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1. 发明申请

WO2023282922A1 ELECTRODE LEADS HAVING MULTI-APPLICATION HELICAL NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2023282922A1
公开(公告)日：2023-01-12
申请号：PCT/US2021/048585
申请日：2021-09-01
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： BRANDT, William, Andrew , DEARDEN, Brian, Ralph
IPC分类号： A61N1/05 , A61N1/36
摘要： An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.

2. 发明申请

WO2022192911A1 PHOTOPLETHYSMOGRAPHY IN COMBINATION WITH MEDICAL DEVICES 审中-公开
公开(公告)号：WO2022192911A1
公开(公告)日：2022-09-15
申请号：PCT/US2022/071107
申请日：2022-03-11
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： MECH, Brian, V. , GREENBERG, Robert, J.
IPC分类号： A61B5/024 , A61B5/02
摘要： The disclosure provides systems and methods for detecting, monitoring, and/or treating obstructive sleep apnea, as well as other conditions, using vital sign and/or biometric data collected and/or imputed from one or more photoplethysmography sensors in conjunction with vital sign and/or biometric data from one or more additional sensors such as activity, body position, ECG, HR, or SpO2 levels, e.g., as feedback to control therapy and/or to titrate therapy on a periodic basis.

3. 发明申请

WO2022099293A1 SENSORS AND METHODS FOR DETERMINING RESPIRATION 审中-公开
公开(公告)号：WO2022099293A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/072248
申请日：2021-11-04
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： ELYAHOODAYAN, Sahar , SHELTON, Brian, M. , TALBOT, Neal, H.
IPC分类号： A61B5/00 , A61N1/00 , A61F5/56
摘要： The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

4. 发明申请

WO2022099292A1 SENSORS AND METHODS FOR DETERMINING RESPIRATION 审中-公开
公开(公告)号：WO2022099292A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/072247
申请日：2021-11-04
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： ELYAHOODAYAN, Sahar , SHELTON, Brian M. , TALBOT, Neal H.
IPC分类号： A61B5/00 , A61F5/56 , A61N1/05 , A61N1/36 , A61N1/372
摘要： The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

5. 发明申请

WO2022051314A1 ELECTRODE LEADS HAVING MULTI-APPLICATION NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2022051314A1
公开(公告)日：2022-03-10
申请号：PCT/US2021/048583
申请日：2021-09-01
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： DEARDEN, Brian Ralph , SHELTON, Brian, M. , TALBOT, Neil
IPC分类号： A61N1/05 , A61N1/36
摘要： An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

6. 发明申请

WO2018080600A1 NERVE CUFF ELECTRODES FABRICATED USING OVER-MOLDED LCP SUBSTRATES 审中-公开
标题翻译：使用过模LCP基片制造的神经袖电极
公开(公告)号：WO2018080600A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/039424
申请日：2017-06-27
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： SCHMIDT, Siegmar , NG, Boon Khai , DEARDEN, Brian R. , HANSEN, Morten
IPC分类号： A61N1/05 , A61N1/36 , A61N1/375 , A61B5/0488
摘要： An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.
摘要翻译：电极引线可以包括柔性电路，柔性电路包括平面电介质基板，电介质基板包括具有相对端部的细长引线基板部分，设置在引线基板部分的一端上的电极承载基板部分，以及连接器衬底部分，布置在所述引线衬底部分的另一端上，其中所述引线衬底部分被预成形为三维结构。柔性电路还可以包括从连接器基体部向电极承载基底部分延伸的导电迹线，形成在连接器基底部分的第一窗口，以露出导电迹线，以形成一个连接器焊盘，和第二窗口形成在电极承载衬底部分以暴露导电迹线以形成电极焊盘。电极引线可以进一步包括结合连接器基底部分的引线连接器。

