专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

IN1519CH2007A Process for the preparation of O-desmethylvenlafaxine succinate polymorphic forms 未知
公开(公告)号：IN1519CH2007A
公开(公告)日：2009-09-11
申请号：IN1519CH2007
申请日：2007-07-16
申请人： MATRIX LAB LTD , JETTI RAMAKOTESWARA RAO , KOILKONDA PURANDHAR , TUMMANAPALLY JAGAN MOHANA CHAR , VADLAMUDI MOHANA VAMSI KRISHNA , BARIK PRASANTH KUMAR , TYAGI OM DUTT
发明人： JETTI RAMAKOTESWARA RAO , KOILKONDA PURANDHAR , TUMMANAPALLY JAGAN MOHANA CHARY , VADLAMUDI MOHANA VAMSI KRISHNA , BARIK PRASANTH KUMAR , TYAGI OM DUTT
摘要： The present invention relates to process for the preparation of novel crystalline Desmethylvenlafaxine succinate polymorphic Forms-A, B. The present invention also relates to novel processes for the preparation of 0-Desmethylvenlafaxine succinate polymorphic Forms-(I), (II), (III) and amorphous.

2. 发明申请

WO2009087679A3 PROCESS FOR PREPARING POLYMORPHIC FORMS OF (S)-6-CHLORO-(CYCLOPROPYLETHYNYL)-1,4-DIHYDRO-4-(TRIFLUOROMETHYL)-2H-3,1-BENZOXAZIN-2-ONE 审中-公开
标题翻译：制备（S）-6-氯 - （环丙基乙基）-1,4-二氢-4-（三氟甲基）-2H-3,1-苯并恶嗪-2-酮的多晶型的方法
公开(公告)号：WO2009087679A3
公开(公告)日：2010-01-21
申请号：PCT/IN2008000860
申请日：2008-12-24
申请人： MATRIX LAB LTD , TYAGI OM DUTT , JETTI RAM K R , RAMIREDDY B A
发明人： TYAGI OM DUTT , JETTI RAM K R , RAMIREDDY B A
IPC分类号： C07D265/18
CPC分类号： C07D265/18
摘要： Disclosed herein is a novel process for preparing polymorphic Forms of (S)-6- chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2- one referred as M1, I, II, ß, and ?.
摘要翻译：本文公开了一种制备（S）-6-氯 - （环丙基乙炔基）-1,4-二氢-4-（三氟甲基）-2H-3,1-苯并恶嗪-2-酮的多晶形式的新颖方法，称为M1， I，II，ß和？

3. 发明申请

WO2009010990A3 PROCESS FOR THE PREPARATION OF O-DESMETHYLVENLAFAXINE SUCCINATE POLYMORPHIC FORMS 审中-公开
标题翻译： O-DESMETHYLVENLAFAXINE琥珀酸盐多晶型的制备方法
公开(公告)号：WO2009010990A3
公开(公告)日：2009-12-03
申请号：PCT/IN2008000450
申请日：2008-07-15
申请人： MATRIX LAB LTD , JETTI RAMAKOTESWARA RAO , KOILKONDA PURANDHAR , TUMMANAPALLY JAGAN MOHANA CHAR , VADLAMUDI MOHANA VAMSI KRISHNA , BARIK PRASANTH KUMAR , TYAGI OM DUTT
发明人： JETTI RAMAKOTESWARA RAO , KOILKONDA PURANDHAR , TUMMANAPALLY JAGAN MOHANA CHARY , VADLAMUDI MOHANA VAMSI KRISHNA , BARIK PRASANTH KUMAR , TYAGI OM DUTT
IPC分类号： C07C213/10 , C07C215/52
CPC分类号： C07C213/10 , C07B2200/13 , C07C2601/14 , C07C215/64
摘要： The present invention relates to process for the preparation of novel crystalline Desmethylvenlafaxine succinate polymorphic Forms- A, B. The present invention also relates to novel processes for the preparation of 0-Desmethylvenlafaxine succinate polymorphic Forms-(I), (II), (III) and amorphous.
摘要翻译：本发明还涉及制备O-去甲基文拉法辛琥珀酸盐多晶型物 - （I），（II），（III）的新颖方法，）和无定形的。

