes a capacitance sensor for sensing the contents of the medication container (e.g., pill count or quantity of liquid medication). The capacitance sensor may include interleaved or interdigitated electrodes oriented vertically, horizontally, or angularly (e.g., diagonally) relative to an axis of the medication container. Reminders and/or alerts to the patient may be triggered based at least in part on the contents of the medication container, when a cap of the container was last opened and/or closed, the location of the medication container, and/or the container's surroundings.

2. 发明专利

TW200801190A 蛋白質摺疊錯誤及聚集之調節劑與其使用方法 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME 审中-公开
简体标题：蛋白质折叠错误及聚集之调节剂与其使用方法 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME
公开(公告)号：TW200801190A
公开(公告)日：2008-01-01
申请号：TW095131221
申请日：2006-08-24
申请人：美國阿拉巴馬大學理事會 THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY O
发明人：蓋A 凱德威 CALDWELL, GUY A. , 金A 凱德威 CALDWELL, KIM A.
IPC分类号： C12N , A61K , G01N
摘要：本發明提供用於由蛋白質聚集來表徵之神經病症之聚核酸分子及由該等分子編碼之蛋白質、診斷及治療方法。本文中所述之基因影響諸如��-突觸核蛋白之易聚集蛋白質之摺疊錯誤及其因此之聚集,且牽制到諸如帕金森式病(Parkinson'sdisease)之與蛋白質聚集相關之神經疾病的診斷及治療。使用RNAi敲除本文中所述之基因的表現導致蛋白質聚集之秀麗隱桿線蟲(C.elegans)模型中��-突觸核蛋白聚集。暴露於神經毒素6-OHDA或��-突觸核蛋白過度表現後的多巴胺能神經保護亦可由蛋白質的過度表現來提供。對與蛋白質摺疊錯誤及聚集相關之基因的認知提供開發診斷性篩檢方法、突變分析及藥物設計資訊之有效方法,用於開發治療諸如帕金森氏病之神經退化性疾病之新穎治療性及神經保護性化合物。
简体摘要：本发明提供用于由蛋白质聚集来表征之神经病症之聚核酸分子及由该等分子编码之蛋白质、诊断及治疗方法。本文中所述之基因影响诸如��-突触核蛋白之易聚集蛋白质之折叠错误及其因此之聚集,且牵制到诸如帕金森式病(Parkinson'sdisease)之与蛋白质聚集相关之神经疾病的诊断及治疗。使用RNAi敲除本文中所述之基因的表现导致蛋白质聚集之秀丽隐杆线虫(C.elegans)模型中��-突触核蛋白聚集。暴露于神经毒素6-OHDA或��-突触核蛋白过度表现后的多巴胺能神经保护亦可由蛋白质的过度表现来提供。对与蛋白质折叠错误及聚集相关之基因的认知提供开发诊断性筛检方法、突变分析及药物设计信息之有效方法,用于开发治疗诸如帕金森氏病之神经退化性疾病之新颖治疗性及神经保护性化合物。

3. 发明专利

TW200526587A 含二級羥基之離子性液體及彼等之製備方法 IONIC LIQUIDS CONTAINING SECONDARY HYDROXYL-GROUPS AND A METHOD FOR THEIR PREPARATION 审中-公开
简体标题：含二级羟基之离子性液体及彼等之制备方法 IONIC LIQUIDS CONTAINING SECONDARY HYDROXYL-GROUPS AND A METHOD FOR THEIR PREPARATION
公开(公告)号：TW200526587A
公开(公告)日：2005-08-16
申请号：TW093126880
申请日：2004-09-06
申请人：美國阿拉巴馬大學理事會 THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
发明人：約翰D 荷伯瑞 HOLBREY, JOHN D. , 梅根B 透納 TURNER, MEGAN B. , 羅賓D 羅傑 ROGERS, ROBIN D.
IPC分类号： C07D , B01J
CPC分类号： B01J31/0284
摘要：本發明提供含有二級羥基之離子性液體，以及一種製備此等離子性液體之原子有效的方法，其係在一有助於離子性液體形成之陰離子存在下，藉由質子化含氮有機鹼(其視情況可於原位製備)之環氧化作用製得。093126880-p01.bmp
简体摘要：本发明提供含有二级羟基之离子性液体，以及一种制备此等离子性液体之原子有效的方法，其系在一有助于离子性液体形成之阴离子存在下，借由质子化含氮有机碱(其视情况可于原位制备)之环氧化作用制得。093126880-p01.bmp

