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1. 发明公开

EP0380060A3 Electronic range of motion apparatus for orthosis, prothesis and CPM machine 失效
标题翻译：运动装置的电子范围用于ORTHOSIS，PROTHESIS和CPM机器
公开(公告)号：EP0380060A3
公开(公告)日：1992-04-15
申请号：EP90101327.6
申请日：1990-01-23
申请人： Singer, Robert D. , Trickey, Ernest A.
发明人： Singer, Robert D. , Trickey, Ernest A.
IPC分类号： A61F2/68
CPC分类号： A61F2/68 , A61F5/0102 , A61H1/024 , A61H1/0277 , A61H2201/1215 , A61H2201/149 , A61H2201/1638 , A61H2201/1642 , A61H2201/1676 , A61H2201/5038 , A61H2201/5092 , A61H2201/5097 , G05B19/408 , G05B19/425 , G05B2219/33207 , G05B2219/34306 , G05B2219/35453 , G05B2219/36169 , G05B2219/36435 , G05B2219/36542 , G05B2219/45172 , Y02P70/163
摘要： A therapeutic electronic range of motion apparatus (10) includes a remote subsystem (12) for generating motion commands which are transmitted to a local subsystem (44) at an orthosis, prosthesis or CPM machine. The local subsystem (44) includes a local controller (60) for controlling and monitoring the position, speed, and direction of an actuator (62) which moves an orthotic brace, prosthesis or CPM machine mounting. The apparatus is programmable enabling a patient to program stopping positions which thereafter are selectable by command. When the actuator is not in motion the local controller (60) enters a sleep mode to conserve power. The controller (60) is automatically awakened when a motion command is received.

2. 发明公开

EP0380060A2 Electronic range of motion apparatus for orthosis, prothesis and CPM machine 失效
标题翻译：被动Bewegungseinrichtung的Elektronischer BewegungsbereichsapparatfürOrthese，Prothese und kontinuierliche。
公开(公告)号：EP0380060A2
公开(公告)日：1990-08-01
申请号：EP90101327.6
申请日：1990-01-23
申请人： Singer, Robert D. , Trickey, Ernest A.
发明人： Singer, Robert D. , Trickey, Ernest A.
IPC分类号： A61F2/68
CPC分类号： A61F2/68 , A61F5/0102 , A61H1/024 , A61H1/0277 , A61H2201/1215 , A61H2201/149 , A61H2201/1638 , A61H2201/1642 , A61H2201/1676 , A61H2201/5038 , A61H2201/5092 , A61H2201/5097 , G05B19/408 , G05B19/425 , G05B2219/33207 , G05B2219/34306 , G05B2219/35453 , G05B2219/36169 , G05B2219/36435 , G05B2219/36542 , G05B2219/45172 , Y02P70/163
摘要： A therapeutic electronic range of motion apparatus (10) includes a remote subsystem (12) for generating motion commands which are transmitted to a local subsystem (44) at an orthosis, prosthesis or CPM machine. The local subsystem (44) includes a local controller (60) for controlling and monitoring the position, speed, and direction of an actuator (62) which moves an orthotic brace, prosthesis or CPM machine mounting. The apparatus is programmable enabling a patient to program stopping positions which thereafter are selectable by command. When the actuator is not in motion the local controller (60) enters a sleep mode to conserve power. The controller (60) is automatically awakened when a motion command is received.
摘要翻译：运动装置（10）的治疗电子范围包括用于产生运动命令的远程子系统（12），所述运动命令在矫形器，假体或CPM机器处传送到本地子系统（44）。本地子系统（44）包括本地控制器（60），用于控制和监视移动矫正支架，假体或CPM机器安装的致动器（62）的位置，速度和方向。该装置是可编程的，使得患者能够编程其后可以通过命令选择的停止位置。当执行器不运动时，本地控制器（60）进入睡眠模式以节省电力。当接收到运动命令时，控制器（60）自动唤醒。

