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1. 发明授权

US06268472B1 Modified HGP-30 peptides, conjugates, compositions and methods of use 失效
标题翻译：修饰的HGP-30肽，缀合物，组合物和使用方法
公开(公告)号：US06268472B1
公开(公告)日：2001-07-31
申请号：US09589768
申请日：2000-06-09
申请人： Daniel H. Zimmerman , Prem S. Sarin
发明人： Daniel H. Zimmerman , Prem S. Sarin
IPC分类号： A61K3800
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16222 , Y10S530/826 , Y10S530/861
摘要： An antigenic peptide fragment from the p17 gag protein of HIV includes a portion from HGP-30 and a contiguous portion from HGP-35 such that the peptide fragment is capable of inducing a TH1 immune response when administered to a person suffering from AIDS or at risk for AIDS. The peptide has from about 25 to about 37 amino acids, such as, for example, the sequence A T L Y S V 1 H Q R I D V K D T SEQ ID NO. 5 K E A L E K I E E E Q N K S
摘要翻译：来自HIV的p17 gag蛋白的抗原肽片段包括来自HGP-30的部分和来自HGP-35的连续部分，使得当向患有AIDS或患有风险的人施用时，该肽片段能够诱导TH1免疫应答为艾滋病。该肽具有约25至约37个氨基酸，例如该序列

2. 发明授权

US06258945B1 HIV-1P-17 peptide fragments, compositions containing and methods for producing and using same 失效
标题翻译： HIV-1P-17肽片段，组合物及其生产和使用方法
公开(公告)号：US06258945B1
公开(公告)日：2001-07-10
申请号：US09588751
申请日：2000-06-07
申请人： Daniel H. Zimmerman , Prem S. Sarin
发明人： Daniel H. Zimmerman , Prem S. Sarin
IPC分类号： C07H2102
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16222
摘要： Peptide fragments of the p17 gag protein of HIV-1 from Clade C of from about 30 to about 50 amino acids, including the region extending from position 75 to position 129, raise antibodies recognizing other subtypes, including Clade A, Clade B, Clade E as well as peptides of non-coextensive but overlapping portions of the p17 gag protein. DNA sequences can be used to encode for the peptides of interest. An example of the Clade C peptide of this invention is a peptide having about 30 to about 32 amino acids taken consecutively from a part or the entirety of the following sequence: (SEQ ID NO:2) 5 10 Ala Thr Leu Xaa Xaa Val His Xaa Xaa Ile Xaa Xaa 15 20 20 Xaa Asp Thr Lys Glu Ala Leu Asp Xaa Xaa Xaa Glu 25 30 35 Glu Gln Asn Lys Xaa Gln Gln Lys Xaa Xaa Thr wherein Xaa at position 4 is Tyr or Trp; Xaa at position 5 is Cys or Ser; Xaa at position 8 is Lys, Glu, or Ala; Xaa at position 9 is Gly, Lys, Asp, Glu, or Arg; Xaa at position 11 is Glu; Xaa at position 12 is Val; Xaa at position 13 is Arg; Xaa at position 21 is Lys; Xaa at position 22 is Ile; Xaa at position 23 is Glu or Lys; Xaa at position 29 is Ile, Ser or Cys; Xaa at position 33 is a direct bond; and Xaa at position 34 is a direct bond.
摘要翻译：含有约30至约50个氨基酸（包括从第75位延伸到第129位的区域）的来自分化蛋白C的HIV-1的p17 gag蛋白的肽片段引起识别其他亚型的抗体，包括分化物A，分支B，分化物E 以及p17 gag蛋白的非共同延伸但重叠部分的肽。 DNA序列可用于编码感兴趣的肽。本发明的肽C肽的实例是从以下序列的一部分或全部连续取代的具有约30至约32个氨基酸的肽：其中4位的Xaa是Tyr或Trp; 5位的Xaa是Cys或Ser; 位置8处的Xaa是Lys，Glu或Ala; 位置9处的Xaa是Gly，Lys，Asp，Glu或Arg; 位置11的Xaa为Glu; 位置12的Xaa为Val; 13位的Xaa是Arg; 21位的Xaa为Lys; 22号的Xaa是Ile; 第23位的Xaa是Glu或Lys; 第29位的Xaa是Ile，Ser或Cys; 33位的Xaa是直接键; 位置34处的Xaa是直接键合。

