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1. 发明公开

EP3354240A3 SEQUESTERED REACTIVE MATERIALS 审中-公开
公开(公告)号：EP3354240A3
公开(公告)日：2018-08-29
申请号：EP18159981.2
申请日：2004-04-23
申请人： The University of Akron , Reneker, Darrell H. , Smith, Daniel J.
发明人： Reneker, Darrell H. , Smith, Daniel J.
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/70 , Y10T442/2525
摘要： A fibrous assembly is provided for performing site-specific chemistry. In general, the present invention provides a fibrous assembly comprising a first nanofiber that sequesters a first reactive component, wherein the first nanofiber is prepared by an electrospinning or gas-jet method, wherein the first nanofiber releases its reactive component when the nanofiber is in the presence of a releasing agent and the first reactive component and the releasing agent chemically react to produce a reaction product. Related methods of manufacture and use are also disclosed.

2. 发明公开

EP1970674A1 Variable area flow rate meter using optical sensing of float position in the duct 审中-公开
标题翻译：流量计使用浮动位置进行光学扫描的信道的可变区
公开(公告)号：EP1970674A1
公开(公告)日：2008-09-17
申请号：EP08250866.4
申请日：2008-03-13
申请人： Smith, Daniel J. , Lakhan, Haresh , Smisek, Quentin
发明人： Smith, Daniel J. , Lakhan, Haresh , Smisek, Quentin
IPC分类号： G01F1/24 , G01F1/66 , G01P5/02
CPC分类号： G01F1/24 , G01F1/22 , G01F15/024 , G01P5/02
摘要： A flowmeter (10) has a variable area, vertically-oriented duct (35) through which flows fluid whose flow rate is to be determined. A float (30) in the duct (35) assumes a position in the duct (35) that depends on the flow rate of fluid in the duct. A window (52) is located at an end of the duct (35) in alignment with a longitudinal axis of the duct. A transducer unit (50) projects a signal beam comprising either light in the ultraviolet, visible, or infrared spectrum, or ultrasound energy. The signal beam propagates in a beam through the window (52) and along the axis toward the float (30). The transducer (50) includes a sensor (60) that detects the signal energy returned by the float (30) by reflection or some other mechanism to the transducer unit (50). The intensity or delay time in the returned signal energy indicates the position of the float (30) in the duct (35), from which the fluid flow rate may be determined.
摘要翻译：一种流量计（10）具有可变区，垂直取向的管道（35），通过该流动流体谁的流量将被确定。在管道中的浮子（30），（35）übernimmt在所述管道（35）的位置处做取决于流体在管道中的流率。一个窗口（52）位于在对准导管（35）与所述导管的纵向轴线的端部。一种换能器单元（50）突出在紫外，可见或红外光谱，或超声能量，其包括任一的光的光束信号。信号光束传播通过所述窗口（52）的光束，并沿朝向所述浮子（30）的轴线。所述换能器（50）包括传感器（60）做了检测由所述浮子（30）通过反射或一些其它机制到换能器单元（50）返回的信号能量。在返回的信号能量的强度或延迟时间表示在所述管道（35），从该流体流率可以是确定性的开采的浮子（30）的位置。

3. 发明公开

EP1624953A2 SEQUESTERED REACTIVE MATERIALS 审中-公开
标题翻译：螯合的反应材料
公开(公告)号：EP1624953A2
公开(公告)日：2006-02-15
申请号：EP04760164.6
申请日：2004-04-23
申请人： The University of Akron , Reneker, Darrell H. , Smith, Daniel J.
发明人： RENEKER, Darrell, H. , SMITH, Daniel, J.
IPC分类号： B01F1/00 , A61F13/00
CPC分类号： A61K9/70 , Y10T442/2525
摘要： A fibrous assembly is provided for performing site-specific chemistry. In general the present invention provides a fibrous assembly comprising a first fiber that sequesters a first reactive component; and a second fiber that sequesters a second reactive component, wherein at least the first or second fiber releases its reactive component when the fiber is in the presence of a releasing agent, and wherein when the at least first or second fiber releases its reactive component, the first and second reactive components react with each other to form a reaction product. Related methods of manufacture and use are also provided.

