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1. 发明申请

WO1997037045A1 IMPROVED TECHNIQUE FOR DIFFERENTIAL DISPLAY 审中-公开
标题翻译：改进的差异显示技术
公开(公告)号：WO1997037045A1
公开(公告)日：1997-10-09
申请号：PCT/US1997005814
申请日：1997-04-02
申请人： JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. , COMBATES, Nicholas , PARDINAS, Jose, R. , PARIMOO, Satish , PROUTY, Stephen, M. , STENN, Kurt, S.
发明人： JOHNSON & JOHNSON CONSUMER PRODUCTS, INC.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6809 , C12N15/1096 , C12Q2563/131 , C12Q2525/173
摘要： The method of this invention relates to the use of improved anchor primers and a novel purification process to increase the efficiency and accuracy of the differential display technique.
摘要翻译：本发明的方法涉及使用改进的锚定引物和新的纯化方法来提高差示显示技术的效率和精度。

2. 发明申请

WO2002093124A3 MARKERS FOR EVALUATING ESTROGENIC ACTIVITY 审中-公开
公开(公告)号：WO2002093124A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/014597
申请日：2002-05-10
申请人： SIGNAL PHARMACEUTICALS, INC. , BARBOSA, Miguel, S. , BRADY, Helen, A. , CHAN, Kyle, W., H. , PARDINAS, Jose, R.
发明人： BARBOSA, Miguel, S. , BRADY, Helen, A. , CHAN, Kyle, W., H. , PARDINAS, Jose, R.
IPC分类号： C12N15/02
摘要： Methods are provided for evaluating estrogenic and antiestrogenic effects of candidate therapeutic agents. Such methods are generally based on assays to detect modulation of estrogen-regulated marker expression in one or more specific cell types. Agents identified using such methods may be used, for example, in the prevention and treatment of diseases such as osteoporosis, cardiovascular disease and cancer. In addition, the gene discovery approaches discussed have identified a using gene profile for estrogen regulation in vascular endothelial cells. This gene profile will allow characterization of the effects of potential SERMs in the cardiovascular system this gene profile and the assays established with these genes will enable more extensive evaluation of tissue specific properties of SERM compounds and provide a better understanding of cardiovascular effects of SERMs.

3. 发明申请

WO2012051111A3 HUMAN ONCOSTATIN M ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：人类ONCOSTATIN M抗体和使用方法
公开(公告)号：WO2012051111A3
公开(公告)日：2012-06-21
申请号：PCT/US2011055606
申请日：2011-10-10
申请人： JANSSEN BIOTECH INC , ALMAGRO JUAN CARLOS , DUBELL WILLIAM , FRANSSON JOHAN , PARDINAS JOSE
发明人： ALMAGRO JUAN CARLOS , DUBELL WILLIAM , FRANSSON JOHAN , PARDINAS JOSE
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07H21/00 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
摘要翻译：能够中和制瘤素M生物学功能的抗体和组合物可用于治疗与制瘤素M相关的疾病和病症，例如骨关节炎和特发性肺纤维化。

4. 发明申请

WO2011112511A1 METHODS AND ALGORITHMS FOR SELECTING POLYNUCLEOTIDES FOR SYNTHETIC ASSEMBLY 审中-公开
标题翻译：选择合成聚氨酯的方法和算法
公开(公告)号：WO2011112511A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027392
申请日：2011-03-07
申请人： CENTOCOR ORTHO BIOTECH INC. , PARDINAS, Jose , ZHAO, Shanrong
发明人： PARDINAS, Jose , ZHAO, Shanrong
IPC分类号： C40B50/06 , C40B40/06
CPC分类号： C12N15/1089 , C12N15/1044 , C40B40/08 , C40B50/02 , G06F19/22
摘要： The present invention relates to methods and algorithms for identifying, synthesizing and co-assembling combinatorial libraries of polynucleotide variants.
摘要翻译：本发明涉及用于鉴定，合成和共同组合多核苷酸变体组合文库的方法和算法。