3. 发明申请

US20050119493A1 Process for the preparation of amorphous atorvastin calcium salt (2:1) 有权
标题翻译：无定形阿托伐他汀钙盐（2：1）制备方法
公开(公告)号：US20050119493A1
公开(公告)日：2005-06-02
申请号：US10488411
申请日：2001-08-31
申请人： Sanjay Suri , J. Singh , S. Sarin , R. Bansal
发明人： Sanjay Suri , J. Singh , S. Sarin , R. Bansal
IPC分类号： C07D207/34 , C07D207/40 , C07D207/416 , C07D409/06 , C07D27/333
CPC分类号： C07D207/416 , C07D207/34 , C07D405/06 , C07D409/06
摘要： Improved process for the preparation of amorphous atorvastatin calcium salt (2:1) comprises hydrolyzing the lactone form of atorvastatin of formula of FIG. 1 with aqueous alkali or alkaline earth metal base, extracting with organic solvent the reaction mixture and adding the same to an anti-solvent to precipitate the product and finally filtering the product to afford amorphous atorvastatin calcium (2:1). The process also comprises the preparation of amorphous atorvastatin calcium salt (2:1) from its crystalline form.
摘要翻译：用于制备无定形阿托伐他汀钙盐（2:1）的改进方法包括水解式（I）的阿托伐他汀的内酯形式。 1，用碱金属或碱土金属碱处理，用有机溶剂萃取反应混合物，并加入到反溶剂中沉淀产物，最后过滤产物，得到无定形阿托伐他汀钙（2:1）。该方法还包括从其结晶形式制备无定形阿托伐他汀钙盐（2:1）。

4. 发明授权

US06111068A HIV-1 p-17 peptide fragments, compositions containing and methods for producing and using same 失效
标题翻译： HIV-1 p-17肽片段，组合物及其生产和使用方法
公开(公告)号：US06111068A
公开(公告)日：2000-08-29
申请号：US824800
申请日：1997-03-26
申请人： Daniel H. Zimmerman , Prem S. Sarin
发明人： Daniel H. Zimmerman , Prem S. Sarin
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/16
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16222 , Y10S530/826 , Y10S530/861
摘要： Peptide fragments of the p17 gag protein of HIV-1 from Clade C of from about 30 to about 50 amino acids, including the region extending from position 75 to position 129, raise antibodies recognizing other subtypes, including Clade A, Clade B, Clade E as well as peptides of non-coextensive but overlapping portions of the p17 gag protein. DNA sequences can be used to encode for the peptides of interest. An example of the Clade C peptide of this invention is a peptide having about 30 to about 32 amino acids taken consecutively from a part or the entirety of the following sequence:(SEQ ID NO:2) 5 10 Ala Thr Leu Xaa Xaa Val His Xaa Xaa Ile Xaa Xaa Xaa - 15 20 25 Asp Thr Lys Glu Ala Leu Asp Xaa Xaa Xaa Glu Glu Gln - 30 35 Asn Lys Xaa Gln Gln Lys Xaa Xaa Thr wherein Xaa at position 4 is Tyr or Trp; Xaa at position 5 is Cys or Ser; Xaa at position 8 is Lys, Glu, or Ala; Xaa at position 9 is Gly, Lys, Asp, Glu, or Arg; Xaa at position 11 is Glu; Xaa at position 12 is Val; Xaa at position 13 is Arg; Xaa at position 21 is Lys; Xaa at position 22 is Ile; Xaa at position 23 is Glu or Lys; Xaa at position 29 is Ile, Ser or Cys; Xaa at position 33 is a direct bond; and Xaa at position 34 is a direct bond.
摘要翻译：含有约30至约50个氨基酸（包括从第75位延伸到第129位的区域）的来自分化蛋白C的HIV-1的p17 gag蛋白的肽片段引起识别其他亚型的抗体，包括分化物A，分支B，分化物E 以及p17 gag蛋白的非共同延伸但重叠部分的肽。 DNA序列可用于编码感兴趣的肽。本发明的肽C肽的实例是从以下序列的一部分或全部连续取代的具有约30至约32个氨基酸的肽： - （SEQ ID NO：2）-5 10-Ala Thr Leu Xaa Xaa Val他的Xaa Xaa Ile Xaa Xaa Xaa - - 15 20 25 - Asp Thr Lys Glu Ala Leu Asp Xaa Xaa Xaa Glu Glu Gln - - 30 35 - Asn Lys Xaa Gln Gln Lys Xaa Xaa Thr - 其中第4位的Xaa是Tyr 或Trp; 5位的Xaa是Cys或Ser; 位置8处的Xaa是Lys，Glu或Ala; 位置9处的Xaa是Gly，Lys，Asp，Glu或Arg; 位置11的Xaa为Glu; 位置12的Xaa为Val; 13位的Xaa是Arg; 21位的Xaa为Lys; 22号的Xaa是Ile; 第23位的Xaa是Glu或Lys; 第29位的Xaa是Ile，Ser或Cys; 33位的Xaa是直接键; 位置34处的Xaa是直接键合。

5. 发明授权

US06287565B1 Modified HGP-30 heteroconjugates, compositions and methods of use 失效
标题翻译：改性HGP-30杂合物，组合物和使用方法
公开(公告)号：US06287565B1
公开(公告)日：2001-09-11
申请号：US09594845
申请日：2000-06-15
申请人： Daniel H. Zimmerman , Prem S. Sarin
发明人： Daniel H. Zimmerman , Prem S. Sarin
IPC分类号： A61K3800
CPC分类号： C07K14/005 , A61K39/00 , C07K14/70539 , C07K16/1054 , C12N2740/16222 , Y10S530/826
摘要： A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of &bgr;-2 microglobulin to a modified HGP-30 antigentic peptide fragment of p17 gag peptide, such as, for example A T L Y S V H Q R I D V K D T (SEQ ID NO: 5) K E A L E K I E E E Q N K S The heteroconjugate is effective in eliciting a THI directed immune response and provides a vaccine composition for treating or preventing AIDS.
摘要翻译：通过将诸如β-2微球蛋白的肽J的T细胞结合配体（TCBL）与p17 gag肽的修饰的HGP-30抗原肽片段连接形成异源偶联物，例如异源偶联物有效引发THI指导免疫应答，并提供用于治疗或预防艾滋病的疫苗组合物。

