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    • 10. 发明申请
    • MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
    • 用于治疗相关疾病的前列腺素(PGI2)受体的调节剂
    • WO2010077275A1
    • 2010-07-08
    • PCT/US2009/006408
    • 2009-12-07
    • ARENA PHARMACEUTICALS, INC.TRAN, Thuy-AnhHAYASHI, RenaIBARRA, Jason B.ULLMAN, BrettZOU, Ning
    • TRAN, Thuy-AnhHAYASHI, RenaIBARRA, Jason B.ULLMAN, BrettZOU, Ning
    • C07D237/14C07D401/04C07D403/04C07D409/04C07D253/07A61K31/50A61K31/501A61K31/53A61P11/08
    • C07D237/14C07D253/07C07D401/04C07D403/04C07D409/04
    • Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
    • 式Ia的环己烷衍生物及其药物组合物,其调节PGI 2受体的活性。 本发明的化合物及其药物组合物涉及可用于治疗肺动脉高压(PAH)和相关疾病的方法; 血小板聚集; 冠状动脉疾病; 心肌梗死; 短暂性脑缺血发作; 心绞痛; 行程; 缺血再灌注损伤; 再狭窄; 房颤; 在血管成形术或冠状动脉旁路手术个体或患有心房颤动的个体中血凝块形成; 动脉粥样硬化; 动脉粥样硬化; 哮喘或其症状; 糖尿病性相关疾病如糖尿病性周围神经病变,糖尿病性肾病或糖尿病性视网膜病变; 青光眼或其他眼睛异常眼内疾病; 高血压; 炎; 银屑病; 牛皮癣关节炎 类风湿关节炎; 克罗恩病; 移植排斥反应 多发性硬化症 系统性红斑狼疮(SLE); 溃疡性结肠炎 缺血再灌注损伤; 再狭窄; 动脉粥样硬化; 粉刺; 1型糖尿病; 2型糖尿病; 败血症; 和慢性阻塞性肺疾病(COPD)。