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1. 发明申请

WO2012051016A1 SAMPLE AND HOLD CIRCUITRY FOR MONITORING VOLTAGES IN AN IMPLANTABLE NEUROSTIMULATOR 审中-公开
标题翻译：采样和保持电路用于监测可植入神经元的电压
公开(公告)号：WO2012051016A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054879
申请日：2011-10-05
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
发明人： SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
IPC分类号： A61N1/08 , A61B5/04 , A61N1/372
CPC分类号： A61N1/36125 , A61B5/04001 , A61N1/025 , A61N1/08 , A61N1/378 , A61N1/3937
摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.
摘要翻译：公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。电容器串联连接以增加存储在电容器上的两个电压，然后将串联连接顶部和底部的电压输入到差分放大器以计算其差值。采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

2. 发明申请

WO2011063111A3 AN EFFICIENT EXTERNAL CHARGER FOR CHARGING A PLURALITY OF IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2011063111A3
公开(公告)日：2011-08-11
申请号：PCT/US2010057212
申请日：2010-11-18
申请人： BOSTON SCIENT NEUROMODULATION , CARBUNARU RAFAEL , PARRAMON JORDI , OZAWA ROBERT , SHI JESS , CHEN JOEY , RAHMAN MIZANUR
发明人： CARBUNARU RAFAEL , PARRAMON JORDI , OZAWA ROBERT , SHI JESS , CHEN JOEY , RAHMAN MIZANUR
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/37288
摘要： An improved external charger for a battery in an implantable medical device (implant), and technique for charging batteries in multiple implants using such improved external charger, is disclosed. During charging, values for a parameter measured in the implants are reported from the implants to the external charger. The external charger infers from the magnitudes of the parameters which of the implants has the highest and lowest coupling to the external charger, and so designates those implants as "hot" and "cold." The intensity of the magnetic charging field is optimized for the cold implant consistent with the simulation to ensure that that the cold implant is charged with a maximum (fastest) battery charging current. The duty cycle of the magnetic charging field is also optimized for the hot implant consistent with the simulation to ensure that the hot implant does not exceed the power dissipation limit. As a result, charging is optimized to be fast for all of the implants, while still safe from a tissue heating perspective.

3. 发明申请

WO2011063111A2 AN EFFICIENT EXTERNAL CHARGER FOR CHARGING A PLURALITY OF IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：有效的外部充电器，用于充电多种可植入医疗器械
公开(公告)号：WO2011063111A2
公开(公告)日：2011-05-26
申请号：PCT/US2010/057212
申请日：2010-11-18
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , CARBUNARU, Rafael , PARRAMON, Jordi , OZAWA, Robert , SHI, Jess , CHEN, Joey , RAHMAN, Mizanur
发明人： CARBUNARU, Rafael , PARRAMON, Jordi , OZAWA, Robert , SHI, Jess , CHEN, Joey , RAHMAN, Mizanur
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/37288
摘要： An improved external charger for a battery in an implantable medical device (implant), and technique for charging batteries in multiple implants using such improved external charger, is disclosed. During charging, values for a parameter measured in the implants are reported from the implants to the external charger. The external charger infers from the magnitudes of the parameters which of the implants has the highest and lowest coupling to the external charger, and so designates those implants as "hot" and "cold." The intensity of the magnetic charging field is optimized for the cold implant consistent with the simulation to ensure that that the cold implant is charged with a maximum (fastest) battery charging current. The duty cycle of the magnetic charging field is also optimized for the hot implant consistent with the simulation to ensure that the hot implant does not exceed the power dissipation limit. As a result, charging is optimized to be fast for all of the implants, while still safe from a tissue heating perspective.
摘要翻译：公开了一种用于可植入医疗装置（植入物）中的电池的改进的外部充电器，以及使用这种改进的外部充电器为多个植入物中的电池充电的技术。在充电期间，在植入物中测量的参数的值从植入物报告给外部充电器。外部充电器从参数的大小推断出植入物具有最高和最低耦合到外部充电器的参数，因此将这些植入物称为“热”和“冷”。对于与模拟一致的冷植入物，磁充电场的强度被优化，以确保冷植入物以最大（最快）的电池充电电流充电。对于与模拟一致的热注入，磁充电场的占空比也被优化，以确保热植入不超过功率耗散极限。因此，对于所有植入物，充电被优化为快速，同时从组织加热的角度来看仍然是安全的。