3. 发明公开

EP1131469A2 VISUALIZATION OF RNA IN LIVING CELLS 审中-公开
标题翻译： RNA在活细胞可视化
公开(公告)号：EP1131469A2
公开(公告)日：2001-09-12
申请号：EP99970691.4
申请日：1999-09-30
申请人： Singer, Robert H. , Bertrand, Edouard
发明人： Singer, Robert H. , Bertrand, Edouard
IPC分类号： C12Q1/68 , C12Q1/02 , C12N15/62 , C12N15/63
CPC分类号： G01N33/5035 , C07K14/005 , C07K14/43595 , C07K2319/00 , C07K2319/09 , C07K2319/42 , C07K2319/735 , C12N15/62 , C12N2795/18122 , C12Q1/6841 , C12Q1/6844 , G01N33/5008 , G01N33/5308
摘要： A method for visualizing the location and movement of a specific RNA of interest in a living cell, in real time, is disclosed. The method includes the following steps: (a) providing a DNA encoding the RNA, which RNA includes a protein-binding site; (b) providing a nucleic acid encoding a fusion protein, which fusion protein comprises a fluorescent domain and an RNA-binding domain; (c) introducing the DNA encoding the RNA, and the nucleic acid encoding the fusion protein, into a eukaryotic cell so that the DNA encoding the RNA and the nucleic acid encoding the fusion protein are expressed in the cell; and (d) detecting fluorescence outside the nucleus or inside the nucleus of the cell, with the fluorescence being from the fusion protein bound to the RNA. In some embodiments, the fusion protein also includes an intracellular localization domain.

4. 发明申请

WO2013083101A1 RHENIUM-FREIE ODER RHENIUM-REDUZIERTE NICKEL-BASIS-SUPERLEGIERUNG 审中-公开
标题翻译：铼免费或减铼的镍基超耐热不锈钢
公开(公告)号：WO2013083101A1
公开(公告)日：2013-06-13
申请号：PCT/DE2012/001009
申请日：2012-10-17
申请人： MTU AERO ENGINES GMBH , SINGER, Robert, F. , AFFELDT, Ernst , WEISS, Michael , GÖHLER, Thomas , RETTIG, Ralf
发明人： SINGER, Robert, F. , AFFELDT, Ernst , WEISS, Michael , GÖHLER, Thomas , RETTIG, Ralf
IPC分类号： C22C19/05
CPC分类号： F01D5/28 , C22C19/057 , F05D2300/173 , F05D2300/174 , F05D2300/175 , F05D2300/177
摘要： Die vorliegende Erfindung betrifft eine Nickel-Basis-Superlegierung, die neben Nickel Aluminium, Kobalt, Chrom, Molybdän, Tantal, Titan und Wolfram als Legierungsbestandteile umfasst, wobei zusätzlich Rhenium enthalten sein kann und der Rhenium-Gehalt kleiner oder gleich 2 Gew.-% ist, und wobei der Titan-Gehalt größer oder gleich 1,5 Gew.-% ist. Außerdem betrifft die Erfindung Bauteile aus der Nickel-Basis-Superlegierung.
摘要翻译：本发明涉及镍基超合金，其包含除了镍铝，钴，铬，钼，钽，钛和钨作为合金成分，通过加入铼可以被包含和铼的含量小于或等于2重量％并且其中所述钛含量大于或等于1.5重量％。本发明还涉及由镍基超合金制成的组件。

5. 发明申请

WO2008122858A8 CRYSTALLINE FORMS OF 6- [2- (METHYLCARBAMOYL) PHENYLSULFANYL] -3-E- [2- (PYRIDIN-2-YL) ETHENYL] INDAZOLE SUITABLE FOR THE TREATMENT OF ABNORMAL CELL GROWTH IN MAMMALS 审中-公开
标题翻译： 6- [2-（甲基亚磺酰基）苯基]亚胺] -3-E- [2-（吡啶-2-基）乙基]吲哚的结晶形式适用于治疗哺乳动物异常细胞生长
公开(公告)号：WO2008122858A8
公开(公告)日：2009-11-26
申请号：PCT/IB2008000792
申请日：2008-03-25
申请人： PFIZER PROD INC , CAMPETA ANTHONY MICHAEL , CHEKAL BRIAN PATRICK , MCLAUGHLIN ROBERT WILLIAM , SINGER ROBERT ALAN
发明人： CAMPETA ANTHONY MICHAEL , CHEKAL BRIAN PATRICK , MCLAUGHLIN ROBERT WILLIAM , SINGER ROBERT ALAN
IPC分类号： C07D401/06 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/06
摘要： The present invention relates to crystalline polymorphic and amorphous form of 6- [2- (methylcarbamoyl) phenyl sulfanyl] -3-E- [2- (pyridin-2- yl) ethenyl] indazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one polymorphic form and to the therapeutic or prophylactic use of such polymorphic forms and compositions.
摘要翻译：本发明涉及6- [2-（甲基氨基甲酰基）苯基硫烷基] -3-E- [2-（吡啶-2-基）乙烯基]吲唑的结晶多晶型和无定形形式及其制备方法。本发明还涉及含有至少一种多晶形式的药物组合物以及这种多晶型物和组合物的治疗或预防用途。

