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1. 发明申请

WO02033770A1 IMPROVEMENTS IN AND RELATING TO FUEL CELLS 审中-公开
标题翻译：对燃料电池的改进和相关
公开(公告)号：WO02033770A1
公开(公告)日：2002-04-25
申请号：PCT/GB2001/004631
申请日：2001-10-18
申请人： BRITISH NUCLEAR FUELS PLC , LEWIN, Robert, Glynn , BARNETT, Stephen, Vernon
发明人： LEWIN, Robert, Glynn , BARNETT, Stephen, Vernon
IPC分类号： H01M8/02
CPC分类号： H01M8/2404 , H01M8/0202 , H01M8/1213 , H01M8/2425 , H01M8/2457 , Y02P70/56
摘要： A method of production of, and apparatus for, a fuel cell which comprises three nested truncated cones (100, 106, 112). The inner core (100) of the fuel cell is made of a porous metal sponge, such as nickel and provides a media through which fuel can pass. The second cone (106) is provided around the core cone (100) in use, and acts as a diffuser for the fuel to promote efficient contact with the third cone (112). The third cone (112) is the fuel cell itself and includes an electrolyte component which provides a gas impermeable layer between fuel and oxidation sides of the cell. A cathode and anode are provided on outer and inner surfaces (112, 114) respectively of the electrolyte component. The fuel cell is configured such that the lower surface (121) of the fuel cell a cross-sectional profile of greater area than the top surface (119). The top surface (119) is provided with an aperture (120) which allows furl to exit the diffuser cone (106). A plurality of fuel cells may be arranged in an array.
摘要翻译：一种燃料电池的制造方法和装置，包括三个嵌套截锥体（100,106,112）。燃料电池的内芯（100）由诸如镍的多孔金属海绵制成，并提供燃料可以通过的介质。第二锥体（106）在使用中围绕芯锥体（100）设置，并且用作燃料的扩散器以促进与第三锥体（112）的有效接触。第三锥体（112）是燃料电池本身并且包括在电池的燃料和氧化侧之间提供气体不可渗透层的电解质组分。阴极和阳极分别设置在电解质组分的外表面和内表面（112,114）上。燃料电池构造成使得燃料电池的下表面（121）的面积大于顶表面（119）的横截面轮廓。上表面（119）设置有孔（120），其允许furl离开扩散器锥体（106）。多个燃料电池可以排列成阵列。

2. 发明申请

WO9414833A3 SUBSTITUTED 6-AZAANDROSTENONES 审中-公开
标题翻译：取代的6-氮杂
公开(公告)号：WO9414833A3
公开(公告)日：1994-09-29
申请号：PCT/US9312419
申请日：1993-12-17
申请人： GLAXO INC , ANDREWS ROBERT CARL , CRIBBS CYNTHIA MARKERT , FRYE STEPHEN VERNON , HAFFNER CURT DALE , MALONEY PATRICK REED
发明人： ANDREWS ROBERT CARL , CRIBBS CYNTHIA MARKERT , FRYE STEPHEN VERNON , HAFFNER CURT DALE , MALONEY PATRICK REED
IPC分类号： A61K31/58 , A61K20060101 , A61P37/08 , C07C20060101 , C07C211/41 , C07C211/45 , C07D309/14 , C07D317/58 , C07D335/02 , C07J20060101 , C07J3/00 , C07J63/00 , C07J73/00 , C07J75/00 , C07C211/40 , C07C211/52
CPC分类号： C07D317/58 , C07C211/41 , C07C211/45 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/46 , C07D309/14 , C07D335/02 , C07J73/005
摘要： The present invention relates to certain substituted 17β-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R?1 and R2¿ i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R?1 and R2¿ is a single or a double bond, or ii) taken together are a -CH¿2?- group forming a cyclopropane ring, and the bond between the carbons bearing R?1 and R2¿ is a single bond; R3 is preferably hydrogen, halogen or lower alkyl, R4 is preferably hydrogen or lower alkyl, X is preferably CH¿2?, Y is preferably hydrogen and Z is preferably CONR?14R15 and R14 and R15¿ are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.

