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    • 1. 发明授权
    • Inhibition of HIV infection through chemoprophylaxis
    • 通过化学预防来抑制艾滋病毒感染
    • US09044509B2
    • 2015-06-02
    • US11669547
    • 2007-01-31
    • Walid M. HeneineThomas M. FolksRobert JanssenRonald OttenJose Gerardo Garcia Lerma
    • Walid M. HeneineThomas M. FolksRobert JanssenRonald OttenJose Gerardo Garcia Lerma
    • A61K31/675A61K31/505A61K45/06A61K31/7072A61K31/513
    • A61K31/675A61K9/0034A61K9/0053A61K31/513A61K31/683A61K31/7072A61K45/06A61K2300/00
    • A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation.
    • 提供了一种保护灵长类动物宿主免受免疫缺陷逆转录病毒的自身复制感染的过程。 在暴露于免疫缺陷型逆转录病毒之前,通过向灵长类动物宿主施用药学有效量的核苷逆转录酶抑制剂和药学有效量的核苷酸逆转录酶抑制剂的组合来实现保护。 如果在暴露后24小时内以单一剂量提供,则该药物是有效的。 定期日剂量的方案对于在感染灵长类动物宿主后免疫缺陷逆转录病毒变得自我复制也是有效的。 用于控制群体内的逆转录病毒传播的方法包括在性暴露于免疫缺陷型逆转录病毒来源之前对具有高免疫缺陷型逆转录病毒感染的细菌组合的高风险亚群的施用,以排除免疫缺陷型逆转录病毒在自身复制中的自我复制 一个亚群的成员。
    • 4. 发明申请
    • INHIBITION OF HIV INFECTION FHROUGH CHEMOPROPHYALXIS
    • 艾滋病毒感染的化学抑制作用
    • US20070265227A1
    • 2007-11-15
    • US11669547
    • 2007-01-31
    • Walid HeneineThomas FolksRobert JanssenRonald OttenJ. Garcia-Lerma
    • Walid HeneineThomas FolksRobert JanssenRonald OttenJ. Garcia-Lerma
    • A61K31/52A61K31/505A61K31/675A61P31/18
    • A61K31/675A61K9/0034A61K9/0053A61K31/513A61K31/683A61K31/7072A61K45/06A61K2300/00
    • A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation.
    • 提供了一种保护灵长类动物宿主免受免疫缺陷逆转录病毒的自身复制感染的过程。 在暴露于免疫缺陷型逆转录病毒之前,通过向灵长类动物宿主施用药学有效量的核苷逆转录酶抑制剂和药学有效量的核苷酸逆转录酶抑制剂的组合来实现保护。 如果在暴露后24小时内以单一剂量提供,则该药物是有效的。 定期日剂量的方案对于在感染灵长类动物宿主之后提供免疫缺陷型逆转录病毒变得自我复制的保护也是有效的。用于控制群体内的逆转录病毒传播的方法包括向接种免疫缺陷型逆转录病毒感染的高风险的亚群施用 性暴露于免疫缺陷型逆转录病毒来源之前的详细组合,以排除免疫缺陷逆转录病毒在亚群中成为自我复制。
    • 6. 发明申请
    • Halogen-free flame-retarded polyester composition
    • 无卤阻燃聚酯组合物
    • US20070161725A1
    • 2007-07-12
    • US10587267
    • 2005-01-28
    • Robert Janssen
    • Robert Janssen
    • C08K5/34
    • C08L67/02C08K5/34924C08L27/18C08L2666/04
    • The invention relates to a halogen-free flame-retarded thermoplastic polyester moulding composition consisting of: (A) a polymer composition consisting of a (A-a) 30-67 mass % at least one thermoplastic polyester polymer and (A-b) 0-15 mass % other polymers, of which 0-0.3 mass % of a fluorine polymer, (B) a flame retardant system consisting of (B-a) 33-55 mass % melamine cyanurate, (B-b) 0 to less than 2 mass % of a phosphorous containing flame retardant not comprising elementary phosphorous and (B-c) 0-5 mass % of an inorganic flame retardant synergist not comprising phosphorous, and (C) 0-10 mass % other additives, of which 0-5 mass fibrous reinforcing agents. The invention also relates to a moulded part for use in electrical or electronic applications comprising said polyester composition.
    • 本发明涉及一种无卤阻燃热塑性聚酯成型组合物,由以下组成:(A)由(Aa)30-67质量%至少一种热塑性聚酯聚合物和(Ab)0-15质量% 其他聚合物,其中含氟聚合物为0-0.3质量%,(B)由(Ba)33-55质量%氰尿酸三聚氰胺组成的阻燃体系,(Bb)0至小于2质量%的含磷火焰 不含基本磷的阻燃剂和(Bc)0-5质量%的不含磷的无机阻燃增效剂,和(C)0-10质量%的其它添加剂,其中0-5质量的纤维增强剂。 本发明还涉及一种用于包含所述聚酯组合物的电气或电子应用的模制部件。