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1. 发明专利

JP2014205070A 経鼻配送装置有权
标题翻译： NASAL交付设备
公开(公告)号：JP2014205070A
公开(公告)日：2014-10-30
申请号：JP2014139045
申请日：2014-07-04
申请人：オプティノーズアズOptinose As , Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE , RODERICK PETER HAFFNER , SHELDRAKE COLIN DAVID
IPC分类号： A61M15/00 , A61M15/08 , A61M16/06 , A61M16/10
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要：【課題】患者の鼻腔に物質を配送するための経鼻配送装置又は方法を提供する。【解決手段】配送装置は、患者の鼻腔に配送される物質を含有したカプセルCを受け入れるための、入口及び出口を有する容器室を備えた容器受けユニットと、患者の鼻腔に嵌合すると共に容器室の出口に流体連通したノーズピースを有するノーズピースユニット17と、容器室の入口に流体連通したマウスピース77を有すると共に、そこを通して使用時に患者が呼気して、容器からの物質を飛沫同伴すると共にノーズピースを通して同物質を配送するマウスピースユニット19と、容器からの物質を飛沫同伴する際の呼息内の湿度の影響を緩和するための湿度緩和手段とを備える。この手段は、例えば、交換可能な容器包含部材内に容器を設けることにより、容器室とマウスピースユニットの間の流体接続を常時閉鎖する感圧弁26と、容器室上流の温度調節器79とによって与えられる。【選択図】図1(e)
摘要翻译：要解决的问题：提供一种用于将物质输送到患者鼻腔的鼻输送装置。解决方案：输送装置包括：容器接收单元，其包括用于容纳包含待被物质的物质的胶囊C的容器室输送到患者的鼻腔，容器室包括入口和出口; 鼻梁单元17，其包括用于装配到患者的鼻腔并与容器室的出口流体连通的鼻梁; 口器单元19，其包括与容器室的入口流体连通的接口管77，患者在使用中呼气，从而将物质夹带在容器中并将其传送通过鼻梁; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的减湿装置，该装置例如通过将压力容器容纳在可更换容器的构件中，由压敏阀 26，其通常关闭容器室和接口单元之间的流体连接，以及在容器室上游的温度调节器79。

2. 发明专利

JP2014166593A Nasal delivery devices 有权
标题翻译： NASAL交付设备
公开(公告)号：JP2014166593A
公开(公告)日：2014-09-11
申请号：JP2014125822
申请日：2014-06-18
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE , SHELDRAKE COLIN DAVID
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M11/006 , A61M11/007 , A61M11/02 , A61M11/08 , A61M15/0003 , A61M15/0015 , A61M15/002 , A61M15/0021 , A61M15/009 , A61M15/0095 , A61M15/0098 , A61M2202/0468 , A61M2202/064 , A61M2205/8281
摘要： PROBLEM TO BE SOLVED: To provide nasal delivery devices and nasal delivery methods for delivering a substance to a nasal cavity of a patient.SOLUTION: A nasal delivery device used for a method of delivering a substance to a nasal airway of a patient comprises: a mouthpiece (519) through which the patient in use exhales to cause closure of the oropharyngeal velum of the patient; a nosepiece (517) for fitting to a nostril of the patient, the nosepiece including a nozzle (549) through which the substance is delivered to the nasal airway; and a manually actuatable, substance supply unit (520) for delivering the substance through the nozzle of the nosepiece.
摘要翻译：要解决的问题：提供用于将物质递送到患者鼻腔的鼻输送装置和鼻输送方法。解决方案：用于将物质递送到患者的鼻气道的方法的鼻输送装置包括：吸嘴（519），患者在其中呼吸呼气以使患者的口咽膜闭合; 用于装配到患者鼻孔的鼻梁（517），鼻梁包括喷嘴（549），物质通过该喷嘴传送到鼻气道; 以及用于通过喷嘴的喷嘴输送物质的可手动致动的物质供应单元（520）。

