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1. 发明专利

IL283932D0 Systems and methods for a wearable device for substantially non-destructive acoustic stimulation 未知
公开(公告)号：IL283932D0
公开(公告)日：2021-07-29
申请号：IL28393221
申请日：2021-06-13
申请人： LIMINAL SCIENCES INC , KABRAMS ERIC , CAMARA JOSE , KAYE KAUDERER OWEN , LEFFELL ALEXANDER B , ROTHBERG JONATHAN M , ARIENZO MAURIZIO , FIROUZI KAMYAR
发明人： KABRAMS ERIC , CAMARA JOSE , KAYE-KAUDERER OWEN , LEFFELL ALEXANDER B , ROTHBERG JONATHAN M , ARIENZO MAURIZIO , FIROUZI KAMYAR
IPC分类号： A61B5/00 , A61B5/16 , A61B5/375 , A61N7/00 , G06N3/04 , G06N3/08 , G16H20/30 , G16H20/70 , G16H40/63 , G16H50/20 , G16H50/30 , G16H50/50 , H04L29/08
摘要： In some aspects, a device wearable by a person includes a transducer configured to apply to the brain of the person acoustic signals.

2. 发明专利

IL283727D0 Systems and methods for a wearable device including stimulation and monitoring components 未知
公开(公告)号：IL283727D0
公开(公告)日：2021-07-29
申请号：IL28372721
申请日：2021-06-06
申请人： LIMINAL SCIENCES INC , KABRAMS ERIC , CAMARA JOSE , KAYE KAUDERER OWEN , LEFFELL ALEXANDER B , ROTHBERG JONATHAN M , ARIENZO MAURIZIO , FIROUZI KAMYAR
发明人： KABRAMS ERIC , CAMARA JOSE , KAYE-KAUDERER OWEN , LEFFELL ALEXANDER B , ROTHBERG JONATHAN M , ARIENZO MAURIZIO , FIROUZI KAMYAR
IPC分类号： A61B5/00 , A61B5/16 , A61B5/375 , A61N7/00 , G06N3/04 , G06N3/08 , G16H20/30 , G16H20/70 , G16H40/63 , G16H50/20 , G16H50/30 , G16H50/50 , H04L29/08
摘要： In some aspects, a device wearable by a person includes a transducer configured to apply to the brain of the person acoustic signals.

3. 发明申请

WO2022133177A1 DEVICE-ASSISTED EYE IMAGING AND/OR MEASUREMENT 审中-公开
公开(公告)号：WO2022133177A1
公开(公告)日：2022-06-23
申请号：PCT/US2021/063967
申请日：2021-12-17
申请人： TESSERACT HEALTH, INC. , RALSTON, Tyler, S. , ROTHBERG, Jonathan, M. , GLENN, Paul, E. , MEYERS, Mark, M. , COUMANS, Jacob , GLENN, John
发明人： ARIENZO, Maurizio , DEHOOG, Edward, A.
IPC分类号： A61B3/14 , A61B3/00 , A61B3/113 , A61B3/12 , A61B3/18
摘要： Aspects of the present disclosure provide improved techniques to assist imaging and/or measuring a subject's eye that are suitable for use in an imaging and/or measuring apparatus operated by the subject, even in the absence of a clinician or technician, thereby improving access to medical grade imaging and/or measurement. Some aspects relate to techniques for receiving user input and capturing a medical grade image and/or measurement of a subject's eye responsive to receiving the user input. Some aspects relate to techniques for providing visual feedback to a user of an imaging and/or measuring apparatus indicating a location of a subject's eye in a field of view of the imaging and/or measuring apparatus. Some aspects relate to techniques for selectively illuminating a first portion of a subject's eye with illumination light and capturing an image of the first portion of the subject's eye.

