会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 9. 发明申请
    • Methods for Fabrication of Antimicrobial Surfaces
    • 抗微生物表面的制备方法
    • US20090233935A1
    • 2009-09-17
    • US12083478
    • 2006-10-12
    • Robert Engel
    • Robert Engel
    • A61K31/504A61K31/497A61K31/13
    • D06M13/46A01N25/10D06M13/467D06M13/47A01N33/04A01N33/12A01N43/32A01N43/90
    • A method for rendering a carboxyl-containing polymer surface resistant to microbial growth, the method comprising: (i) reacting the carboxyl-containing polymer surface with a metal borohydride in a solvent system comprising a water-soluble alcohol having one to three hydroxy groups and one to four carbon atoms, and optionally up to about fifty percent water, in a temperature range having a minimum of about 60° C. and a maximum of about 80° C., and for an amount of time sufficient for reducing carboxyl groups on the carboxyl-containing polymer surface to surface hydroxymethyl groups without altering the nature of the bulk of the polymer; and either: (iia) converting hydroxy groups of the surface hydroxymethyl groups to leaving groups and displacing the leaving groups with one or a combination of antimicrobial agents; or (iib) displacing the hydrogen atoms of the hydroxy groups of the surface hydroxymethyl groups with one or a combination of antimicrobial agents.
    • 一种使含羧基的聚合物表面对微生物生长具有抗性的方法,所述方法包括:(i)使含羧基的聚合物表面与金属硼氢化物在包含具有1-3个羟基的水溶性醇的溶剂体系中反应,以及 一至四个碳原子,以及任选地至多约百分之五十的水,在最低约60℃和最多约80℃的温度范围内,并且足够的时间足以还原羧基上的羧基 含羧基聚合物表面到羟甲基,而不改变聚合物本体的性质; 并且:(ii)将表面羟甲基的羟基转化为离去基团,并用一种​​或组合的抗微生物剂置换离去基团; 或者(iib)用一种或其组合的抗微生物剂置换表面羟甲基的羟基的氢原子。