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1. 发明申请

WO2010127143A2 NEUROPROTECTIVE GANODERMA COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：神经保护GANODERMA组合物及其使用方法
公开(公告)号：WO2010127143A2
公开(公告)日：2010-11-04
申请号：PCT/US2010033005
申请日：2010-04-29
申请人： PURAPHARM INT HK LTD , CHAN BILL PIU , ZHANG RUIPING
发明人： CHAN BILL PIU , ZHANG RUIPING
IPC分类号： A61K36/074 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： A61K36/074
摘要： The subject invention provides methods for treatment of degenerative neurological disorders such as Parkinson's disease and Alzheimer's disease comprising administration of a Ganoderma lucidum extract. The subject invention also provides a method for inhibiting the activation of microglial cells by applying the Ganoderma lucidum extract to the cells.
摘要翻译：本发明提供治疗退行性神经障碍如帕金森病和阿尔茨海默病的方法，其包括灵芝提取物的施用。本发明还提供了通过将灵芝提取物应用于细胞来抑制小胶质细胞的活化的方法。

2. 发明申请

WO2010079406A9 COMPOUNDS AND USES THEREOF FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES 审中-公开
标题翻译：用于治疗炎症和调节免疫应答的化合物及其用途
公开(公告)号：WO2010079406A9
公开(公告)日：2010-12-29
申请号：PCT/IB2009055970
申请日：2009-12-28
申请人： PURAPHARM INT HK LTD , VERSITECH LTD
发明人： LAU ALLAN SY , YANG LAI HUNG CINDY , CHIK CHI CHUNG STANLEY , LI CHUN BONG JAMES
IPC分类号： C07C39/21 , A61K31/05 , A61K31/09 , A61P35/00 , C07C43/215
CPC分类号： C07C59/64 , A61K31/235 , C07C69/734
摘要： Compounds and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
摘要翻译：包含这些化合物的化合物和组合物，其具有免疫调节活性和/或抗炎活性。

3. 发明申请

WO2012014085A3 USES OF CIMIRACEMATE A AND RELATED COMPOUNDS FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES 审中-公开
标题翻译：用于治疗炎症和调节免疫应答的CIMIRACEMATE A和相关化合物的使用
公开(公告)号：WO2012014085A3
公开(公告)日：2012-05-18
申请号：PCT/IB2011002582
申请日：2011-07-29
申请人： PURAPHARM INT HK LTD , LAU ALLAN SIK YIN , YANG CINDY LAI HUNG , VERSITECH LTD
发明人： LAU ALLAN SIK YIN , YANG CINDY LAI HUNG
IPC分类号： A61K31/216 , A61K36/71 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/08
CPC分类号： A61K31/216
摘要： The present invention discloses cimiracemate A and related compounds inhibiting 5 -lipoxygenase activity and various proinflammatory mediators such as lipoxins, leukotrienes, prostaglandins, and thromboxanes. The present invention also provides therapeutic methods and compositions for treatment of inflammation and inflammatory conditions, including allergic reactions, diseases associated with cell proliferation, neoangiogenesis, and cardiovascular diseases.
摘要翻译：本发明公开了嘧菌酯A和抑制5-脂氧合酶活性的相关化合物和各种促炎介质如脂氧素，白三烯，前列腺素和血栓烷。本发明还提供了用于治疗炎症和炎性病症的治疗方法和组合物，包括过敏反应，与细胞增殖，新血管生成和心血管疾病相关的疾病。

