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1. 发明公开

EP1886677A1 Use of an inducing agent for the treatment of blood, viral and cellular disorders 失效
标题翻译：与用于血液，细胞和病毒疾病的治疗的诱导剂和抗病毒剂的组合物
公开(公告)号：EP1886677A1
公开(公告)日：2008-02-13
申请号：EP07014281.5
申请日：1997-07-28
申请人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
发明人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
IPC分类号： A61K31/195 , A61K31/19 , A61P7/06 , A61P35/00
CPC分类号： A61K31/19 , A61K31/195 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel compositions and to novel methods for the administration of compositions to a patient or to cells in vitro for the treatment of human disorders. In one embodiment, compositions contain chemical compounds that stimulate the expression of fetal hemoglobin and/or stimulate the proliferation of red blood cells, white blood cells and platelets in patients and ex vivo for reconstitution of hematopoiesis in vivo. These methods are useful to treat or prevent the symptoms associated with anemia, sickle cell disease, thalassemia and other blood disorders. In another embodiment, compositions contain an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thymidine kinase, increasing the sensitivity of proliferating cells to the anti-viral agent. Typical anti-viral agents include nucleoside analogs such as ganciclovir that inhibit viral replication. Methods involve administration of therapeutically effective amounts of the inducing agent with the anti-viral agent to destroy virus-infected cells. Viral infections that can be treated include infections by herpes viruses such as Kaposi's-associated herpes virus and Epstein-Barr virus, HIV infections and HTLV infections. These compositions and methods are particularly effective against episomal and latent infections in proliferating cells. The invention also relates to novel methods for the pulsed administration of compositions to patients for the treatment and prevention of cell proliferative disorders including deficiencies such as cytopenia and malignancies such as viral-induced tumors, other forms of neoplasia and for expansion of cells for hematopoietic transplantation.
摘要翻译：本发明涉及新颖的组合物和方法，以用于新颖的组合物到患者或在体外对人类疾病的治疗中的细胞的施用。在一个，实施例的组合物含有化学的化合物确实刺激胎儿血红蛋白的表达和/或刺激红血细胞，白血细胞和血小板的患者增殖和体外用于体内造血重建。这些方法是治疗或预防贫血，镰状细胞病，地中海贫血等血液疾病相关的症状。在另一个实施方式的组合物含有在诱导剂和抗病毒剂的。诱导剂诱导细胞或病毒产品，颜色的表达：如病毒胸苷激酶，增加增殖的细胞的抗病毒剂的灵敏度。典型的抗病毒剂包括核苷类似物：如更昔洛韦没有抑制病毒复制。方法涉及与抗病毒剂破坏病毒感染细胞的诱导剂的治疗有效量的管理。病毒感染可以治疗并包括由疱疹病毒感染：如卡波西相关疱疹病毒和EB病毒，HIV感染和HTLV感染。这些组合物和方法是针对游离的和在增殖细胞中潜伏感染特别有效。因此，本发明涉及用于组合物的脉冲式给药的新颖的方法给患者，用于治疗和预防细胞增殖性病症，包括缺陷：如血细胞减少症和恶性肿瘤：如病毒诱导的肿瘤，其它形式的瘤形成和细胞扩增造血移植，

2. 发明公开

EP0617966A1 Augmenting fetal hemoglobin by treatment with activin and/or inhibin and a method of in vitro diagnosis 失效
标题翻译：通过与激活和/或抑制素治疗以及用于体外诊断的方法胎儿血红蛋白的增加。
公开(公告)号：EP0617966A1
公开(公告)日：1994-10-05
申请号：EP94200748.5
申请日：1989-11-01
申请人： Perrine, Susan P. , Albers, Norbert
发明人： Perrine, Susan P. , Albers, Norbert
IPC分类号： A61K37/02
CPC分类号： G01N33/721 , A61K38/22 , A61K38/24 , G01N33/74
摘要： A method is described for inhibiting the γ-globin to β-globin switching in subjects afflicted with β-globin disorders. The method is effected as a result of the use of medicaments which ameliorate the clinical symptoms of sickle cell disease or β-thalassemia by introducing into the subject prior to natural completion of the switching process activin, inhibin, an inhibin chain or mixtures thereof.
摘要翻译：描述了一种方法用于抑制伽马球蛋白到β珠蛋白开关与β珠蛋白疾病的对象。该方法被实现，使用一个通过引入到切换过程激活素自然完成，抑制素前的受试者，在抑制素链或其混合物改善镰状细胞病或β地中海贫血的临床症状的药物中的结果。