6. 发明申请

WO0065094A3 ASSAY OF GENE EXPRESSION PATTERNS BY MULTI-FLUOR FISH 审中-公开
标题翻译：通过多荧光鱼检测基因表达模式
公开(公告)号：WO0065094A3
公开(公告)日：2001-08-16
申请号：PCT/US0010879
申请日：2000-04-21
申请人： EINSTEIN COLL MED , SINGER ROBERT H
发明人： SINGER ROBERT H
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6841 , C12Q2565/102 , C12Q2563/185 , C12Q2563/107 , C12Q2537/143
摘要： An in situ hybridization method for detecting and specifically identifying transcription of a multiplicity of different target sequences in a cell is disclosed. The method includes assigning a different bar code to at least five target sequences, with each target sequence containing at least one predetermined subsequence. Each bar code contains at least one fluorochrome, and at least one bar code comprises at least two different, spectrally distinguishable fluorochromes. A probe set specific for each target sequence is provided in the method. Each probe set contains a hybridization probe complementary to each subsequence in the target sequence. Each probe is labeled with a fluorochrome, and the fluorochromes in each probe set collectively correspond to the bar code for the target sequence of that probe set.
摘要翻译：公开了用于检测和特异性鉴定细胞中多种不同靶序列的转录的原位杂交方法。该方法包括将不同的条形码分配给至少五个目标序列，每个目标序列包含至少一个预定的子序列。每个条形码包含至少一个荧光染料，并且至少一个条形码包含至少两个不同的光谱可区分的荧光染料。在该方法中提供了针对每个靶序列特异的探针组。每个探针组含有与目标序列中每个亚序列互补的杂交探针。每个探针用荧光染料标记，并且每个探针组中的荧光染料集合对应于该探针组的靶序列的条形码。

7. 发明申请

WO9820995A3 METHOD AND DEVICE FOR DIRECTED SOLIDIFICATION OF A MOLTEN MASS 审中-公开
标题翻译：用于固定质量的指导性固化的方法和装置
公开(公告)号：WO9820995A3
公开(公告)日：1998-08-27
申请号：PCT/EP9706197
申请日：1997-11-07
申请人： SIEMENS AG , TFB FEINGUSSWERK BOCHUM GMBH , LOHMUELLER ANDREAS , KRUG PETER , SINGER ROBERT
发明人： LOHMUELLER ANDREAS , KRUG PETER , SINGER ROBERT
IPC分类号： B22D27/04 , C30B11/00 , B22D
CPC分类号： C30B11/003 , B22D27/045
摘要： The invention relates to a method for directed solidification of a molten mass (1) of a metal in a casting mould (2). The molten mass (1) is prepared in a casting mould (2) at a first high temperature and directely solidified by dipping the casting mould (2) in a bath (3) consisting of a liquid cooling medium at a lower second temperature. To regulate the second temperature, heat exchange is conducted between the cooling medium and an inorganic heat transfer medium (19). Independently thereof or complementary thereto, boroxide or an inorganic salt containing an alkali hydroxide, an alkali nitrite or an alkali nitrate is used as cooling medium. The invention further relates to a device for directed solidification of a molten mass (1).

