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1. 发明申请

WO2005020794A8 TAXANE CHEMOSENSITIVITY PREDICTION TEST 审中-公开
标题翻译：紫杉烷化学敏感性预测试验
公开(公告)号：WO2005020794A8
公开(公告)日：2005-08-18
申请号：PCT/US2004027661
申请日：2004-08-25
申请人： UNIV TEXAS , SYSMEX CORP , UENO NAOTO T , ISHIHARA HIDEKI , SUDO TAMOTSU , MATSUSHIMA TOMOKO
发明人： UENO NAOTO T , ISHIHARA HIDEKI , SUDO TAMOTSU , MATSUSHIMA TOMOKO
IPC分类号： A61B20060101 , B05D5/00 , C07H21/02 , C07H21/04 , C08K5/00 , C12Q1/48 , C12Q1/68 , G01N33/50 , A61B
CPC分类号： G01N33/5011 , A61K31/337 , C12Q1/485 , G01N2800/52
摘要： The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cylce molecules in a cancer cell. Such a method makes use of an automated analyzer system wherein cell cycle paramteres (molecules) such as CDKI kinase activity, CDK1 expression, CDK2 kinase activity, CDK2 expression, MAD2 expression, Cyclin Bl, Cyclin E expression, p2l expression, and CDK6 expression; are assessed. The present invention further provides a method of obtaining a cell cycle profile of a cancer cell that is sensitive to a taxane.
摘要翻译：本发明提供了测定癌细胞对紫杉烷的化学敏感性的方法，包括评估紫杉烷对癌细胞中一种或多种细胞环分子的表达水平或活性的影响。这种方法利用自动分析系统，其中细胞周期参数（分子）如CDKI激酶活性，CDK1表达，CDK2激酶活性，CDK2表达，MAD2表达，细胞周期蛋白B1，细胞周期蛋白E表达，p21表达和CDK6表达; 进行评估。本发明还提供了获得对紫杉烷敏感的癌细胞的细胞周期分布的方法。

2. 发明申请

WO2013035074A1 METHOD FOR ASSAYING PLASMINOGEN IN A LIQUID MEDIUM, ASSOCIATED COMPOSITIONS AND KIT 审中-公开
标题翻译：在液体中相关组合物和试剂盒中测定浆细胞的方法
公开(公告)号：WO2013035074A1
公开(公告)日：2013-03-14
申请号：PCT/IB2012054634
申请日：2012-09-07
申请人： SYSMEX CORP , AMIRAL JEAN
发明人： AMIRAL JEAN
IPC分类号： C12Q1/56 , G01N33/86
CPC分类号： C12Q1/56 , G01N33/86
摘要： The invention relates to a method for assaying plasminogen in a sample comprising a step consisting in particular of reacting a streptokinase (Rl), and a streptokinase activator, with a control solution or a diluted plasma sample, in which the streptokinase activator is selected from the group comprising a fibrin DD fragment and/or at least one DD fragment derivative. The invention also relates to a liquid composition, a plasminogen assay kit for implementing this method and the use of a streptokinase activator selected from the group comprising a fibrin DD fragment and/or at least one DD fragment derivative.
摘要翻译：本发明涉及一种用于在样品中测定纤溶酶原的方法，其包括特别是使链激酶（R1）和链激酶激活剂与对照溶液或稀释的血浆样品反应的步骤，其中链激酶激活剂选自其包含纤维蛋白DD片段和/或至少一种DD片段衍生物。本发明还涉及液体组合物，用于实施该方法的纤溶酶原测定试剂盒和选自包含纤维蛋白DD片段和/或至少一种DD片段衍生物的链激酶激活剂的用途。