3. 发明公开

EP0367590A2 Augmenting fetal hemoglobin by treatment with activin and/or inhibin 失效
标题翻译： Erhöhungdes fetalenHämoglobinsdurch Behandlung mit Aktivin und / oder Inhibin。
公开(公告)号：EP0367590A2
公开(公告)日：1990-05-09
申请号：EP89311297.9
申请日：1989-11-01
申请人： Perrine, Susan P. , Albers, Norbert
发明人： Perrine, Susan P. , Albers, Norbert
IPC分类号： A61K38/24 , A61K38/04 , G01N33/68 , C12Q1/02
CPC分类号： G01N33/721 , A61K38/22 , A61K38/24 , G01N33/74
摘要： A method is described for inhibiting the γ-globin to β-globin switching in subjects afflicted with β-globin disorders. The method is effected as a result of the use of medicaments which ameliorate the clinical symptoms of sickle cell disease or β-thalassemia by introducing into the subject prior to natural completion of the switching process activin, inhibin, an inhibin chain or mixtures thereof. The invention includes the use of the aforesaid compounds in manufacturing such medicaments.
摘要翻译：描述了一种用于抑制患有β-珠蛋白病的受试者的γ-珠蛋白到β-珠蛋白转换的方法。该方法是通过使用药物来实现的，所述药物通过在切换过程激活素，抑制素，抑制素链或其混合物自然完成之前引入受试者而改善镰状细胞病或β-地中海贫血的临床症状。本发明包括上述化合物在制备这些药物中的用途。

4. 发明公开

EP2298350A2 Composition comprising an inducing agent and an anti-viral agent for the treatment of viral disorders 失效
标题翻译：成分含有诱导WIKSTOFF和抗病毒活性病毒疾病的治疗
公开(公告)号：EP2298350A2
公开(公告)日：2011-03-23
申请号：EP10184726.7
申请日：1997-07-28
申请人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
发明人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
IPC分类号： A61K45/06 , A61K31/52 , A61K31/195 , A61K31/70 , A61K31/19
CPC分类号： A61K31/19 , A61K31/195 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel compositions and to novel methods for the administration of compositions to a patient or to cells in vitro for the treatment of human disorders. In one embodiment, compositions contain chemical compounds that stimulate the expression of fetal hemoglobin and/or stimulate the proliferation of red blood cells, white blood cells and platelets in patients and ex vivo for reconstitution of hematopoiesis in vivo . These methods are useful to treat or prevent the symptoms associated with anemia, sickle cell disease, thalassemia and other blood disorders. In another embodiment, compositions contain an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thymidine kinase, increasing the sensitivity of proliferating cells to the anti-viral agent. Typical anti-viral agents include nucleoside analogs such as ganciclovir that inhibit viral replication. Methods involve administration of therapeutically effective amounts of the inducing agent with the anti-viral agent to destroy virus-infected cells. Viral infections that can be treated include infections by herpes viruses such as Kaposi's-associated herpes virus and Epstein-Barr virus, HIV infections and HTLV infections. These compositions and methods are particularly effective against episomal and latent infections in proliferating cells. The invention also relates to novel methods for the pulsed administration of compositions to patients for the treatment and prevention of cell proliferative disorders including deficiencies such as cytopenia and malignancies such as viral-induced tumors, other forms of neoplasia and for expansion of cells for hematopoietic transplantation.
摘要翻译：本发明涉及新颖的组合物和方法，以用于新颖的组合物到患者或在体外对人类疾病的治疗中的细胞的施用。在一个，实施例的组合物含有化学的化合物确实刺激胎儿血红蛋白的表达和/或刺激红血细胞，白血细胞和血小板的患者增殖和体外用于体内造血重建。这些方法是治疗或预防贫血，镰状细胞病，地中海贫血等血液疾病相关的症状。在另一个实施方式的组合物含有在诱导剂和抗病毒剂的。诱导剂诱导细胞或病毒产品，颜色的表达：如病毒胸苷激酶，增加增殖的细胞的抗病毒剂的灵敏度。典型的抗病毒剂包括核苷类似物：如更昔洛韦没有抑制病毒复制。方法涉及与抗病毒剂破坏病毒感染细胞的诱导剂的治疗有效量的管理。病毒感染可以治疗并包括由疱疹病毒感染：如卡波西相关疱疹病毒和EB病毒，HIV感染和HTLV感染。这些组合物和方法是针对游离的和在增殖细胞中潜伏感染特别有效。因此，本发明涉及用于组合物的脉冲式给药的新颖的方法给患者，用于治疗和预防细胞增殖性病症，包括缺陷：如血细胞减少症和恶性肿瘤：如病毒诱导的肿瘤，其它形式的瘤形成和细胞扩增造血移植，

