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1. 发明申请

WO2005029031A3 METHOD AND APPARATUS FOR QUANTITATING SURFACE-BINDING OPTICAL RESONANCE PROFILES 审中-公开
公开(公告)号：WO2005029031A3
公开(公告)日：2005-03-31
申请号：PCT/US2004/024788
申请日：2004-08-02
申请人： BIACORE AB , TRACY, David, H.
发明人： TRACY, David, H.
IPC分类号： G01N27/26
摘要： Empirical profile curve fits (260) are used to quantitative the surface optical resonance profiles (268) using two EPF stages of calibration and fit. The calibration surface binding optical resonance scan is obtained with fine angle or wavelength spacing over a range including the full resonance profiles for all regions. The main calibration module (210) together with the first derivative curves and the diagnostic information generates each profile region of interest. The individual ROI scans are used for measurements of the resonance shifts relative to the empirical profile. In a preferred embodiment the instrument control and data acquisition software sets the internal parameters in the EPT calibration module and sends the raw data from a calibration scan to the EPF Calibration module which funnels the data through a sub sampler and a Savitsky-Golan smoothing routine before taking derivatives and characterizing the data to create the empirical profile for the chip (202).

2. 发明申请

WO2005029031A2 METHOD AND APPARATUS FOR QUANTITATING SURFACE-BINDING OPTICAL RESONANCE PROFILES 审中-公开
标题翻译：用于定量表面结合光学共振谱的方法和装置
公开(公告)号：WO2005029031A2
公开(公告)日：2005-03-31
申请号：PCT/US2004024788
申请日：2004-08-02
申请人： HTS BIOSYSTEMS INC , TRACY DAVID H
发明人： TRACY DAVID H
IPC分类号： G01N21/55 , G01N
CPC分类号： G01N21/274 , G01N21/553 , G01N21/648
摘要： Empirical Profile Fits are used to quantitate Surface-binding Optical Resonance profiles. The EPF process has two stages, Calibration and Fit. In the Calibration stage, a calibration surface-binding optical resonance scan is obtained with relatively fine angle or wavelength spacing over a range sufficient to include full resonance profiles for all regions. Smoothed, subsampled empirical profiles for each Region of Interest are generated by the main calibration module, together with first derivative curves and diagnostic information. Properties returned may include approximate resonance position, depth, and width. In the Fit stage, individual ROI scans are used for measurement of resonance shifts relative to the empirical profile. The fitting module identifies the region of the experimental scan encompassing the resonance and fits that region using the previously stored empirical profiles, quantifying and returning the desired values, including the shift in the resonance as compared to its location at calibration, estimated absolute angles or wavelengths, time of resonance minimum, and additional diagnostic and quality information. Optionally, data obtained from either Calibration or Fit stages may be exported for analysis on other systems. In a preferred embodiment, Instrument Control and Data Acquisition Software sets internal parameters in the EPF Calibration module and sends raw data from a calibration scan to the EPF Calibration module, which funnels the data through a Subsampler and a Savitsky-Golay smoothing routine before taking derivatives and characterizing the data to create an empirical profile for the chip. The empirical profiles are then optionally stored. Next, Instrument Control and Data Acquisition Software sets internal parameters in the EPF Fitting module and sends raw data from a run-time scan performed utilizing the chip to the EPF Fitting module, which qualifies it, queries the EPF Calibration module for the empirical profile for the chip, and fits the curve, iterating when necessary. Results from the fitting process are then returned and thereby provided to the user.
摘要翻译：经验描述适合用于定量表面结合光学共振特征。 EPF过程有两个阶段：校准和拟合。在校准阶段，在足以包括所有区域的完整共振分布的范围内，获得具有相对精细的角度或波长间隔的校准表面结合光学共振扫描。每个感兴趣区域的平滑，二次抽样经验概况由主校准模块，一阶导数曲线和诊断信息一起生成。返回的属性可能包括近似共振位置，深度和宽度。在Fit阶段，单独的ROI扫描用于相对于经验分布的谐振偏移的测量。拟合模块识别包含谐振的实验扫描的区域，并使用先前存储的经验曲线拟合该区域，量化并返回期望值，包括与其在校准时的位置相比较的谐振偏移，估计绝对角度或波长，谐振时间最小，以及额外的诊断和质量信息。可选地，可以导出从校准或拟合阶段获得的数据，以便在其他系统上进行分析。在优选实施例中，仪器控制和数据采集软件在EPF校准模块中设置内部参数，并将原始数据从校准扫描发送到EPF校准模块，EPF校准模块通过采样器和Savitsky-Golay平滑程序在获取衍生物之前漏出数据并表征数据以创建芯片的经验概况。然后可选地存储经验概况。接下来，仪器控制和数据采集软件在EPF Fitting模块中设置内部参数，并将使用芯片执行的运行时扫描的原始数据发送到EPF Fitting模块（符合此要求），查询EPF校准模块的经验配置文件芯片，并适合曲线，必要时进行迭代。然后从装配过程中得到的结果返回给用户。

