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1. 发明授权

US06180763B2 Cyclin D binding factor, and uses thereof 失效
标题翻译：细胞周期蛋白D结合因子及其用途
公开(公告)号：US06180763B2
公开(公告)日：2001-01-30
申请号：US08928941
申请日：1997-09-12
申请人： Charles J. Sherr , Hiroshi Hirai , Kazushi Inoue , Sara M. Bodner
发明人： Charles J. Sherr , Hiroshi Hirai , Kazushi Inoue , Sara M. Bodner
IPC分类号： C07K122
CPC分类号： C07K14/4705 , A01K2217/05 , A01K2217/075 , C07K2319/00
摘要： The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.
摘要翻译：本发明公开了D型细胞周期蛋白与与细胞周期蛋白D2特异性相互作用的新型myb样转录因子DMP1之间的直接相互作用。本发明还提供了D型细胞周期蛋白以不依赖RB的方式调节基因表达的证据。还包括DMP1，转录因子由包含三个非典型myb重复的中心DNA结合结构域组成，其侧翼为位于其氨基末端和羧基末端的高度酸性的片段。本发明包括编码DMP1的氨基酸序列，以及编码氨基酸序列的DNA和RNA核苷酸序列。公开了DMP1作为转录因子的用途，因为它在与含有非标记共有序列CCCG（G / T）ATGT的寡核苷酸的结合中具有特异性。在本发明的这个方面，当转染到哺乳动物细胞中时，DMP1激活由含有连接的DMP1结合位点的最小启动子驱动的报道基因的转录。

2. 发明授权

US06673902B2 Cyclin D binding factor, and uses thereof 失效
标题翻译：细胞周期蛋白D结合因子及其用途
公开(公告)号：US06673902B2
公开(公告)日：2004-01-06
申请号：US09892398
申请日：2001-06-27
申请人： Charles J. Sherr , Hiroshi Hirai , Sara M. Bodner , Kazushi Inoue
发明人： Charles J. Sherr , Hiroshi Hirai , Sara M. Bodner , Kazushi Inoue
IPC分类号： C07K1600
CPC分类号： C07K14/4705 , A01K2217/05 , A01K2217/075 , C07K2319/00
摘要： The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.
摘要翻译：本发明公开了D型细胞周期蛋白与与细胞周期蛋白D2特异性相互作用的新型myb样转录因子DMP1之间的直接相互作用。本发明还提供了D型细胞周期蛋白以不依赖RB的方式调节基因表达的证据。还包括DMP1，转录因子由包含三个非典型myb重复的中心DNA结合结构域组成，其侧翼为位于其氨基末端和羧基末端的高度酸性的片段。本发明包括编码DMP1的氨基酸序列，以及编码氨基酸序列的DNA和RNA核苷酸序列。公开了DMP1作为转录因子的用途，因为它在与含有非标记共有序列CCCG（G / T）ATGT的寡核苷酸的结合中具有特异性。在本发明的这个方面，当转染到哺乳动物细胞中时，DMP1激活由含有连接的DMP1结合位点的最小启动子驱动的报道基因的转录。

3. 发明授权

US06303772B1 Cyclin D binding factor, and uses thereof 有权
公开(公告)号：US06303772B1
公开(公告)日：2001-10-16
申请号：US09280590
申请日：1999-03-29
申请人： Charles J. Sherr , Hiroshi Hirai , Sara M. Bodner , Kazushi Inoue
发明人： Charles J. Sherr , Hiroshi Hirai , Sara M. Bodner , Kazushi Inoue
IPC分类号： C07K122
CPC分类号： C07K14/4705 , A01K2217/05 , A01K2217/075 , C07K2319/00
摘要： The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

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