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1. 发明专利

JP2005334573A Infant umbrella having ferrule equipped with handle 审中-公开
标题翻译：带有手柄的婴儿奶粉
公开(公告)号：JP2005334573A
公开(公告)日：2005-12-08
申请号：JP2004180310
申请日：2004-05-22
申请人： Shigeo Yagi , 茂生八木
发明人： YAGI SHIGEO
IPC分类号： A45B9/04
摘要： PROBLEM TO BE SOLVED: To provide a ferrule having a function of a handle for an infant umbrella capable of easily allowing an accompanying person to help an infant in walking while stably holding a spread infant umbrella alone because actually it is difficult for two or three years old infant to walk with the spread infant umbrella alone and very unstable when the wind blows, and also dangerous for walkers around the infant because conventional infant umbrellas are made assuming that the infants can hold the umbrella for themselves similarly to adults.
SOLUTION: The ferrule of an infant umbrella is proposed as an appropriate portion for assisting an infant in carrying the umbrella by easily holding up the same by a fingertip while his or her parent or accompanying person is walking with the infant also under cover of an umbrella. The ferrule 2 is formed in a shape of T, O or the like, which can be easily hooked by an adult's fingertip.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种具有婴儿伞手柄功能的套圈，其能够容易地允许伴随者帮助婴儿步行，同时稳定地保持单独的婴儿伞，因为实际上难以对两个或三岁的婴儿单独散步的婴儿伞，风吹时非常不稳定，对婴儿周围的步行者也很危险，因为常规的婴儿伞被假定为与成年人一样可以为自己保持伞。
解决方案：婴儿伞的套圈被提议作为适当的部分，以帮助婴儿携带伞，当他或她的父母或伴随着与婴儿同时在其下方的步行时，用指尖轻轻地握住它的伞。套圈2形成为T，O等的形状，能够容易地被成人的指尖钩住。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2009120163A Mask for blowout hole of car air-conditioner 审中-公开
标题翻译：汽车空气调节器的排气孔面罩
公开(公告)号：JP2009120163A
公开(公告)日：2009-06-04
申请号：JP2007317689
申请日：2007-11-09
申请人： Shigeo Yagi , 茂生八木
发明人： YAGI SHIGEO
IPC分类号： B60H3/06
CPC分类号： Y02A50/2352
摘要： PROBLEM TO BE SOLVED: To provide a mask for a blowout hole of car air-conditioner capable of catching pollen or other particulates effectively and of being removed simply when it is to be replaced or not necessary.
SOLUTION: The arrangement includes a mounting tool which is for mounting at the blowout hole of air-conditioner and made of a resilient material such as low-repulsion urethane, soft silicone, etc. This is compressed and inserted toward the innermost when it is intruded with a light force into the blowout hole using a finger or a pen, and inhales there the air and expands, or is willing to restore its original shape, so that it exerts an effect to stay in the position stably. An air purifying filter exerts a good effect when a net or a sheet itself is formed from a material having a high adsorbing effect for pollen or dust. As the construction can cover the whole area of the blowout hole, a great majority of the wind blowing out passes through the filter.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够有效地捕获花粉或其它颗粒物的汽车空调的吹出孔的掩模，并且在被更换或不需要时被简单地移除。解决方案：该装置包括安装在空调吹瓶孔上并由诸如低排斥聚氨酯，软硅胶等弹性材料制成的安装工具。该装置被压缩并插入到最内侧使用手指或笔将其引入喷孔，并在那里吸入空气并膨胀，或愿意恢复其原始形状，从而使其保持稳定的位置。当网片或片材本身由对花粉或粉尘具有高吸附效果的材料形成时，空气净化过滤器效果良好。由于施工可以覆盖井口的整个区域，大部分吹出的风吹过滤器。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2006315758A Pet bottle cover for use on beach 审中-公开
标题翻译： PET瓶盖用于海滩
公开(公告)号：JP2006315758A
公开(公告)日：2006-11-24
申请号：JP2005171600
申请日：2005-05-16
申请人： Shigeo Yagi , 茂生八木
发明人： YAGI SHIGEO
IPC分类号： B65D81/38 , B65D65/04 , B65D81/18 , F25D3/00
摘要： PROBLEM TO BE SOLVED: To provide a PET bottle cover suitable for use on a beach or a pool side in midsummer, which can be cooled easily in a freezer chamber of a refrigerator at home and can demonstrate a sunshade effect, a cold preservation effect and a cooling effect by capping it on a PET bottle when it is used.
SOLUTION: The PET bottle cover having a tubular shape without a bottom is made by cutting out a sheet in accordance with the size of a PET bottle and joining a shoulder part (2) and a side part (3) of the sheet (1). When a cooling function is given, a cold reserving material is attached on the inner face of the cover making contact with the PET bottle by adhesion or sewing or the like. When it is used, the cover, to which the cold reserving material is attached, is cooled in the freezing chamber of a refrigerator below 0°C and is capped on the PET bottle to demonstrate a strong cold preservation effect and cooling effect. With regard to storing performance, it can be stored in the refrigerator or the like without taking space in the case of one piece or two or more piled pieces since it has a plane structure without the bottom.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供适合在夏季海滩或泳池边使用的PET瓶盖，可以在家中的冰箱的冷冻室中容易地冷却，并且可以显示遮阳效果，感冒使用PET瓶时，将其封盖在保鲜效果和冷却效果上。解决方案：通过根据PET瓶的尺寸切割片材并且接合片材的肩部（2）和侧部（3）而制成具有没有底部的管状形状的PET瓶盖（1）。当给出冷却功能时，通过粘合或缝合等将冷藏材料附着在盖的内表面上，与PET瓶接触。当使用时，将冷藏材料所附盖的盖子在冰箱低于0℃的冷冻室中冷却并且被盖在PET瓶上以显示出强的冷藏保鲜效果和冷却效果。关于存储性能，由于其具有没有底部的平面结构，所以可以将其存储在冰箱等中，而不会在一个或两个或更多个堆叠的情况下占用空间。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007207211A Portable terminal device for crime prevention with school attending/leaving mode 审中-公开
标题翻译：便携式终端设备，用于学校预防/离开模式预防犯罪
公开(公告)号：JP2007207211A
公开(公告)日：2007-08-16
申请号：JP2006055502
申请日：2006-02-02
申请人： Shigeo Yagi , 茂生八木
发明人： YAGI SHIGEO
IPC分类号： G08B25/04 , G08B25/00 , G08B25/10
摘要： PROBLEM TO BE SOLVED: To provide a crime prevention system for school children provided with a photographing function and a photographic data transmission function.
SOLUTION: While a school child is on his/her way to/from the school, a mobile terminal mounted to his/her school bag automatically photographs the surrounding of him/her every preset seconds, and automatically transmits photographic data to a server designated whenever the surrounding is photographed. Data stored in the server can be erased when confirming safety everyday, but it can be stored for a fixed period to be utilized as data when there is information of a suspicious person later.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有拍摄功能和摄影数据传输功能的学童的犯罪预防系统。
解决方案：当一名学童正在上学时，安装在他/她的书包上的移动终端每隔预设几秒自动拍摄周围的人，并自动将照片数据传输到当周围拍照时指定服务器。存储在服务器中的数据可以在每天确认安全性时被擦除，但是可以将其存储一段固定的时间段，以便在以后有可疑人员的信息时被用作数据。版权所有（C）2007，JPO＆INPIT

