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1. 发明专利

TW201625269A 含有高溶性元素和維生素Ｄ並能預防和改善補鈣期間的腸胃狀況的組合物审中-公开
简体标题：含有高溶性元素和维生素Ｄ并能预防和改善补钙期间的肠胃状况的组合物
公开(公告)号：TW201625269A
公开(公告)日：2016-07-16
申请号：TW104129003
申请日：2015-09-02
申请人：加拿大生維達有限公司 , SINOVEDA CANADA, INC.
发明人：譚潤球 , TAM, YUN KAU
IPC分类号： A61K31/593 , A61K33/06 , A61K33/30 , A61P1/10 , A61P19/10
摘要：本發明提供了有效改善腸道功能並有利於骨骼健康的新穎組合物和方法。在一個實施例中，本發明提供了所述組合物在製備用於改善腸道功能或便秘的用途。在一個實施例中，本發明提供了所述組合物在製備用於維持或促進骨骼健康而，不會使腸道功能惡化的用途。在一個實施例中，腸道問題或便秘由鈣補充劑引起。在另一個實施例中，腸道問題或便秘與其他狀況或病因相關。在一個實施例中，本發明的組合物包含鈣和鎂的乙酸鹽。在另一個實施例中，本發明的組合物進一步包括鋅的乙酸鹽和/或維生素D3。
简体摘要：本发明提供了有效改善肠道功能并有利于骨胳健康的新颖组合物和方法。在一个实施例中，本发明提供了所述组合物在制备用于改善肠道功能或便秘的用途。在一个实施例中，本发明提供了所述组合物在制备用于维持或促进骨胳健康而，不会使肠道功能恶化的用途。在一个实施例中，肠道问题或便秘由钙补充剂引起。在另一个实施例中，肠道问题或便秘与其他状况或病因相关。在一个实施例中，本发明的组合物包含钙和镁的乙酸盐。在另一个实施例中，本发明的组合物进一步包括锌的乙酸盐和/或维生素D3。

2. 发明申请

US20170266246A1 PHYTOESTROGEN PRODUCT OF RED CLOVER AND PHARMACEUTICAL USES THEREOF 审中-公开
公开(公告)号：US20170266246A1
公开(公告)日：2017-09-21
申请号：US15149183
申请日：2016-05-09
申请人： Sinoveda Canada Inc.
发明人： Yun Kau Tam , Yi-Chan James Lin , Brian Duff Sloley , Chih-Yuan Tseng
IPC分类号： A61K36/48 , G06F19/00
CPC分类号： A61K36/48 , A61K31/352 , A61K31/353 , G06F19/00 , G06F19/704 , G16H50/50
摘要： The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

3. 发明申请

US20140342018A1 FORMULAS COMPRISING HIGHLY SOLUBLE ELEMENTS AND VITAMIN FOR THE PREVENTION AND AMELIORATION OF OSTEOPOROSIS 审中-公开
标题翻译：包含高可溶性元素和维生素用于预防和改善骨质疏松症的配方
公开(公告)号：US20140342018A1
公开(公告)日：2014-11-20
申请号：US14231744
申请日：2014-04-01
申请人： Sinoveda Canada Inc.
发明人： Yun Kau TAM
IPC分类号： A61K33/06 , A61K31/593 , A23L1/303 , A23L2/02 , A23L1/304 , A61K33/30 , A61K9/20
CPC分类号： A61K33/06 , A23L2/02 , A23L33/15 , A23L33/155 , A23L33/16 , A23L33/165 , A23L33/40 , A23V2002/00 , A61K9/20 , A61K9/2095 , A61K31/19 , A61K31/593 , A61K33/30 , A61K35/02 , A61K35/60 , A61K45/06 , A61K2300/00 , A23V2250/7106 , A23V2250/1642 , A23V2250/1578 , A23V2250/161 , A23V2200/306
摘要： The present invention provides formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D3. The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.
摘要翻译：本发明提供包含钙，镁和锌的乙酸盐以及维生素D3的元素组合物的配方。乙酸盐可以从天然来源如珍珠，珊瑚和牡蛎中提取，或者使用合成材料进行复合。使用体外和体内估计估计钙与镁的剂量和比例。用于促进骨骼健康和缓解骨质疏松症的剂量约为常规剂量的四分之一至三分之一。

4. 发明申请

US20140296329A1 PHYTOESTROGEN PRODUCT OF RED CLOVER AND PHARMACEUTICAL USES THEREOF 有权
标题翻译：红茶和其药物用途的植物色素产品
公开(公告)号：US20140296329A1
公开(公告)日：2014-10-02
申请号：US14242981
申请日：2014-04-02
申请人： Sinoveda Canada Inc.
发明人： Yun Kau TAM , Yi-Chan James LIN , Brian Duff SLOLEY , Chih-Yuan TSENG
IPC分类号： A61K31/353
CPC分类号： A61K31/353 , A61K36/48 , G06F19/704
摘要： The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.
摘要翻译：本发明提供了通过专有的基于生理学的药代动力学和药效学模型测定的包含红三叶草植物雌激素的优化比例的组合物。该组合物可用于调节骨重塑，以及预防和治疗骨质疏松症。