4. 发明公开

EP0118547A1 METHOD FOR THE PREPARATION OF GLUCOSYLTRANSFERASE 失效
标题翻译：用于生产葡糖基转移酶。
公开(公告)号：EP0118547A1
公开(公告)日：1984-09-19
申请号：EP83903053.0
申请日：1983-09-09
申请人： FORSYTH DENTAL INFIRMARY FOR CHILDREN , TAUBMAN, Martin A. , SMITH, Daniel J.
发明人： FORSYTH DENTAL INFIRMARY FOR CHILDREN , TAUBMAN, Martin A. , SMITH, Daniel J.
IPC分类号： A61K39 , C12N9 , C12R1
CPC分类号： C12N9/1051 , Y10S435/814 , Y10S435/815
摘要： Procédé de préparation de glucocyl transférase purifié (GTF) destiné à être utilisé dans l'immunisation contre la carie dentaire, consistant à: préparer une culture de Streptococcus mutans dans un bouillon de culture contenant du glucose et des substances nutritives dyalisables pour former un mélange de cellules de culture et de surnageant; séparer le surnageant par extraction des cellules de culture; mélanger le surnageant séparé avec un polysaccharide polymérisé insoluble dans l'eau sous forme de matériau particulaire pendant une certaine période de temps, de manière à obtenir un complexe particulaire solide de GTF; extraire par filtration le complexe GTF sous la forme particulaire solide; laver le complexe GTF solide pour séparer le GTF non lié et les composants du bouillon de culture; extraire le GTF du matériau particulaire solide grâce à un solvant de dénaturation; extraire le matériau particulaire insoluble dans l'eau pour le réutiliser dans le procédé; et extraire le GTF du polysaccharide insoluble dans l'eau et purifier le GTF extrait.

5. 发明公开

EP3354240A2 SEQUESTERED REACTIVE MATERIALS 审中-公开
公开(公告)号：EP3354240A2
公开(公告)日：2018-08-01
申请号：EP18159981.2
申请日：2004-04-23
申请人： The University of Akron , Reneker, Darrell H. , Smith, Daniel J.
发明人： Reneker, Darrell H. , Smith, Daniel J.
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/70 , Y10T442/2525
摘要： A fibrous assembly is provided for performing site-specific chemistry. In general, the present invention provides a fibrous assembly comprising a first nanofiber that sequesters a first reactive component, wherein the first nanofiber is prepared by an electrospinning or gas-jet method, wherein the first nanofiber releases its reactive component when the nanofiber is in the presence of a releasing agent and the first reactive component and the releasing agent chemically react to produce a reaction product. Related methods of manufacture and use are also disclosed.

6. 发明公开

EP1648527A4 STABILIZATION AND IONIC TRIGGERING OF NITRIC OXIDE RELEASE 审中-公开
标题翻译：稳定与离子释放氮氧化物-RELEASE的
公开(公告)号：EP1648527A4
公开(公告)日：2008-04-23
申请号：EP04779101
申请日：2004-07-26
申请人： UNIV AKRON , SMITH DANIEL J
发明人： SMITH DANIEL J
IPC分类号： A61L9/04 , A61K20060101 , A61K9/00 , A61K9/14 , A61K33/00 , A61K47/48
CPC分类号： C01B21/24 , A61K9/0014 , A61K9/145 , A61K33/00 , A61K47/585 , B01J39/04 , B01J41/04
摘要： Provided is a method for producing nitric oxide that employs an ion exchange resin. Also provided is a method for producing nitric oxide that combines a salt with a gel or cream. A method is provided for producing nitric oxide that combines a Ph adjuster with a diazeniumdiolate-containing compound or composition.