4. 发明申请

WO2011080593A3 MATERIALS AND METHODS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS 审中-公开
标题翻译：用于防止和治疗病毒感染的材料和方法
公开(公告)号：WO2011080593A3
公开(公告)日：2011-08-25
申请号：PCT/IB2010003482
申请日：2010-12-30
申请人： PURAPHARM INT HK LTD , VERSITECH LTD , LAU ALLAN SIK-YIN , YANG LAI HUNG CINDY , LAW ANNA HING-YEE
发明人： LAU ALLAN SIK-YIN , YANG LAI HUNG CINDY , LAW ANNA HING-YEE
IPC分类号： A61K31/7048 , A61K31/192 , A61K31/215 , A61K31/7032 , A61K36/28 , A61K36/34 , A61K36/35 , A61K36/48 , A61K36/484 , A61K36/534 , A61K36/538 , A61K36/634 , A61K36/899 , A61P31/16
CPC分类号： A61K31/7028 , A61K31/192 , A61K31/215 , A61K36/33 , A61K36/355 , A61K36/48 , A61K36/484 , A61K36/534 , A61K36/538 , A61K36/634 , A61K45/06 , A61K2300/00
摘要： The subject invention provides a novel and advantageous method for preventing and treating viral infection. Specifically exemplified herein are therapeutic uses of forsythoside A and jacaranone, compounds isolated from traditional Chinese medicinal material such as Fructus f?rsythiae (Lian Qiao). Also provided is use of a Yin Qiao San composition for preventing and treating viral infection.
摘要翻译：本发明提供了一种预防和治疗病毒感染的新颖且有利的方法。本文具体列举的是连翘酯苷A和jacaranone的治疗用途，即从传统中药材如裂果蝇（连翘）分离的化合物。还提供了阴翘散组合物用于预防和治疗病毒感染的用途。

5. 发明申请

WO2011013007A3 ONTOLOGICAL INFORMATION RETRIEVAL SYSTEM 审中-公开
标题翻译：本科信息检索系统
公开(公告)号：WO2011013007A3
公开(公告)日：2011-04-07
申请号：PCT/IB2010002237
申请日：2010-07-29
申请人： PURAPHARM INT HK LTD , LIN WILFRED WAN KEI , WONG ALLAN KANG YING , WONG JACKEI HO KEI , KONG JEWELS CHUN WING
发明人： LIN WILFRED WAN KEI , WONG ALLAN KANG YING , WONG JACKEI HO KEI , KONG JEWELS CHUN WING
IPC分类号： G06F17/30
CPC分类号： G06F17/30734 , G06F19/324 , G16H50/70
摘要： An ontological information retrieval system is provided. According Io an embodiment, the subject ontological information retrieval system can be utilized for computer-aided clinical Traditional Chinese Medicine ( TCM) practice. In one implementation, a graphical user interface (GUI) is provided, enabling a user to input a query} with symptoms determined from a patient, and the system's parser can find instances of the symptoms in a document object model (DOM) tree of the TCM ontological information. Diagnosis based upon the symptoms can be communicated to the user through the GUI. A relevance index (RI) and/or a frequency index (FI) can be further provided for evaluating a diagnosis by comparing the symptoms determined from a patient with the expected symptoms of the diagnosed illness and returning a value based on the number of matched symptoms, or a weighted index of matched symptoms.
摘要翻译：提供本体信息检索系统。根据实施例，本体本体信息检索系统可用于计算机辅助临床中医（TCM）实践。在一个实现中，提供图形用户界面（GUI），使得用户能够输入具有从患者确定的症状的查询，并且系统的解析器可以在文档对象模型（DOM）树中找到症状的实例，中医本体信息。基于症状的诊断可以通过GUI传达给用户。可以进一步提供相关性指数（RI）和/或频率指数（FI），用于通过将从患者确定的症状与诊断出的疾病的预期症状进行比较并基于匹配症状的数量返回值来评估诊断，或匹配症状的加权指数。

6. 发明申请

WO2012046145A3 CORIOLUS VERSICOLOR EXTRACTS, METHODS OF PREPARATION AND USES THEREOF 审中-公开
标题翻译： CORIOLUS VERSICOLOR EXTRACTS，其制备方法及其用途
公开(公告)号：WO2012046145A3
公开(公告)日：2012-06-07
申请号：PCT/IB2011002845
申请日：2011-10-06
申请人： PURAPHARM INT HK LTD , VERSITECH LTD , LAU ALLAN SIK-YIN , CHIK STANLEY CHI CHUNG , LAW ANNA HING-YEE , YANG CINDY LAI HUNG
发明人： LAU ALLAN SIK-YIN , CHIK STANLEY CHI CHUNG , LAW ANNA HING-YEE , YANG CINDY LAI HUNG
IPC分类号： A61K31/715 , A61K36/074
CPC分类号： A61K36/07 , A61K2236/333
摘要： The subject invention provides Coriolus versicolor extracts, pharmaceutical compositions comprising the Coriolus versicolor extracts, methods of preparation, and therapeutic uses thereof. Advantageously, the subject Coriolus versicolor extract has immunomodulatory, anti-tumor, anti-microbial, and antiviral effects. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells. In certain preferred embodiments, the subject invention can be used to treat glioblastoma multiforme, nasopharyngeal carcinoma, breast carcinoma, lung carcinoma, prostate cancer, and colon carcinoma, as well as bacterial, viral, fungal, protozoan, and/or other microbial infection.
摘要翻译：本发明提供了Coriolus versicolor提取物，包含Coriolus versicolor提取物的药物组合物，其制备方法及其治疗用途。有利地，主题Coriolus versicolor提取物具有免疫调节，抗肿瘤，抗微生物和抗病毒作用。在优选的实施方案中，本发明可用于抑制癌细胞的转移扩散。在某些优选实施方案中，本发明可用于治疗多形性成胶质细胞瘤，鼻咽癌，乳腺癌，肺癌，前列腺癌和结肠癌，以及细菌，病毒，真菌，原生动物和/或其他微生物感染。