4. 发明申请

WO2009009290A1 TELEMETRY LISTENING WINDOW MANAGEMENT FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：远程医疗窗口管理用于可植入医疗设备
公开(公告)号：WO2009009290A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/068079
申请日：2008-06-25
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , SHI, Jess, W.
发明人： PARRAMON, Jordi , SHI, Jess, W.
IPC分类号： A61N1/372 , A61N1/378
CPC分类号： A61N1/37252 , A61N1/3605 , A61N1/37205 , Y10S128/903
摘要： An improved arbitration scheme for allowing concurrent stimulation and telemetry listening in a microstimulator is disclosed. A listening window for telemetry is permitted to proceed, and access to the microstimulator' s coil granted, during at least a portion of the inter-pulse period that follows the issuance of a stimulation pulse. This is permissible because access to the coil is not needed during the entirety of the inter-pulse period. For example, the listening window can issue during that portion of the inter-pulse period when the decoupling capacitor is discharged, but cannot issue during that portion of the inter-pulse period when the compliance voltage is being generated for the next stimulation pulse. However, because compliance voltage generation occupies only a small portion of the inter-pulse period, the technique is not substantially limited. By allowing the listening window to issue during the majority of the inter-pulse period, the listening window produces smaller gaps between the pulses, and stimulation therapy is thus brought closer to its ideal.
摘要翻译：公开了一种用于允许微型激励器中的并发刺激和遥测监听的改进的仲裁方案。允许进行遥测的监听窗口，并且在发出刺激脉冲之后的脉冲间期间的至少一部分期间允许访问微型激励器的线圈。这是允许的，因为在整个脉冲间期间不需要对线圈的访问。例如，当解耦电容器放电时，在脉冲周期的该部分期间可以发出监听窗口，但是当为下一个刺激脉冲产生顺从性电压时，不能在脉冲间期间的那部分期间发出监听窗口。然而，由于顺应性电压产生仅占脉冲周期的一小部分，所以该技术基本上不受限制。通过允许在大多数脉冲间期间发出听音窗口，收听窗口在脉冲之间产生较小的间隙，因此刺激疗法更接近其理想。

5. 发明申请

WO2011063111A4 AN EFFICIENT EXTERNAL CHARGER FOR CHARGING A PLURALITY OF IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：一种有效的外部充电器，用于充电多个可植入的医疗设备
公开(公告)号：WO2011063111A4
公开(公告)日：2011-09-29
申请号：PCT/US2010057212
申请日：2010-11-18
申请人： BOSTON SCIENT NEUROMODULATION , CARBUNARU RAFAEL , PARRAMON JORDI , OZAWA ROBERT , SHI JESS , CHEN JOEY , RAHMAN MIZANUR
发明人： CARBUNARU RAFAEL , PARRAMON JORDI , OZAWA ROBERT , SHI JESS , CHEN JOEY , RAHMAN MIZANUR
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/37288
摘要： An improved external charger for a battery in an implantable medical device (implant), and technique for charging batteries in multiple implants using such improved external charger, is disclosed. During charging, values for a parameter measured in the implants are reported from the implants to the external charger. The external charger infers from the magnitudes of the parameters which of the implants has the highest and lowest coupling to the external charger, and so designates those implants as "hot" and "cold." The intensity of the magnetic charging field is optimized for the cold implant consistent with the simulation to ensure that that the cold implant is charged with a maximum (fastest) battery charging current. The duty cycle of the magnetic charging field is also optimized for the hot implant consistent with the simulation to ensure that the hot implant does not exceed the power dissipation limit. As a result, charging is optimized to be fast for all of the implants, while still safe from a tissue heating perspective.
摘要翻译：公开了用于可植入医疗装置（植入物）中的电池的改进的外部充电器，以及使用这种改进的外部充电器为多个植入物中的电池充电的技术。在充电过程中，植入物中测量的参数值将从植入物报告给外部充电器。外部充电器根据参数的大小推断哪些植入物与外部充电器具有最高和最低的耦合，并且因此将这些植入物指定为“热”和“冷”。对于与模拟一致的冷植入物，磁充电场的强度被优化，以确保冷植入物以最大（最快）电池充电电流充电。磁充电场的占空比也针对与仿真一致的热注入进行优化，以确保热注入不超过功耗限制。因此，对于所有植入物来说，充电都经过优化，以便从组织加热的角度来看仍然安全。

6. 发明申请

WO2009002579A1 IMPROVED ARCHITECTURES FOR AN IMPLANTABLE MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：改进的医疗设备系统的架构
公开(公告)号：WO2009002579A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/059134
申请日：2008-04-02
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , GRIFFITH, Paul, J. , PARRAMON, Jordi , MARNFELDT, Goran, N. , AGHASSIAN, Daniel , NIMMAGADDA, Kiran , FELDMAN, Emanuel , SHI, Jess, W.
发明人： GRIFFITH, Paul, J. , PARRAMON, Jordi , MARNFELDT, Goran, N. , AGHASSIAN, Daniel , NIMMAGADDA, Kiran , FELDMAN, Emanuel , SHI, Jess, W.
IPC分类号： A61N1/372 , G06F13/12
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.
摘要翻译：公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。为了与总线通信并遵守协议，每个电路块都包含与该协议相关的总线接口电路。由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。