4. 发明申请

WO2020257711A1 MULTI-MODAL EYE IMAGING TECHNIQUES AND APPARATUS 审中-公开
公开(公告)号：WO2020257711A1
公开(公告)日：2020-12-24
申请号：PCT/US2020/038817
申请日：2020-06-19
申请人： TESSERACT HEALTH, INC. , ARIENZO, Maurizio , KAYE-KAUDERER, Owen , RALSTON, Tyler, S. , ROSENBLUTH, Benjamin , ROTHBERG, Jonathan, M. , WEST, Lawrence, C. , GLENN, Paul, E.
发明人： ARIENZO, Maurizio , KAYE-KAUDERER, Owen , RALSTON, Tyler, S. , ROSENBLUTH, Benjamin , ROTHBERG, Jonathan, M. , WEST, Lawrence, C. , GLENN, Paul, E.
IPC分类号： A61B18/20 , A61B3/12 , G01B9/02
摘要： Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status. Imaging apparatuses and techniques described herein provide medical grade retina fundus images and may be produced or conducted at low cost, thus increasing access to medical grade imaging.

5. 发明申请

WO2018098267A1 PORTABLE LOW-FIELD MAGNETIC RESONANCE IMAGING METHODS AND APPARATUS 审中-公开
公开(公告)号：WO2018098267A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/063000
申请日：2017-11-22
申请人： HYPERFINE RESEARCH, INC. , POOLE, Michael, Stephen , HUGON, Cedric , DYVORNE, Hadrien, A. , REARICK, Todd , SACOLICK, Laura , JORDAN, Jeremy, Christopher , MCNULTY, Christopher, Thomas , ROTHBERG, Jonathan, M. , KATZE, Alan, B. Jr. , MILESKI, William, J.
发明人： POOLE, Michael, Stephen , HUGON, Cedric , DYVORNE, Hadrien, A. , REARICK, Todd , SACOLICK, Laura , JORDAN, Jeremy, Christopher , MCNULTY, Christopher, Thomas , ROTHBERG, Jonathan, M. , KATZE, Alan, B. Jr. , MILESKI, William, J.
IPC分类号： A61B5/055 , G01R33/20 , G01R33/32 , G01R33/34
摘要： According to some aspects, a low-field magnetic resonance imaging system is provided. The low-field magnetic resonance imaging system comprises a magnetics system having a plurality of magnetics components configured to produce magnetic fields for performing magnetic resonance imaging, the magnetics system comprising, a Bo magnet configured to produce a Bo field for the magnetic resonance imaging system at a low-field strength of less than.2 Tesla (T), a plurality of gradient coils configured to, when operated, generate magnetic fields to provide spatial encoding of magnetic resonance signals, and at least one radio frequency coil configured to, when operated, transmit radio frequency signals to a field of view of the magnetic resonance imaging system and to respond to magnetic resonance signals emitted from the field of view, a power system comprising one or more power components configured to provide power to the magnetics system to operate the magnetic resonance imaging system to perform image acquisition, and a power connection configured to connect to a single-phase outlet to receive mains electricity and deliver the mains electricity to the power system to provide power needed to operate the magnetic resonance imaging system. According to some aspects, the power system operates the low-field magnetic resonance imaging system using an average of less than 1.6 kilowatts during image acquisition.

6. 发明申请

WO2010047804A1 INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS 审中-公开
标题翻译：用于生物和化学分析的集成传感器阵列
公开(公告)号：WO2010047804A1
公开(公告)日：2010-04-29
申请号：PCT/US2009005745
申请日：2009-10-22
申请人： ION TORRENT SYSTEMS INC , ROTHBERG JONATHAN M , SCHULTZ JONATHAN C , JOHNSON KIM L , REARICK TODD M , MILGREM MARK JAMES , MARRAN DAVID , BUSTILLO JAMES M
发明人： ROTHBERG JONATHAN M , SCHULTZ JONATHAN C , JOHNSON KIM L , REARICK TODD M , MILGREM MARK JAMES , MARRAN DAVID , BUSTILLO JAMES M
IPC分类号： G01N27/416 , C12M1/34
CPC分类号： G01N27/4145
摘要： The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 µm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.
摘要翻译：本发明涉及包括大规模化学场效应晶体管阵列的装置和芯片，其包括能够保留来自样品流体的化学或生物样品用于分析的样品保持区阵列。在一个方面，这种晶体管阵列具有10μm或更小的间距，并且每个采样保持区域位于至少一个化学场效应晶体管上，该晶体管被配置为产生与化学或生物样品的特性相关的至少一个输出信号在这样的样品保留区域中。在一个实施方案中，所述化学或生物样品的特征是带电物质的浓度，并且其中每个所述化学场效应晶体管是离子敏感场效应晶体管，其具有在其表面上具有介电层的浮置栅极，电介质层与所述样品流体接触并且能够与所述样品流体中的带电物质的浓度成比例地积累电荷。在一个实施方案中，这种带电物质是氢离子，使得传感器测量样品流体在其样品保持区域中或其附近的pH值的变化。本发明的装置和芯片可适用于大规模的基于pH的DNA测序和其他生物科学和生物医学应用。