7. 发明申请

WO2006098791A2 SYSTEM AND METHOD FOR LOCATING OBJECTS AND COMMUNICATING WITH THE SAME 审中-公开
标题翻译：用于定位对象并与之通信的系统和方法
公开(公告)号：WO2006098791A2
公开(公告)日：2006-09-21
申请号：PCT/US2005/046333
申请日：2005-12-20
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH , KARR, Lawrence, J.
发明人： KARR, Lawrence, J.
IPC分类号： H01Q11/02
CPC分类号： G01S13/765 , G01S13/878
摘要： Communication between a remote locator and a transponder is used to determine the relative position of the transponder. The transponder and locator each include a transmitter and a receiver. The locator transmits an inquiry in the form of a relatively powerful cyclically encoded signal with repetitive elements, uniquely associated with a target transponder. Periodically, each transponder correlates its coded ID against a possible inquiry signal, determining frequency, phase and framing in the process. Upon a match, the transponder transmits a synthesized response coherent with the received signal. The locator integrates multiple cyclical response elements, allowing low-power transmissions from the transponder. The locator correlates the integrated response, determines round-trip Doppler shift, time-of-flight, and then computes the distance and angle to the transponder. The transponder can be wearable, bionically implanted, or attached to, or embedded in, some object.
摘要翻译：远程定位器和应答器之间的通信用于确定应答器的相对位置。应答器和定位器各自包括发射机和接收机。定位器以具有与目标应答器唯一相关联的重复元素的相对强大的周期性编码信号的形式发送查询。定期地，每个应答器将其编码的ID与可能的查询信号相关联，从而确定该过程中的频率，相位和帧。在匹配时，应答器发送与接收信号相干的合成响应。定位器集成了多个循环响应元件，允许来自应答器的低功率传输。定位器将综合响应相关联，确定往返多普勒频移，飞行时间，然后计算与应答器的距离和角度。应答器可以是穿戴式的，仿生植入的，或附着到或嵌入到某物中。

8. 发明申请

WO2021207740A1 ACOUSTIC SENSING FOR RESPIRATION DETECTION 审中-公开
公开(公告)号：WO2021207740A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/026916
申请日：2021-04-12
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： SHELTON, Brian M. , ELYAHOODAYAN, Sahar , SURI, Harshit R.
IPC分类号： A61N1/36 , A61B5/00 , A61B5/113
摘要： The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

9. 发明申请

WO2017180670A2 PRESSURE SENSORS WITH TENSIONED MEMBRANES 审中-公开
标题翻译：带张紧膜的压力传感器
公开(公告)号：WO2017180670A2
公开(公告)日：2017-10-19
申请号：PCT/US2017/027074
申请日：2017-04-11
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： SCHMIDT, Siegmar , DAI, William A. , NG, Boon Khai
IPC分类号： G01L9/00 , G01L19/04 , G01L19/14 , G01L19/06
摘要： Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.
摘要翻译：公开了具有环张紧膜的压力传感器。张紧环以这样的方式结合到膜上，该方式导致张紧环对膜施加张力，使膜变平并减少或消除在生产期间可能发生的缺陷。膜在张紧环外部的点处与传感器壳体结合，防止将膜结合到壳体的过程将缺陷引入到膜的张紧部分中。可以在电容式压力传感器中将电介质引入膜和反电极之间的间隙中，从而导致改善的动态范围。

10. 发明申请

WO2006062710A1 DIAPHRAGMATIC PACING WITH PHYSIOLOGICAL NEED ADJUSTMENT 审中-公开
标题翻译：具有生理需要调整的膜片
公开(公告)号：WO2006062710A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/041485
申请日：2005-11-16
申请人： THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
发明人： MANDELL, Lee, J.
IPC分类号： A61N1/05
CPC分类号： A61N1/37288 , A61N1/36003 , A61N1/3601 , A61N1/36139 , A61N1/37205 , A61N1/3787
摘要： A system and method that provides adjustable diaphragmatic pacing to a patient having an associated neurological deficit with adjustments occurring automatically in response to the patient’s physiological need. In a first implementation, physiological need is determined according to the patient’s activity level, e.g., as determined by the patient’s motion as detected by one or more accelerometers. In a second implementation, physiological need is determined by an oximeter measuring the current oxygen level of the patient’s blood. In a third implementation, physiological need is determined by a combination of the first and second implementation according to sensed motion and sensed oxygen level. Preferably, systems of the present invention are implantable and powered by rechargeable batteries and may be integrated with a system of implantable devices that restores motor functions to an injured patient and this restoration then requires an adjustable respiration rate in response to the patient’s restored movements.
摘要翻译：一种系统和方法，其向具有相关神经功能缺损的患者提供可调节的膈肌起搏，其响应于患者的生理需要自动进行调整。在第一实施方案中，根据患者的活动水平来确定生理需要，例如，由患者的运动确定，如由一个或多个加速度计所检测的。在第二实施方案中，生理需求由测量患者血液的当前氧气水平的血氧计来确定。在第三实施方式中，根据感测到的运动和感测的氧水平，通过第一和第二实施方式的组合来确定生理需要。优选地，本发明的系统是可植入的并且由可再充电电池供电并且可以与将可运动功能恢复到受伤患者的可植入装置的系统集成，并且该恢复然后响应于患者恢复的运动需要可调节的呼吸速率。

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