3. 发明申请

WO0233770A9 IMPROVEMENTS IN AND RELATING TO FUEL CELLS 审中-公开
标题翻译：对燃料电池的改进和相关
公开(公告)号：WO0233770A9
公开(公告)日：2003-10-16
申请号：PCT/GB0104631
申请日：2001-10-18
申请人： BRITISH NUCLEAR FUELS PLC , LEWIN ROBERT GLYNN , BARNETT STEPHEN VERNON
发明人： LEWIN ROBERT GLYNN , BARNETT STEPHEN VERNON
IPC分类号： H01M8/02 , H01M8/12 , H01M8/24 , H01M8/10
CPC分类号： H01M8/2425 , H01M8/0202 , H01M8/1213 , Y02P70/56
摘要： A method of production of, and apparatus for, a fuel cell which comprises three nested truncated cones (100, 106, 112). The inner core (100) of the fuel cell is made of a porous metal sponge, such as nickel and provides a media through which fuel can pass. The second cone (106) is provided around the core cone (100) in use, and acts as a diffuser for the fuel to promote efficient contact with the third cone (112). The third cone (112) is the fuel cell itself and includes an electrolyte component which provides a gas impermeable layer between fuel and oxidation sides of the cell. A cathode and anode are provided on outer and inner surfaces (112, 114) respectively of the electrolyte component. The fuel cell is configured such that the lower surface (121) of the fuel cell a cross-sectional profile of greater area than the top surface (119). The top surface (119) is provided with an aperture (120) which allows furl to exit the diffuser cone (106). A plurality of fuel cells may be arranged in an array.
摘要翻译：一种燃料电池的制造方法和装置，包括三个嵌套截锥体（100,106,112）。燃料电池的内芯（100）由诸如镍的多孔金属海绵制成，并提供燃料可以通过的介质。第二锥体（106）在使用中围绕芯锥体（100）设置，并且用作燃料的扩散器以促进与第三锥体（112）的有效接触。第三锥体（112）是燃料电池本身并且包括在电池的燃料和氧化侧之间提供气体不可渗透层的电解质组分。阴极和阳极分别设置在电解质组分的外表面和内表面（112,114）上。燃料电池构造成使得燃料电池的下表面（121）的面积大于顶表面（119）的横截面轮廓。上表面（119）设置有孔（120），其允许furl离开扩散器锥体（106）。多个燃料电池可以排列成阵列。

4. 发明申请

WO1995007926A1 ANDROSTENONES 审中-公开
标题翻译：对雄激素
公开(公告)号：WO1995007926A1
公开(公告)日：1995-03-23
申请号：PCT/US1994010479
申请日：1994-09-16
申请人： GLAXO INC. , BATCHELOR, Kenneth, William , FRYE, Stephen, Vernon
发明人： GLAXO INC.
IPC分类号： C07J73/00
CPC分类号： C07J3/005 , C07C235/82 , C07C2603/14 , C07J41/0066 , C07J73/005
摘要： The present invention relates to compounds of formula (I), wherein carbons 1 and 2 are joined by either a single or a double bond; R is hydrogen or methyl; R is hydrogen or methyl; R is (A) or (B) wherein X, W, Z, R , R , R , R and R are various groups, and pharmaceutically acceptable solvates thereof and their use in the treatment of androgen responsive and mediated diseases.
摘要翻译：本发明涉及式（I）化合物，其中碳1和2通过单键或双键连接; R 1是氢或甲基; R 2是氢或甲基; R 3为（A）或（B）其中X，W，Z，R 4，R 5，R 6，R 7和R 8为各种基团，溶剂化物及其用于治疗雄激素反应性和介导性疾病的用途。

5. 发明申请

WO1993013124A1 INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE 审中-公开
标题翻译： 5-ALPHA-TESTOSTERONE还原酶的抑制剂
公开(公告)号：WO1993013124A1
公开(公告)日：1993-07-08
申请号：PCT/US1992011109
申请日：1992-12-18
申请人： GLAXO INC. , FRYE, Stephen, Vernon , CRIBBS, Cynthia, Markert , HAFFNER, Curt, Dale , MALONEY, Patrick, Reed , ANDREWS, Robert, Carl
发明人： GLAXO INC.
IPC分类号： C07J73/00
CPC分类号： C07J73/005
摘要： The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) wherein R and R are: i) independently hydrogen or lower alkyl and the bond between the carbons bearing R and R is a single or a double bond, or ii) taken together are a -CH2- group to form a cyclopropane ring, and the bond between the carbons bearing R and R is a single bond; R is hydrogen; R is hydrogen, lower alkyl, lower cycloalkyl, lower alkenyl, alkanoyl of 2-6 carbons, -(CH2)mCO2R , -(CH2)mAr , -(CH2)n'CONR R , -(CH2)n'NR R or -(CH2)n'OR , wherein R is hydrogen, lower alkyl or lower alkenyl; R and R are independly hydrogen, lower alkyl lower cycloalkyl or lower alkenyl; Ar is an aromatic group of 6 to 12 carbons; n' is 0 or an integer from 1 to 5; m is an integer from 1 to 5; R and R are independently hydrogen or lower alkyl, or taken together R and R form a carbonyl group(=O); R is lower alkyl, lower alkenyl, lower cycloalkyl, lower alkoxy, or NR R , wherein R and R are independently hydrogen, lower alkyl or lower alkenyl; and pharmaceutically acceptable salts thereof, their preparation, medical use and pharmaceutical formulations.
摘要翻译：本发明涉及式（I）的某些取代的17β-取代的羰基-6-氮杂雄甾-4-烯-3-酮，特别是其中R 1和R 1的式（I 1）的那些：i ）独立地是氢或低级烷基，并且具有R 1和R 2的碳之间的键是单键或双键，或者ii）一起是-CH 2 - 基团以形成环丙烷环，并且键在具有R 1和R 2的碳之间是单键; R 3c是氢; R 2是氢，低级烷基，低级环烷基，低级链烯基，2-6个碳原子的烷酰基， - （CH 2）m CO 2 R 16， - （CH 2）mAr a， - （CH 2）n CONR 17 R 18， - （CH 2）n R NR 17或 - （CH 2）n'OR 16，其中R 16是氢，低级烷基或低级烯基; R 17和R 18独立地是氢，低级烷基低级环烷基或低级烯基; Ar a是6〜12个碳的芳香族基团; n'为0或1〜5的整数; m为1〜5的整数; R 19和R 20独立地为氢或低级烷基，或一起R 19和R 20形成羰基（= O）; R 5c是低级烷基，低级烯基，低级环烷基，低级烷氧基或NR 21 R 22，其中R 21和R 22独立地是氢，低级烷基或低级烯基; 及其药学上可接受的盐，它们的制备，医疗用途和药物制剂。