7. 发明申请

WO2010016937A2 METHODS FOR SEQUENCING INDIVIDUAL NUCLEIC ACIDS UNDER TENSION 审中-公开
标题翻译：在张力下测定单个核酸的方法
公开(公告)号：WO2010016937A2
公开(公告)日：2010-02-11
申请号：PCT/US2009/004546
申请日：2009-08-07
申请人： ION TORRENT SYSTEMS INCORPORATED , ROTHBERG, Jonathan, M. , LEAMON, John, H. , DAVIDSON, John, F. , VAN OIJEN, Antoine, M. , HINZ, Wolfgang , DAVEY, Melville , HANN, Bradley , SCHULTZ, Jonathan
发明人： ROTHBERG, Jonathan, M. , LEAMON, John, H. , DAVIDSON, John, F. , VAN OIJEN, Antoine, M. , HINZ, Wolfgang , DAVEY, Melville , HANN, Bradley , SCHULTZ, Jonathan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2523/303 , C12Q2565/131 , C12Q2525/204 , C12Q2521/101 , C12Q2535/122
摘要： The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.
摘要翻译：本发明提供了用于对受到力作用的核酸进行测序并因此在张力下考虑的装置和其使用方法。该方法可以使用但不依赖于掺入外在可检测标记的核苷酸。

8. 发明申请

WO0218661A2 METHODS FOR IDENTIFYING NOVEL THERAPEUTIC AGENTS 审中-公开
标题翻译：识别新型治疗药物的方法
公开(公告)号：WO0218661A2
公开(公告)日：2002-03-07
申请号：PCT/US0141982
申请日：2001-09-04
申请人： CURAGEN CORP , HERRMANN JOHN L , RASTELLI LUCA , BURGESS CATHERINE E , GOULD ROTHBERG BONNIE E , ROTHBERG JONATHAN M , SKIMKETS RICHARD A
发明人： HERRMANN JOHN L , RASTELLI LUCA , BURGESS CATHERINE E , GOULD-ROTHBERG BONNIE E , ROTHBERG JONATHAN M , SKIMKETS RICHARD A
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/18 , G06F19/24 , G01N33/53 , G06F17/00
CPC分类号： G06F19/18 , C12Q2600/158 , G06F19/24
摘要： The invention provides a method for identifying a therapeutic agent. The method includes detecting a nucleic acid in a test sample, e.g. cells, cell lines or tissue, which contains a plurality of nucleic acid species, determining if the detected nucleic acid contributes to a disease state and is thus a qualified therapeutic target, and establishing if the qualified therapeutic target plays a role in disease progress and is thus a verified therapeutic candidate that can function as a therapeutic agent.
摘要翻译：本发明提供了用于鉴定治疗剂的方法。该方法包括检测测试样品中的核酸，例如，包含多个核酸物质的细胞，细胞系或组织，确定所检测的核酸是否有助于疾病状态，因此是合格的治疗靶标，并确定合格的治疗靶标是否在疾病进展中起作用，并且是因此可以用作治疗剂的已验证的治疗候选物。