7. 发明申请

WO2012051740A1 DISPENSING SYSTEM FOR TRADITIONAL CHINESE MEDICINE 审中-公开
标题翻译：传统中医药分配系统
公开(公告)号：WO2012051740A1
公开(公告)日：2012-04-26
申请号：PCT/CN2010001649
申请日：2010-10-21
申请人： PURAPHARM INT HK LTD , LIM ADRIAN WAI MING , CHAN YU LING ABRAHAM
发明人： LIM ADRIAN WAI MING , CHAN YU LING ABRAHAM
IPC分类号： A47B67/02 , A61G12/00
CPC分类号： A47B37/00 , A47B13/10 , A47B67/02 , A47B83/04 , A47B83/045 , G07F17/0092
摘要： A dispensing system (100) for traditional Chinese medicine includes an independent dispensing unit (B2). The dispensing unit (B2) includes a bottle placing rack (1) and a worktable (2). The bottle placing rack (1) has a back board (12) which has a semi-cylindrical inner surface (121) and a semi-cylindrical outer surface (122) and multiple horizontal arc shelves (11) which are formed as one with the semi-cylindrical inner surface (121) of the back board (12). Each arc shelf (11) has a radial inner edge (111) and a radial outer edge (112). The worktable (2) has an approximately big semicircular horizontal plate-like part (21) provided for operators to do dispensing operation on it. The plate-like part (21) is located under the bottle placing rack (1). When viewed in the top viewport, the approximately semicircular outline of the plate-like part (21) roughly coincides with the vertical projection of the semi-cylindrical outer surface (122) of the back board (12). The center (C21) of the plate-like part (21) is basically located on the central axis (C12) corresponding with the semi-cylindrical outer surface (122). Wherein, the radial inner edges (111) of those shelves, from each of which the vertical distance to the plate-like part (21) is greater than or equal to a predetermined value (H), are gradually closer to the central axis (C12) of the back board (12) with the increase of the height of the shelves (11).
摘要翻译：用于中药的分配系统（100）包括独立的分配单元（B2）。分配单元（B2）包括瓶放置架（1）和工作台（2）。瓶放置架（1）具有背板（12），其具有半圆柱形内表面（121）和半圆柱形外表面（122）和多个水平弧架（11），其形成为与背板（12）的半圆柱形内表面（121）。每个电弧架（11）具有径向内边缘（111）和径向外边缘（112）。工作台（2）具有大致半圆形的水平板状部件（21），用于操作者对其进行分配操作。板状部（21）位于瓶放置架（1）的下方。当在顶部视口中观察时，板状部分（21）的大致半圆形轮廓大致与背板（12）的半圆柱形外表面（122）的垂直投影重合。板状部件（21）的中心（C21）基本上位于与半圆柱形外表面（122）对应的中心轴线（C12）上。其中，从板状部分（21）的垂直距离大于或等于预定值（H）的那些搁板的径向内边缘（111）逐渐靠近中心轴线随着搁架（11）的高度的增加，后板（12）的C12（C12）。

