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1. 发明申请

US20090186394A1 Crystallizable JNK complexes 失效
标题翻译：可结晶JNK复合物
公开(公告)号：US20090186394A1
公开(公告)日：2009-07-23
申请号：US12150328
申请日：2008-04-25
申请人： Xiaoling Xie , Yong Gu , William Markland , Michael S. Su , Paul R. Caron , Edward Fox , Keith P. Wilson
发明人： Xiaoling Xie , Yong Gu , William Markland , Michael S. Su , Paul R. Caron , Edward Fox , Keith P. Wilson
IPC分类号： C12N9/12 , G06F17/50
CPC分类号： C12Q1/485 , C07K2299/00 , G01N2333/9121 , G01N2500/00 , G06F19/16
摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.
摘要翻译：本发明涉及用包含JNK3的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。包括这种数据存储材料的计算机能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。此外，本发明涉及使用结构坐标筛选和设计与JNK3或其同系物结合的化合物（包括抑制性化合物）的方法。本发明还涉及分子和分子复合物，其包含JNK3的活性位点结合口袋或活性位点结合口袋的紧密结构同源物。

2. 发明授权

US06183121B2 Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets 有权
标题翻译：丙型肝炎病毒解旋酶晶体和坐标定义解旋酶结合口袋
公开(公告)号：US06183121B2
公开(公告)日：2001-02-06
申请号：US09128314
申请日：1998-08-03
申请人： Joseph L. Kim , Kurt A. Morgenstern , Paul R. Caron , Chao Lin
发明人： Joseph L. Kim , Kurt A. Morgenstern , Paul R. Caron , Chao Lin
IPC分类号： G01N2320
CPC分类号： C07K14/005 , C12N9/90 , C12N2770/24222 , G01N33/5767 , G06F19/16
摘要： The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.
摘要翻译：本发明涉及丙型肝炎病毒解旋酶结构域的X射线晶体结构。更具体地，本发明涉及HCV解旋酶和寡核苷酸的结晶复合物，HCV解旋酶和寡核苷酸的可结晶组合物以及结晶HCV解旋酶 - 寡核苷酸复合物的方法。本发明还涉及一种用HCV解旋酶寡核苷酸结合口袋或HCV解旋酶核苷酸三磷酸盐袋的结构坐标编程的计算机，其中所述计算机能够显示该结合口袋的三维表示。

3. 发明授权

US6094209A Card printing and laminating apparatus 失效
标题翻译：卡片印刷和层压装置
公开(公告)号：US6094209A
公开(公告)日：2000-07-25
申请号：US939865
申请日：1997-09-29
申请人： Edward A. Nardone , Paul R. Caron , Christian S. Rothwell , Harold D. Schofield , Gary Field
发明人： Edward A. Nardone , Paul R. Caron , Christian S. Rothwell , Harold D. Schofield , Gary Field
IPC分类号： B08B7/00 , B41J2/325
CPC分类号： B08B7/0028 , B32B38/162 , B32B38/18 , B41J2/325 , B32B2425/00 , B32B2429/00 , B41J2202/35
摘要： An apparatus for printing and laminating plastic cards consists of a thermal transfer printing station including ribbon and a thermal printhead for printing an image on a receptor surface of a receptor card, a laminating station including laminating film and a heated laminating roller mounted for engagement with said receptor surface of said receptor card during a laminating operation, and a guided carriage for transporting the receptor card beneath the printhead and the heated laminating roller. The carriage includes a resilient surface for receiving the receptor card with a receptor surface facing upwardly. The carriage is guided on a pair of rails to insure proper registration and tracking of the receptor card. The carriage is driven by a threaded rod which passes through a threaded bore in the carriage wherein rotation of the threaded rod by a motor causes movement of the carriage along the guide rails. The apparatus further includes a hopper for storing a plurality of cards for printing, a cleaning station for cleaning the receptor surface of the card prior to printing, and a pair of output nip rollers including a heated lower roller for engaging and heating a lower surface of the receptor card. The carriage enable the card to be transported by a single carrier from the hopper to the output nip rollers.
摘要翻译：用于印刷和层压塑料卡的装置包括热转印印刷站，包括色带和用于在接收器卡的受体表面上印刷图像的热打印头，包括层压膜的层压站和安装成与所述在层压操作期间所述接收器卡的受体表面，以及用于将接收卡传送到打印头和加热的层压辊下面的导向托架。滑架包括用于接收接收器卡的弹性表面，接收器表面朝上。托架在一对轨道上引导，以确保接收卡的正确对准和跟踪。托架由穿过托架中的螺纹孔的螺杆驱动，其中螺杆通过马达的旋转引起托架沿导轨运动。该装置还包括用于存储多张用于打印的卡的料斗，用于在打印之前清洁卡的接收器表面的清洁站以及包括加热的下辊的一对输出夹持辊，用于接合和加热卡的下表面接收卡。托架使得卡能够通过单个载体从料斗输送到输出夹紧辊。