5. 发明申请

US20050036981A1 USE OF PLP WITH PEG-rMETase IN VIVO FOR ENHANCED EFFICACY 审中-公开
标题翻译：在血液中使用PEG-rMETase的PLP用于增强功效
公开(公告)号：US20050036981A1
公开(公告)日：2005-02-17
申请号：US10891662
申请日：2004-07-15
申请人： Shigeo Yagi , Zhijian Yang , Shukuan Li , Xinghua Sun , Yuying Tan
发明人： Shigeo Yagi , Zhijian Yang , Shukuan Li , Xinghua Sun , Yuying Tan
IPC分类号： A61K31/74 , A61K38/51 , A61K38/44
CPC分类号： A61K38/51 , A61K31/675 , A61K31/74 , A61K2300/00
摘要： This invention relates to methods of modifying pyridoxal 5′ phosphate (PLP) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred PLP-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rMETase). The invention further relates to compositions comprising a modified PLP-dependent enzyme and methods of using the same.
摘要翻译：本发明涉及修饰吡哆醛5'磷酸（PLP）依赖性酶的方法以延长酶的血清半衰期，延长宿主中甲硫氨酸消耗的体内周期，并降低酶的免疫原性。待修饰的优选的PLP依赖性酶是蛋氨酸酶，优选重组蛋氨酸酶（rMETase）。本发明还涉及包含修饰的PLP依赖性酶的组合物及其使用方法。