6. 发明授权

US5145955A Process for the preparation and composition of a fraction containing picroside I and kutkoside 失效
$Process for the preparation and composition of a fraction containing picroside I and kutkoside$
标题翻译：制备和组成含有微血小板I和kutkoside的级分的方法
公开(公告)号：US5145955A
公开(公告)日：1992-09-08
申请号：US783410
申请日：1991-10-28
申请人： Bacchan S. Aswal , Ramesh Chander , Sunil K. Chatterji , Bhola N. Dhawan , Yogesh Dwivedi , Narendra K. Garg , Poonam Jain , Narinder K. Kapoor , Dinesh K. Kulshreshtha , Bishan N. Mehrotra , Gyanendra K. Patnaik , Ravi Rastogi , Jagat P. S. Sarin , Krishna C. Saxena , Shekhar C. Sharma , Shri K. Sharma , Binduja Shukla , Pradeep K. S. Visen
发明人： Bacchan S. Aswal , Ramesh Chander , Sunil K. Chatterji , Bhola N. Dhawan , Yogesh Dwivedi , Narendra K. Garg , Poonam Jain , Narinder K. Kapoor , Dinesh K. Kulshreshtha , Bishan N. Mehrotra , Gyanendra K. Patnaik , Ravi Rastogi , Jagat P. S. Sarin , Krishna C. Saxena , Shekhar C. Sharma , Shri K. Sharma , Binduja Shukla , Pradeep K. S. Visen
IPC分类号： A61K36/80 , C07H17/04
CPC分类号： C07H17/04 , A61K36/80 , Y10S514/893 , Y10S514/894
摘要： The present invention describes a process for the preparation of a fraction, mainly containing picroside I and kurrooa, from the plant Picrorhiza kurrooa.
摘要翻译：本发明描述了用于制备主要含有赤霉素（I）和赤藓红（Kurrooa）的级分的方法。

7. 发明授权

US6103239A Modified HGP-30 heteroconjugates, compositions and methods of use 失效
标题翻译：改性HGP-30杂合物，组合物和使用方法
公开(公告)号：US6103239A
公开(公告)日：2000-08-15
申请号：US695304
申请日：1996-08-09
申请人： Daniel H. Zimmerman , Prem S. Sarin
发明人： Daniel H. Zimmerman , Prem S. Sarin
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , A61P37/04 , C07K14/16 , C07K14/74 , C07K16/00 , C07K16/10 , C07K19/00 , A61K39/21
CPC分类号： C07K14/005 , C07K14/70539 , C07K16/1054 , A61K39/00 , C12N2740/16222 , Y10S530/826
摘要： A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of .beta.-2 microglobulin to a modified HGP-30 antigentic peptide fragment of p17 gag peptide, such as. for exampleATL YSV HQR IDV KDTKEA LEK IEE EQN KS (SEQ ID NO: 5)The heteroconjugate is effective in eliciting a THI directed immune response and provides a vaccine composition for treating or preventing AIDS.
摘要翻译：通过将诸如β-2微球蛋白的肽J的T细胞结合配体（TCBL）与p17 gag肽的修饰的HGP-30抗原肽片段连接形成杂合物。例如ATL YSV HQR IDV KDT KEA LEK IEE EQN KS（SEQ ID NO：5）异源偶联物有效引发THI定向免疫应答，并提供用于治疗或预防AIDS的疫苗组合物。

8. 发明授权

US06093400A Modified HGP-30 peptides, conjugates, compositions and methods of use 失效
标题翻译：修饰的HGP-30肽，缀合物，组合物和使用方法
公开(公告)号：US06093400A
公开(公告)日：2000-07-25
申请号：US695301
申请日：1996-08-09
申请人： Daniel H. Zimmerman , Prem S. Sarin
发明人： Daniel H. Zimmerman , Prem S. Sarin
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/16 , A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16222 , Y10S530/826 , Y10S530/861
摘要： An antigenic peptide fragment from the p17 gag protein of HIV includes a portion from HGP-30 and a contiguous portion from HGP-35 such that the peptide fragment is capable of inducing a TH1 immune response when administered to a person suffering from AIDS or at risk for AIDS. The peptide has from about 25 to about 37 amino acids, such as, for example, the sequence ##EQU1##
摘要翻译：来自HIV的p17 gag蛋白的抗原肽片段包括来自HGP-30的部分和来自HGP-35的连续部分，使得当向患有AIDS或患有风险的人施用时，该肽片段能够诱导TH1免疫应答为艾滋病。该肽具有约25至约37个氨基酸，例如该序列

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