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1. 发明申请

US20120064513A1 Cell Sensor, And Monitoring Method Using Same For The Real-Time Monitoring Of Cell Capacitance 审中-公开
标题翻译：细胞传感器和使用相同的监测方法进行细胞电容的实时监测
公开(公告)号：US20120064513A1
公开(公告)日：2012-03-15
申请号：US13264096
申请日：2010-04-07
申请人： Kyung Hwa Yoo , Chae Ok Yun , Dong Hyun Kim , Ri Mi Lee , Kyu Jung Kim , Pyung Hwan Kim
发明人： Kyung Hwa Yoo , Chae Ok Yun , Dong Hyun Kim , Ri Mi Lee , Kyu Jung Kim , Pyung Hwan Kim
IPC分类号： C12Q1/70 , G01N27/22 , C12Q1/02 , C12M1/34
CPC分类号： C12Q1/02 , G01N33/54373
摘要： The present invention relates to a cell sensor for real-time monitoring of cell capacitance and a monitoring method using the same, and more particularly, to a cell sensor capable of monitoring an endocytosis process of a biomolecule through a cell surface receptor by attaching a cell between electrodes and then measuring in real time the capacitance between the electrodes over time, and a monitoring method using the same. A cell sensor for the real-time monitoring of cell capacitance according to an exemplary embodiment of the present invention includes a substrate; a first electrode and a second electrode that are formed on the substrate and spaced apart by a gap from each other, in which at least one or more cells are introduced to be attached onto the gap; and a passivation layer that is formed on each of the tops of the first electrode and the second electrode to prevent the cells from being attached onto the top of the first electrode and the second electrode. The cell sensor for the real-time monitoring of cell capacitance and the method for real-time monitoring of the cell condition using the same according to an exemplary embodiment of the present invention have the effect of being able to monitor an endocytosis process of a biomolecule through a cell surface receptor in real time, by attaching cells having a receptor for the particular biomolecule between electrodes and then measuring in real time the capacitance between the electrodes over time.
摘要翻译：本发明涉及一种用于实时监测细胞电容的细胞传感器和使用该细胞电容的监测方法，更具体地说，涉及能够通过细胞表面受体监测生物分子的内吞过程的细胞传感器在电极之间，然后实时测量电极之间的电容随时间的变化，以及使用其的监测方法。根据本发明的示例性实施例的用于实时监测单元电容的单元传感器包括基板; 第一电极和第二电极，其形成在基板上并且彼此间隔开间隔开，其中至少一个或多个电池被引入以附着到间隙上; 以及钝化层，形成在第一电极和第二电极的每个顶部上，以防止电池附着在第一电极和第二电极的顶部上。根据本发明的示例性实施方式，用于实时监测细胞电容的细胞传感器和用于实时监测细胞状态的方法具有能够监测生物分子的内吞过程的效果通过在电极之间附着具有用于特定生物分子的受体的细胞，然后实时测量电极之间的电容，实时地通过细胞表面受体。

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