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1. 发明授权

US07629345B2 Prostaglandin derivatives 有权
标题翻译：前列腺素衍生物
公开(公告)号：US07629345B2
公开(公告)日：2009-12-08
申请号：US12210975
申请日：2008-09-15
申请人： Ennio Ongini , Valerio Chiroli , Francesca Benedini , Piero Del Soldato
发明人： Ennio Ongini , Valerio Chiroli , Francesca Benedini , Piero Del Soldato
IPC分类号： A61K31/4965 , A61K31/49 , C07C69/76
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译：描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。可用于治疗青光眼和高眼压症。

2. 发明申请

US20090281093A1 ANTI-INFLAMMATORY COMPOUNDS 审中-公开
标题翻译：抗炎化合物
公开(公告)号：US20090281093A1
公开(公告)日：2009-11-12
申请号：US11911802
申请日：2005-07-29
申请人： Anna Sparatore , Piero Del Soldato
发明人： Anna Sparatore , Piero Del Soldato
IPC分类号： A61K47/48 , A61K31/196 , A61K31/44 , A61K31/415 , A61K31/4025 , A61K31/5415 , A61K31/18 , A61K31/365 , A61K31/42 , A61P29/00
CPC分类号： C07D339/04
摘要： The present invention relates to novel non steroidal anti-inflammatory compounds (NSAIDs) that release hydrogen sulfide (H2S). The present invention also provides methods for treating, preventing and/or reducing inflammation-associated diseases by releasing H2S in the cardiovascular, connective tissue, pulmonary, gastrointestinal, respiratory, urogenital, nervous, or cutaneous systems as well as infective diseases employing said compounds.
摘要翻译：本发明涉及释放硫化氢（H2S）的新型非甾体抗炎化合物（NSAID）。本发明还提供了通过在心血管，结缔组织，肺，胃肠，呼吸，泌尿生殖，神经或皮肤系统中释放H 2 S以及使用所述化合物的感染性疾病来治疗，预防和/或减少炎症相关疾病的方法。

3. 发明申请

US20090221543A1 NEW CORTICOSTEROIDS 审中-公开
标题翻译：新的角质层
公开(公告)号：US20090221543A1
公开(公告)日：2009-09-03
申请号：US12464562
申请日：2009-05-12
申请人： Piero Del SOLDATO , Ennio ONGINI
发明人： Piero Del SOLDATO , Ennio ONGINI
IPC分类号： A61K31/58 , A61P11/00
CPC分类号： C07J43/003 , C07J41/005
摘要： Nitrooxy derivatives of steroidal compounds of general formula B—X1—NO2 (I) or esters or salts thereof, wherein: B is a steroidal radical, X1 is a bivalent linking group comprising an aromatic or heterocyclic ring.
摘要翻译： B-X1-NO2（I）<？in-line-formula description =“In-line-formula”=“In-line formula”end =“lead” 或其酯或其盐，其中：B是甾族基团，X 1是包含芳族或杂环的二价连接基团。

4. 发明申请

US20090017003A1 THIOSULFONATE ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：硫代磷酸盐抗炎剂
公开(公告)号：US20090017003A1
公开(公告)日：2009-01-15
申请号：US12281600
申请日：2007-03-01
申请人： Piero Del Soldato , Giancarlo Santus , Anna Sparatore
发明人： Piero Del Soldato , Giancarlo Santus , Anna Sparatore
IPC分类号： A61K38/44 , C07C69/00 , C07C53/122 , C07D239/02 , C07D209/44 , C07D491/02 , C07C229/00 , A61K31/60 , A61K31/5415 , A61P9/00 , A61K31/496 , A61K31/235 , A61K31/43 , C07D499/00 , A61K31/55 , C07D223/14 , A61K31/56 , C07J1/00 , A61P31/00 , A61P35/00 , A61P25/00 , A61P11/00 , A61P1/00 , C07D279/02 , A61K31/195 , A61K31/407 , A61K31/4035 , A61K31/505 , A61K31/19 , C12N9/04
CPC分类号： C07C381/04 , C07D487/04
摘要： The present invention relates to novel thiosulfonates derivatives. The present invention also provides methods for preventing, treating and/or reducing inflammation-associated diseases in the cardiovascular, connective tissue, pulmonary, gastrointestinal, respiratory, urogenital, nervous or cutaneous systems as well as infective and tumoral diseases employing said compounds.
摘要翻译：本发明涉及新型硫代磺酸酯衍生物。本发明还提供了用于预防，治疗和/或减少心血管，结缔组织，肺，胃肠，呼吸，泌尿生殖，神经或皮肤系统中的炎症相关疾病以及使用所述化合物的感染性和肿瘤性疾病的方法。