4. 发明授权

US5588763A System and method for cleaning and producing data bearing cards 失效
标题翻译：清洁和生产数据承载卡的系统和方法
公开(公告)号：US5588763A
公开(公告)日：1996-12-31
申请号：US324731
申请日：1994-10-18
申请人： Richard C. Nubson , Glenn R. Carney , Luc DeBleeckere , Ronald B. Howes , Milo B. Squires , David E. Wickstrom , Dennis J. Warwick , Benjamin H. Sannel , Gretchen J. Moeller , Paul R. Caron , Harold D. Schofield
发明人： Richard C. Nubson , Glenn R. Carney , Luc DeBleeckere , Ronald B. Howes , Milo B. Squires , David E. Wickstrom , Dennis J. Warwick , Benjamin H. Sannel , Gretchen J. Moeller , Paul R. Caron , Harold D. Schofield
IPC分类号： B41J13/00 , B41J2/315 , B41J2/32 , B41J3/407 , B41J13/12 , B41J25/304 , B41J25/312 , B41J25/316 , B41J29/17 , B41J35/00 , B41J35/28 , B42D15/10 , B65H5/00 , G06K1/12 , G06K19/12
CPC分类号： B42D25/48 , B41J13/12 , B41J2/315 , B41J3/00 , B41J3/407 , B42D25/00 , B42D25/425 , B42D25/47 , G06K1/125 , G06K1/126 , G06K19/12
摘要： A magnetically encoded plastic card production system is provided which includes a supply mechanism for supplying a series of blank plastic cards. An encoder is operatively coupled to the supply mechanism which encodes a magnetic strip on each card. A separating mechanism is operatively coupled following the encoder which has a roller surface for adhesively attracting loose particles from a surface of each card. A design placing mechanism is operatively coupled immediately following the separating mechanism which places a graphic design on each card. In this arrangement, the loose particles are separated from each card subsequent to encoding the magnetic strip on each card and prior to placing the graphic design on each card. A collecting mechanism is operatively coupled to the design placing mechanism which collects each card after each card has passed through the encoder, separating mechanism, and design placing mechanism. A method for producing magnetically encoded plastic cards is also provided.
摘要翻译：提供了一种磁编码塑料卡生产系统，其包括用于供应一系列空白塑料卡的供应机构。编码器可操作地耦合到供应机构，其对每个卡上的磁条进行编码。分离机构在编码器之后可操作地耦合，编码器具有用于从每个卡的表面粘附地吸引松散颗粒的辊表面。设计放置机构在分离机构之后可操作地耦合，其在每个卡上放置图形设计。在这种布置中，在对每个卡上的磁条进行编码之后并且将图形设计放置在每张卡上之前，松散的颗粒与每个卡片分离。收集机构可操作地耦合到设计放置机构，每个卡已经通过编码器，分离机构和设计放置机构之后收集每张卡。还提供了一种用于制造磁编码塑料卡的方法。