6. 发明授权

US5484725A Norbornane type ester hydrolase from Acetobacter pasteurianus 失效
标题翻译：醋酸醋杆菌的降冰片烷型酯水解酶
公开(公告)号：US5484725A
公开(公告)日：1996-01-16
申请号：US232519
申请日：1994-04-22
申请人： Bunji Kageyama , Masanori Nakae , Shigeo Yagi
发明人： Bunji Kageyama , Masanori Nakae , Shigeo Yagi
IPC分类号： C12N1/21 , C12N9/16 , C12N15/09 , C12N15/55 , C12P7/02 , C12P41/00 , C12R1/02 , C12R1/19 , C12N9/18
CPC分类号： C12P7/02 , C12N9/16 , C12P41/004 , Y10S435/823
摘要： A norbornane type ester hydrolase that enantio-selectively hydrolyzes a (.+-.)-exo-norbornane type ester represented by Formula I is provided: ##STR1## wherein R is acyl, and A and B are hydrogens, respectively, or where A and B are absent, resulting in a carbon-carbon double bond between the carbons to which A and B are attached in Formula I. The norbornane type ester hydrolase has an optimal pH of approximately 8 and a stable pH range of approximately 6 to 8.
摘要翻译：提供了对映体选择性水解由式I表示的（+/-） - 外降冰片烷型酯的降冰片烷型酯水解酶：其中R是酰基，A和B分别是氢或其中A和B不存在，导致在式I中A和B连接的碳之间的碳 - 碳双键。降冰片烷型酯水解酶具有约8的最佳pH，并且稳定的pH范围为约6至 8。

7. 发明授权

US4696897A Process for preparing 2-keto-L-gulonic acid 失效
标题翻译：制备2-酮-L-古洛糖酸的方法
公开(公告)号：US4696897A
公开(公告)日：1987-09-29
申请号：US747393
申请日：1985-06-21
申请人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama
发明人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama
IPC分类号： C12P7/58 , C12P7/60 , C12P39/00 , C12R1/13 , C12R1/15 , C12R1/18
CPC分类号： C12P39/00 , C12P7/58 , C12P7/60
摘要： 2-Keto-L-gulonic acid is prepared directly from D-glucose by microbial conversion utilizing mixed culturing on a medium containing D-glucose, employing two kinds of microorganisms; the first, a 2,5-diketo-D-gluconic acid producing microorganism which belongs to genus Erwinia and the second, a 2-keto-L-gulonic acid producing microorganism which belongs to genus Brevibacterium or Corynebacterium. The incubation of the microorganisms in a medium containing D-glucose is used in the disclosed process. By-production of 2-keto-D-gluconic acid, the undesired isomer of the intended product is effectively prevented by employing mixed culturing because of the co-existence of both microorganisms in the medium during at least part of the entire cultivation. Namely, 2-keto-D-gluconic acid produced by the second microorganism is utilized by the first microorganism to produce 2,5-diketo-D-gluconic acid which is subsequently converted into 2-keto-L-gulonic acid by the second microorganism.
摘要翻译：通过使用两种微生物在含有D-葡萄糖的培养基上进行混合培养，通过微生物转化从D-葡萄糖直接制备2-酮-L-古洛糖酸; 第一个属于欧文氏菌属的2,5-二酮-D-葡萄糖酸生产微生物，其次是属于短杆菌属或棒状杆菌属的2-酮-L-古洛糖酸生产微生物。在所公开的方法中使用微生物在含有D-葡萄糖的培养基中培养。由于2-酮-D-葡萄糖酸的副产物，因为在整个培养的至少一部分期间由于培养基中的两种微生物的共存，因此通过采用混合培养来有效地防止了所需产物的不需要的异构体。也就是说，由第二微生物产生的2-酮-D-葡萄糖酸被第一微生物利用以产生2,5-二酮-D-葡萄糖酸，随后由第二微生物转化成2-酮-L-古洛糖酸。