5. 发明公开

EP1611885A8 Use of an inducing agent for the treatment of blood, viral and cellular disorders 失效
标题翻译：使用的诱导剂用于治疗血液，病毒和细胞紊乱
公开(公告)号：EP1611885A8
公开(公告)日：2007-10-24
申请号：EP05012584.8
申请日：1997-07-28
申请人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
发明人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
IPC分类号： A61K31/195 , A61K31/19 , A61P7/06 , A61P35/00
CPC分类号： A61K31/19 , A61K31/195 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel compositions and to novel methods for the administration of compositions to a patient or to cells in vitro for the treatment of human disorders. In one embodiment, compositions contain chemical compounds that stimulate the expression of fetal hemoglobin and/or stimulate the proliferation of red blood cells, white blood cells and platelets in patients and ex vivo for reconstitution of hematopoiesis in vivo. These methods are useful to treat or prevent the symptoms associated with anemia, sickle cell disease, thalassemia and other blood disorders. In another embodiment, compositions contain an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thymidine kinase, increasing the sensitivity of proliferating cells to the anti-viral agent. Typical anti-viral agents include nucleoside analogs such as ganciclovir that inhibit viral replication. Methods involve administration of therapeutically effective amounts of the inducing agent with the anti-viral agent to destroy virus-infected cells. Viral infections that can be treated include infections by herpes viruses such as Kaposi's-associated herpes virus and Epstein-Barr virus, HIV infections and HTLV infections. These compositions and methods are particularly effective against episomal and latent infections in proliferating cells. The invention also relates to novel methods for the pulsed administration of compositions to patients for the treatment and prevention of cell proliferative disorders including deficiencies such as cytopenia and malignancies such as viral-induced tumors, other forms of neoplasia and for expansion of cells for hematopoietic transplantation.