5. 发明授权

US5322069A Ambulatory ECG triggered blood pressure monitoring system and method therefor 失效
标题翻译：动态心电图触发血压监测系统及其方法
公开(公告)号：US5322069A
公开(公告)日：1994-06-21
申请号：US64928
申请日：1993-05-24
申请人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer
发明人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/022 , A61B5/0402 , A61B5/0432 , A61B5/0452 , A61B5/02
CPC分类号： A61B5/0225 , A61B5/0205 , A61B5/02208 , A61B5/02225 , A61B5/04325 , A61B5/7232 , A61B5/7285 , Y10S128/90 , Y10S128/908
摘要： An ambulatory patient monitoring system (100) is provided for measuring and storing predetermined diagnostic parameters of a patient. The monitoring system includes a personal type computer (120) which may be selectively coupled to the portable portion (102) of system (100). Portable portion (102) may include one or more monitoring modules, such as ECG monitoring unit (110) and blood pressure monitoring unit (210). When ECG monitoring unit (110) and blood pressure monitoring unit (210) are disposed in side-by-side relationship and with respective optical interfaces (50, 254) in optical alignment, the two units operate in concert. ECG monitoring unit (110) supplies an R-wave gating signal to blood pressure monitoring unit (210) for establishing a window in which the receipt of a Korotkoff sound is expected. Additionally, the ECG unit (110) may trigger the blood pressure unit (210) to take a reading responsive to unit (110) identifying a predetermined abnormality in the ECG signal. Alternately, ECG monitoring unit (110) and blood pressure monitoring unit (210) may be used independently of one another as separate monitoring devices.
摘要翻译：提供了一种用于测量和存储患者的预定诊断参数的步行病人监护系统（100）。监视系统包括可以选择性地耦合到系统（100）的便携式部分（102）的个人计算机（120）。便携式部分（102）可以包括一个或多个监测模块，例如ECG监测单元（110）和血压监测单元（210）。当ECG监视单元（110）和血压监测单元（210）以并排关系设置并且相应的光学接口（50,254）以光学对准方式布置时，两个单元协调工作。 ECG监测单元（110）向血压监测单元（210）提供R波选通信号，用于建立其中期望收到Korotkoff声音的窗口。此外，ECG单元（110）可以触发血压单元（210）响应于识别ECG信号中的预定异常的单元（110）进行读取。或者，ECG监测单元（110）和血压监测单元（210）可以彼此独立地用作单独的监视设备。

6. 发明授权

US5309920A Ambulatory electrocardiographic patient monitoring system and method therefor 失效
标题翻译：动态心电图患者监护系统及其方法
公开(公告)号：US5309920A
公开(公告)日：1994-05-10
申请号：US64454
申请日：1993-05-21
申请人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer
发明人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/022 , A61B5/0402 , A61B5/0432 , A61B5/0452
CPC分类号： A61B5/0225 , A61B5/0205 , A61B5/02208 , A61B5/02225 , A61B5/04325 , A61B5/7232 , A61B5/7285 , Y10S128/90 , Y10S128/908
摘要： An ambulatory patient monitoring system (100) is provided for measuring and storing predetermined diagnostic parameters of a patient. The monitoring system includes a personal type computer (120) which may be selectively coupled to the portable portion (102) of system (100). Portable portion (102) may include one or more monitoring modules, such as ECG monitoring unit (110) and blood pressure monitoring unit (210). When ECG monitoring unit (110) and blood pressure monitoring unit (210) are disposed in side-by-side relationship and with respective optical interfaces (50, 254) in optical alignment, the two units operate in concert. ECG monitoring unit (110) supplies an R-wave gating signal to blood pressure monitoring unit (210) for establishing a window in which the receipt of a Korotkoff sound is expected. Additionally, the ECG unit (110) may trigger the blood pressure unit (210) to take a reading responsive to unit (110) identifying a predetermined abnormality in the ECG signal. Alternately, ECG monitoring unit (110) and blood pressure monitoring unit (210) may be used independently of one another as separate monitoring devices.
摘要翻译：提供了一种用于测量和存储患者的预定诊断参数的步行病人监护系统（100）。监视系统包括可以选择性地耦合到系统（100）的便携式部分（102）的个人计算机（120）。便携式部分（102）可以包括一个或多个监测模块，例如ECG监测单元（110）和血压监测单元（210）。当ECG监视单元（110）和血压监测单元（210）以并排关系设置并且相应的光学接口（50,254）以光学对准方式布置时，两个单元协调工作。 ECG监测单元（110）向血压监测单元（210）提供R波选通信号，用于建立其中期望收到Korotkoff声音的窗口。此外，ECG单元（110）可以触发血压单元（210）响应于识别ECG信号中的预定异常的单元（110）进行读取。或者，ECG监测单元（110）和血压监测单元（210）可以彼此独立地用作单独的监视设备。