4. 发明申请

WO2009084039A2 PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL 审中-公开
标题翻译： 1- [2-（二甲基氨基）-1-（4-苯酚）乙基]环己醇的制备方法
公开(公告)号：WO2009084039A2
公开(公告)日：2009-07-09
申请号：PCT/IN2008000867
申请日：2008-12-26
申请人： MATRIX LAB LTD , TYAGI OM DUTT , LAHARI SASWATA , KOILKONDA PURANDHAR , MOHANA CHARY TUMMANAPALL JAGAN , VADLAMUDI MOHAN VAMSI KRISHNA , SARMA INUPAKUTIKA VENKATA BALA KISHORE , RAO ACHANTA SURYA NAGESWARA
发明人： TYAGI OM DUTT , LAHARI SASWATA , KOILKONDA PURANDHAR , MOHANA CHARY TUMMANAPALL JAGAN , VADLAMUDI MOHAN VAMSI KRISHNA , SARMA INUPAKUTIKA VENKATA BALA KISHORE , RAO ACHANTA SURYA NAGESWARA
IPC分类号： C07C213/02 , C07C215/60
CPC分类号： C07C215/64 , C07C2601/14
摘要： The present invention relates to an improved, process for large scale production of 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol (O- desmethylvenlafaxine) or its pharmaceutically acceptable salts with increased yield and minimal impurities.
摘要翻译：本发明涉及一种改进的大规模生产1- [2-（二甲基氨基）-1-（4-苯酚）乙基]环己醇（O-去甲基文拉法新）或其药学上可接受的盐的方法，其具有增加的产率和最小的杂质。

5. 发明申请

WO2009044413A3 IMPROVED PROCESS FOR PREPARING PALIPERIDONE, NOVEL POLYMORPHIC FORMS OF THE SAME AND PROCESS THEREOF 审中-公开
公开(公告)号：WO2009044413A3
公开(公告)日：2009-04-09
申请号：PCT/IN2008/000642
申请日：2008-10-06
申请人： MATRIX LABORATORIES LIMITED , TYAGI, Om, Dutt , VELLENKI, Siva, Ram, Parasad , SAHU, Arabinda , BALSU, RajaBabu , PHADHURI, Naveen, Kumar , JETTI, Ramakoteswara, Rao , GORANTLA, Asha, Rani , DATTA, Debashish
发明人： TYAGI, Om, Dutt , VELLENKI, Siva, Ram, Parasad , SAHU, Arabinda , BALSU, RajaBabu , PHADHURI, Naveen, Kumar , JETTI, Ramakoteswara, Rao , GORANTLA, Asha, Rani , DATTA, Debashish
IPC分类号： C07D471/04
摘要： Disclosed herein is an improved process for producing paliperidone, wherein the process includes hydrogenating 3-(2-chloroethyl)-2-methyl-9-(hydroxyprotected)-4H- pyrido[1.2-a] pyrimidin-4-one in presence of an acid and a catalyst under hydrogen pressure to give 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H- pyrido[l,2-a]-pyrimidin-4-one and condensing 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9- hydroxy-2-methyl-4H-pyrido[l,2-a] -pyrimidin-4-one with 6-fluoro-3-(4-piperidinyl)- 1,2-benzisoxazole in presence of a base and a solvent to give paliperidone. In addition, the invention discloses novel polymorphic Forms VI and VII of paliperidone. Furthermore the invention discloses processes for producing the novel polymorphic forms and Form I from the novel polymorphic forms thereof.