8. 发明授权

US4543331A Fermentative or enzymatic production of 2-keto-L-gulonic acid 失效
标题翻译：发酵或酶促生产2-酮-L-古洛糖酸
公开(公告)号：US4543331A
公开(公告)日：1985-09-24
申请号：US469780
申请日：1983-02-25
申请人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama
发明人： Takayasu Sonoyama , Shigeo Yagi , Bunji Kageyama
IPC分类号： C12P7/60
CPC分类号： C12R1/15 , C12P7/60 , Y10S435/843 , Y10S435/847
摘要： Fermentative or enzymatic production of 2-keto-L-gulonic acid from 2,5-diketo-D-gluconic acid using living or processed mutants, being defective in metabolizing 5-keto-D-gluconic acid and incapable of producing 2-keto-D-gluconic acid. The mutant is derived from 2-keto-L-gluconic acid producing microorganisms of genus Corynebacterium. The production is carried out in the presence of nitrates and/or hydrogen donors in a preliminarily sterilized fermentation broth in which a 2,5-diketo-D-gluconic acid producing microorganism of genus Gluconobacter or Erwinia has been cultivated.
摘要翻译：使用活的或加工的突变体从2,5-diketo-D-葡萄糖酸发酵或酶促生产2-酮-L-古洛糖酸，在代谢5-酮-D-葡萄糖酸中是有缺陷的，不能产生2-酮基-D-葡萄糖酸， D-葡萄糖酸。突变体衍生自产生棒状杆菌属的2-酮-L-葡萄糖酸生成微生物。在硝酸盐和/或氢供体的存在下，在已经培养了葡萄糖酸杆菌或欧文氏菌属的2,5-二酮-D-葡糖酸的微生物的预先灭菌的发酵液中进行生产。

9. 发明授权

US08465734B2 Methods for increasing protein polyethylene glycol (PEG) conjugation 失效
标题翻译：增加蛋白质聚乙二醇（PEG）缀合的方法
公开(公告)号：US08465734B2
公开(公告)日：2013-06-18
申请号：US12875377
申请日：2010-09-03
申请人： Shukuan Li , Zhijian Yang , Xinghua Sun , Yuying Tan , Shigeo Yagi
发明人： Shukuan Li , Zhijian Yang , Xinghua Sun , Yuying Tan , Shigeo Yagi
IPC分类号： A61K38/43 , C07K17/08 , C12N9/96 , G01N33/574
CPC分类号： A61K47/48215 , A61K38/51 , A61K47/60 , C07K1/1077 , C12N9/88
摘要： The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.
摘要翻译：本发明涉及高度缀合的蛋白质及其制备方法。特别地，本发明涉及将附加位点与蛋白质连接以与活化聚乙二醇（PEG）接头共轭的方法，而不使蛋白质变性。本发明还涉及具有降低的免疫原性和增加的循环半衰期的高度缀合的蛋白质。

10. 发明申请

US20080153740A1 Methods for increasing protein polyethylene glycol (PEG) conjugation 有权
公开(公告)号：US20080153740A1
公开(公告)日：2008-06-26
申请号：US12001304
申请日：2007-12-10
申请人： Shukuan Li , Zhijian Yang , Xinghua Sun , Yuying Tan , Shigeo Yagi
发明人： Shukuan Li , Zhijian Yang , Xinghua Sun , Yuying Tan , Shigeo Yagi
IPC分类号： A61K47/48 , C07K2/00 , A61P35/00
CPC分类号： A61K47/48215 , A61K38/51 , A61K47/60 , C07K1/1077 , C12N9/88
摘要： The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.

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