5. 发明授权

US07449469B2 Prostaglandin derivatives 有权
标题翻译：前列腺素衍生物
公开(公告)号：US07449469B2
公开(公告)日：2008-11-11
申请号：US11841628
申请日：2007-08-20
申请人： Ennio Ongini , Valerio Chiroli , Francesca Benedini , Piero Del Soldato
发明人： Ennio Ongini , Valerio Chiroli , Francesca Benedini , Piero Del Soldato
IPC分类号： A61K31/4965 , A61K31/49
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译：描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。可用于治疗青光眼和高眼压症。

6. 发明授权

US07399878B2 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US07399878B2
公开(公告)日：2008-07-15
申请号：US11642783
申请日：2006-12-21
申请人： Piero Del Soldato
发明人： Piero Del Soldato
IPC分类号： C07C203/00
CPC分类号： C07D295/088 , C07C203/04 , C07C219/22 , C07C219/24 , C07C229/42 , C07C233/25 , C07C317/44 , C07C2602/08 , C07D219/10 , C07D309/30 , C07D401/12 , C07D499/00 , C07F9/3873 , C07H15/252
摘要： Compounds or their salts of general formula (I): A-B-N(O)s wherein: s is an integer equal to 1 or 2; A=R-T1-, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X=O, S, NR1c, R1c is H or a linear or branched alkyl or a free valence, t and t′ are integers and equal to zero or 1, with the proviso that t=1 when t′=0; t=0 when t′=1; B=-TB-X2—O— wherein TB=(CO) when t=0, TB=X when t′=0, X being as above defined; X2 is equal to R1B-X-R2B radical wherein X is as above defined, R1B and R2B, equal to or different from each other, are linear or branched C1-C6 alkylenes, or X2 is a radical wherein two alkylene chains C1-C4 are linked to nonadjacent positions of a central ring having 4 or 6 atoms, said ring being an unsaturated cycloaliphatic ring, or a saturated or aromatic heterocylic ring, containing one or two heteroatoms, equal or different, selected from O, S, N; wherein the unsaturated cycloaliphatic ring does not have aromatic character according to Huckel's rule.
摘要翻译：通式（I）的化合物或其盐：A-B-N（O）n其中：s为等于1或2的整数; A = RT 1 - ，其中R是药物基团，并且T 1 =（CO）t或（X）T' 其中X = O，S，NR 1c，R 1c是H或直链或支链烷基或自由价，t和t'是整数并且等于0或1，条件是当t'= 0时t = 1; 当t'= 1时，t = 0; B = -T B-X 2 -O-O其中当B = 0时，T B =（CO），T B < / SUB> =当t'= 0时，X如上所定义; X 2等于其中X如上所定义的R 1B-XR 2B基团，R 1B和R 彼此相同或不同的是直链或支链C 1 -C 6亚烷基，或X 2， SUB>是其中两个亚烷基链C 1 -C 4连接到具有4或6个原子的中心环的不相邻位置的基团，所述环是不饱和脂环族环或含有一个或两个相同或不同的选自O，S，N的杂原子的饱和或芳族杂环; 其中不饱和脂环族环根据Huckel的规则不具有芳香性质。

7. 发明授权

US07368442B2 Nitrate esters of corticoid compounds and pharmaceutical applications thereof 失效
标题翻译：皮质激素化合物的硝酸酯及其药物应用
公开(公告)号：US07368442B2
公开(公告)日：2008-05-06
申请号：US11714724
申请日：2007-03-07
申请人： Piero Del Soldato
发明人： Piero Del Soldato
IPC分类号： A61K31/56 , C07J41/00
CPC分类号： C07J43/00 , C07J41/005 , C07J71/00 , Y10S514/825
摘要： Compounds of the formula and use of the compounds as medicaments.
摘要翻译：式的化合物和化合物作为药物的用途。