6. 发明申请

WO0189011A3 IMPROVEMENTS IN AND RELATING TO FUEL CELL CONSTRUCTIONS 审中-公开
标题翻译：燃油电池结构的改进和相关
公开(公告)号：WO0189011A3
公开(公告)日：2002-03-21
申请号：PCT/GB0101878
申请日：2001-04-30
申请人： BRITISH NUCLEAR FUELS PLC , BARNETT STEPHEN VERNON
发明人： BARNETT STEPHEN VERNON
IPC分类号： H01M8/00 , H01M8/02 , H01M8/04 , H01M8/06 , H01M8/12 , H01M8/24
CPC分类号： H01M8/04067 , H01M8/00 , H01M8/04089 , H01M8/0662
摘要： A fuel cell system, the system including one or more fuel cells (2), one or more of the fuel cells including an electrolyte material, a first electrode and first electrical conductor on one side of the electrolyte material and a second electrode and second electrical conductor on the other side of the electrolyte material, the electrolyte material of a fuel cell defining a fuel space, the fuel space being connected to a fuel supply (12), within the system, the one or more fuel cells being provided within an oxidant space (16), the oxidant space being connected to an oxidant supply (20), the oxidant space and one or more fuel spaces being provided within a gas impermeable barrier (18), the gas impermeable barrier defining a heating space (22) outside of the gas impermeable barrier, a source of heat (24) being provided in the heating space. The invention has amongst its aims the provision of a structure which avoids exhaust gas contamination of the fuel cell and the provision of a reliable, simple and cost effective fuel cell structure.
摘要翻译：一种燃料电池系统，该系统包括一个或多个燃料电池（2），一个或多个燃料电池包括电解质材料，第一电极和在电解质材料的一侧上的第一电导体，第二电极和第二电极在电解质材料的另一侧的导体，限定燃料空间的燃料电池的电解质材料，所述燃料空间连接到所述系统内的燃料供应源（12），所述一个或多个燃料电池提供在氧化剂空间（16），所述氧化剂空间连接到氧化剂供应源（20），所述氧化剂空间和一个或多个燃料空间设置在气体不可渗透的屏障（18）内，所述气体不可渗透的屏障在外部限定加热空间（22）的不透气屏障，在加热空间中设置有热源（24）。本发明的目的在于提供一种避免燃料电池废气污染并提供可靠，简单且具有成本效益的燃料电池结构的结构。

7. 发明申请

WO1996028856A1 SOLID OXIDE FUEL CELLS WITH SPECIFIC ELECTRODE LAYERS 审中-公开
标题翻译：具有特定电极层的固体氧化物燃料电池
公开(公告)号：WO1996028856A1
公开(公告)日：1996-09-19
申请号：PCT/GB1996000639
申请日：1996-03-18
申请人： BRITISH NUCLEAR FUELS PLC , LEWIN, Robert, Glyn , BARNETT, Stephen, Vernon , WOOD, Geoffrey, Alan
发明人： BRITISH NUCLEAR FUELS PLC
IPC分类号： H01M08/12
CPC分类号： H01M8/1213 , H01M4/9025 , H01M4/9033 , H01M8/0206 , H01M8/2404 , H01M8/2425 , H01M2008/1293 , H01M2300/0074 , Y02P70/56
摘要： A solid oxide fuel cell (110) and method of production. The cell (110) may have a layer of electrolyte material (112) and a first and second electrode (116, 120) on either side thereof. The electrodes are separated from electrolyte by separator layers (114, 118) which are a mixed conductor. The fuel cell may be used in a stack.
摘要翻译：一种固体氧化物燃料电池（110）及其制造方法。电池（110）可以在其任一侧上具有一层电解质材料（112）和第一和第二电极（116,120）。通过作为混合导体的隔离层（114,118）将电极与电解质分离。燃料电池可以用于堆叠。