3. 发明申请

WO1997039474A1 ION DETECTOR, DETECTOR ARRAY AND INSTRUMENT USING SAME 审中-公开
标题翻译：离子检测器，检测器阵列和仪器使用相同
公开(公告)号：WO1997039474A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006077
申请日：1997-04-11
申请人： THE PERKIN-ELMER CORPORATION , TRACY, David, H. , PATKIN, Adam, J. , WELKIE, David, G. , CROCKETT, Michael, I.
发明人： THE PERKIN-ELMER CORPORATION
IPC分类号： H01J49/02
CPC分类号： G01T1/2928 , H01J49/025
摘要： An array of ion detectors (30) comprising a plurality of pickup electrodes (20, 34) for receiving ions; a substrate (32); a plurality of insulators (22, 35) positioned respectively between said pickup electrodes (20, 34) and said substrate (32); a plurality of charge storage areas (12, 38) for storing charge received by said pickup electrodes (20, 34), wherein each area (12, 38) is connected to a particular pickup electrode (20, 34) and means (44) for determining the amount of charge collected by each charge storage area.
摘要翻译：包括用于接收离子的多个拾取电极（20,34）的离子检测器阵列（30）衬底（32）; 分别位于所述拾取电极（20,34）和所述衬底（32）之间的多个绝缘体（22,35）; 多个电荷存储区域（12,38），用于存储由所述拾取电极（20,34）接收的电荷，其中每个区域（12,38）连接到特定拾取电极（20,34）和装置（44）用于确定由每个电荷存储区域收集的电荷量。

4. 发明申请

WO2005012878A3 OPTICAL RESONANCE ANALYSIS UNIT 审中-公开
标题翻译：光学谐振分析单元
公开(公告)号：WO2005012878A3
公开(公告)日：2006-09-08
申请号：PCT/US2004024789
申请日：2004-08-02
申请人： BIACORE AB , TRACY DAVID H , BROCKMAN JENNIFER M , FERRARA KEITH S , SHENKER MARTIN , KERSTEN ROBERT , COHEN STEVEN E , BODLEY GARY , TUXBURY PATRICK , HETHERINGTON PAUL , PICOZZA ENRICO
发明人： TRACY DAVID H , BROCKMAN JENNIFER M , FERRARA KEITH S , SHENKER MARTIN , KERSTEN ROBERT , COHEN STEVEN E , BODLEY GARY , TUXBURY PATRICK , HETHERINGTON PAUL , PICOZZA ENRICO
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： An optical analysis unit especially suitable for performing grating coupled surface plasmon resonance (SPR) imaging features a pivoting light source capable of scanning through a range of angles of incident light projected onto a stationary target sensor, such as an SPR sensor. The reflected image from the illuminated sensor is detected, e.g., by a CCD camera and the image and angular scan data are processed, for example by a fitting algorithm, to provide real time analysis of reactions taking place on the surface of the sensor.
摘要翻译：特别适用于执行光栅耦合表面等离子体共振（SPR）成像的光学分析单元具有能够扫描投射到固定目标传感器（例如SPR传感器）上的入射光的角度范围的枢转光源。例如通过CCD照相机检测来自照明传感器的反射图像，并且例如通过拟合算法处理图像和角度扫描数据，以提供在传感器的表面上发生的反应的实时分析。