3. 发明专利

JP2010234075A Delivery device and method 审中-公开
标题翻译：交付设备和方法
公开(公告)号：JP2010234075A
公开(公告)日：2010-10-21
申请号：JP2010141906
申请日：2010-06-22
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE
IPC分类号： A61M15/00 , A61M13/00 , A61M15/08 , A61M16/04
CPC分类号： A61M15/0098 , A61M15/0021 , A61M15/009 , A61M15/0091 , A61M15/08 , A61M16/0434 , A61M16/0493 , A61M16/0495 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2202/30 , A61M2210/065
摘要： PROBLEM TO BE SOLVED: To provide a delivery device and method for delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject.
SOLUTION: The delivery device includes a mouthpiece unit 10 and an oral outlet unit. The mouthpiece unit 10 is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity to close the oropharyngeal velum of the subject. The oral outlet unit 14 includes at least one outlet 30, from which substance is delivered to a mucosal surface within the oral cavity of the subject, when it is used.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于将物质特别是疫苗递送到受试者口腔内的粘膜表面的递送装置和方法。
解决方案：输送装置包括吹口单元10和口腔出口单元。接口单元10被构造成使得在呼出或尝试呼气时，在口腔中产生压力以封闭受试者的口咽膜。口腔出口单元14包括至少一个出口30，当使用物质时，物质被输送到受试者口腔内的粘膜表面。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2013066797A Nasal device 审中-公开
标题翻译： NASAL DEVICE
公开(公告)号：JP2013066797A
公开(公告)日：2013-04-18
申请号：JP2013011530
申请日：2013-01-24
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE
IPC分类号： A61K9/08 , A61M15/08 , A61K9/12 , A61K9/14 , A61K39/00 , A61M11/00 , A61M11/02 , A61M15/00 , A61M16/06 , A61P27/16 , A61P29/00 , A61P37/08
CPC分类号： A61M15/0098 , A61M15/0021 , A61M15/0091 , A61M15/08 , A61M2202/064 , A61M2210/0618 , A61M2210/0625
摘要： PROBLEM TO BE SOLVED: To provide an improved nasal delivery device and nasal delivery method for delivering substance to the nasal cavity of a patient.SOLUTION: The nasal delivery device for delivering substance to the nasal cavity of the patient includes a nosepiece 17, and a delivery unit for delivering the substance through a nozzle of the nozzle piece 17. The nozzle piece 17 includes the nozzle 25 through which the substance is in use delivered to the nasal cavity, and at least one inflatable cuff member 27 which is configured to provide, when inflated, a fluid-tight seal between the nosepiece 17 and the inner wall of the nasal cavity of the patient.
摘要翻译：要解决的问题：提供一种改进的鼻输送装置和用于将物质输送到患者鼻腔的鼻输送方法。解决方案：用于将物质输送到患者鼻腔的鼻输送装置包括鼻梁17和用于通过喷嘴件17的喷嘴输送物质的输送单元。喷嘴件17包括喷嘴25通过所述物质被使用传送到鼻腔，以及至少一个可充气套囊构件27，其构造成在膨胀时提供鼻梁17和患者鼻腔内壁之间的流体密封。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2013027724A Powder delivery device 有权
标题翻译：粉末输送装置
公开(公告)号：JP2013027724A
公开(公告)日：2013-02-07
申请号：JP2012213089
申请日：2012-09-26
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE , SHELDRAKE COLIN DAVID , HAFNER RODERICK PETER
IPC分类号： A61M15/08 , A61M15/00 , A61M16/00 , A61M16/10 , A61M16/12
CPC分类号： A61M15/08 , A61M15/0021 , A61M15/0028 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0086 , A61M15/0098 , A61M16/0066 , A61M16/105 , A61M16/1075 , A61M16/127 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/07 , A61M2205/076 , A61M2205/3606 , A61M2205/3673 , A61M2205/8218 , A61M2206/14 , A61M2210/0618 , A61M2210/0625
摘要： PROBLEM TO BE SOLVED: To provide a delivery device using exhalation breath of a patient to deliver a powdered substance.SOLUTION: The delivery device includes: a substance supply unit having an inlet and an outlet for supplying a dose of substance to be delivered to a nasal cavity of the patient; a nosepiece unit having a nosepiece 30 for fitting to the nasal cavity of the patient and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit having a mouthpiece 25 in fluid communication with the inlet of the substance supply unit and through which the patient in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.
摘要翻译：要解决的问题：提供使用患者的呼气呼吸以递送粉末状物质的输送装置。输送装置包括：物质供应单元，其具有用于供应待递送到患者鼻腔的物质的剂量的入口和出口; 鼻梁单元，其具有用于装配到患者的鼻腔并与物质供应单元的出口流体连通的鼻梁30; 以及具有与所述物质供应单元的入口流体连通的接口管25的接口管单元，并且所述患者在使用中呼气，从而将物质从容器室中夹带并将其传送通过鼻梁，以及至少一个温度调节器用于降低呼出气流的温度，以降低其绝对湿度。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2012071156A Nasal delivery device 有权
标题翻译： NASAL交付设备
公开(公告)号：JP2012071156A
公开(公告)日：2012-04-12
申请号：JP2011252063
申请日：2011-11-17
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE , HAFNER RODERICK PETER , SHELDRAKE COLIN DAVID
IPC分类号： A61M15/00 , A61M15/08 , A61M16/06 , A61M16/10
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： PROBLEM TO BE SOLVED: To provide a nasal delivery system which is suited to deliver substances, in particular particulate substances, such as powdered substances, to a nasal cavity of a subject, and in particular a nasal powder delivery system for both topical delivery and nose- to-brain (N2B) delivery.SOLUTION: A delivery device includes: a capsule-receiving unit 16 having a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit 17 for fitting to the nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece 77 in fluid communication with the inlet of the container chamber and through which the subject in use exhales, to entrain substance from the container and deliver the same through the nosepiece; and a moisture mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.