7. 发明授权

US5238001A Ambulatory patient monitoring system having multiple monitoring units and optical communications therebetween 失效
标题翻译：具有多个监测单位的有效患者监测系统和光通信
公开(公告)号：US5238001A
公开(公告)日：1993-08-24
申请号：US790500
申请日：1991-11-12
申请人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer
发明人： Stuart L. Gallant , Paul R. Caron , Walter E. Palmer
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/022 , A61B5/0402 , A61B5/0432 , A61B5/0452
CPC分类号： A61B5/0225 , A61B5/0205 , A61B5/02208 , A61B5/02225 , A61B5/04325 , A61B5/7232 , A61B5/7285 , Y10S128/90 , Y10S128/908
摘要： An ambulatory patient monitoring system (100) is provided for measuring and storing predetermined diagnostic parameters of a patient. The monitoring system includes a personal type computer (120) which may be selectively coupled to the portable portion (102) of system (100). Portable portion (102) may include one or more monitoring modules, such as ECG monitoring unit (110) and blood pressure monitoring unit (210). When ECG monitoring unit (110) and blood pressure monitoring unit (210) are disposed in side-by-side relationship and with respective optical interfaces (50, 254) in optical alignment, the two units operate in concert. ECG monitoring unit (110) supplies an R-wave gating signal to blood pressure monitoring unit (210) for establishing a window in which the receipt of a Korotkoff sound is expected. Additionally, the ECG unit (110) may trigger the blood pressure unit (210) to take a reading responsive to unit (110) identifying a predetermined abnormality in the ECG signal. Alternately, ECG monitoring unit (110) and blood pressure monitoring unit (210) may be used independently of one another as separate monitoring devices.

8. 发明授权

US4316249A Automatic high speed Holter scanning system 失效
标题翻译：自动高速动态心电扫描系统
公开(公告)号：US4316249A
公开(公告)日：1982-02-16
申请号：US92925
申请日：1979-11-09
申请人： Stuart L. Gallant , Paul R. Caron , Stanley M. Dunn , Walter E. Palmer , Ernest G. Schmitt , Michael Taddeo
发明人： Stuart L. Gallant , Paul R. Caron , Stanley M. Dunn , Walter E. Palmer , Ernest G. Schmitt , Michael Taddeo
IPC分类号： A61B5/044 , G06F17/00 , G06F15/42
CPC分类号： A61B5/044
摘要： An automatic high speed Holter scanning system operates in a nonautomatic mode or in an automatic mode to receive electrocardiogram signals which have been prerecorded in dissimilar formats having different known parameters, and to process same in accordance with an operator input. The automatic arrhythmia processor of the present invention detects ectopic cardiac information, stores the detected information in time sequence, and selectively reads out and displays the stored ectopic information in response to operator command. In addition, the automatic arrhythmia processor compares QRS complexes in received ECG signals to a desired normal QRS complex, and continuously updates the R-R interval and area of the normal QRS complex following each comparison of the normal QRS complex with the subsequent QRS complexes. The system of the present invention basically comprises a front panel for operator control, an input interface unit, converter unit, freeze memories with freeze memory control, CRT with CRT control, a chart recorder, an arrhythmia detection and scanning system, a central processing unit, and various front panel lamps and indicators.
摘要翻译：自动高速动态心电扫描系统以非自动模式或自动模式操作，以接收已经以不同格式具有不同已知参数的预先记录的心电图信号，并根据操作员输入进行处理。本发明的自动心律不齐处理器检测异位心脏信息，按时间顺序存储检测到的信息，并且响应于操作者命令选择性地读出并显示存储的异位信息。此外，自动心律不齐处理器将接收的ECG信号中的QRS复合物与期望的正常QRS复合物进行比较，并且在正常QRS复合物与随后的QRS复合物进行每次比较之后，连续地更新正常QRS复合物的R-R间期和面积。本发明的系统基本上包括用于操作员控制的前面板，输入接口单元，转换器单元，具有冷冻存储器控制的冷冻存储器，具有CRT控制的CRT，图表记录器，心律失常检测和扫描系统，中央处理单元，以及各种前面板灯和指示灯。

