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1. 发明公开

EP1239860A1 USE OF DEXTROMETHORPHAN AND OXIDASE INHIBITOR FOR WEANING PATIENTS FROM NARCOTICS AND ANTI-DESPRESSANTS 审中-公开
标题翻译：右美沙芬和使用的氧化酶抑制剂麻醉剂和抗抑郁药EINTWOÖHNUNG
公开(公告)号：EP1239860A1
公开(公告)日：2002-09-18
申请号：EP00990294.1
申请日：2000-12-22
申请人： Smith, Richard, Alan
发明人： Smith, Richard, Alan
IPC分类号： A61K31/485 , A61K31/49 , A61P25/36
CPC分类号： A61K31/135 , A61K31/27 , A61K31/44 , A61K31/485 , A61K31/49 , A61K2300/00
摘要： Patients can be helped to break free of addictive or habit-forming narcotics and anti-depressants, by treatment using two drugs. One drug is dextromethorphan (DM), which has been used for decades as an anti-tussive (cough-suppressing) drug in cough syrups. The other drug is an oxidase inhibitor which suppresses activity of a liver enzyme called cytochrome P450-2D6 (also called debrisoquin hydroxylase, sparteine monooxygenase, cytochrome P450-DB, and CYP2D6). In most patients, this oxidase enzyme rapidly degrades DM and converts it into a metabolite called dextrorphan. An oxidase inhibitor (such as quinidine) which suppresses cytochrome P450-2D6 activity increases the half-life and concentration of DM in the circulating blood. When this combined treatment was administered orally to patients who had become dependent on morphine and anti-depressant drugs because of chronic intractable pain, it initially helped the patients reduce their dosages of morphine and other drugs, including anti-depressants. When additional testing was done, the combined treatment allowed patients to entirely terminate all use of morphine and anti-depressants, with minimal withdrawal or other adverse effects. Importantly, these same patients received no substantial benefit from taking dm by itself, without an oxidase inhibitor. Accordingly, the combination of dextromethorphan plus an anti-oxidase drug can allow at least some patients to break entirely free of narcotics and/or anti-depressants, even after years of use for chronic pain and other medical problems, even when they are not substantially helped by dextromethorphan alone.

2. 发明公开

EP1700601A3 USE OF DEXTROMETHORPHAN AND AN OXIDASE INHIBITOR FOR WEANING PATIENTS FROM NARCOTICS AND ANTI-DESPRESSANTS 审中-公开
标题翻译：右美沙芬和使用AN氧化酶抑制剂断奶麻醉药品和抗抑郁药
公开(公告)号：EP1700601A3
公开(公告)日：2006-09-27
申请号：EP06111654.7
申请日：2000-12-22
申请人： Smith, Richard, Alan
发明人： Smith, Richard, Alan
IPC分类号： A61K31/485 , A61K31/49 , A61P25/36
CPC分类号： A61K31/135 , A61K31/27 , A61K31/44 , A61K31/485 , A61K31/49 , A61K2300/00
摘要： Patients can be helped to break free of addictive or habit-forming narcotics and anti-depressants, by treatment using two drugs. One drug is dextromethorphan (DM), which has been used for decades as an anti-tussive (cough-suppressing) drug in cough syrups. The other drug is an oxidase inhibitor which suppresses activity of a liver enzyme called cytochrome P450-2D6 (also called debrisoquin hydroxylase, sparteine monooxygenase, cytochrome P450-2D6). In most patients, this oxidase enzyme rapidly degrades DM and converts it into a metabolite called dextrorphan. An oxidase inhibitor (such as quinidine) which suppresses cytochrome P450-2D6 activity increases the half-life and concentration of DM in the circulating blood. When this combined treatment was administered orally to patients who had become dependent on morphine and other drugs including narcotics and anti-depressant drugs because of chronic intractable pain, it initially helped the patients reduce their dosages of morphine and other drugs, including narcotics and anti-depressants.