3. 发明申请

WO0196868A2 IMMUNOASSAY AND IMMUNOASSAY APPARATUS 审中-公开
标题翻译：免疫和免疫设备
公开(公告)号：WO0196868A2
公开(公告)日：2001-12-20
申请号：PCT/JP0104917
申请日：2001-06-11
申请人： SYSMEX CORP , NAKASHIMA KAZUHIRO , TORII TSUNEYOSHI , TSUCHIYA HIROSHI , UCHIDA SHINYA , KONISHI AYA , TANAKA KUNIO
发明人： NAKASHIMA KAZUHIRO , TORII TSUNEYOSHI , TSUCHIYA HIROSHI , UCHIDA SHINYA , KONISHI AYA , TANAKA KUNIO
IPC分类号： G01N15/00 , G01N15/14 , G01N33/49 , G01N33/543 , G01N33/53
CPC分类号： G01N33/54366 , G01N15/1459 , G01N33/54313 , G01N2015/0065 , G01N2015/0092 , G01N2015/1486 , Y10S435/962 , Y10T436/101666 , Y10T436/106664 , Y10T436/25125
摘要： An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b) introducing the resulting immune agglutination reaction mixture including agglutinated particles and unagglutinated particles to a flow cell, irradiating the particles passing through the flow cell with laser light, and detecting scattered lights generated thereby; (c) setting a threshold value for distinguishing unagglutinated particles from agglutinated particles and a threshold value for distinguishing the agglutinated particles from blood cells with regard to intensity of the scattered light; and (d) distinguishing and counting the unagglutinated particles, the agglutinated particles and the blood cells from the scattered lights detected in the step (b), in reference to the threshold values set in the step (c).
摘要翻译：免疫测定法包括以下步骤：（a）将全血样品与小于红细胞的致敏不溶性载体颗粒混合以引起免疫凝集反应; （b）将所得到的包含凝集颗粒和未凝集颗粒的免疫凝集反应混合物引入流动池，用激光照射通过流动池的颗粒，并检测由此产生的散射光; （c）设定用于将未凝集的颗粒与凝集的颗粒区分开的阈值和用于区分凝集的颗粒与血细胞相关的散射光的强度的阈值; 和（d）参照步骤（c）中设定的阈值，从步骤（b）中检测到的散射光中区分和计数未凝集的颗粒，凝集颗粒和血细胞。

4. 发明申请

WO2005020794A3 TAXANE CHEMOSENSITIVITY PREDICTION TEST 审中-公开
公开(公告)号：WO2005020794A3
公开(公告)日：2005-10-20
申请号：PCT/US2004027661
申请日：2004-08-25
申请人： UNIV TEXAS , SYSMEX CORP , UENO NAOTO T , ISHIHARA HIDEKI , SUDO TAMOTSU , MATSUSHIMA TOMOKO
发明人： UENO NAOTO T , ISHIHARA HIDEKI , SUDO TAMOTSU , MATSUSHIMA TOMOKO
IPC分类号： A61B20060101 , B05D5/00 , C07H21/02 , C07H21/04 , C08K5/00 , C12Q1/48 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/5011 , A61K31/337 , C12Q1/485 , G01N2800/52
摘要： The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cylce molecules in a cancer cell. Such a method makes use of an automated analyzer system wherein cell cycle paramteres (molecules) such as CDKI kinase activity, CDK1 expression, CDK2 kinase activity, CDK2 expression, MAD2 expression, Cyclin Bl, Cyclin E expression, p2l expression, and CDK6 expression; are assessed. The present invention further provides a method of obtaining a cell cycle profile of a cancer cell that is sensitive to a taxane.

5. 发明公开

KR20180058052A 세포 검출 장치 및 세포 검출 방법 审中-公开
公开(公告)号：KR20180058052A
公开(公告)日：2018-05-31
申请号：KR20160156684
申请日：2016-11-23
申请人： SYSMEX CORP
发明人： TABATA SEIICHIRO , YANAGIDA MASATOSHI
IPC分类号： G01N15/10 , G01N21/64 , G02B21/08 , G02B21/36
摘要： 측정대상이되는세포의화상을효율좋게취득할수 있는세포검출장치및 세포검출방법이제공된다. 세포검출장치는입자를포함한측정시료가흐르도록야기하는플로우셀, 플로우셀에공급된측정시료중의입자를검출하기위한입자검출부, 입자검출부에의한검출결과에근거해서, 검출조건을만족하는입자와그 외의입자를선별하기위한입자선별부, 입자선별부에의해선별된검출조건을만족하는입자를포함하는촬상용시료를플로우셀에공급하기위한시료공급부, 및플로우셀에공급된선별된촬상용시료중의입자를촬상하기위한입자촬상부를포함한다.

6. 发明公开

KR20180023061A 소변 시료 분석 방법, 소변 시료 분석용 시약 및 소변 시료 분석용 시약 키트 审中-公开
标题翻译：尿液样本分析试剂的尿样分析试剂盒和尿样分析试剂盒的方法
公开(公告)号：KR20180023061A
公开(公告)日：2018-03-06
申请号：KR20187005496
申请日：2015-02-27
申请人： SYSMEX CORP
发明人： KAWAI AKINORI , ITOSE YUJI
IPC分类号： G01N33/493 , G01N15/14 , G01N21/64 , G01N33/52 , G01N33/80
CPC分类号： G01N15/06 , G01N1/30 , G01N15/1456 , G01N21/6428 , G01N21/6458 , G01N33/493 , G01N33/80 , G01N2015/0065 , G01N2015/0693 , G01N2021/6439 , G01N2201/0612
摘要： 본발명은소변중 유형성분으로서적어도원주및 적혈구를검출하기위한소변시료분석방법, 소변시료분석용시약및 소변시료분석용시약키트에관한것이다.
摘要翻译：尿样分析方法，尿样分析试剂和尿样分析试剂盒技术领域本发明涉及一种尿样分析方法，尿样分析试剂和用于分析尿样的试剂盒，其至少用于检测作为尿颗粒的铸型和红血球。

