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    • 8. 发明申请
    • COMPOSITION FOR VACCINATION
    • 组合物用于疫苗接种
    • WO2004030696A3
    • 2004-05-06
    • PCT/DK0300654
    • 2003-10-02
    • NORDIC VACCINE TECHNOLOGY ASCOLOPLAST ASKIRKBY NIKOLAI SOERENSAMUELSEN PETER BOMAN
    • KIRKBY NIKOLAI SOERENSAMUELSEN PETER BOMAN
    • A61K39/39A61L15/44
    • A61K39/39A61K2039/55577
    • The present invention provides novel compositions for transdermal delivery of at least one immunogen to an individual, which compositions comprise (a) said at least one immunogen (b) an occlusion vehicle and (c) an immunogen delivery system in the form of a PosIntro or a cationic ISCOM or comprising at least one saponin and at as well as a process for preparation of the compositions. The invention further provides constructs comprising these compositions. The compositions and constructs may be used in methods for generating an immunological response, methods for treating or preventing a condition of illness and methods for vaccination. The occlusion vehicle is e.g. a pressure sensitive adhesive, such as a hydrocolloid adhesive or a hydrogel adhesive, which may be cross-linked, or the occlusion vehicle may be non-adherent.
    • 本发明提供了用于向个体透皮递送至少一种免疫原的新型组合物,该组合物包含(a)所述至少一种免疫原(b)阻塞载体和(c)PosIntro形式的免疫原递送系统或 阳离子型ISCOM或包含至少一种皂苷,以及制备该组合物的方法。 本发明还提供包含这些组合物的构建体。 组合物和构建体可用于产生免疫应答的方法,用于治疗或预防疾病状况的方法和用于疫苗接种的方法。 阻塞载体是例如。 可以交联的压敏粘合剂,例如水胶体粘合剂或水凝胶粘合剂,或者阻塞载体可以是非粘着的。