8. 发明申请

WO1996030391A1 SUBSTITUTED 6-AZACHOLESTEN-3-ONES 审中-公开
标题翻译：取代6-AZACHOLESTEN-3-ONES
公开(公告)号：WO1996030391A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004042
申请日：1996-03-25
申请人： GLAXO WELLCOME INC. , HAFFNER, Curt, Dale , FRYE, Stephen, Vernon
发明人： GLAXO WELLCOME INC.
IPC分类号： C07J73/00
CPC分类号： C07J73/005
摘要： The present invention relates to 17 beta -substituted-6-azacholesten-3-ones of Formula (I) wherein: R and R represent independently hydrogen or alkyl and the bond between carbons 1 and 2 is a single or a double bond, or R and R may be joined together to form a fused cyclopropane ring; R represents hydrogen, alkyl or halogen; R and R represent independently hydrogen or alkyl; R represents alkyl; and the pharmaceutically acceptable salts and solvates thereof, and their use as 5 alpha -testosterone reductase inhibitors.
摘要翻译：本发明涉及式（I）的17β-取代-6-氮杂胆固醇-3-酮，其中：R 1和R 2独立地表示氢或烷基，碳原子1和2之间的键是单或双键或R 1和R 2可以连接在一起形成稠环丙烷环; R 3表示氢，烷基或卤素; R 4和R 5独立地表示氢或烷基; R 6表示烷基; 及其药学上可接受的盐和溶剂合物，以及它们作为5α-睾酮还原酶抑制剂的用途。

9. 发明申请

WO1995007927A1 ANDROSTENONE DERIVATIVE 审中-公开
标题翻译：雄激素衍生物
公开(公告)号：WO1995007927A1
公开(公告)日：1995-03-23
申请号：PCT/US1994010530
申请日：1994-09-16
申请人： GLAXO INC. , BATCHELOR, Kenneth, William , FRYE, Stephen, Vernon
发明人： GLAXO INC.
IPC分类号： C07J73/00
CPC分类号： C07J3/005 , C07C235/82 , C07C2603/14 , C07J41/0066 , C07J73/005
摘要： The present invention relates to the compound of formula (I), also known as 17 beta -N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5 alpha -androst-1-en-3-one, solvates thereof, its preparation, intermediates used in its preparation, pharmaceutical formulations thereof and its use in the treatment of androgen responsive and mediated diseases.
摘要翻译：本发明涉及式（I）化合物，也称为17β-N-（2,5-双（三氟甲基））苯基氨基甲酰基-4-氮杂-5α-雄甾-1-烯-3-酮，其溶剂化物，其制备方法，其制备中使用的中间体，其药物制剂及其在治疗雄激素反应性和介导性疾病中的用途。

10. 发明申请

WO1994014833A2 SUBSTITUTED 6-AZAANDROSTENONES 审中-公开
标题翻译：取代的6-氮杂
公开(公告)号：WO1994014833A2
公开(公告)日：1994-07-07
申请号：PCT/US1993012419
申请日：1993-12-17
申请人： GLAXO INC. , ANDREWS, Robert, Carl , CRIBBS, Cynthia, Markert , FRYE, Stephen, Vernon , HAFFNER, Curt, Dale , MALONEY, Patrick, Reed
发明人： GLAXO INC.
IPC分类号： C07J03/00
CPC分类号： C07D317/58 , C07C211/41 , C07C211/45 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/46 , C07D309/14 , C07D335/02 , C07J73/005
摘要： The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R and R i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R and R is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R and R is a single bond; R is preferably hydrogen, halogen or lower alkyl, R is preferably hydrogen or lower alkyl, X is preferably CH2, Y is preferably hydrogen and Z is preferably CONR R and R and R are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.
摘要翻译：本发明涉及式（I）的某些取代的17β-取代的羰基-6-氮杂雄甾-4-烯-3-酮，其中R 1和R 2独立地是氢或低级烷基，带有R 1和R 2的碳之间的键是单键或双键，或ii）一起形成环丙烷环的-CH 2 - 基团，并且具有R 1和 R 2是单键; R 3优选为氢，卤素或低级烷基，R 4优选为氢或低级烷基，X优选为CH 2，Y优选为氢，Z优选为CONR 14 R 15和R 14，和R 15是各种有机基团及其药学上可接受的盐，制剂，医疗用途和药物制剂。

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