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3. 实用新型

TWM468253U 吸管蓋失效
简体标题：吸管盖
公开(公告)号：TWM468253U
公开(公告)日：2013-12-21
申请号：TW102216915
申请日：2013-09-09
申请人：侯仁豊 , HOU, REN LI
发明人：侯仁豊 , HOU, REN LI
IPC分类号： A47G21/18

4. 发明申请

WO2013055645A1 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES 审中-公开
标题翻译： 5,7-取代的咪唑并[1,2-C]嘧啶类
公开(公告)号：WO2013055645A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059282
申请日：2012-10-09
申请人： ARRAY BIOPHARMA INC. , BOYS, Mark Laurence , BURGESS, Laurence E. , EARY, C. Todd , GRONEBERG, Robert , HACHE, Bruno P. , HARVEY, Darren , HICKEN, Erik James , KRASER, Christopher F. , LAIRD, Ellen , MORENO, David A. , MUNSON, Mark C. , REN, Li , ROBINSON, John E. , SCHLACHTER, Stephen T.
发明人： BOYS, Mark Laurence , BURGESS, Laurence E. , EARY, C. Todd , GRONEBERG, Robert , HACHE, Bruno P. , HARVEY, Darren , HICKEN, Erik James , KRASER, Christopher F. , LAIRD, Ellen , MORENO, David A. , MUNSON, Mark C. , REN, Li , ROBINSON, John E. , SCHLACHTER, Stephen T.
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
CPC分类号： C07D487/04
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 and X 2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
摘要翻译： R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有本说明书中给出的含义的式I化合物及其立体异构体及其药学上可接受的盐和溶剂合物是一种或多种JAK激酶的抑制剂，并且是有用的治疗自身免疫性疾病，炎症性疾病，移植器官，组织和细胞排斥，以及血液系统疾病和恶性肿瘤及其并发症。

5. 发明申请

WO2011036084A2 A CONVERTOR FOR X-RAY RADIOGRAPHY AND ITS MANUFACTURING METHOD AND AN X-RAY DETECTOR 审中-公开
标题翻译： X射线辐射的转换器及其制造方法和X射线探测器
公开(公告)号：WO2011036084A2
公开(公告)日：2011-03-31
申请号：PCT/EP2010063599
申请日：2010-09-16
申请人： SIEMENS AG , CAO LEI , CAO DIAN SONG , REN LI RONG , DU GUANG WEI , XU XIAO DONG
发明人： CAO LEI , CAO DIAN SONG , REN LI RONG , DU GUANG WEI , XU XIAO DONG
IPC分类号： G01T1/20
CPC分类号： G01T1/2002
摘要： The present invention provides a convertor for X-ray radiography and its manufacturing method and an X-ray detector, wherein the surface of the scintillator facing the X-ray is covered with photonic crystals of a two-dimensional or three-dimensional spatial structure capable of reflecting the visible light facing the photonic crystals generated by the scintillator to increase the intensity of the output light of the scintillator by more than 100%, thus enhancing the image brightness and improving the image resolution, in addition to reducing to a certain extent the interference between pixels due to the ability of the photonic crystals to control the direction of the light being reflected, for example, by controlling the reflecting direction so as to be vertical to the surface of the scintillator, and the manufacturing method and material for the photonic crystals are low in cost without toxicity, enabling it to be used more widely.
摘要翻译：本发明提供一种用于X射线摄影的转换器及其制造方法和X射线检测器，其中面向X射线的闪烁体的表面被二维或三维空间结构的光子晶体覆盖，反射由闪烁体产生的面向光子晶体的可见光，以将闪烁器的输出光的强度提高大于100％，从而增强图像亮度并提高图像分辨率，除了在一定程度上降低由于光子晶体控制反射光的方向的像素之间的干涉，例如通过控制反射方向以垂直于闪烁体的表面，以及光子的制造方法和材料晶体成本低，无毒性，使其可以更广泛地使用。