4. 发明授权

US12042819B1 Systems and methods for forming uniform monolayers of nanoparticles 有权
公开(公告)号：US12042819B1
公开(公告)日：2024-07-23
申请号：US18328194
申请日：2023-06-02
申请人： Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
发明人： Jeffrey J. Weimer , Jimmie L. Mitchell
IPC分类号： B05D7/24 , B05D1/20 , C09D5/22 , C09K11/08
CPC分类号： B05D1/204 , B05D7/24 , C09D5/22 , C09K11/08
摘要： The present disclosure is directed to methods for preparing nanoparticle monolayers on a sub-phase by controlling the spreading rate of the nanoparticles. The nanoparticles are first prepared in a nanoparticle solution at a predetermined concentration with a solvent. The sub-phase solution is prepared to have a density and viscosity compatible with the desired spreading rate. Additives, such as glycerol, are used to alter the density of the sub-phase solution. A volume of nanoparticle solution is deposited on the surface of the sub-phase solution and allowed to spread in a controlled manner on the unconstrained surface, forming a uniform nanoparticle monolayer. A substrate is then placed in contact with the nanoparticle monolayer to form a uniform nanoparticle coating on the surface of the substrate.

5. 发明授权

US11554244B2 Systems and methods for multi-modal and non-invasive stimulation of the nervous system 有权
公开(公告)号：US11554244B2
公开(公告)日：2023-01-17
申请号：US16884246
申请日：2020-05-27
申请人： Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
发明人： Emil Jovanov
IPC分类号： A61N1/04 , A61N1/36 , A61N2/00 , A61N5/06 , A61M21/00 , A61B5/021 , A61B5/024 , A61B5/369 , A61B5/00 , A61H23/02 , A61H23/00
摘要： Systems and methods are provided to combine multiple stimulation modalities to significantly increase the effectiveness of non-invasive stimulation. Multiple sensor and stimulation devices and modalities can be combined into a single, compact unit that minimizes the need for additional sensors or stimulation devices. The system features several subunits, referred to as sensory and stimulation devices (SSD), that are integrated into a headphone setup. The system is controlled by a centralized controller that communicates with all of the SSDs and with an external computer system that delivers learning material synchronized with the delivery of stimulations and the collection of user responses based on physiological signals.

6. 发明授权

US11346330B1 Additively manufactured components for electric propulsion thrusters 有权
公开(公告)号：US11346330B1
公开(公告)日：2022-05-31
申请号：US16111840
申请日：2018-08-24
申请人： Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
发明人： Kunning Gabriel Xu , Ethan Paul Hopping
IPC分类号： F03H1/00 , H05H1/54 , B33Y80/00 , B33Y10/00 , B33Y70/00
摘要： A Hall effect thruster is provided having one or more components fabricated using additive manufacturing techniques. Additive manufacturing can be used to fabricate the propellant distributor and the discharge channel of the thruster. The propellant distributor can be separated from the anode of the thruster and can form the base of the discharge channel. The discharge channel can be detachably connected to the propellant distributor using one of a threaded connection or a snap-fit connection. The discharge channel can have an annular shape and electromagnets and magnetic poles can be placed in the surrounding areas of the discharge channel.

7. 发明授权

US09404861B2 Nanostructure diffraction gratings for integrated spectroscopy and sensing 有权
$Nanostructure diffraction gratings for integrated spectroscopy and sensing$
公开(公告)号：US09404861B2
公开(公告)日：2016-08-02
申请号：US14617635
申请日：2015-02-09
申请人： Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
发明人： Junpeng Guo
IPC分类号： G01N21/552 , G01J3/18 , G02B5/18 , G01N21/65 , G02B5/00
CPC分类号： G01N21/554 , G01J3/1804 , G01N21/658 , G01N2201/02 , G01N2201/06113 , G02B5/008 , G02B5/18 , G02B5/1809
摘要： The present disclosure pertains to metal or dielectric nanostructures of the subwavelength scale within the grating lines of optical diffraction gratings. The nanostructures have surface plasmon resonances or non-plasmon optical resonances. A linear photodetector array is used to capture the resonance spectra from one of the diffraction orders. The combined nanostructure super-grating and photodetector array eliminates the use of external optical spectrometers for measuring surface plasmon or optical resonance frequency shift caused by the presence of chemical and biological agents. The nanostructure super-gratings can be used for building integrated surface enhanced Raman scattering (SERS) spectrometers. The nanostructures within the diffraction grating lines enhance Raman scattering signal light while the diffraction grating pattern of the nanostructures diffracts Raman scattering light to different directions of propagation according to their wavelengths. Therefore, the nanostructure super-gratings allows for the use of a photodetector array to capture the surface enhanced Raman scattering spectra.