5. 发明申请

WO1998005105A1 TUNABLE EXTERNAL CAVITY DIODE LASER 审中-公开
标题翻译： TUNABLE外部腔体二极管激光器
公开(公告)号：WO1998005105A1
公开(公告)日：1998-02-05
申请号：PCT/US1997013152
申请日：1997-07-28
申请人： THE PERKIN-ELMER CORPORATION , The University of Connecticut , ROYCHOUDHURI, Chandra , TRACY, David, H. , HUBBARD, William, J.
发明人： THE PERKIN-ELMER CORPORATION , The University of Connecticut
IPC分类号： H01S03/10
CPC分类号： H01S5/141 , H01S5/0612 , H01S5/0617 , H01S5/0622 , H01S5/068 , H01S5/06804 , H01S5/06808 , H01S5/06812 , H01S5/06837 , H01S5/0687
摘要： An external cavity laser system composed of a semiconductor diode laser (10), a temperature control (30) and injection current control (40) means the diode laser, an external cavity (60) with a wavelength selector and means for controlling the laser temperature (20), laser injection current and the wavelength selector (110) to obtain arbitrary frequencies within the tuning range of the laser.
摘要翻译：由半导体二极管激光器（10），温度控制（30）和注入电流控制（40）组成的外腔激光器系统意味着二极管激光器，具有波长选择器的外部空腔（60）和用于控制激光温度的装置（20），激光注入电流和波长选择器（110），以在激光器的调谐范围内获得任意频率。

6. 发明申请

WO2005012878A2 OPTICAL RESONANCE ANALYSIS UNIT 审中-公开
标题翻译：光学谐振分析单元
公开(公告)号：WO2005012878A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024789
申请日：2004-08-02
申请人： HTS BIOSYSTEMS, INC. , TRACY, David, H. , BROCKMAN, Jennifer, M. , FERRARA, Keith, S. , SHENKER, Martin , KERSTEN, Robert , COHEN, Steven, E. , BODLEY, Gary , TUXBURY, Patrick , HETHERINGTON, Paul , PICOZZA, Enrico
发明人： TRACY, David, H. , BROCKMAN, Jennifer, M. , FERRARA, Keith, S. , SHENKER, Martin , KERSTEN, Robert , COHEN, Steven, E. , BODLEY, Gary , TUXBURY, Patrick , HETHERINGTON, Paul , PICOZZA, Enrico
IPC分类号： G01N
CPC分类号： G01N21/553
摘要： An optical analysis unit especially suitable for performing grating coupled surface plasmon resonance (SPR) imaging features a pivoting light source capable of scanning through a range of angles of incident light projected onto a stationary target sensor, such as an SPR sensor. The reflected image from the illuminated sensor is detected, e.g., by a CCD camera and the image and angular scan data are processed, for example by a fitting algorithm, to provide real time analysis of reactions taking place on the surface of the sensor.
摘要翻译：特别适用于执行光栅耦合表面等离子体共振（SPR）成像的光学分析单元具有能够扫描投射到固定目标传感器（例如SPR传感器）上的入射光的角度范围的枢转光源。例如通过CCD照相机检测来自照明传感器的反射图像，并且例如通过拟合算法处理图像和角度扫描数据，以提供在传感器的表面上发生的反应的实时分析。

7. 发明申请

WO9930135B1 OPTICAL RESONANCE ANALYSIS SYSTEM 审中-公开
标题翻译：光学谐振分析系统
公开(公告)号：WO9930135B1
公开(公告)日：1999-07-29
申请号：PCT/US9826543
申请日：1998-12-14
申请人： PERKIN ELMER CORP , BAHATT DAR , CAHILL JERRY E , NISHIKIDA KOICHI , PICOZZA ENRICO G , SAVIANO PAUL G , TRACY DAVID H , WANG YONGDONG
发明人： BAHATT DAR , CAHILL JERRY E , NISHIKIDA KOICHI , PICOZZA ENRICO G , SAVIANO PAUL G , TRACY DAVID H , WANG YONGDONG
IPC分类号： G01N21/27 , G01N21/55
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）上产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

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