摘要翻译：要解决的问题：提供一种鼻输送系统，其适于将物质，特别是颗粒物质如粉末物质输送到受试者的鼻腔，特别是用于两种局部的鼻腔输送系统分娩和鼻 - 脑（N2B）递送。解决方案：输送装置包括：胶囊容纳单元16，其具有用于接收含有物质的容纳室，所述容器容纳物容纳待物质被输送到被检体的鼻腔，所述容器室包括入口和出口 ; 鼻梁单元17，用于装配到被检体的鼻腔并与容器室的出口流体连通; 一个接口单元，其包括与容器室的入口流体连通的接口件77，被吸入物体通过其吸入，将物质从容器中夹带并通过物镜传送; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的湿气减轻装置。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2010012291A Nasal delivery device 审中-公开
标题翻译： NASAL交付设备
公开(公告)号：JP2010012291A
公开(公告)日：2010-01-21
申请号：JP2009209845
申请日：2009-09-10
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE
IPC分类号： A61M15/08 , A61J15/00 , A61M15/00 , A61M16/00 , A61M16/06 , A61M16/20
CPC分类号： A61M16/0666 , A61M15/002 , A61M15/0065 , A61M15/009 , A61M15/0098 , A61M15/08 , A61M16/20 , A61M16/202 , A61M16/204 , A61M16/205 , A61M2016/0021 , A61M2016/0039 , A61M2202/064
摘要： PROBLEM TO BE SOLVED: To provide an improved nasal delivery device and method for delivering substance to a nasal airway of a patient.
SOLUTION: The nasal delivery device 11 for delivering substance to a nasal airway 1 of a patient comprises: first and second nosepiece units 17, 19, each including a nosepiece 21, 23 for fitting to respective nostrils of the patient; at least one substance supply unit 13, 15 for supplying substance for delivery to the nasal airway 1 of the patient; and a valve unit 35, 37 for selectively fluidly connecting the at least one substance supply unit 13, 15 alternately to respective ones of the nosepiece units 17, 19.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种改进的鼻输送装置和用于将物质输送到患者的鼻气道的方法。解决方案：用于将物质输送到患者的鼻气道1的鼻输送装置11包括：第一和第二鼻梁单元17,19，每个包括用于装配到患者的各个鼻孔的鼻梁21,23; 至少一个物质供应单元13,15，用于供应物质以输送到患者的鼻气道1; 以及用于选择性地将至少一个物质供应单元13,15交替地连接到各个喷嘴单元17,19中的阀单元35,37。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009261976A Nasal delivery device 有权
标题翻译： NASAL交付设备
公开(公告)号：JP2009261976A
公开(公告)日：2009-11-12
申请号：JP2009159604
申请日：2009-07-06
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE
IPC分类号： A61K9/08 , A61M15/08 , A61K9/12 , A61K9/14 , A61K39/00 , A61M11/00 , A61M13/00 , A61M15/00 , A61M16/06 , A61P27/16 , A61P29/00 , A61P37/08
CPC分类号： A61M15/0098 , A61M15/0021 , A61M15/0091 , A61M15/08 , A61M2202/064 , A61M2210/0618 , A61M2210/0625
摘要： PROBLEM TO BE SOLVED: To provide a nasal delivery device and a nasal delivery method which are used for delivering, to the nasal duct of a patient, one selected from a substance containing a combination drug (especially a systemic agent or a topical agent) or a vaccine, liquid, especially a suspension or a solution, or powder. SOLUTION: The nasal delivery device for delivering a substance to the nasal duct of a patient is provided. The nasal delivery device comprises a nosepiece 17 fitted to the nostril of a subject and a delivery unit for delivering the substance through a nozzle 25 of the nosepiece 17. The nosepiece 17 has the nozzle 25 through which the substance delivered to the nose duct passes during use and at least one inflatable cuff member 27 which inflates after the patient exhales. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种鼻输送装置和鼻输送方法，其用于向患者的鼻导管输送选自含有组合药物的物质（特别是全身性药剂或局部用药物）药剂）或疫苗，液体，特别是悬浮液或溶液或粉末。解决方案：提供用于将物质输送到患者鼻管的鼻输送装置。鼻输送装置包括装配到被检体的鼻孔的鼻梁17和用于通过鼻梁17的喷嘴25输送物质的输送单元。鼻梁17具有喷嘴25，输送到鼻管的物质通过该喷嘴25通过使用和至少一个可膨胀的袖口构件27，其在患者呼气后充气。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2011031088A Nasal device 审中-公开
标题翻译： NASAL DEVICE
公开(公告)号：JP2011031088A
公开(公告)日：2011-02-17
申请号：JP2010258376
申请日：2010-11-18
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE
IPC分类号： A61K9/08 , A61M11/02 , A61K9/12 , A61K9/14 , A61K39/00 , A61M11/00 , A61M15/00 , A61M15/08 , A61M16/06 , A61P27/16 , A61P29/00 , A61P37/08
CPC分类号： A61M15/0098 , A61M15/0021 , A61M15/0091 , A61M15/08 , A61M2202/064 , A61M2210/0618 , A61M2210/0625
摘要： PROBLEM TO BE SOLVED: To provide an improved nasal delivery device and nasal delivery method for delivering substance to the nasal cavity of a patient. SOLUTION: The nasal delivery device for delivering substance to the nasal cavity of a patient includes a nosepiece 17, and a delivery unit for delivering the substance through a nozzle of the nozzle piece 17. The nozzle piece 17 includes the nozzle 25 through which the substance is in use delivered to the nasal cavity, and at least one inflatable cuff member 27 which is configured to provide, when inflated, a fluid-tight seal between the nosepiece 17 and the inner wall of the nasal cavity of the patient. COPYRIGHT: (C)2011,JPO&INPIT