3. 发明授权

EP0788359B1 COMBINATION OF DEXTROMETHORPHAN WITH QUINIDINE OR QUININE SULFATE FOR TREATING A VARIETY OF INTRACTABLE DISORDERS 失效
标题翻译：右美沙芬的组合或奎尼丁硫酸奎宁难治各种病症的治疗
公开(公告)号：EP0788359B1
公开(公告)日：2006-07-12
申请号：EP94931762.2
申请日：1994-09-22
申请人： Smith, Richard, Alan , Licht, Jonathan, M.
发明人： Smith, Richard, Alan , Licht, Jonathan, M.
IPC分类号： A61K31/485 , A61K31/49 , A61P11/14 , A61P15/00 , A61P17/00 , A61P27/16 , A61P25/02
CPC分类号： A61K31/485 , A61K31/49 , A61K45/06 , A61K31/415 , A61K31/145 , A61K31/135 , A61K2300/00
摘要： The present invention relates to pharmacology and provides for the use of certain compositions in the preparation of medicaments for the treatment of a variety of intractable disorders. These compositions are a combination of dextromethorphan and an inhibitor of the liver enzyme debrisoquin hydroxylase. This combination of compositions has proven successful in the treatment of intractable coughing, dermatitis, chronic pain, and tinnitus.

4. 发明公开

EP0788359A4 COMPOSITIONS USEFUL FOR THE PREPARATION OF MEDICINES FOR TREATING A VARIETY OF INTRACTABLE DISORDERS 失效
标题翻译： MEANS药品难治性的各种疾病的治疗中制备
公开(公告)号：EP0788359A4
公开(公告)日：1998-08-19
申请号：EP94931762
申请日：1994-09-22
申请人： SMITH RICHARD ALAN , LICHT JONATHAN M
发明人： SMITH RICHARD ALAN , LICHT JONATHAN M
IPC分类号： A61K31/485 , A61K31/49 , A61K45/06 , A61P11/14 , A61P17/00 , A61P25/04 , A61P27/16 , A61P43/00 , A61K31/44
CPC分类号： A61K31/485 , A61K31/49 , A61K45/06 , A61K31/415 , A61K31/145 , A61K31/135 , A61K2300/00

5. 发明公开

EP1634597A1 Compositions comprising dextromethorphan and quinidine or quinine for the treatment of emotional lability 失效
标题翻译：右美沙芬和奎宁（Quinidin enthaltende）Zusammensetzungen zur Behandlung derGemütslabilität
公开(公告)号：EP1634597A1
公开(公告)日：2006-03-15
申请号：EP05018018.1
申请日：1994-09-22
申请人： Smith, Richard, Alan , Licht, Jonathan, M.
发明人： Smith, Richard, Alan , Licht, Jonathan, M.
IPC分类号： A61K31/485 , A61K31/49 , A61P25/00
CPC分类号： A61K31/485 , A61K31/49 , A61K45/06 , A61K31/415 , A61K31/145 , A61K31/135 , A61K2300/00
摘要： The present invention relates to pharmacology and provides for the use of certain compositions in the preparation of medicaments for the treatment of a variety of intractable disorders. These compositions are a combination of dextromethorphan and an inhibitor of the liver enzyme debrisoquin hydroxylase. This combination of compositions has proven successful in the treatment of intractable coughing, dermatitis, chronic pain, and tinnitus.
摘要翻译：本发明涉及药理学，并提供某些组合物在制备用于治疗各种难治性疾病的药物中的用途。这些组合物是右美沙芬和肝酶的错配羟化酶的抑制剂的组合。组合物的这种组合已被证明在治疗顽固性咳嗽，皮炎，慢性疼痛和耳鸣方面是成功的。