5. 发明授权

US10114931B2 Pharmaceutical platform technology for the development of natural products 有权
公开(公告)号：US10114931B2
公开(公告)日：2018-10-30
申请号：US14327529
申请日：2014-07-09
申请人： Sinoveda Canada Inc.
发明人： Yun Kau Tam , Jack Adam Tuszynski
IPC分类号： G06F19/00 , G06K9/62 , A61K36/48 , G06F19/12 , C40B30/02
摘要： The present invention provides a set of in vitro and in silico methodologies for predicting in vivo pharmacokinetics and pharmacodynamics of multiple components; the methodologies comprise mathematical models for solving multiple unknowns which are linearly independent and/or interacting with each other. The present invention can be applied to develop phytomedicines which contain multiple active ingredients without prior identification, isolation and purification of these components.

6. 发明申请

US20140348963A1 PHARMACEUTICAL PLATFORM TECHNOLOGY FOR THE DEVELOPMENT OF NATURAL PRODUCTS 审中-公开
标题翻译：医药平台技术开发天然产品
公开(公告)号：US20140348963A1
公开(公告)日：2014-11-27
申请号：US14327529
申请日：2014-07-09
申请人： Sinoveda Canada Inc.
发明人： Yun Kau Tam , Jack Adam Tuszynski
IPC分类号： G06F19/00 , G06F19/12 , A61K36/48
CPC分类号： G06F19/704 , A61K36/48 , C40B30/02 , G06F19/12 , G06K9/6228
摘要： The present invention provides a set of in vitro and in silico methodologies for predicting in vivo pharmacokinetics and pharmacodynamics of multiple components; the methodologies comprise mathematical models for solving multiple unknowns which are linearly independent and/or interacting with each other. The present invention can be applied to develop phytomedicines which contain multiple active ingredients without prior identification, isolation and purification of these components.
摘要翻译：本发明提供一组用于预测多组分的体内药代动力学和药效学的体外和计算机方法; 该方法包括用于求解彼此线性独立和/或相互作用的多个未知数的数学模型。本发明可以用于开发含有多种活性成分的植物药，而无需事先鉴别，分离和纯化这些组分。

7. 发明授权

US11123389B2 Phytoestrogen product of red clover and pharmaceutical uses thereof 有权
公开(公告)号：US11123389B2
公开(公告)日：2021-09-21
申请号：US16376044
申请日：2019-04-05
申请人： Sinoveda Canada Inc.
发明人： Yun Kau Tam , Yi-Chan James Lin , Brian Duff Sloley , Chih-Yuan Tseng
IPC分类号： A61K36/48 , G16H50/50 , A61K31/353 , A61K31/352 , G16C20/30
摘要： The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

8. 发明授权

US09333192B2 Phytoestrogen product of red clover and pharmaceutical uses thereof 有权
标题翻译：红三叶草的植物雌激素产品及其药用用途
公开(公告)号：US09333192B2
公开(公告)日：2016-05-10
申请号：US14242981
申请日：2014-04-02
申请人： Sinoveda Canada Inc.
发明人： Yun Kau Tam , Yi-Chan James Lin , Brian Duff Sloley , Chih-Yuan Tseng
IPC分类号： A61K31/353 , A61K36/48 , G06F19/00
CPC分类号： A61K31/353 , A61K36/48 , G06F19/704
摘要： The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.
摘要翻译：本发明提供了通过专有的基于生理学的药代动力学和药效学模型测定的包含红三叶草植物雌激素的优化比例的组合物。该组合物可用于调节骨重塑，以及预防和治疗骨质疏松症。

9. 发明申请

US20190247454A1 PHYTOESTROGEN PRODUCT OF RED CLOVER AND PHARMACEUTICAL USES THEREOF 审中-公开
公开(公告)号：US20190247454A1
公开(公告)日：2019-08-15
申请号：US16376044
申请日：2019-04-05
申请人： Sinoveda Canada Inc.
发明人： Yun Kau TAM , Yi-Chan James LIN , Brian Duff SLOLEY , Chih-Yuan TSENG
IPC分类号： A61K36/48 , A61K31/352 , G16H50/50 , A61K31/353
CPC分类号： A61K36/48 , A61K31/352 , A61K31/353 , G16C20/30 , G16H50/50
摘要： The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

10. 发明授权

US10307451B2 Phytoestrogen product of red clover and pharmaceutical uses thereof 有权
公开(公告)号：US10307451B2
公开(公告)日：2019-06-04
申请号：US15149183
申请日：2016-05-09
申请人： Sinoveda Canada Inc.
发明人： Yun Kau Tam , Yi-Chan James Lin , Brian Duff Sloley , Chih-Yuan Tseng
IPC分类号： A61K36/48 , G16H50/50 , A61K31/353 , G06F19/00 , A61K31/352 , G16C20/30
摘要： The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

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