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    • 3. 发明授权
    • Aminopropylidene derivative
    • 氨基亚丙基衍生物
    • US08653285B2
    • 2014-02-18
    • US13055780
    • 2009-07-31
    • Kunihiko HigashiuraTakashi OginoTaizo ItoKoji KunimasuKazuhito Furukawa
    • Kunihiko HigashiuraTakashi OginoTaizo ItoKoji KunimasuKazuhito Furukawa
    • C07D313/08C07D333/50A61K31/38A61K31/335
    • C07D495/04C07D333/78
    • An aminopropylidene derivative having excellent histamine receptor antagonistic action, a compound which is useful as a pharmaceutical composition, especially as an active ingredient, having alleviated side effects in the central nervous system is described. In the aminopropylidene derivative, R1 and R2, which may be identical or different, stand for a hydrogen, a substituted carbonyl, a substituted carbonylalkyl, and acrylic acid, excluding a case where both are hydrogen; R3 and R4, which may be identical or different, stand for hydrogen, an alkyl which may be substituted with phenyl, or the like; A stands for unsubstituted or an oxo; B stands for a carbon or an oxygen; one of X and Y stands for a carbon and the other stands for a sulfur, a broken line part stands for a single bond or a double bond, and a wavy line stands for cis-form and/or trans-form.
    • 描述了具有优异的组胺受体拮抗作用的氨基亚丙基衍生物,可用作药物组合物的化合物,特别是作为活性成分,在中枢神经系统中具有缓解的副作用。 在氨基亚丙基衍生物中,R 1和R 2可以相同或不同,代表氢,取代的羰基,取代的羰基烷基和丙烯酸,不包括两者均为氢的情况; R3和R4可以相同或不同,代表氢,可被苯基取代的烷基等; A代表未取代或氧代; B代表碳或氧; X和Y中的一个代表碳,另一个代表硫,虚线部分代表单键或双键,波浪线代表顺式和/或反式。
    • 4. 发明授权
    • Oxepin derivative
    • 奥克辛衍生物
    • US08222419B2
    • 2012-07-17
    • US12311215
    • 2007-09-27
    • Kunihiko HigashiuraTakashi OginoKazuhito FurukawaYuriko Yamazaki
    • Kunihiko HigashiuraTakashi OginoKazuhito FurukawaYuriko Yamazaki
    • C07D401/00
    • C07D405/04
    • The present invention provides a compound, an oxepin derivative having excellent histamine receptor antagonistic action, which is useful as an antihistamine. The oxepin derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low intracerebral migration even when a mouse that is orally administered with the compound is subjected to an intracerebral receptor binding test, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The oxepin derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
    • 本发明提供一种化合物,具有优异的组胺受体拮抗作用的氧杂环丁衍生物,其可用作抗组胺药。 本发明的oxepin衍生物具有有效的组胺受体拮抗作用。 此外,本发明的化合物即使经口给予该化合物的小鼠进行脑内受体结合试验,也显示低脑内迁移,使得该化合物具有优选的减轻中枢神经系统副作用的性质,例如 作为嗜睡 本发明的oxepin衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药如睡意觉是非常有用的。
    • 5. 发明授权
    • Clamp of disk rotation driver
    • 磁盘旋转驱动器夹
    • US08199428B2
    • 2012-06-12
    • US12596909
    • 2008-03-24
    • Toshimitsu ArakiTakashi OginoAtsushi Shitama
    • Toshimitsu ArakiTakashi OginoAtsushi Shitama
    • G11B17/02
    • G11B17/0284
    • A clamp for a disk rotation driver stably and surely supports a disk in the disk rotation driver.The clamp 7 for a disk rotation driver 1 having a central portion and a periphery being circumferentially provided with a contact portion 13, the central portion fastened to a hub 5 to be rotated, and the contact portion 13 pressed against a recordable disk 3 attached to the hub 5 to apply a pressing force Fv to the disk 3 in a rotation axis direction and fixedly support the magnetic disk 3 on the hub 5, the clamp 7 comprising: a wall portion 25 extending from the periphery and being oriented in the rotation axis direction to form the contact portion 13 so that a frictional force μFy produced between the contact portion 13 and the magnetic disk 3 and resisting a locomotion Fx that acts on the contact portion 13 and radially outwardly biases the contact portion 13 when the contact portion 13 is in contact with the magnetic disk 3 is equal to or larger than the locomotion Fx.