6. 发明公开

EP0788359A1 COMPOSITIONS USEFUL FOR THE PREPARATION OF MEDICINES FOR TREATING A VARIETY OF INTRACTABLE DISORDERS 失效
标题翻译：右美沙芬的组合或奎尼丁硫酸奎宁难治各种病症的治疗
公开(公告)号：EP0788359A1
公开(公告)日：1997-08-13
申请号：EP94931762.0
申请日：1994-09-22
申请人： Smith, Richard, Alan , Licht, Jonathan, M.
发明人： Smith, Richard, Alan , Licht, Jonathan, M.
IPC分类号： A61K31 , A61K45 , A61P11 , A61P17 , A61P25 , A61P27 , A61P43
CPC分类号： A61K31/485 , A61K31/49 , A61K45/06 , A61K31/415 , A61K31/145 , A61K31/135 , A61K2300/00
摘要： The present invention relates to pharmacology and provides for the use of certain compositions in the preparation of medicaments for the treatment of a variety of intractable disorders. These compositions are a combination of dextromethorphan and an inhibitor of the liver enzyme debrisoquin hydroxylase. This combination of compositions has proven successful in the treatment of intractable coughing, dermatitis, chronic pain, and tinnitus.

7. 发明公开

EP1700601A2 USE OF DEXTROMETHORPHAN AND AN OXIDASE INHIBITOR FOR WEANING PATIENTS FROM NARCOTICS AND ANTI-DESPRESSANTS 审中-公开
标题翻译： VERWENDUNG VON DEXTROMETHORPHAN UND EINEM OXIDASE-INHIBITOR ZURENTWÖHNUNGVON NARKOTIKA UND ANTIDEPRESSIVA
公开(公告)号：EP1700601A2
公开(公告)日：2006-09-13
申请号：EP06111654.7
申请日：2000-12-22
申请人： Smith, Richard, Alan
发明人： Smith, Richard, Alan
IPC分类号： A61K31/485 , A61K31/49 , A61P25/36
CPC分类号： A61K31/135 , A61K31/27 , A61K31/44 , A61K31/485 , A61K31/49 , A61K2300/00
摘要： Patients can be helped to break free of addictive or habit-forming narcotics and anti-depressants, by treatment using two drugs. One drug is dextromethorphan (DM), which has been used for decades as an anti-tussive (cough-suppressing) drug in cough syrups. The other drug is an oxidase inhibitor which suppresses activity of a liver enzyme called cytochrome P450-2D6 (also called debrisoquin hydroxylase, sparteine monooxygenase, cytochrome P450-2D6). In most patients, this oxidase enzyme rapidly degrades DM and converts it into a metabolite called dextrorphan. An oxidase inhibitor (such as quinidine) which suppresses cytochrome P450-2D6 activity increases the half-life and concentration of DM in the circulating blood. When this combined treatment was administered orally to patients who had become dependent on morphine and other drugs including narcotics and anti-depressant drugs because of chronic intractable pain, it initially helped the patients reduce their dosages of morphine and other drugs, including narcotics and anti-depressants.
摘要翻译：通过使用两种药物治疗，可以帮助患者摆脱成瘾或习惯形成的麻醉剂和抗抑郁药物。一种药物是右美沙芬（DM），它几十年来被用作止咳糖浆中的抗咳嗽药（止咳药）。另一种药物是抑制称为细胞色素P450-2D6（也称为无色羟化酶，斯巴汀单加氧酶，细胞色素P450-2D6）的肝酶活性的氧化酶抑制剂。在大多数患者中，这种氧化酶迅速降解DM并将其转化为称为右美沙芬的代谢物。抑制细胞色素P450-2D6活性的氧化酶抑制剂（如奎尼丁）会增加循环血液中DM的半衰期和浓度。当这种联合治疗口服给予因吗啡和其他药物（包括麻醉药和抗抑郁药物）因慢性顽固性疼痛而依赖的患者时，最初帮助患者减少吗啡和其他药物的剂量，包括麻醉剂和抗生素，镇静剂。

8. 发明专利

DE69434794T2 未知
公开(公告)号：DE69434794T2
公开(公告)日：2007-07-12
申请号：DE69434794
申请日：1994-09-22
申请人： SMITH RICHARD ALAN , LICHT JONATHAN M
发明人： SMITH ALAN , LICHT M
IPC分类号： A61K31/485 , A61K31/49 , A61K45/06 , A61P11/14 , A61P15/00 , A61P17/00 , A61P25/02 , A61P25/04 , A61P27/16 , A61P43/00
摘要： The present invention relates to pharmacology and provides for the use of certain compositions in the preparation of medicaments for the treatment of a variety of intractable disorders. These compositions are a combination of dextromethorphan and an inhibitor of the liver enzyme debrisoquin hydroxylase. This combination of compositions has proven successful in the treatment of intractable coughing, dermatitis, chronic pain, and tinnitus.