9. 发明授权

US5673076A Card printing and laminating apparatus 失效
标题翻译：卡片印刷和层压装置
公开(公告)号：US5673076A
公开(公告)日：1997-09-30
申请号：US403072
申请日：1995-03-13
申请人： Edward A. Nardone , Paul R. Caron , Christian S. Rothwell , Harold D. Schofield , Gary Field
发明人： Edward A. Nardone , Paul R. Caron , Christian S. Rothwell , Harold D. Schofield , Gary Field
IPC分类号： B08B7/00 , B41J2/325
CPC分类号： B08B7/0028 , B32B38/162 , B32B38/18 , B41J2/325 , B32B2425/00 , B32B2429/00 , B41J2202/35
摘要： An apparatus for printing and laminating plastic cards consists of a thermal transfer printing station including ribbon and a thermal printhead for printing an image on a receptor surface of a receptor card, a laminating station including laminating film and a heated laminating roller mounted for engagement with said receptor surface of said receptor card during a laminating operation, and a guided carriage for transporting the receptor card beneath the printhead and the heated laminating roller. The carriage includes a resilient surface for receiving the receptor card with a receptor surface facing upwardly. The carriage is guided on a pair of rails to insure proper registration and tracking of the receptor card. The carriage is driven by a threaded rod which passes through a threaded bore in the carriage wherein rotation of the threaded rod by a motor causes movement of the carriage along the guide rails. The apparatus further includes a hopper for storing a plurality of cards for printing, a cleaning station for cleaning the receptor surface of the card prior to printing, and a pair of output nip rollers including a heated lower roller for engaging and heating a lower surface of the receptor card. The carriage enable the card to be transported by a single carrier from the hopper to the output nip rollers.
摘要翻译：用于印刷和层压塑料卡的装置包括热转印印刷站，包括色带和用于在接收器卡的受体表面上印刷图像的热打印头，包括层压膜的层压站和安装成与所述在层压操作期间所述接收器卡的受体表面，以及用于将接收卡传送到打印头和加热的层压辊下面的导向托架。滑架包括用于接收接收器卡的弹性表面，接收器表面朝上。托架在一对轨道上引导，以确保接收卡的正确对准和跟踪。托架由穿过托架中的螺纹孔的螺杆驱动，其中螺杆通过马达的旋转引起托架沿导轨运动。该装置还包括用于存储多张用于打印的卡的料斗，用于在打印之前清洁卡的接收器表面的清洁站以及包括加热的下辊的一对输出夹持辊，用于接合和加热卡的下表面接收卡。托架使得卡能够通过单个载体从料斗输送到输出夹紧辊。

10. 发明授权

US5401111A System and method for cleaning data bearing cards 失效
标题翻译：清理数据承载卡的系统和方法
公开(公告)号：US5401111A
公开(公告)日：1995-03-28
申请号：US20005
申请日：1993-02-17
申请人： Richard C. Nubson , Glenn R. Carney , Luc DeBleeckere , Ronald B. Howes , Milo B. Squires , David E. Wickstrom , Dennis J. Warwick , Benjamin H. Sannel , Gretchen J. Moeller , Paul R. Caron , Harold D. Schofield
发明人： Richard C. Nubson , Glenn R. Carney , Luc DeBleeckere , Ronald B. Howes , Milo B. Squires , David E. Wickstrom , Dennis J. Warwick , Benjamin H. Sannel , Gretchen J. Moeller , Paul R. Caron , Harold D. Schofield
IPC分类号： B41J13/00 , B41J2/315 , B41J2/32 , B41J3/407 , B41J13/12 , B41J25/304 , B41J25/312 , B41J25/316 , B41J29/17 , B41J35/00 , B41J35/28 , B42D15/10 , B65H5/00 , G06K1/12 , G06K19/12
CPC分类号： B42D25/48 , B41J13/12 , B41J2/315 , B41J3/00 , B41J3/407 , B42D25/00 , B42D25/425 , B42D25/47 , G06K1/125 , G06K1/126 , G06K19/12
摘要： An apparatus and method are described for removing particulate matter from one or more surfaces of a workpiece, such as a credit card blank, prior to printing a graphic design thereon. The apparatus includes a pair of cleaning rollers which engage both sides of the card, the cleaning rollers having an adhesive coating for removing loose particulate matter from the surfaces of the card. The apparatus also includes a stripper system for stripping collected particulate matter away from the cleaning rollers after a predetermined number of cards have been cleaned.
摘要翻译：描述了一种用于在打印其上的图形设计之前从工件（例如信用卡坯件）的一个或多个表面去除颗粒物质的装置和方法。该装置包括一对与卡的两侧啮合的清洁辊，清洁辊具有用于从卡的表面去除松散的颗粒物质的粘合剂涂层。该装置还包括一个剥离器系统，用于在已经清洁了预定数量的卡之后，将收集的颗粒物质从清洁辊上剥离。

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