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1. 发明公开

EP0573722A3 Improvement of wear-resistance of solid lubricants by ionic impact 失效
标题翻译：离子冲击提高固体润滑剂的耐磨性
公开(公告)号：EP0573722A3
公开(公告)日：1994-02-23
申请号：EP92610074.4
申请日：1992-10-26
申请人： Sorensen, Gunnar Dr.
发明人： Gupta, Balkishan K. , Janting, Jakob , Pedersen, Gorm N. , Sorensen, Gunnar
IPC分类号： C23C14/48 , C23C26/00
CPC分类号： B05D5/08 , B05D3/068 , B05D3/148 , C23C14/48
摘要： A solid lubricating material, preferentially as a coating, deposited on a substrate surface by conventional technique such as dipping in a suspension, painting, or spraying is bombarded with energetic ions fron an ion accelerator or in a plasma discharge. By such a treatment the wear resistance of said lubricating material is improved considerably due to changes in the crystalline structure of the surface layer, and further the adherence to the component to be lubricated can be improved. The effect according to the invention, which can be both a reduced friction coefficient and a longer sliding-life can be verified in an experiment with a ball with a certain load oscillating on the surface layer to be tested measuring the time dependence of the friction coefficient. The ion-induced changes in the surface crystallinity can be recognized by a reduced reflection of X- rays from the sliding crystalline planes which are parellel to the component surface to be lubricated.
摘要翻译：用离子加速器或等离子体放电器中的高能离子轰击通过常规技术沉积在基底表面上的固体润滑材料，优选作为涂层，所述常规技术例如浸入悬浮液，喷漆或喷雾。通过这样的处理，由于表面层的晶体结构的变化，所述润滑材料的耐磨性显着提高，并且进一步提高了待润滑部件的粘附性。根据本发明的效果可以是降低的摩擦系数和更长的滑动寿命，可以在具有一定负载的球在待测试的表面层上振荡的实验中验证，测量摩擦系数的时间依赖性。离子诱导的表面结晶度的变化可以通过X射线从与要润滑的部件表面平行的滑动结晶面的减少的反射来识别。

2. 发明公开

EP0573722A2 Improvement of wear-resistance of solid lubricants by ionic impact 失效
标题翻译：通过离子轰击改善干润滑剂Verschleissfestikeit。
公开(公告)号：EP0573722A2
公开(公告)日：1993-12-15
申请号：EP92610074.4
申请日：1992-10-26
申请人： Sorensen, Gunnar Dr.
发明人： Gupta, Balkishan K. , Janting, Jakob , Pedersen, Gorm N. , Sorensen, Gunnar
IPC分类号： C23C14/48 , C23C26/00
CPC分类号： B05D5/08 , B05D3/068 , B05D3/148 , C23C14/48
摘要： A solid lubricating material, preferentially as a coating, deposited on a substrate surface by conventional technique such as dipping in a suspension, painting, or spraying is bombarded with energetic ions fron an ion accelerator or in a plasma discharge. By such a treatment the wear resistance of said lubricating material is improved considerably due to changes in the crystalline structure of the surface layer, and further the adherence to the component to be lubricated can be improved. The effect according to the invention, which can be both a reduced friction coefficient and a longer sliding-life can be verified in an experiment with a ball with a certain load oscillating on the surface layer to be tested measuring the time dependence of the friction coefficient. The ion-induced changes in the surface crystallinity can be recognized by a reduced reflection of X- rays from the sliding crystalline planes which are parellel to the component surface to be lubricated.
摘要翻译：固体润滑材料，优选作为涂层沉积在通过现有技术中的基片表面：如以悬浮液，绘画，或喷涂浸渍轰击高能离子氟利昂离子加速器中或在等离子体放电。通过寻求治疗所述润滑材料的耐磨损性显着改善，由于在表面层中的晶体结构的变化，并且进一步的粘附到待润滑部件可以得到改善。效果雅丁到本发明的，既可以是一个减小的摩擦系数和更长的滑动寿命可以被验证以与表面层上的某些负载摆动球试验将待测试测量摩擦系数的时间依赖性，在表面结晶性的离子引起的变化可以通过从滑动晶面哪些中并行到部件表面被润滑的X射线的减少的反射进行识别。