6. 发明申请

WO2009044413A2 IMPROVED PROCESS FOR PREPARING PALIPERIDONE, NOVEL POLYMORPHIC FORMS OF THE SAME AND PROCESS THEREOF 审中-公开
标题翻译：改进的制备哌拉西酮的新方法及其新形式的多晶型物及其加工
公开(公告)号：WO2009044413A2
公开(公告)日：2009-04-09
申请号：PCT/IN2008000642
申请日：2008-10-06
申请人： MATRIX LAB LTD , TYAGI OM DUTT , VELLENKI SIVA RAM PARASAD , SAHU ARABINDA , BALSU RAJABABU , PHADHURI NAVEEN KUMAR , JETTI RAMAKOTESWARA RAO , GORANTLA ASHA RANI , DATTA DEBAHISH
发明人： TYAGI OM DUTT , VELLENKI SIVA RAM PARASAD , SAHU ARABINDA , BALSU RAJABABU , PHADHURI NAVEEN KUMAR , JETTI RAMAKOTESWARA RAO , GORANTLA ASHA RANI , DATTA DEBAHISH
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Disclosed herein is an improved process for producing paliperidone, wherein the process includes hydrogenating 3-(2-chloroethyl)-2-methyl-9-(hydroxyprotected)-4H- pyrido[1.2-a] pyrimidin-4-one in presence of an acid and a catalyst under hydrogen pressure to give 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H- pyrido[l,2-a]-pyrimidin-4-one and condensing 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9- hydroxy-2-methyl-4H-pyrido[l,2-a] -pyrimidin-4-one with 6-fluoro-3-(4-piperidinyl)- 1,2-benzisoxazole in presence of a base and a solvent to give paliperidone. In addition, the invention discloses novel polymorphic Forms VI and VII of paliperidone. Furthermore the invention discloses processes for producing the novel polymorphic forms and Form I from the novel polymorphic forms thereof.
摘要翻译：本文公开了一种用于生产帕潘立酮的改进方法，其中该方法包括在存在下列物质的情况下氢化3-（2-氯乙基）-2-甲基-9-（羟基保护的）-4H-吡啶并[1,2-a]嘧啶-4-酮（2-氯乙基）-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a] - 嘧啶-4-酮，并将3-（2-氯乙基）-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a] - 嘧啶-4-酮与6-氟 - 3-（4-哌啶基）-1,2-苯并异恶唑在碱和溶剂存在下反应，得到帕潘立酮。另外，本发明公开了帕潘立酮的新型多晶型物VI和VII。此外，本发明公开了由其新多晶型形式制备新型多晶型和晶型I的方法。

7. 发明申请

WO2008026220A1 A PROCESS FOR PURIFICATION OF 7-(4-BROMOBUTOXY)-3,4 DIHYDROCARBOSTYRIL, AN INTERMEDIATE FOR MANUFACTURE OF ARIPIRAZOLE 审中-公开
标题翻译：一种用于纯化7-（4-溴甲氧基）-3,4二氢碳二恶烷的方法，用于制备阿维拉唑的中间体
公开(公告)号：WO2008026220A1
公开(公告)日：2008-03-06
申请号：PCT/IN2007/000310
申请日：2007-07-24
申请人： LUPIN LIMITED , TYAGI, Om, Dutt , THAPER, Rajesh , PRABHAVAT, Manoj, Devilalji , MANE, Narendra, Dattatreya , MAHAJAN, Sanjay , SRIVASTAVA, Tushar, Kumar
发明人： TYAGI, Om, Dutt , THAPER, Rajesh , PRABHAVAT, Manoj, Devilalji , MANE, Narendra, Dattatreya , MAHAJAN, Sanjay , SRIVASTAVA, Tushar, Kumar
IPC分类号： C07D401/12 , A61K31/496
CPC分类号： C07D401/12 , C07D215/227
摘要： A process for the purification of 7- (4-bromobutoxy)-3,4- dihydrocarbostyril, substantially free of dimer impurity, said process comprising providing a solution of crude 7- (4-bromobutoxy)-3,4- dihydrocarbostyril containing the dimer impurity in an organic solvent selected from the group of halogenated hydrocarbon solvent, aromatic hydrocarbon, alcohols, alkyl esters of C1-C4 alkanoic acids, ethers, diethyl ester and ketones ; converting to a salt by the addition of an inorganic acid; separation of 1,4-bis [3,4-dihydro-2 (1H)-quinolinone-7-oxy] butane salt (dimer impurity salt) from the mixture, based on the difference in at least one physical property of 7- (4-bromobutoxy)-3,4- dihydrocarbostyril salt and the salt of dimer impurity; liberating the 7- (4-bromobutoxy)-3,4- dihydrocarbostyril salt by treating with an inorganic base; precipitating 7- (4-bromobutoxy)-3,4- dihydrocarbostyril by adding an anti-solvent.
摘要翻译：一种净化7-（4-溴丁氧基）-3,4-二氢喹诺酮的方法，基本上不含二聚体杂质，所述方法包括提供含有二聚体的粗7-（4-溴丁氧基）-3,4-二氢喹诺酮的溶液选自卤代烃溶剂，芳族烃，醇，C1-C4链烷酸的烷基酯，醚，二乙基酯和酮的有机溶剂中的杂质; 通过加入无机酸转化成盐; 基于七（（（（））的至少一种物理性质的不同，从混合物中分离1,4-双[3,4-二氢-2（1H） - 喹啉酮-7-氧]丁烷盐（二聚体杂质盐） 4-溴丁氧基）-3,4-二氢喹诺酮和二聚体杂质盐; 通过用无机碱处理释放7-（4-溴丁氧基）-3,4-二氢喹诺酮，通过加入抗溶剂沉淀7-（4-溴丁氧基）-3,4-二氢喹诺酮。