6. 发明公开

EP2298350A3 COMPOSITION COMPRISING AN INDUCING AGENT AND AN ANTI-VIRAL AGENT FOR THE TREATMENT OF VIRAL DISORDERS 失效
标题翻译：成分含有诱导WIKSTOFF和抗病毒活性病毒疾病的治疗
公开(公告)号：EP2298350A3
公开(公告)日：2011-06-08
申请号：EP10184726.7
申请日：1997-07-28
申请人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
发明人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
IPC分类号： A61K45/06 , A61K31/52 , A61K31/195 , A61K31/70 , A61K31/19
CPC分类号： A61K31/19 , A61K31/195 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel compositions and to novel methods for the administration of compositions to a patient or to cells in vitro for the treatment of human disorders. In one embodiment, compositions contain chemical compounds that stimulate the expression of fetal hemoglobin and/or stimulate the proliferation of red blood cells, white blood cells and platelets in patients and ex vivo for reconstitution of hematopoiesis in vivo . These methods are useful to treat or prevent the symptoms associated with anemia, sickle cell disease, thalassemia and other blood disorders. In another embodiment, compositions contain an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thymidine kinase, increasing the sensitivity of proliferating cells to the anti-viral agent. Typical anti-viral agents include nucleoside analogs such as ganciclovir that inhibit viral replication. Methods involve administration of therapeutically effective amounts of the inducing agent with the anti-viral agent to destroy virus-infected cells. Viral infections that can be treated include infections by herpes viruses such as Kaposi's-associated herpes virus and Epstein-Barr virus, HIV infections and HTLV infections. These compositions and methods are particularly effective against episomal and latent infections in proliferating cells. The invention also relates to novel methods for the pulsed administration of compositions to patients for the treatment and prevention of cell proliferative disorders including deficiencies such as cytopenia and malignancies such as viral-induced tumors, other forms of neoplasia and for expansion of cells for hematopoietic transplantation.

7. 发明公开

EP1611885A1 Use of an inducing agent for the treatment of blood, viral and cellular disorders 失效
标题翻译：使用的诱导剂用于治疗血液，病毒和细胞紊乱
公开(公告)号：EP1611885A1
公开(公告)日：2006-01-04
申请号：EP05012584.8
申请日：2005-06-13
申请人： Perrine, Susan P.
发明人： Perrine, Susan P.
IPC分类号： A61K31/195 , A61K31/19 , A61P7/06 , A61P35/00
CPC分类号： A61K31/19 , A61K31/195 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel compositions and to novel methods for the administration of compositions to a patient or to cells in vitro for the treatment of human disorders. In one embodiment, compositions contain chemical compounds that stimulate the expression of fetal hemoglobin and/or stimulate the proliferation of red blood cells, white blood cells and platelets in patients and ex vivo for reconstitution of hematopoiesis in vivo. These methods are useful to treat or prevent the symptoms associated with anemia, sickle cell disease, thalassemia and other blood disorders. In another embodiment, compositions contain an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thymidine kinase, increasing the sensitivity of proliferating cells to the anti-viral agent. Typical anti-viral agents include nucleoside analogs such as ganciclovir that inhibit viral replication. Methods involve administration of therapeutically effective amounts of the inducing agent with the anti-viral agent to destroy virus-infected cells. Viral infections that can be treated include infections by herpes viruses such as Kaposi's-associated herpes virus and Epstein-Barr virus, HIV infections and HTLV infections. These compositions and methods are particularly effective against episomal and latent infections in proliferating cells. The invention also relates to novel methods for the pulsed administration of compositions to patients for the treatment and prevention of cell proliferative disorders including deficiencies such as cytopenia and malignancies such as viral-induced tumors, other forms of neoplasia and for expansion of cells for hematopoietic transplantation.
摘要翻译：本发明涉及新颖的组合物和方法，以用于新颖的组合物到患者或在体外对人类疾病的治疗中的细胞的施用。在一个，实施例的组合物含有化学的化合物确实刺激胎儿血红蛋白的表达和/或刺激红血细胞，白血细胞和血小板的患者增殖和体外用于体内造血重建。这些方法是治疗或预防贫血，镰状细胞病，地中海贫血等血液疾病相关的症状。在另一个实施方式的组合物含有在诱导剂和抗病毒剂的。诱导剂诱导细胞或病毒产品，颜色的表达：如病毒胸苷激酶，增加增殖的细胞的抗病毒剂的灵敏度。典型的抗病毒剂包括核苷类似物：如更昔洛韦没有抑制病毒复制。方法涉及与抗病毒剂破坏病毒感染细胞的诱导剂的治疗有效量的管理。病毒感染可以治疗并包括由疱疹病毒感染：如卡波西相关疱疹病毒和EB病毒，HIV感染和HTLV感染。这些组合物和方法是针对游离的和在增殖细胞中潜伏感染特别有效。因此，本发明涉及用于组合物的脉冲式给药的新颖的方法给患者，用于治疗和预防细胞增殖性病症，包括缺陷：如血细胞减少症和恶性肿瘤：如病毒诱导的肿瘤，其它形式的瘤形成和细胞扩增造血移植，