8. 发明申请

US20080096908A1 Statin derivatives 失效
标题翻译：他汀衍生物
公开(公告)号：US20080096908A1
公开(公告)日：2008-04-24
申请号：US11905910
申请日：2007-10-05
申请人： Francesca Benedini , Ennio Ongini , Piero Del Soldato
发明人： Francesca Benedini , Ennio Ongini , Piero Del Soldato
IPC分类号： A61K31/404 , A61K31/215 , A61K31/44 , A61P9/00 , C07D207/333 , C07D213/26 , C07D239/42 , C07D209/04 , C07C69/66 , A61K31/505 , A61K31/40
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译：描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。它们可用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。

9. 发明申请

US20070197499A1 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US20070197499A1
公开(公告)日：2007-08-23
申请号：US11642783
申请日：2006-12-21
申请人： Piero Del Soldato
发明人： Piero Del Soldato
IPC分类号： A61K31/397
CPC分类号： C07D295/088 , C07C203/04 , C07C219/22 , C07C219/24 , C07C229/42 , C07C233/25 , C07C317/44 , C07C2602/08 , C07D219/10 , C07D309/30 , C07D401/12 , C07D499/00 , C07F9/3873 , C07H15/252
摘要： Compounds or their salts of general formula (I): A-B—N(O)s wherein: s is an integer equal to 1 or 2; A=R-T1-, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X═O, S, NR1c, R1c is H or a linear or branched alkyl or a free valence, t and t′ are integers and equal to zero or 1, with the proviso that t=1 when t′=0; t=0 when t′=1; B=-TB-X2—O—wherein TB=(CO) when t=0, TB=X when t′=0, X being as above defined; X2 is equal to R1B—X—R2B radical wherein X is as above defined, R1B and R2B, equal to or different from each other, are linear or branched C1-C6 alkylenes, or X2 is a radical wherein two alkylene chains C1-C4 are linked to nonadjacent positions of a central ring having 4 or 6 atoms, said ring being an unsaturated cycloaliphatic ring, or a saturated or aromatic heterocylic ring, containing one or two heteroatoms, equal or different, selected from O, S, N; wherein the unsaturated cycloaliphatic ring does not have aromatic character according to Huckel's rule.
摘要翻译：通式（I）的化合物或其盐：A-B-N（O）n其中：s为等于1或2的整数; A = RT 1 - ，其中R是药物基团，并且T 1 =（CO）t或（X）T' 其中XO，S，NR 1c，R 1c是H或直链或支链烷基或自由价，t和t'是整数并且相等为零或1，条件是当t'= 0时t = 1; 当t'= 1时，t = 0; 当t = 0时，B = -T B--X 2 -O - 其中T B =（CO），T B' / SUB> =当t'= 0时，X如上所定义; X 2等于其中X如上所定义的R 1B-XR 2B基团，R 1B和R 彼此相同或不同的是直链或支链C 1 -C 6亚烷基，或X 2， SUB>是其中两个亚烷基链C 1 -C 4连接到具有4或6个原子的中心环的不相邻位置的基团，所述环是不饱和脂环族环或含有一个或两个相同或不同的选自O，S，N的杂原子的饱和或芳族杂环; 其中不饱和脂环族环根据Huckel的规则不具有芳香性质。

10. 发明申请

US20070112194A1 Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof 失效
标题翻译：制备硝基氧基烷基取代的羧酸酯的方法，可用于所述方法的中间体及其制备方法
公开(公告)号：US20070112194A1
公开(公告)日：2007-05-17
申请号：US10522986
申请日：2003-08-06
申请人： Piero Del Soldato , Giancarlo Santus , Francesca Benedini
发明人： Piero Del Soldato , Giancarlo Santus , Francesca Benedini
IPC分类号： C07D241/04 , C07C201/04
CPC分类号： C07C269/06 , C07C67/10 , C07C69/734 , C07C201/02 , C07C203/04 , C07C271/28 , C07C303/28 , C07C309/73
摘要： The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.
摘要翻译：本发明涉及制备通式（A）化合物的方法，如说明书所述，其中R为药物基团，R 1 -R 12为氢或烷基，m，n，o，q， r和s各自独立地为0〜6的整数，p为0或1，X为O，S，SO，SO 2，NR 13或PR 13或芳基杂芳基，所述方法包括使式 B）R-COOZ（B）其中R如上所定义，Z是氢或选自：Li +，Na +，K +，Ca ++，Mg ++，四烷基铵，四烷基鏻与式（C）化合物的阳离子，如其描述其中R1-R12和m，n，o，p，q，r，s如上所定义，Y是合适的离去基团。

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