8. 发明申请

WO2006106529A1 A CO-SPRAY DRIED COMPOSITION OF CEFEPIME WITH BASE AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：具有基础的CO喷雾干燥组合物及其制备方法
公开(公告)号：WO2006106529A1
公开(公告)日：2006-10-12
申请号：PCT/IN2006/000114
申请日：2006-04-03
申请人： LUPIN LIMITED , TYAGI, Om, Dutt , CHAUHAN, Yogendra, Kumar , MEHARE, Kishor, Gulabrao
发明人： TYAGI, Om, Dutt , CHAUHAN, Yogendra, Kumar , MEHARE, Kishor, Gulabrao
IPC分类号： C07D501/00 , A61K31/545
CPC分类号： C07D501/00
摘要： Stable and sterile composition of cefepime and a process for preparing the same. Amorphous composition containing cefepime acid addition salt or solvates thereof and organic or inorganic base obtained by spray drying of their aqueous solution. The process comprises dissolving a composition containing mixture of cefepime acid addition salt and a pharmaceutically acceptable non-toxic organic or inorganic base in water to obtain aqueous solution, filtration of aqueous solution through 0.2 micron membrane filter and subjecting the clear aqueous solution to spray drying, or dissolving a cefepime acid addition salt in water, dissolving a pharmaceutically acceptable non-toxic organic or inorganic base in water, addition of solution from operation (v) to solution from operation (iv) at 0-30°C, preferably at 0-10°C to obtain a solution having a pH in the range of 3.0-7.0, filtration of aqueous solution through 0.2 micron membrane filter, and subjecting the clear aqueous solution to spray drying.
摘要翻译：头孢吡肟的稳定无菌组合物及其制备方法。含有头孢吡肟酸加成盐或溶剂合物的无定形组合物和通过其水溶液的喷雾干燥获得的有机或无机碱。该方法包括将含有头孢吡肟酸加成盐和药学上可接受的无毒有机或无机碱的混合物的组合物溶解在水中以获得水溶液，通过0.2微米膜过滤器过滤水溶液并使透明水溶液喷雾干燥，或将头孢吡肟酸加成盐溶解在水中，将药学上可接受的无毒有机或无机碱溶解在水中，在操作（v）中加入溶液至0-30℃，优选0〜 10℃，得到pH范围为3.0-7.0的溶液，通过0.2微米膜过滤器过滤水溶液，并对透明水溶液进行喷雾干燥。

9. 发明申请

WO2005100348A1 AMORPHOUS ZIPRASIDONE HYDROCHLORIDE 审中-公开
公开(公告)号：WO2005100348A1
公开(公告)日：2005-10-27
申请号：PCT/IN2005/000115
申请日：2005-04-15
申请人： LUPIN LIMITED , TYAGI, Om, Dutt , SRIVASTAVA, Tushar, Kumar , CHAVAN, Yuvraj, Atmaram
发明人： TYAGI, Om, Dutt , SRIVASTAVA, Tushar, Kumar , CHAVAN, Yuvraj, Atmaram
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： A process for preparation of ziprasidone hydrochloride which is in amorphous form. The process comprises providing a ziprasidone hydrochloride solution in a mixture of alcoholic solvent and acetonitrile and spray drying the solution of ziprasidone hydrochloride.
摘要翻译：一种无定形形式的齐拉西酮盐酸盐的制备方法。该方法包括在醇溶剂和乙腈的混合物中提供齐拉昔酮盐酸盐溶液并喷雾干燥齐拉昔酮盐酸盐溶液。

10. 发明申请

WO2002094742A1 PROCESS FOR THE PREPARATION OF AMORPHOUS CILASTATIN SODIUM 审中-公开
标题翻译：制备无定形青TIN素钠的方法
公开(公告)号：WO2002094742A1
公开(公告)日：2002-11-28
申请号：PCT/IB2002/001696
申请日：2002-05-17
申请人： RANBAXY LABORATORIES LIMITED , KUMAR, Yatendra , TYAGI, Om, Dutt , ROHTAGI, Amit
发明人： KUMAR, Yatendra , TYAGI, Om, Dutt , ROHTAGI, Amit
IPC分类号： C07B57/00
CPC分类号： C07C319/28 , C12N9/48 , C07C323/59
摘要： The present invention relates to a cost effective and industrially advantageous process for the preparation of amorphous cilastatin sodium.
摘要翻译：本发明涉及制备无定形西司他丁钠的成本效益和工业上有利的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式