3. 发明申请

WO1987003281A1 PROPANE-1,3-DIOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：丙-1,3-二醇衍生物，其生产方法和药物组合物
公开(公告)号：WO1987003281A1
公开(公告)日：1987-06-04
申请号：PCT/DK1986000128
申请日：1986-11-20
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S , GRUE-SORENSEN, Gunnar , NIELSEN, Christian, Kaergaard
发明人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S
IPC分类号： C07C93/04
CPC分类号： C07D277/24 , C07C271/06 , C07C333/02
摘要： A derivative of 2-methylenepropane-1,3-diol of general formula (I), where O-A and O-A , which can be the same or different, each represents O, O-C(O), O-C(O)NH, O-C(S)NH or O-C(O)O, R represents an alkyl or alkenyl group of 10 - 22 carbon atoms, n is an integer from 1 to 11, B represents a quaternary ammonium group, either NR R R , or N(Het), where R , R and R are similar or different alkyl groups of 1 - 4 carbon atoms, or two or all of R , R and R may be incorporated into a cyclic or bicyclic structure, which may contain additional hetero atoms; X means the anion of a pharmaceutically acceptable inorganic or organic acid; and R and R are the same or different, and represent hydrogen or alkyl groups of 1 - 4 carbon atoms. The present compounds have been shown to possess a PAF antagonistic effect and an inhibitory effect on the growth of tumor cells, and are thus valuable in the human and veterinary practice as platelet aggregation inhibitors, anti-thrombotic agents, anti-asthmatic agents, anti-allergic agents, anti-inflammatory agents, anti-hypotensive agents, anti-ulcer agents, anti-psoriatic agents, anti-graft rejection agents, anti-conception agents and anti-tumor agents.
摘要翻译：通式（I）的2-亚甲基丙烷-1,3-二醇的衍生物，其中OA 1和OA 2可以相同或不同，各自表示O，OC（O），OC（O ）NH，OC（S）NH或OC（O）O，R 1表示10-22个碳原子的烷基或烯基，n是1至11的整数，B +表示季铵基 NR 4 R 5 R 6或N（Het），其中R 4，R 5和R 6是相同或不同的1-4个碳原子的烷基，或 R 4，R 5和R 6中的两个或全部可以并入环状或双环结构，其可以含有另外的杂原子; 是指药学上可接受的无机酸或有机酸的阴离子; R 2和R 3相同或不同，代表氢或1-4个碳原子的烷基。本发明化合物已被证明具有PAF拮抗作用和对肿瘤细胞生长的抑制作用，因此在人和兽医学实践中作为血小板聚集抑制剂，抗血栓形成剂，抗哮喘药，抗 - 过敏剂，抗炎剂，抗低血压剂，抗溃疡剂，抗牛皮癣剂，抗移植物排斥剂，抗受孕剂和抗肿瘤剂。

4. 发明申请

WO1997037972A1 NOVEL VITAMIN D ANALOGUES 审中-公开
标题翻译：新维生素D类似物
公开(公告)号：WO1997037972A1
公开(公告)日：1997-10-16
申请号：PCT/DK1997000128
申请日：1997-03-21
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) , GRUE-SORENSEN, Gunnar
发明人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)
IPC分类号： C07C401/00
CPC分类号： C07C401/00
摘要： The present invention relates to compounds of formula (I) in which Q stands for a C1-C8 hydrocarbylene diradical, R stands for hydrogen or C1-C6 hydrocarbyl, or two R groups, taken together with the carbon atom bearing the hydroxy group can form a C3-C8 carbocyclic ring. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
摘要翻译：本发明涉及式（I）化合物，其中Q代表C1-C8亚烃基双基，R代表氢或C1-C6烃基，或两个R基团与带有羟基的碳原子一起形成一个C3-C8碳环。这些化合物显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。

5. 发明申请

WO1994014766A1 NOVEL VITAMIN D ANALOGUES 审中-公开
标题翻译：新维生素D类似物
公开(公告)号：WO1994014766A1
公开(公告)日：1994-07-07
申请号：PCT/DK1993000425
申请日：1993-12-17
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS ... , GRUE-SORENSEN, Gunnar , OTTOSEN, Erik, Rytter
发明人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS ...
IPC分类号： C07C401/00
CPC分类号： C07C401/00
摘要： The present invention relates to compounds of formula (I) in which formula Y is sulfur, S(O), or S(O)2; R stands for C1-C3 alkyl, or (a) can form a C3-C8 carbocyclic ring, Q is a C1-C8 hydrocarbylene diradical; and derivatives thereof. The compounds show antiinflammatroy and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
摘要翻译：本发明涉及式（I）化合物，其中式Y为硫，S（O）或S（O）2; R代表C 1 -C 3烷基，或（a）可以形成C 3 -C 8碳环，Q是C 1 -C 8亚烷基双基; 及其衍生物。这些化合物显示抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。