8. 发明申请

WO2012014082A3 ARTIFICIAL INTELLIGENCE AND METHODS FOR RELATING HERBAL INGREDIENTS WITH ILLNESSES IN TRADITIONAL CHINESE MEDICINE 审中-公开
标题翻译：人工智能与传统中医药相关成分的方法
公开(公告)号：WO2012014082A3
公开(公告)日：2012-04-26
申请号：PCT/IB2011002500
申请日：2011-07-28
申请人： PURAPHARM INT HK LTD , LIN WILFRED WAN KEI , WONG JACKEI HO KEI , WONG ALLAN KANG YING
发明人： LIN WILFRED WAN KEI , WONG JACKEI HO KEI , WONG ALLAN KANG YING
IPC分类号： G06F17/15 , A61K36/00 , G06N3/02
CPC分类号： G06N3/02 , G06F17/10 , G06F19/18 , G06F19/3456 , G06F19/706 , G06F19/707 , G16H50/20 , Y02A90/26
摘要： Described herein are systems and methods for identifying herbal ingredients effective in treating illnesses in Traditional Chinese Medicine (TCM) using an artificial neural network.
摘要翻译：本文描述了使用人造神经网络鉴定有效治疗中医（TCM）疾病的草药成分的系统和方法。

9. 发明申请

WO2012014085A8 USES OF CIMIRACEMATE A AND RELATED COMPOUNDS FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES 审中-公开
标题翻译：用于治疗炎症和调节免疫应答的CIMIRACEMATE A和相关化合物的使用
公开(公告)号：WO2012014085A8
公开(公告)日：2012-03-29
申请号：PCT/IB2011002582
申请日：2011-07-29
申请人： PURAPHARM INT HK LTD , LAU ALLAN SIK YIN , YANG CINDY LAI HUNG , VERSITECH LTD
发明人： LAU ALLAN SIK YIN , YANG CINDY LAI HUNG
IPC分类号： A61K31/05
CPC分类号： A61K31/216
摘要： The present invention pertains to Cimiracemate A and related compounds that are useful as inhibitors of 5 -lipoxygenase (5-1. OX) activity and various proinflammatory mediators such as lipoxins, leukotrienes (e.g., LTA4, LTB4, LTC4, LTD4, and LTE4), prostaglandins, and thromboxanes. The present invention also provides therapeutic methods and compositions for treatment of inflammation and inflammatory conditions, including allergenic reactions, diseases associated with cell proliferation, neoangiogenesis, and cardiovascular diseases.
摘要翻译：本发明涉及可用作5-脂氧合酶（5-1OX）活性抑制剂和各种促炎介质如脂氧素，白细胞三烯（例如LTA4，LTB4，LTC4，LTD4和LTE4）的相关化合物，，前列腺素和血栓素。本发明还提供用于治疗炎症和炎性病症的治疗方法和组合物，包括变应原反应，与细胞增殖相关的疾病，新血管生成和心血管疾病。

10. 发明申请

WO2010150102A3 METHOD FOR ISOLATING CIMIRACEMATE A 审中-公开
标题翻译：分离CIMIRACEMATE A的方法
公开(公告)号：WO2010150102A3
公开(公告)日：2011-03-24
申请号：PCT/IB2010001772
申请日：2010-06-21
申请人： PURAPHARM INT HK LTD , VERSITECH LTD , YANG LAI HUNG CINDY , LAU ALLAN SY
发明人： YANG LAI HUNG CINDY , LAU ALLAN SY
IPC分类号： C07C39/21 , A61K31/05 , A61K36/28 , A61K36/71
CPC分类号： A61K38/47 , A61K36/71 , C07C67/56 , C07C69/734
摘要： A method for isolating cimiracemate A from a Cimicifuga species is disclosed, comprising the steps of a) providing a sufficient quantity of raw materials from the Cimicifuga species, b) mixing the raw materials from the Cimicifuga species with an aqueous polar solvent at a temperature of about 20 °C to about 28 °C to obtain a solvent extract comprising cimiracemate A, and c) isolating cimiracemate A from the solvent extract.
摘要翻译：公开了从Cimicifuga物种分离cimiracemate A的方法，包括以下步骤：a）从Cimicifuga物质提供足量的原料，b）将来自Cimicifuga物种的原料与极性溶剂水溶液混合，约20℃至约28℃，以获得包含嘧菌酯A的溶剂提取物，和c）从所述溶剂提取物中分离西咪利酸酯A.

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