6. 发明申请

WO2011025940A1 RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译： RAF抑制剂化合物及其使用方法
公开(公告)号：WO2011025940A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046955
申请日：2010-08-27
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , ALIAGAS, Ignacio , GRADL, Stefan , GUNZNER, Janet , MATHIEU, Simon , PULK, Rebecca , RUDOLPH, Joachim , WEN, Zhaoyang , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MORENO, David , REN, Li , WENGLOWSKY, Steven Mark
发明人： ALIAGAS, Ignacio , GRADL, Stefan , GUNZNER, Janet , MATHIEU, Simon , PULK, Rebecca , RUDOLPH, Joachim , WEN, Zhaoyang , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MORENO, David , REN, Li , WENGLOWSKY, Steven Mark
IPC分类号： C07D487/04 , C07D495/04 , C07D513/04 , A61K31/38 , A61P35/00
CPC分类号： C07D487/04 , C07D495/04 , C07D513/04
摘要： Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物可用于抑制Raf激酶。公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

7. 发明申请

WO2009111280A1 N- (6-AMINOPYRIDIN-3-YL) -3- (SULFONAMIDO) BENZAMIDE DERIVATIVES AS B-RAF INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：作为治疗癌症的B-RAF抑制剂的N-（6-氨基吡啶-3-基）-3-（磺酰胺基）苯甲酰胺衍生物
公开(公告)号：WO2009111280A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/035383
申请日：2009-02-27
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B. , MORENO, David, A.
发明人： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B. , MORENO, David, A.
IPC分类号： C07C311/08 , C07D213/75 , A61K31/44 , A61P35/00
CPC分类号： C07D213/75 , C07C311/48 , C07D213/80 , C07D213/82 , C07D213/85 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/04
摘要： Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式（I）的化合物可用于抑制Raf激酶。公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

8. 发明申请

WO2018071454A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS 审中-公开
标题翻译：取代的吡唑并[1,5-a]吡啶类化合物作为RET激酶抑制剂
公开(公告)号：WO2018071454A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/055993
申请日：2017-10-10
申请人： ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDHUBER, Barbara J. , COLLIER, James , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , MCNULTY, Oren T. , METCALF, Andrew T. , MORENO, David A. , RAMANN, Ginelle A. , TANG, Tony P. , REN, Li , WALLS, Shane M.
发明人： ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDHUBER, Barbara J. , COLLIER, James , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , MCNULTY, Oren T. , METCALF, Andrew T. , MORENO, David A. , RAMANN, Ginelle A. , TANG, Tony P. , REN, Li , WALLS, Shane M.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X 1 , X 2 , X 3 , X 4 , Ring D, E, R a , R b , n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
摘要翻译：本文提供了式I的化合物：（I）或其药学上可接受的盐或溶剂合物，其中A，B，X 1，X 2， X 3，X 4，D环，E，R a，R b，n和 m具有在说明书中给出的含义，它们是RET激酶的抑制剂，并且可用于治疗和预防可以用RET激酶抑制剂治疗的疾病，包括RET相关的疾病和病症。

9. 发明申请

WO2013130976A1 SERINE/THREONINE KINASE INHIBITORS 审中-公开
标题翻译：丝氨酸/螺旋激酶抑制剂
公开(公告)号：WO2013130976A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028622
申请日：2013-03-01
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
发明人： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：提供式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐，其可用于治疗过度增生，疼痛和炎性疾病。公开了使用式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

10. 发明申请

WO2012118492A1 HETEROCYCLIC SULFONAMIDES AS RAF INHIBITORS 审中-公开
标题翻译：杂环磺酰胺作为RAF抑制剂
公开(公告)号：WO2012118492A1
公开(公告)日：2012-09-07
申请号：PCT/US2011/026700
申请日：2011-03-01
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MATHIEU, Simon , MORENO, David , REN, Li , RUDOLPH, Joachim , WENGLOWSKY, Steven Mark
发明人： GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MATHIEU, Simon , MORENO, David , REN, Li , RUDOLPH, Joachim , WENGLOWSKY, Steven Mark
IPC分类号： C07D239/74 , C07D239/88 , C07D239/94 , C07D241/44 , C07D403/04 , C07D405/14 , A61K31/498 , A61K31/517 , A61P35/00
CPC分类号： C07D239/88 , C07D239/74 , C07D239/94 , C07D241/44 , C07D403/04 , C07D405/14
摘要： Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I), stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for i n vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式（I）的化合物可用于抑制Raf激酶。公开了使用式（I）化合物，立体异构体，互变异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

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