9. 发明申请

WO0040757A9 METHOD OF IDENTIFYING NUCLEIC ACIDS 审中-公开
标题翻译：鉴定核酸的方法
公开(公告)号：WO0040757A9
公开(公告)日：2001-09-20
申请号：PCT/US0000402
申请日：2000-01-07
申请人： CURAGEN CORP , ROTHBERG JONATHAN M , MCKENNA MICHAEL , PREDKI PAUL , WINDEMUTH ANDREAS , SHIMKETS RICHARD A
发明人： ROTHBERG JONATHAN M , MCKENNA MICHAEL , PREDKI PAUL , WINDEMUTH ANDREAS , SHIMKETS RICHARD A
IPC分类号： G01N33/50 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： C12N15/1096 , C12N15/1034 , C12N15/1093
摘要： Disclosed are methods for identifying nucleic acids in a sample of nucleic acids in which nucleic acids are initially present in unequal amounts. The methods include partitioning the starting population of nucleic acids to form one or more subpopulations, and then identifying nucleic acids that are present in different amounts in the partitioned nucleic acid sample as compared to the starting population.
摘要翻译：公开了用于鉴定核酸样品中核酸最初以不等量存在的核酸的方法。所述方法包括将起始核酸群体分配以形成一个或多个亚群体，然后鉴定与起始群体相比在分配的核酸样品中以不同的量存在的核酸。

10. 发明申请

WO9907896A3 DETECTION AND CONFIRMATION OF NUCLEIC ACID SEQUENCES BY USE OF OLIGONUCLEOTIDES COMPRISING A SUBSEQUENCE HYBRIDIZING EXACTLY TO A KNOWN TERMINAL SEQUENCE AND A SUBSEQUENCE HYBRIDIZING TO AN UNIDENTIFIED SEQUENCE 审中-公开
标题翻译：核苷酸序列的检测和确认通过使用包含随机杂交的寡核苷酸完全杂交到已知的终末序列和随机杂交到未经鉴别的序列
公开(公告)号：WO9907896A3
公开(公告)日：1999-04-29
申请号：PCT/US9816548
申请日：1998-08-07
申请人： CURAGEN CORP , ROTHBERG JONATHAN M , DEEM MICHAEL W , SIMPSON JOHN W
发明人： ROTHBERG JONATHAN M , DEEM MICHAEL W , SIMPSON JOHN W
IPC分类号： C12N15/09 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/1093 , C12Q1/6809 , C12Q1/6813 , C12Q1/6855 , C12Q2525/191 , C12Q2565/125
摘要： The present invention discloses a methodology which is directed to providing positive confirmation that nucleic acids, possessing putatively identified sequences predicted to generate observed GeneCalling signals, are actually present within the sample from which the signal was originally derived. The putatively identified nucleic acid fragment within the sample possesses 3'- and 5'-ends with known terminal subsequences, said method comprising: contacting said nucleic acid fragments in said sample in amplifying conditions with (i) a nucleic acid polymerase; (ii) "regular" primer oligonucleotides having sequences comprising hybridizable portions of said known terminal subsequences; and (iii) a "poisoning" oligonucleotide primer, said poisoning primer having a sequence comprising a first subsequence that is a portion of the sequence of one of said known terminal subsequences and a second subsequence that is a hybridizable portion of said putatively unidentified sequence which is adjacent to said one known terminal subsequence, wherein nucleic acids amplified with said poisoning primer are distinguishable upon detection from nucleic acids amplified with said nucleic acids amplified only with said regular primers; separating the products of the contacting step; and the detecting sequence is confirmed if the nucleic acids amplified with said poisoning primer are detected.
摘要翻译：本发明公开了一种旨在提供肯定确认的方法，核酸具有预测产生观察到的GeneCalling TM信号的推定鉴定序列实际上存在于最初得到信号的样本内。所述样品中的推测鉴定的核酸片段具有已知末端亚序列的3'和5'末端，所述方法包括：使扩增条件下的所述样品中的所述核酸片段与（i）核酸聚合酶; （ii）具有包含所述已知末端子序列的可杂交部分的序列的“规则”引物寡核苷酸; 所述中毒引物具有包含作为所述已知末端子序列之一序列的一部分的第一子序列和作为所述假定未鉴定序列的可杂交部分的第二子序列的序列，与所述一个已知末端子序列相邻，其中用所述中毒引物扩增的核酸在从用所述常规引物扩增的所述核酸扩增的核酸检测时是可区分的; 分离接触步骤的产物; 如果检测到用所述中毒引物扩增的核酸，则确认检测序列。

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