    • 用于盘旋转驱动器的夹具稳定且可靠地支撑盘旋转驱动器中的盘。 用于具有中心部分和周边的盘旋转驱动器1的夹具7周向地设置有接触部分13,中心部分紧固到要旋转的轮毂5,并且接触部分13压靠在可记录盘3上,附接到 轮毂5沿旋转轴线方向将压力Fv施加到盘3,并将磁盘3固定地支撑在轮毂5上,夹具7包括:壁部25,其从周边延伸并且沿旋转轴定向 方向形成接触部分13,使得在接触部分13和磁盘3之间产生的摩擦力μFy抵抗作用在接触部分13上的运动Fx并且当接触部分13为径向向外偏压接触部分13时 与磁盘3接触等于或大于运动Fx。
    • 7. 发明申请
    • PIPERIDINE DERIVATIVE
    • 哌啶衍生物
    • US20100331365A1
    • 2010-12-30
    • US12864878
    • 2008-11-20
    • Kunihiko HigashiuraTakashi OginoTaizo ItoHiroyuki Iwatsuki
    • Kunihiko HigashiuraTakashi OginoTaizo ItoHiroyuki Iwatsuki
    • A61K31/4535C07D409/02A61P37/08
    • C07D495/04C07D409/04C07D497/04
    • The present invention provides a compound a piperidine derivative having excellent histamine receptor antagonistic action, which is useful as active ingredients of a pharmaceutical composition, especially an antihistamine. The piperidine derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low brain transfer even in a cerebral receptor binding test where a mouse is orally administered with the compound, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The piperidine derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
    • 本发明提供了具有优异的组胺受体拮抗作用的化合物哌啶衍生物,其可用作药物组合物,特别是抗组胺药的活性成分。 本发明的哌啶衍生物具有有效的组胺受体拮抗作用。 此外,本发明的化合物即使在小鼠口服给药化合物的脑受体结合试验中也显示低脑转移,因此该化合物具有减轻中枢神经系统中的副作用的优选性质,例如嗜睡。 本发明的哌啶衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药例如嗜睡是非常有用的。
    • 9. 发明申请
    • CLAMP OF DISK ROTATION DRIVER
    • 盘旋转驱动器
    • US20100097719A1
    • 2010-04-22
    • US12596909
    • 2008-03-24
    • Toshimitsu ArakiTakashi OginoAtsushi Shitama
    • Toshimitsu ArakiTakashi OginoAtsushi Shitama
    • G11B17/02
    • G11B17/0284
    • A disc can be supported stably and surely. The clamp (7) of a disc rotation driver (1) provided with an abutting portion (13) circularly at the outer circumferential part with the central part being secured and fixed to a rotary drivable hub (5), and supporting a magnetic disc (3) fixedly on the hub (5) by bringing the abutting portion (13) into contact with the magnetic disc (3) attached to the hub (5) to enable recording of information thereby imparting a pushing force (Fy) in the direction of the axis of rotation, characterized in that a wall portion (25) provided with the abutting portion (13) and directed in the direction of the axis of rotation is provided at the outer circumferential part in order to make the frictional force (μFy) between the abutting portion (13) and the magnetic disc (3), resisting against a radial outward moving force (Fx) acting on the abutting portion (13) under a state where the abutting portion (13) is in contact with the magnetic disc (3), equal to or higher than the moving force (Fx).
    • 可以稳定可靠地支撑光盘。 盘旋转驱动器(1)的夹具(7)在外圆周部分设有一圆形的邻接部分(13),其中心部分被固定并固定到旋转可驱动轮毂(5)上,并且支撑磁盘 3)通过使邻接部分(13)与附接到轮毂(5)的磁盘(3)接触而固定在轮毂(5)上,以便能够记录信息,从而在方向上施加推力(Fy) 旋转轴线,其特征在于,在外周部分设置有设置有抵接部分(13)并沿着旋转轴线方向指向的壁部分(25),以使摩擦力(μFy)在 抵靠部分(13)和磁盘(3)在抵靠部分(13)与磁盘接触的状态下抵抗作用在邻接部分(13)上的径向向外移动力(Fx) 3),等于或高于移动力(Fx)。