8. 发明公开

EP0969869A2 COMPOSITIONS COMPRISING AN INDUCING AGENT AND AN ANTI-VIRAL AGENT FOR THE TREATMENT OF BLOOD, VIRAL AND CELLULAR DISORDERS 失效
标题翻译：成分含有诱导WIKSTOFF和抗病毒活跃的病毒和细胞疾病的治疗
公开(公告)号：EP0969869A2
公开(公告)日：2000-01-12
申请号：EP97936153.2
申请日：1997-07-28
申请人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
发明人： Perrine, Susan P. , Faller, Douglas V. , White, Brian F.
IPC分类号： A61K45/06 , A61K31/52 , A61K31/195 , A61K31/70 , A61K31/19
CPC分类号： A61K31/19 , A61K31/195 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel compositions and to novel methods for the administration of compositions to a patient or to cells in vitro for the treatment of human disorders. In one embodiment, compositions contain chemical compounds that stimulate the expression of fetal hemoglobin and/or stimulate the proliferation of red blood cells, white blood cells and platelets in patients and ex vivo for reconstitution of hematopoiesis in vivo. These methods are useful to treat or prevent the symptoms associated with anemia, sickle cell disease, thalassemia and other blood disorders. In another embodiment, compositions contain an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thymidine kinase, increasing the sensitivity of proliferating cells to the anti-viral agent. Typical anti-viral agents include nucleoside analogs such as ganciclovir that inhibit viral replication. Methods involve administration of therapeutically effective amounts of the inducing agent with the anti-viral agent to destroy virus-infected cells. Viral infections that can be treated include infections by herpes viruses such as Kaposi's-associated herpes virus and Epstein-Barr virus, HIV infections and HTLV infections. These compositions and methods are particularly effective against episomal and latent infections in proliferating cells. The invention also relates to novel methods for the pulsed administration of compositions to patients for the treatment and prevention of cell proliferative disorders including deficiencies such as cytopenia and malignancies such as viral-induced tumors, other forms of neoplasia and for expansion of cells for hematopoietic transplantation.

9. 发明授权

EP0367590B1 Augmenting fetal hemoglobin by treatment with activin and/or inhibin 失效
标题翻译：通过与激活和/或抑制素治疗胎儿血红蛋白的增加。
公开(公告)号：EP0367590B1
公开(公告)日：1995-03-08
申请号：EP89311297.9
申请日：1989-11-01
申请人： Perrine, Susan P. , Albers, Norbert
发明人： Perrine, Susan P. , Albers, Norbert
IPC分类号： A61K38/24 , A61K38/04 , G01N33/68 , C12Q1/02
CPC分类号： G01N33/721 , A61K38/22 , A61K38/24 , G01N33/74

10. 发明公开

EP0367590A3 Augmenting fetal hemoglobin by treatment with activin and/or inhibin 失效
标题翻译：通过用激活和/或抑制剂治疗和维生素D诊断方法来治疗终极HEMOGLOBIN
公开(公告)号：EP0367590A3
公开(公告)日：1992-01-02
申请号：EP89311297.9
申请日：1989-11-01
申请人： Perrine, Susan P. , Albers, Norbert
发明人： Perrine, Susan P. , Albers, Norbert
IPC分类号： A61K38/24 , A61K38/04 , G01N33/68 , C12Q1/02
CPC分类号： G01N33/721 , A61K38/22 , A61K38/24 , G01N33/74
摘要： A method is described for inhibiting the γ-globin to β-globin switching in subjects afflicted with β-globin disorders. The method is effected as a result of the use of medicaments which ameliorate the clinical symptoms of sickle cell disease or β-thalassemia by introducing into the subject prior to natural completion of the switching process activin, inhibin, an inhibin chain or mixtures thereof. The invention includes the use of the aforesaid compounds in manufacturing such medicaments.

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