5. 发明申请

WO2010002785A1 DIFFERENTIATION OF PLURIPOTENT STEM CELLS 审中-公开
标题翻译：多发性干细胞的分化
公开(公告)号：WO2010002785A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/049049
申请日：2009-06-29
申请人： CENTOCOR ORTHO BIOTECH INC. , DAVIS, Janet , LIU, Jia, Jian , RAGHUNATHAN, Gopalan , HUNTER, Michael, Joseph , PARDINAS, Jose, Ramon , CONNOR, Judith, Ann , SWANSON, Ronald, Vernon , CHI, Ellen
发明人： DAVIS, Janet , LIU, Jia, Jian , RAGHUNATHAN, Gopalan , HUNTER, Michael, Joseph , PARDINAS, Jose, Ramon , CONNOR, Judith, Ann , SWANSON, Ronald, Vernon , CHI, Ellen
IPC分类号： C12N5/06 , C12N5/00
CPC分类号： C12N5/0603 , C12N5/0606 , C12N2501/16 , C12N2506/02
摘要： The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable of differentiating pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
摘要翻译：本发明涉及分化多能干细胞的方法。特别地，本发明涉及将多能干细胞分化成表达定形内胚层谱系特征性标志物的细胞的方法和组合物。本发明还提供了产生和纯化能够将多能干细胞分化成表达定形内胚层谱系特征性标志物的细胞的方法。

6. 发明申请

WO2012051111A2 HUMAN ONCOSTATIN M ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：人类癌症M抗体及其使用方法
公开(公告)号：WO2012051111A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/055606
申请日：2011-10-10
申请人： JANSSEN BIOTECH, INC. , ALMAGRO, Juan, Carlos , DUBELL, William , FRANSSON, Johan , PARDINAS, Jose
发明人： ALMAGRO, Juan, Carlos , DUBELL, William , FRANSSON, Johan , PARDINAS, Jose
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13 , C12N5/10 , C12P21/02 , A61P19/02 , A61P17/06 , A61P11/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P19/08 , A61P9/10 , A61P13/12 , A61P35/00
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07H21/00 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
摘要翻译：能够中和制瘤素M生物功能的抗体和组合物可用于治疗与制瘤素M相关的疾病和病症，例如骨关节炎和特发性肺纤维化。

7. 发明申请

WO2002093124A2 MARKERS FOR EVALUATING ESTROGENIC ACTIVITY 审中-公开
标题翻译：评估雌激素活性的标记
公开(公告)号：WO2002093124A2
公开(公告)日：2002-11-21
申请号：PCT/US2002/014597
申请日：2002-05-10
申请人： SIGNAL PHARMACEUTICALS, INC. , BARBOSA, Miguel, S. , BRADY, Helen, A. , CHAN, Kyle, W., H. , PARDINAS, Jose, R.
发明人： BARBOSA, Miguel, S. , BRADY, Helen, A. , CHAN, Kyle, W., H. , PARDINAS, Jose, R.
IPC分类号： G01N
CPC分类号： G01N33/743 , G01N2500/04
摘要： Methods are provided for evaluating estrogenic and antiestrogenic effects of candidate therapeutic agents. Such methods are generally based on assays to detect modulation of estrogen-regulated marker expression in one or more specific cell types. Agents identified using such methods may be used, for example, in the prevention and treatment of diseases such as osteoporosis, cardiovascular disease and cancer. In addition, the gene discovery approaches discussed have identified a using gene profile for estrogen regulation in vascular endothelial cells. This gene profile will allow characterization of the effects of potential SERMs in the cardiovascular system this gene profile and the assays established with these genes will enable more extensive evaluation of tissue specific properties of SERM compounds and provide a better understanding of cardiovascular effects of SERMs.
摘要翻译：提供了评估候选治疗剂的雌激素和抗雌激素作用的方法。这样的方法通常基于检测在一种或多种特定细胞类型中调节雌激素调节标记物表达的测定。使用这些方法鉴定的药剂可以用于例如预防和治疗诸如骨质疏松症，心血管疾病和癌症的疾病。此外，所讨论的基因发现方法已经确定了在血管内皮细胞中使用雌激素调节的基因概况。该基因概况将允许表征潜在的SERMs在心血管系统中的作用，该基因谱和用这些基因建立的测定将能够更广泛地评估SERM化合物的组织特异性，并且更好地了解SERM的心血管效应。

8. 发明专利

ES133184U Juguete instructor 未知
公开(公告)号：ES133184U
公开(公告)日：1968-04-01
申请号：ES133184
申请日：1967-10-17
申请人： SORIANO PARDINAS JOSE ANTONIO , GARRIDO FUENTES CARLOS
摘要： Juguete instructivo caracterizado por comprender una placa básica de fondo que en su parte inferior presenta una ranura-guía abierta en sentido horizontal sobre la cual va establecida una tabla triangular de resultados constituida por grupos de cifras distribuidos convencionalmente habiéndose previsto por debajo de la propia ranura-guía una escala numérica que aporta las combinaciones en que está implicada la incógnita.

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