7. 发明公开

EP1624953A4 SEQUESTERED REACTIVE MATERIALS 审中-公开
标题翻译： SEQUESTRIERTE REAKING MATERIALIEN
公开(公告)号：EP1624953A4
公开(公告)日：2007-07-04
申请号：EP04760164
申请日：2004-04-23
申请人： UNIV AKRON , RENEKER DARRELL H , SMITH DANIEL J
发明人： RENEKER DARRELL H , SMITH DANIEL J
IPC分类号： A61F13/00 , A61K9/70 , B01F20060101
CPC分类号： A61K9/70 , Y10T442/2525
摘要： A fibrous assembly is provided for performing site-specific chemistry. In general the present invention provides a fibrous assembly comprising a first fiber that sequesters a first reactive component; and a second fiber that sequesters a second reactive component, wherein at least the first or second fiber releases its reactive component when the fiber is in the presence of a releasing agent, and wherein when the at least first or second fiber releases its reactive component, the first and second reactive components react with each other to form a reaction product. Related methods of manufacture and use are also provided.
摘要翻译：提供纤维组件用于进行特定场地的化学。通常，本发明提供了一种纤维集合体，其包括隔离第一反应性组分的第一纤维; 以及隔离第二反应性组分的第二纤维，其中当所述纤维存在脱模剂时，至少所述第一或第二纤维释放其反应性组分，并且其中当所述至少第一或第二纤维释放其反应性组分时，第一和第二反应性组分彼此反应以形成反应产物。还提供了相关的制造和使用方法。

8. 发明公开

EP1648527A2 STABILIZATION AND IONIC TRIGGERING OF NITRIC OXIDE RELEASE 审中-公开
标题翻译：稳定与离子释放氮氧化物-RELEASE的
公开(公告)号：EP1648527A2
公开(公告)日：2006-04-26
申请号：EP04779101.7
申请日：2004-07-26
申请人： The University of Akron , Smith, Daniel J.
发明人： SMITH, Daniel, J.
IPC分类号： A61L9/04 , A61K9/00 , A61K33/00
CPC分类号： C01B21/24 , A61K9/0014 , A61K9/145 , A61K33/00 , A61K47/585 , B01J39/04 , B01J41/04
摘要： Provided is a method for producing nitric oxide that employs an ion exchange resin. Also provided is a method for producing nitric oxide that combines a salt with a gel or cream. A method is provided for producing nitric oxide that combines a Ph adjuster with a diazeniumdiolate-containing compound or composition.

9. 发明公开

EP1069909A2 CONJUGATE VACCINES FOR THE PREVENTION OF DENTAL CARIES 有权
标题翻译：结合疫苗进行预防龋齿
公开(公告)号：EP1069909A2
公开(公告)日：2001-01-24
申请号：EP99916570.7
申请日：1999-04-09
申请人： Lees, Andrew , TAUBMAN, Martin A. , Smith, Daniel J.
发明人： Lees, Andrew , TAUBMAN, Martin A. , Smith, Daniel J.
IPC分类号： A61K39/09 , A61K39/39 , A61K38/45 , C12N15/54
CPC分类号： C12N9/1051 , A61K39/092 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/315 , C07K14/33 , Y10S424/831 , Y10S514/835 , Y10S530/806
摘要： The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan or to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutants streptococcus.

10. 发明授权

EP1069909B1 CONJUGATE VACCINES FOR THE PREVENTION OF DENTAL CARIES 有权
标题翻译：结合疫苗进行预防龋齿
公开(公告)号：EP1069909B1
公开(公告)日：2007-06-13
申请号：EP99916570.7
申请日：1999-04-09
申请人： Lees, Andrew , TAUBMAN, Martin A. , Smith, Daniel J.
发明人： Lees, Andrew , TAUBMAN, Martin A. , Smith, Daniel J.
IPC分类号： A61K39/09 , A61K39/39 , A61K38/45 , C12N15/54
CPC分类号： C12N9/1051 , A61K39/092 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/315 , C07K14/33 , Y10S424/831 , Y10S514/835 , Y10S530/806
摘要： The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan or to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutants streptococcus.

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