8. 发明申请

WO2010052101A3 AUXETISCHES MATERIAL 审中-公开
公开(公告)号：WO2010052101A3
公开(公告)日：2010-05-14
申请号：PCT/EP2009/063414
申请日：2009-10-14
申请人： FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG , KÖRNER, Carolin , HEINL, Peter , SINGER, Robert, Friedrich
发明人： KÖRNER, Carolin , HEINL, Peter , SINGER, Robert, Friedrich
IPC分类号： A61L27/50 , B32B3/10 , E04C2/36 , F16S1/00 , G01L7/02
摘要： Die Erfindung betrifft ein auxetisches Material, welches aus einer periodischen Anordnung miteinander verbundener dreidimensionaler Gerüstelemente (G, G1, G2, G3) gebildet ist, wobei jedes der Gerüstelemente (G) ein erstes (3) und zumindest drei zweite Stützelemente (4) umfasst, wobei das erste (3) und die zweiten Stützelemente (4) mit ihren einen Enden in einem gemeinsamen Knotenpunkt (1) verbunden sind, und wobei ein erster Winkel (α) zwischen dem ersten Stützelement (3) und den zweiten Stützelementen (4) kleiner als 90° ist.

9. 发明申请

WO2009154669A1 PREDICTION OF CHEMOTHERAPEUTIC RESPONSE VIA SINGLE-CELL PROFILING OF TRANSCRIPTION SITE ACTIVATION 审中-公开
标题翻译：通过单细胞表达转录酶活性预测化疗反应
公开(公告)号：WO2009154669A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/002819
申请日：2009-05-07
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , MONTEFIORE MEDICAL CENTER , SINGER, Robert, H. , PEZO, Rossanna , AUGENLICHT, Leonard, H.
发明人： SINGER, Robert, H. , PEZO, Rossanna , AUGENLICHT, Leonard, H.
IPC分类号： G01N33/574
CPC分类号： G01N33/5011 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present invention generally relates to methods for determining tumor resistance or sensitivity to chemotherapeutic agents and the likelihood of tumor reoccurrence based on the expression levels of genes known to correlate to the chemotherapeutic agent. In particular, the expression levels of TYMS, MRGX, ATP7B and/or BAK in tumor cells, as measured by the number of active transcription sites detected by fluorescence in situ hybridization (FISH), are predictive of resistance and sensitivity to chemotherapy and the likelihood of reoccurrence following chemotherapy treatment.
摘要翻译：本发明一般涉及用于确定肿瘤抗性或对化学治疗剂的敏感性的方法以及基于已知与化学治疗剂相关的基因的表达水平的肿瘤再发生的可能性。特别地，通过荧光原位杂交（FISH）检测到的活性转录位点的数量，肿瘤细胞中的TYMS，MRGX，ATP7B和/或BAK的表达水平预示着对化疗的抗性和敏感性以及可能性化疗后复发。

10. 发明申请

WO2009105881A1 IONIC LIQUIDS COMPRISING LIGANDS CONTAINING POSITIVELY CHARGED HETEROCYCLIC RING USEFUL AS CATALYST AND FOR METAL EXTRACTIONS 审中-公开
标题翻译：含有正电荷杂环的配体的离子液体有助于催化剂和金属萃取
公开(公告)号：WO2009105881A1
公开(公告)日：2009-09-03
申请号：PCT/CA2009/000229
申请日：2009-02-27
申请人： SAINT MARY'S UNIVERSITY , SINGER, Robert, D. , NAIK, Prashant, Upendra
发明人： SINGER, Robert, D. , NAIK, Prashant, Upendra
IPC分类号： C07D403/12 , A61L9/014 , A62D3/33 , B01D11/04 , C07D233/60 , C07D233/61
CPC分类号： C07D403/12 , A62D3/33 , A62D2101/24 , A62D2101/43 , C07D233/60 , C07D233/61
摘要： The present invention is directed to ligands of formulae I and II: in which, X 1 , X 2 , R 1 , R 2 , R 6 , R 7 , R 8 , L 1 , L 2 , L 3 , T 1 , T 2 , Z 1 , Z 2 are chosen from various possible groups or entities, metal complexes formed from said ligands and their use as an ionic liquid for complexmg cation metal They can therefore be used for decontaminating liquids, purifying air or gas, or as a catalyst
摘要翻译：本发明涉及式I和II的配体：其中，X1，X2，R1，R2，R6，R7，R8，L1，L2，L3，T1，T2，Z1，Z2选自各种可能的基团或实体，由所述配体形成的金属络合物及其作为复合阳离子金属的离子液体的用途它们因此可用于净化液体，净化空气或气体，或作为催化剂

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