10. 发明专利

JP2010179168A Nasal delivery device 审中-公开
标题翻译： NASAL交付设备
公开(公告)号：JP2010179168A
公开(公告)日：2010-08-19
申请号：JP2010118685
申请日：2010-05-24
申请人： Optinose As , オプティノーズアズOptinose As
发明人： DJUPESLAND PER GISLE
IPC分类号： A61K9/08 , A61M15/08 , A61K9/12 , A61K9/14 , A61K39/00 , A61M11/00 , A61M15/00 , A61M16/06 , A61P27/16 , A61P29/00 , A61P37/08
CPC分类号： A61M15/0098 , A61M15/0021 , A61M15/0091 , A61M15/08 , A61M2202/064 , A61M2210/0618 , A61M2210/0625
摘要： PROBLEM TO BE SOLVED: To provide an improved nasal delivery device and an improved nasal delivery method which are used for delivering a substance to the nasal cavity of a patient in improved manner. SOLUTION: The nasal delivery device for delivering a substance to the nasal cavity of a patient comprises a nosepiece 17 for fitting into the nostril of a patient and a delivery unit for delivering a substance through a nozzle 25 of the nosepiece 17. The nosepiece 17 has a nozzle 25 through which the substance to be delivered to the nose cavity passes during use and at least one inflatable cuff member 27 which is constructed so as to be inflated following the expiration of a patient. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供改进的鼻输送装置和改进的鼻输送方法，其用于以改进的方式将物质递送到患者的鼻腔。解决方案：用于将物质输送到患者鼻腔的鼻输送装置包括用于装配到患者的鼻孔的鼻梁17和用于通过鼻梁17的喷嘴25输送物质的输送单元。鼻梁17具有喷嘴25，待使用时要传送到鼻腔的物质通过该喷嘴25，以及至少一个可膨胀的袖口构件27，其构造成在患者期满之后被充气。版权所有（C）2010，JPO＆INPIT

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