7. 发明申请

WO2012051015A1 MONITORING ELECTRODE VOLTAGES IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM HAVING DAISY-CHAINED ELECTRODE-DRIVER INTEGRATED CIRCUITS 审中-公开
标题翻译：在具有电连接电极驱动器集成电路的可植入医疗设备系统中监测电极电压
公开(公告)号：WO2012051015A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054876
申请日：2011-10-05
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , SHI, Jess, W. , FELDMAN, Emanuel
发明人： PARRAMON, Jordi , SHI, Jess, W. , FELDMAN, Emanuel
IPC分类号： A61N1/36
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.
摘要翻译：一种具有多个电极驱动器集成电路（IC）的可植入神经刺激器系统的电极电压监视电路。可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。从IC上的电极电压被路由到主IC，因此主IC可以监控从站上的两个电极电压以及主站上的电极电压。为了各种目的可以监视这样的电压，并且特别地使用这种电压来确定电极之间的电阻并设置用于刺激的顺应性电压。

8. 发明申请

WO2012050998A1 ARCHITECTURES FOR AN IMPLANTABLE MEDICAL DEVICE SYSTEM HAVING DAISY-CHAINED ELECTRODE-DRIVE INTEGRATED CIRCUITS 审中-公开
标题翻译：具有电连接电极驱动集成电路的可植入医疗器械系统的结构
公开(公告)号：WO2012050998A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054599
申请日：2011-10-03
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , FELDMAN, Emanuel , GRIFFITH, Paul, J. , SHI, Jess, W.
发明人： PARRAMON, Jordi , FELDMAN, Emanuel , GRIFFITH, Paul, J. , SHI, Jess, W.
IPC分类号： A61N1/372
CPC分类号： A61N1/372 , A61N1/025 , A61N1/36125
摘要： Architectures for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. A parallel bus operating in accordance with a communication protocol couples the ICs, and certain functional blocks not needed in the slave are disabled. Stimulation parameters are loaded via the bus into each IC, and a stimulation enable command is issued on the bus to ensure simultaneous stimulation from the electrodes on both ICs. Clocking strategies are also disclosed to allow clocking of the master and slave ICs to be independently controlled, and to ensure that relevant internal and bus clocks used in the system are synchronized.
摘要翻译：具有提供的多个电极驱动器集成电路（IC）的可植入神经刺激器系统的结构。可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。根据通信协议操作的并行总线耦合IC，并且禁用从机中不需要的某些功能块。刺激参数通过总线加载到每个IC中，并且在总线上发出刺激使能命令，以确保同时从两个IC上的电极刺激。还公开了时钟策略，以允许主控和从属IC的时钟被独立控制，并确保系统中使用的相关内部和总线时钟同步。

9. 发明申请

WO2007070727A1 TECHNIQUES FOR SENSING AND ADJUSTING A COMPLIANCE VOLTAGE IN AN IMPLANTABLE STIMULATOR DEVICE 审中-公开
标题翻译：用于感应和调节可植入刺激装置中的合格电压的技术
公开(公告)号：WO2007070727A1
公开(公告)日：2007-06-21
申请号：PCT/US2006/060085
申请日：2006-10-19
申请人： ADVANCED BIONICS CORPORATION , SHI, Jess, W. , HE, Yuping , DOAN, Que , PETERSON, David, K.l.
发明人： SHI, Jess, W. , HE, Yuping , DOAN, Que , PETERSON, David, K.l.
IPC分类号： A61N1/08 , A61N1/36 , A61N1/378
CPC分类号： A61N1/36125 , A61N1/36071 , A61N1/37
摘要： Disclosed herein are methods and circuitry for monitoring and adjusting a compliance voltage in an implantable stimulator devices to an optimal value that is sufficiently high to allow for proper circuit performance (i.e., sufficient current output), but low enough that power is not needlessly wasted via excessive voltage drops across the current output circuitry. The algorithm measures output voltages across the current source and sink circuitry during at least periods of actual stimulation when both the current sources and sinks arc operable, and adjusts the compliance voltage so as to reduce these output voltages to within guard band values preferably indicative for operation in transistor saturation. The output voltages can additionally be monitored during periods between stimulation pulses to improve the accuracy of the measurement, and is further beneficial in that such additional measurements are not perceptible to the patient.
摘要翻译：本文公开了用于监测和调整可植入式刺激器装置中的顺应性电压的方法和电路，以达到足够高以允许适当的电路性能（即，足够的电流输出）的最佳值，但是足够低以使得功率不会被无用地浪费通过电流输出电路上的电压过大。当电流源和吸收点两者可操作时，该算法在至少实际刺激期间测量电流源和接收电路两端的输出电压，并调整顺从电压，以便将这些输出电压降低到优选指示操作的保护带值内晶体管饱和。在刺激脉冲之间的周期期间可以另外监视输出电压，以提高测量的准确度，并且进一步有益的是，这种附加测量对于患者是不可察觉的。

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