6. 发明申请

WO1990006050A1 A SEAL OR EARTAG FOR ANIMALS 审中-公开
标题翻译：动物密封或地毯
公开(公告)号：WO1990006050A1
公开(公告)日：1990-06-14
申请号：PCT/DK1989000288
申请日：1989-12-05
申请人： DANSK PLOMBEFABRIK A/S , JACOBSEN, Henrik , SORENSEN, Gunnar
发明人： DANSK PLOMBEFABRIK A/S
IPC分类号： A01K11/00
CPC分类号： A01K11/001
摘要： A seal or eartag (1) for instnce animals and comprising a male member (4) and a female member (5), both members being provided with an information carrier (7). The male member (4) is provided with a pin comprising a shaft, a head and an insertion member. The male member (4) and the female member (5) are made of at least two different materials. The female member (5) is provided with an inner metal ring body capable of co-operating with the pin on the male member (4). The metal ring body of the female member (5) is embedded in said female member (5) and is provided with a plurality of vaulted locking webs projecting towards the centre of the ring and engaging the head behind the insertion member of the male member (4). One or more safety wires may be embedded in the male member (4) and the female member (5) and ensure or indicate that the seal or the eartag (1) is correctly assembled. The object of the invention is to provide a seal or an eartag secured against falsification upon the mounting, and where the mounting can be controlled in such a manner that a remounting of a seal or an eartag removed from the animal is impossible.
摘要翻译：一种用于动物动物的密封件或肛门（1），包括一个阳部件（4）和一个阴部件（5），两个部件设置有信息载体（7）。阳构件（4）设置有包括轴，头部和插入构件的销。阳构件（4）和阴构件（5）由至少两种不同的材料制成。阴构件（5）设置有能够与阳构件（4）上的销配合的内金属环体。阴构件（5）的金属环体嵌入所述阴构件（5）中并且设置有多个拱形锁定腹板，其朝向环的中心突出并且将头部接合在阳构件的插入构件后面（ 4）。一个或多个安全线可以嵌入在阳构件（4）和阴构件（5）中，并且确保或指示密封件或玄物（1）被正确地组装。本发明的目的是提供一种在安装时防止伪造的密封件或铁丝网，并且其中可以以这样的方式控制安装，从而不可能重新安装从动物去除的密封件或烙铁。

7. 发明申请

WO1983002960A1 A POWDER FOR USE IN DRY ACTIVATION FOR ELECTROLESS METALLIZING 审中-公开
标题翻译：用于电铸金属干燥活化的粉末
公开(公告)号：WO1983002960A1
公开(公告)日：1983-09-01
申请号：PCT/DK1983000017
申请日：1983-02-18
申请人： NESELCO A/S , SORENSEN, Gunnar , SVENDSEN, Leo, Gulvad
发明人： NESELCO A/S
IPC分类号： C23C03/00
CPC分类号： C23C18/28
摘要： Poudre catalytiquement active, sa préparation, et un procédé pour la préparer, cette poudre étant utilisée pour fabriquer des substrats isolants activés pour recevoir un métal déposé sans passage de courant dans une couche métallique cohérente. La poudre plastique contient des composés chimiques permettant que l'accélération du catalyseur n'ait pas lieu jusqu'à ce que la poudre est fondue sur le substrat. Le substrat n'a pas besoin d'être décapé avant la métallisation étant donné que le plastique fondu assure une bonne adhésion entre le métal et le plastique et entre le plastique et le substrat. De plus, la nature colloïdale des composés catalyseurs a été stabilisée de manière particulièrement durable par la poudre plastique. L'utilisation de la poudre présente moins de danger à l'environnement étant donné que le catalyseur peut être transporté sous la forme d'une poudre à l'état sec et que le décapage du substrat n'est plus nécessaire.