9. 发明专利

ES2268686T3 COMBINACION DE DEXTROMETORFANO CON QUINIDINA O SULFATO DE QUININA PARA TRATAR DIVERSOS TRASTORNOS DE DIFICIL CURA. 未知
公开(公告)号：ES2268686T3
公开(公告)日：2007-03-16
申请号：ES94931762
申请日：1994-09-22
申请人： SMITH RICHARD ALAN , LICHT JONATHAN M
发明人： SMITH RICHARD ALAN , LICHT JONATHAN M
IPC分类号： A61K31/485 , A61K31/49 , A61K45/06 , A61P11/14 , A61P15/00 , A61P17/00 , A61P25/02 , A61P25/04 , A61P27/16 , A61P43/00
摘要： LA PRESENTE INVENCION SE REFIERE A LA FARMACOLOGIA Y PERMITE EL USO DE CIERTAS COMPOSICIONES EN LA PREPARACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE UNA VARIEDAD DE ENFERMEDADES INTRATABLES. ESTAS COMPOSICIONES SON UNA COMBINACION DE DEXTROMETORFANO Y UN INHIBIDOR DE LA ENZIMA HEPATICA HIDROSILASA DEBRISOQUINA. ESTA COMBINACION DE LAS COMPOSICIONES HA MEJORADO CON EXITO EL TRATAMIENTO DE LA TOS Y DERMATITIS INTRATABLES, EL DOLOR CRONICO Y EL TINITUS.

10. 发明专利

CA2395411A1 USE OF DEXTROMETHORPHAN AND OXIDASE INHIBITOR FOR WEANING PATIENTS FROM NARCOTICS AND ANTI-DEPRESSANTS 未知
公开(公告)号：CA2395411A1
公开(公告)日：2001-06-28
申请号：CA2395411
申请日：2000-12-22
申请人： SMITH RICHARD ALAN
发明人： SMITH RICHARD ALAN
IPC分类号： A61K45/00 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/166 , A61K31/27 , A61K31/44 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/475 , A61K31/485 , A61K31/49 , A61K31/5415 , A61P25/30 , A61P25/36
摘要： Patients can be helped to break free of addictive or habit-forming narcotics and anti-depressants, by treatment using two drugs. One drug is dextromethorphan (DM), which has been used for decades as an anti-tussive (cough-suppressing) drug in cough syrups. The other drug is an oxidase inhibitor which suppresses activity of a liver enzyme called cytochrome P450 - 2D6 (also called debrisoquin hydroxylase, sparteine monooxygenase, cytochrom e P450-DB, and CYP2D6). In most patients, this oxidase enzyme rapidly degrades DM and converts it into a metabolite called dextrorphan. An oxidase inhibito r (such as quinidine) which suppresses cytochrome P450-2D6 activity increases the half-life and concentration of DM in the circulating blood. When this combined treatment was administered orally to patients who had become dependent on morphine and anti-depressant drugs because of chronic intractab le pain, it initially helped the patients reduce their dosages of morphine and other drugs, including anti-depressants. When additional testing was done, t he combined treatment allowed patients to entirely terminate all use of morphin e and anti-depressants, with minimal withdrawal or other adverse effects. Importantly, these same patients received no substantial benefit from taking dm by itself, without an oxidaseinhibitor. Accordingly, the combination of dextromethorphan plus an anti-oxidase drug can allow at least some patients to break entirely free of narcotics and/or anti-depressants, even after years o f use for chronic pain and other medical problems, even when they are not substantially helped by dextromethorphan alone.

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