8. 发明申请

US20140110803A1 METHOD AND SYSTEM FOR PROVIDING MAGNETIC TUNNELING JUNCTION ELEMENTS HAVING AN EASY CONE ANISOTROPY 有权
标题翻译：提供具有简易棱镜的磁性隧道连接元件的方法和系统
公开(公告)号：US20140110803A1
公开(公告)日：2014-04-24
申请号：US13739959
申请日：2013-01-11
申请人： The Board of Trustees of the University of Alabama for and on Behalf of the University of Alabama , Samsung Electronics Co., Ltd.
发明人： Dmytro Apalkov , William H. Butler
IPC分类号： H01L43/02
CPC分类号： H01L43/02 , B82Y25/00 , H01F10/3254 , H01F10/3286 , H01F10/3295 , H01L43/08
摘要： A method and system for providing a magnetic junction usable in a magnetic device are described. The magnetic junction includes a pinned layer, a nonmagnetic spacer layer, and a free layer. The nonmagnetic spacer layer is between the pinned layer and the free layer. The free layer has a magnetic anisotropy, at least a portion of which is a biaxial anisotropy. The magnetic junction is configured such that the free layer is switchable between a plurality of stable magnetic states when a write current is passed through the magnetic junction.
摘要翻译：描述了一种用于提供可用于磁性装置中的磁结的方法和系统。磁结包括钉扎层，非磁性间隔层和自由层。非磁性间隔层位于被钉扎层和自由层之间。自由层具有磁各向异性，其至少一部分是双轴各向异性的。磁结被配置为使得当写入电流通过磁结时，自由层可在多个稳定磁状态之间切换。

9. 发明授权

US11967229B1 Systems and methods for monitoring vehicular traffic 有权
公开(公告)号：US11967229B1
公开(公告)日：2024-04-23
申请号：US16853200
申请日：2020-04-20
申请人： Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
发明人： Biswajit Ray
IPC分类号： G08G1/052 , G08G1/01 , G08G1/04 , H02S20/21
CPC分类号： G08G1/052 , G08G1/0104 , G08G1/04 , H02S20/21
摘要： A traffic monitoring system has a controller and sensors placed in or on roads such that vehicles pass over or near the sensors, thereby casting shadows on the sensors as they pass. The sensors may be configured to detect the shadows, and a controller may be configured to determine any of a variety of information about the passing vehicles based on the detected shadows. For example, the controller may count the number of vehicles that pass, determine a speed of each passing vehicle, and determine a length of each passing vehicle. The sensors can be relatively inexpensive so that a relatively large number of sensors can be used to monitor a large area at a relatively low cost. In some embodiments, solar cells are used to power the sensors, and if desired, the solar cells may be used as the sensors for detecting the shadows of the vehicles being monitored.

10. 发明申请

US20190231645A1 Systems And Methods For Determining Container Contents, Locations, And Surroundings 审中-公开
公开(公告)号：US20190231645A1
公开(公告)日：2019-08-01
申请号：US16058056
申请日：2018-08-08
申请人： AdhereTech Inc. , The Board of Trustees of the University of Alabama For And On Behalf of the University of Alabama
发明人： Joshua Stein , John Langhauser , Michael Morena , Emil Jovanov
IPC分类号： A61J7/04 , G16H20/13
CPC分类号： A61J7/0409 , A61J7/0418 , A61J7/0481 , A61J2200/30 , A61J2200/70 , A61J2200/74 , A61J2200/76 , F04C2270/0421 , G06F19/3462 , G06Q10/10 , G16H20/13
摘要： Systems and methods are provided for determining whether and/or when a patient is taking his or her medication and, when appropriate, providing reminders and/or alerts to the patient to improve adherence to a medication regimen. In some embodiments, a medication container is provided that includes a capacitance sensor for sensing the contents of the medication container (e.g., pill count or quantity of liquid medication). The capacitance sensor may include interleaved or interdigitated electrodes oriented vertically, horizontally, or angularly (e.g., diagonally) relative to an axis of the medication container. Reminders and/or alerts to the patient may be triggered based at least in part on the contents of the medication container, when a cap of the container was last opened and/or closed, the location of the medication container, and/or the container's surroundings.

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