专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060041119A1 Stereospecific reduction of Sapogen-3-ones 失效
标题翻译：皂苷-3-酮的立体特异性还原
公开(公告)号：US20060041119A1
公开(公告)日：2006-02-23
申请号：US10531086
申请日：2003-04-28
申请人： Philip Gunning , Peter Tiffin
发明人： Philip Gunning , Peter Tiffin
IPC分类号： C07J71/00
CPC分类号： C07J71/0005
摘要： A method to stereospecifically prepare a steroidal sapogenin or a derivative thereof by reducing a 3-keto,5β-H steroidal sapogenin with a hindered organoborane or an organo-aluminium hydride. A 3β-hydroxy,5β-H steroidal sapogenin or derivative thereof may be prepared by reducing the 3-keto,5β-H steroidal sapogenin using as reducing agent a relatively highly hindered organoborane reagent or by SN 2 inversion of a 3α-hydroxy,5β-H steroidal sapogenin or derivative thereof. The organo-aluminium hydride may be used to prepare a 3α,5β-H steroidal sapogenin or derivative thereof. The invention provides a convenient route to useful steroidal sapogenins such as sarsasapogenin, episarsasapogenin, smilagenin, epismilagenin and esters thereof, from readily available or easily preparable starting materials (e.g. diosgenone, preparable from diosgenin).
摘要翻译：通过用受阻的有机硼烷或有机氢化铝还原3-酮基，5β-H甾体皂苷元，立体选择性地制备甾体皂苷元或其衍生物的方法。可以通过使用相对高度受阻的有机硼烷试剂的还原剂或通过3α-羟基，5β的SN 2反转来还原3-酮基，5β-H甾体皂苷元来制备3β-羟基，5β-H甾体皂苷元或其衍生物 -H甾体皂苷元或其衍生物。有机铝氢化物可用于制备3α，5β-H甾体皂苷元或其衍生物。本发明提供了从易得的或易于制备的起始物质（例如，由薯os皂苷配制的脱水梭子），可用于甾体皂苷元的方便途径，例如萨洒皂草配基，季节调节素，镰刀菌素，epismilagenin及其酯。

IPRDB

热门服务

关于我们

友情链接

联系方式