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    • 1. 发明申请
    • Blower Housing
    • 鼓风机房
    • US20130343865A1
    • 2013-12-26
    • US13530823
    • 2012-06-22
    • Stephen S. Hancock
    • Stephen S. Hancock
    • F04D29/42
    • F04D29/424F04D17/10F04D29/4226F04D29/441
    • A blower housing has a discharge direction, an axis of rotation, a polar axis that intersects the axis of rotation and is substantially perpendicular to the discharge direction, and an angular sweep of increasing fluid flow area. The fluid flow area, A, increases with increasing angular magnitude, Φ, as a function comprising at least a functional component that is at least one of (1) equal to, (2) substantially mathematically reducible to, and (3) substantially mathematically analogous to the equation, A  ( Φ ) = A co + R ( 1 - 1 - [ ( r i )  ( Φ ) R ] 2 ) , where Aco is a minimum fluid flow area, R is a radius of a first circle, and ri is a radius of a second circle that is smaller than the first circle.
    • 鼓风机壳体具有排出方向,旋转轴线,与旋转轴线相交并且基本上垂直于排出方向的极轴以及增加的流体流动面积的角度扫掠。 流体流动面积A随着角度大小Phi的增加而增加,其作为至少包括功能组件的功能,功能组件至少是(1)等于,(2)基本上可数学地可还原到(3)和 类似于等式,A(Phi)= A co + R(1-1 - [(ri)(Phi)R] 2),其中Aco是最小流体流动面积,R是第一个圆的半径 而ri是小于第一个圆的第二个圆的半径。
    • 6. 发明申请
    • Heat Exchanger
    • 热交换器
    • US20100212876A1
    • 2010-08-26
    • US12390843
    • 2009-02-23
    • Stephen S. HANCOCK
    • Stephen S. HANCOCK
    • F28F99/00
    • F28F1/32F28F13/02F28F13/06
    • A heat exchanger has a first fin having a hole, a collar attached to the first fin and associated with the hole, and a bluff body carried by the first fin. The bluff body is partially directly upstream of the collar. A heat exchanger has a fin having a hole, a collar attached to the fin and associated with the hole, and a bluff body associated with the fin. A configuration of the bluff body is associated with a fin pitch separation distance of the heat exchanger. A method of increasing a heat exchange efficiency of a heat exchanger is provided that includes passing an air flow adjacent a surface of a fin, obstructing the air flow with a bluff body, reducing a thickness of a thermal boundary layer, and locating a reduced thickness portion of the thermal boundary layer adjacent to a collar associated with the fin.
    • 热交换器具有带有孔的第一翅片,附接到第一翅片并与孔相关联的凸缘和由第一翅片承载的非流线形体。 虚张声势的身体部分直接在衣领的上游。 热交换器具有带孔的翅片,附接到翅片并与孔相关联的套环,以及与翅片相关联的非流线形体。 非流线形体的构造与热交换器的翅片间距距离相关联。 提供了一种提高热交换器的热交换效率的方法,其包括使靠近翅片表面的空气流通过,用非流线形体阻挡空气流,减小热边界层的厚度,以及确定减小的厚度 热边界层的与翅片相关联的套环相邻的部分。
    • 9. 发明申请
    • Detection of Disease Associated Proteolysis
    • 疾病相关蛋白水解检测
    • US20090035797A1
    • 2009-02-05
    • US11665403
    • 2005-10-17
    • William S. HancockHaven BakerMarina HincapieXiaoyang Zheng
    • William S. HancockHaven BakerMarina HincapieXiaoyang Zheng
    • C12Q1/37C12Q1/02C07K1/20G01N33/48C12Q1/00
    • G01N33/6848
    • Described herein are methods and techniques to study the “degradome”. The degradome of a specific protease is the complete product of the natural substrate repertoire of that enzyme in a cell, tissue or organism. The complete set of proteases that are expressed at a particular moment or circumstance by a cell, tissue or organism produces the collective degradome. Included in the methods described herein are approaches that allow the direct identification and characterization of degradome peptides from approx. 400 to approx. 12,000 Da. The methods of the invention avoid the inherent problems of studying the peptidome by focusing on specific or unique proteolytic cleavages that occur as a result of endogenous protease activity induced by specific diseases. Once characterized, the presence of, or change in level of, specific peptides of the degradome can be used, e.g., to identify specific peptides having elevated levels compared to a reference normal/or to correlate identified peptides with specific proteins and/or to identify protein fragmentation patterns (e.g., peptide ladders) and the specific protease(s) that brought them about and then correlate this information with the presence or absense of a specific disease or condition. Thus, the methods of the invention can be used, for example, to identify new diagnostic markers and/or therapeutic targets, as specific clinical diagnostic methods for individual patients and as methods of monitoring the progress of a therapeutic regimen for the treatment of a patient.
    • 本文描述了研究“降解物”的方法和技术。 特定蛋白酶的降解物是细胞,组织或生物体中该酶的天然底物的全部产物。 在细胞,组织或生物体的特定时刻或环境下表达的完整蛋白酶产生集体降解物。 包括在本文描述的方法中的方法是允许直接鉴定和表征降解物肽。 400到约 12,000 Da。 本发明的方法通过集中于由特定疾病诱导的内源性蛋白酶活性而产生的特异性或独特的蛋白水解裂解来避免研究肽酶的固有问题。 一旦表征,可以使用降解物的特异性肽的存在或水平的变化,例如,鉴定与参考标准相比具有升高的水平的特异性肽,或将鉴定的肽与特异性蛋白质相关联和/或鉴定 蛋白质断裂模式(例如,肽梯)和特异性蛋白酶,使其与特定疾病或病症的存在或缺失相关联。 因此,本发明的方法可用于例如鉴定新的诊断标记物和/或治疗靶标,作为个体患者的特定临床诊断方法,以及监测用于治疗患者的治疗方案进展的方法 。