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    • 3. 发明公开
    • Topical treatment of diseased skin disorders
    • Topische Behandlung vonStörungenkranker Haut。
    • EP0308210A1
    • 1989-03-22
    • EP88308517.7
    • 1988-09-15
    • Beauchamp, Patrick A.Rogers, James A.
    • Beauchamp, Patrick A.Rogers, James A.
    • A61K33/18
    • A61K33/18A61K31/045A61K31/335A61K31/05A61K31/14A61K2300/00
    • A unique combination of chemical substances and a method of their use is proposed, each chemical substance having individual merit as medicinal agents when used in solution or other pharmaceutical forms has been discovered to be effective in combination in the topical treatment of several diseased skin conditions including Herpes Simplex, acne, psoriasis, and dermatitis. The combination comprises a mixture of:


      (a) at lease one antiseptic and/or anesthetic compound which is

      (i) a terpene (e.g. menthol and eucalyptol, both being oxygenated terpenes);
      (ii) a phenolic compound (e.g. thymol); or,
      (iii) an alcohol;

      (b) a quaternary ammonium antiseptic compound; and,
      (c) an antiseptic compound containing iodine salts thereof and/or complexes thereof
      dissolved in an organic skin penetrating solvent.
    • 提出了化学物质及其使用方法的独特组合,已经发现,当以溶液或其他药物形式使用时,具有单独作为药用物质的化学物质在几种患病皮肤病症的局部治疗中是有效的,包括 单纯疱疹,痤疮,牛皮癣和皮炎。 该组合包含以下混合物:(a)至少一种消毒和/或麻醉化合物,其为(i)萜烯(例如薄荷醇和桉树脑,均为氧化萜烯); (ii)酚类化合物(例如百里酚); 或(iii)酒精; (b)季铵防腐剂; 和(c)含有其碘盐和/或它们的复合物的防腐化合物溶于有机皮肤渗透溶剂中。 ü