7. 发明专利

AU2017276341B2 Analysis method and analyser 未知
公开(公告)号：AU2017276341B2
公开(公告)日：2022-12-15
申请号：AU2017276341
申请日：2017-12-15
申请人： SYSMEX CORP
发明人： KUBO TAKUYA
IPC分类号： G01N13/00
摘要： Disclosed is an analysis method including: a component to be analyzed being set; bringing a carrier and a complex that includes the component into contact with each other, to form the complex on the carrier; selecting a washing process in accordance with the component; and analyzing the component, with use of the washing process selected in accordance with the set component. [Selected Figure] FIG. 1 REACTION UNIT 90 90 80A(80)- S 81 81 (80) 82a(82) 82a(82) 11 WASHING UNIT UNNECESSARY UNNECESSARY WSING COMPONENT WSI COMPONENT LIQUID LIQUID (70) (70) 90 80(8)83 80B 80A(80) 83 (80) 81 82a(82) j 81 82a(82) 13 ANALYSIS UNIT 83 8 -- 83 SIGNAL '-83 8OA(80) SIGNAL 12 82a(82) 82a(82) (80) CONTROLLER 14 TARGET COMPONENT CHOICE SETTING TARGET COMPONENT A WASHING PROCESS A UNIT TARGET COMPONENT B WASHING PROCESS B TARGET COMPONENT C WASHING PROCESS C

8. 发明专利

AU2017200491B2 Method of quality control of nucleic acid amplification and reagent for quality control 未知
公开(公告)号：AU2017200491B2
公开(公告)日：2022-04-21
申请号：AU2017200491
申请日：2017-01-25
申请人： SYSMEX CORP
发明人： NAKANO TSUYOSHI , YOSHIDA YUICHIRO
IPC分类号： C12Q1/68
摘要： Disclosed is a method of quality control of nucleic acid amplification using quality control oligonucleotide. The method comprises a nucleic acid detection step and a determination step. The nucleic acid detection step comprises the steps of: preparing a nucleic acid sample containing a target nucleic acid and a quality control polynucleotide; preparing a compartment containing one molecule of the target nucleic acid and a compartment containing one molecule of the quality control polynucleotide; and carrying out nucleic acid amplification of the target nucleic acid and the quality control polynucleotide, in the compartments, and carrying out signal detection using a detection probe to detect a signal originated from the detection probe. In the determination step, it is determined as to whether or not the nucleic acid detection step is proper on the basis of the result obtained in the signal detection step.

9. 发明专利

AR121102A1 MÉTODO PARA MEJORAR LA AFINIDAD DEL ANTICUERPO POR EL ANTÍGENO Y SU USO 未知
公开(公告)号：AR121102A1
公开(公告)日：2022-04-20
申请号：ARP210100146
申请日：2021-01-22
申请人： SYSMEX CORP
发明人： MAETA SHINGO , FUKUNAGA ATSUSHI , BAJAJ REEMA
IPC分类号： C07K16/00 , C07K16/26 , C07K16/32 , C07K16/40 , C12N15/10 , C12N15/13
摘要： Se describe un método para mejorar la afinidad de un anticuerpo por un antígeno en comparación con un anticuerpo no modificado por, en una secuencia de aminoácidos de una región estructural de una cadena liviana del anticuerpo, el cambio de al menos 3 de los residuos de aminoácidos presentes en las posiciones donde el valor total de las frecuencias de aminoácidos de arginina, serina, treonina, valina, ácido aspártico y ácido glutámico es 35% o más y que tiene una relación del área de superficie expuesta al solvente de 20% o más con residuos de aminoácidos cargados.

10. 发明专利

AU2017232047B2 Method and apparatus for assisting diagnosis of risk of progression to stage 2 or higher diabetic nephropathy 未知
公开(公告)号：AU2017232047B2
公开(公告)日：2021-09-23
申请号：AU2017232047
申请日：2017-09-19
申请人： SYSMEX CORP
发明人： SHIRAHASE YASUSHI , YOSHIDA TOSHIYUKI
IPC分类号： G01N33/68 , C07K16/18
摘要： Disclosed is a method for assisting diagnosis of the risk of progression to stage 2 or higher diabetic nephropathy, comprising measuring urinary apolipoprotein E (ApoE) concentration of a diabetic patient with stage 1 diabetic nephropathy, and determining whether the patient has a high risk of progressing to stage 2 or higher diabetic nephropathy based on a result of the measurement step.

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