8. 发明申请

WO1995002577A1 NOVEL VITAMIN D ANALOGUES 审中-公开
标题翻译：新维生素D类似物
公开(公告)号：WO1995002577A1
公开(公告)日：1995-01-26
申请号：PCT/DK1994000271
申请日：1994-07-01
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) , GRUE-SORENSEN, Gunnar
发明人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)
IPC分类号： C07C401/00
CPC分类号： C07C401/00
摘要： The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R and R , which may be the same or different, stand for hydrogen or C1-C4 hydrocarbyl; or R and R , taken together with the carbon atom bearing the group X, can form a C3-C8 carbocyclic ring; Q is a single bond or a C1-C4 hydrocarbylene diradical; R , R and/or Q may be optionally substituted with one or more fluorine atoms; and prodrugs of formula (I) in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
摘要翻译：本发明涉及式（I）化合物，其中式X为氢或羟基; R 1和R 2可以相同或不同，代表氢或C 1 -C 4烃基; 或R 1和R 2与带有基团X的碳原子一起可以形成C 3 -C 8碳环; Q是单键或C1-C4亚烃基双基; R 1，R 2和/或Q可任选被一个或多个氟原子取代; 和式（I）的前药，其中一个或多个羟基被掩蔽为可在体内再转化为羟基的基团。这些化合物显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。

9. 发明申请

WO1993019044A1 NOVEL VITAMIN D ANALOGUES 审中-公开
标题翻译：新维生素D类似物
公开(公告)号：WO1993019044A1
公开(公告)日：1993-09-30
申请号：PCT/DK1993000105
申请日：1993-03-23
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS ... , BRETTING, Claus, Aage, Svensgaard , GRUE-SORENSEN, Gunnar
发明人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS ...
IPC分类号： C07C401/00
CPC分类号： C07C401/00
摘要： The invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R and R stand for hydrogen or a C1-C6 hydrocarbyl radical; or taken together with the carbon atom bearing the group X, can form a C3-C8 carbocyclic ring; R stands for hydrogen or a C1-C10 hydrocarbyl radical or for YR , in which Y stands for the radicals -CO-, -CO-O-, -CO-S-, -CS-, -CS-O-, -CS-S-, -SO- or -SO2-, and R stands for hydrogen or a C1-C10 hydrocarbyl radical; Q is a single bond or a C1-C8 hydrocarbylene diradical. R , R , R and/or Q may be optionally substitued with one or more deuterium or fluorine atoms. The compounds show an antiinflammatory and immunomodulating effect as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
摘要翻译：本发明涉及式（I）化合物，其中式X为氢或羟基; R 1和R 2代表氢或C 1 -C 6烃基; 或与带有X基团的碳原子一起形成C 3 -C 8碳环; R 3代表氢或C 1 -C 10烃基或YR 4，其中Y代表基团-CO-，-CO-O-，-CO-S-，-CS-，-CS -O - ， - S-S-，-SO-或-SO 2 - ，R 4代表氢或C 1 -C 10烃基; Q是单键或C1-C8亚烃基双基。 R 1，R 2，R 3和/或Q可任选被一个或多个氘或氟原子取代。该化合物显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。

10. 发明申请

WO1991015475A1 NOVEL VITAMIN D ANALOGUES 审中-公开
标题翻译：新维生素D类似物
公开(公告)号：WO1991015475A1
公开(公告)日：1991-10-17
申请号：PCT/DK1991000091
申请日：1991-03-22
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS ... , CALVERLEY, Martin, John , GRUE-SORENSEN, Gunnar , BINDERUP, Ernst, Torndal
发明人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS ...
IPC分类号： C07C401/00
CPC分类号： C07C401/00
摘要： The invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; Y is oxygen or sulphur or oxidized sulphur (S(O) or S(O2)); R and R , which may be the same or different, stand for hydrogen or C1-C6 hydrocarbyl; or R and R , taken together with the carbon atom (starred in formula I) bearing the group X, can form a C3-C8 carbocyclic ring; Q is a C1-C8 hydrocarbylene diradical. R is hydrogen or C1-C6 hydrocarbyl. R , R and/or Q may be optionally substituted with one or more deuterium or fluorine atoms. n is 0 or 1. The present compounds, which find use both in the human and veterinary practice, show an antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells, including cancer cells and skin cells.
摘要翻译：本发明涉及式（I）化合物，其中式X为氢或羟基; Y是氧或硫或氧化硫（S（O）或S（O 2））; R 1和R 2可以相同或不同，代表氢或C 1 -C 6烃基; 或R 1和R 2与带有基团X的碳原子（以式I表示的原子）一起可以形成C 3 -C 8碳环; Q是C1-C8亚烃基双基。 R 3是氢或C 1 -C 6烃基。 R 1，R 2和/或Q可任选被一个或多个氘或氟原子取代。 n是0或1.本发明化合物在人和兽医学实践中都有用，显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞（包括癌细胞和皮肤细胞）的不期望的增殖的强烈活性。

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