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1. 发明申请

US20090186040A1 DOSING METHODS FOR TREATING AUTOIMMUNE DISEASES USING A TACI-Ig FUSION PROTEIN SUCH AS ATACICEPT 审中-公开
标题翻译：使用TACI-Ig融合蛋白治疗自身免疫性疾病的剂量方法如ATACICEPT
公开(公告)号：US20090186040A1
公开(公告)日：2009-07-23
申请号：US12139078
申请日：2008-06-13
申请人： Sharon J. Busby , Jane A. Gross , Jennifer Visich , Ivan Nestorov , Alain Munafo , Orestis Papasouliotis , Claudia Pena Rossi
发明人： Sharon J. Busby , Jane A. Gross , Jennifer Visich , Ivan Nestorov , Alain Munafo , Orestis Papasouliotis , Claudia Pena Rossi
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： A61K9/06 , A61K9/0019 , A61K38/177 , A61K45/06 , A61K47/6835 , A61K2300/00
摘要： In various embodiments, the present invention provides methods, compositions, dosing, and administration schedules for treatment of autoimmune diseases, including systemic erythematosus (SLE), for example, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule such as atacicept. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BLyS and APRIL, in particular the use of multiple administrations of the fusion molecule at relatively low dose over the course of the treatment.
摘要翻译：在各种实施方案中，本发明提供了治疗自身免疫疾病（包括系统性红斑狼疮（SLE））的方法，组合物，给药和给药方案，例如包括向需要这种治疗的患者施用TACI-Ig融合分子，如atacicept。在一个实施方案中，TACI-Ig融合分子以足以减缓，抑制或抑制BLyS和APRIL的增殖诱导功能的量施用，特别是在该过程中以相对低的剂量使用多次施用融合分子治疗。

2. 发明申请

WO2008055324A2 CLAMPING DEVICE AND RETRACTOR SYSTEM USING THE SAME 审中-公开
标题翻译：使用相同的夹紧装置和延迟器系统
公开(公告)号：WO2008055324A2
公开(公告)日：2008-05-15
申请号：PCT/BG2007/000023
申请日：2007-11-01
申请人： NESTOROV, Stanislav
发明人： NESTOROV, Stanislav
IPC分类号： A61B17/02
CPC分类号： A61B17/0293 , A61B17/0206 , A61B17/645 , A61B90/50 , A61B2017/00477 , A61B2017/00862 , F16B7/0493
摘要： The invention relates to a clamping device and retractor system applicable in human and veterinary medicine. The device comprises a body (1) with a threaded end (2) and a transverse cut (3) for a carrier (4), as well as a clamp (5) to fix the carrier (4), with the possibility to move axially along the body (1), having a corresponding transverse cut (6), and a nut (8) to block the clamp (5) on to the body (1). The retractor system comprising a stand with a cradle (17) to be fixed on the operating table and a holder (19), the cradle (17) and the holder (19) being linked by a tie-beam (18), as well as carriers (4, 46), to fasten to the holder (19), retractors (20) to mount on the carriers (46) and clamping devices (67) with cuts to fix the carriers (4, 46) in.
摘要翻译：本发明涉及适用于人兽药的夹紧装置和牵开器系统。该装置包括具有螺纹端（2）的本体（1）和用于载体（4）的横向切口（3）以及用于固定载体（4）的夹具（5），具有移动的可能性沿着主体（1）轴向地具有相应的横向切口（6）和用于将夹具（5）阻挡在主体（1）上的螺母（8）。牵引器系统包括具有固定在操作台上的支架（17）的支架和支架（19），支架（17）和支架（19）也由连接梁（18）连接作为支架（4,66），通过切口将支架（4,66）固定在支架（19）上，牵开器（20）以安装在支架（46）和夹紧装置（67）上。

3. 发明申请

WO2008157369A3 USE OF TACI-IG FUSION PROTEIN SUCH AS ATACICEPT FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING LUPUS ERYTHEMATOSUS 审中-公开
标题翻译： TACI-IG融合蛋白的使用作为治疗LUPUS ERYTHEMATOSUSUS的药物的制造
公开(公告)号：WO2008157369A3
公开(公告)日：2009-02-19
申请号：PCT/US2008066945
申请日：2008-06-13
申请人： ZYMOGENETICS INC , ARES TRADING SA , BUSBY SHARON J , GROSS JANE A , VISICH JENNIFER , NESTOROV IVAN , MUNAFO ALAIN , PAPASOULIOTIS ORESTIS , PENA ROSSI CLAUDIA
发明人： BUSBY SHARON J , GROSS JANE A , VISICH JENNIFER , NESTOROV IVAN , MUNAFO ALAIN , PAPASOULIOTIS ORESTIS , PENA ROSSI CLAUDIA
IPC分类号： A61K9/06 , A61K9/00 , A61K38/00
CPC分类号： A61K9/06 , A61K9/0019 , A61K38/177 , A61K45/06 , A61K47/6835 , A61K2300/00
摘要： In various embodiments, the present invention provides methods, compositions, dosing, and administration schedules for treatment of autoimmune diseases, including systemic erythematosus (SLE), for example, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule such as atacicept. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BLyS and APRIL, in particular the use of multiple administrations of the fusion molecule at relatively low dose over the course of the treatment.
摘要翻译：在各种实施方案中，本发明提供了治疗自身免疫疾病（包括系统性红斑狼疮（SLE））的方法，组合物，给药和给药方案，例如包括向需要这种治疗的患者施用TACI-Ig融合分子，如atacicept。在一个实施方案中，TACI-Ig融合分子以足以减缓，抑制或抑制BLyS和APRIL的增殖诱导功能的量施用，特别是在该过程中以相对低的剂量使用多次施用融合分子治疗。

4. 发明授权

US08784812B2 Methods for treating autoimmune diseases using a TACI-Ig fusion molecule 失效
标题翻译：使用TACI-Ig融合分子治疗自身免疫性疾病的方法
公开(公告)号：US08784812B2
公开(公告)日：2014-07-22
申请号：US11748978
申请日：2007-05-15
申请人： Herve Broly , Jennifer Visich , Ivan Nestorov , Sharon Busby , Jane Gross
发明人： Herve Broly , Jennifer Visich , Ivan Nestorov , Sharon Busby , Jane Gross
IPC分类号： A61K39/395 , A61K31/00
CPC分类号： A61K33/24 , A61K31/198 , A61K31/42 , A61K31/4706 , A61K31/519 , A61K31/52 , A61K31/65 , A61K38/177 , A61K45/06 , C07K2319/30 , A61K2300/00
摘要： In various embodiments, the present invention provides methods and compositions for treatment of autoimmune diseases, including rheumatoid arthritis, for example comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BlyS and APRIL.
摘要翻译：在各种实施方案中，本发明提供了用于治疗自身免疫疾病（包括类风湿性关节炎）的方法和组合物，例如包括向需要这种治疗的患者施用TACI-Ig融合分子。在一个实施方案中，TACI-Ig融合分子以足以减缓，抑制或抑制BlyS和APRIL的增殖诱导功能的量施用。

5. 发明授权

US07842292B2 Methods for treating B-cell malignancies using a TACI-Ig fusion molecule 有权
标题翻译：使用TACI-Ig融合分子治疗B细胞恶性肿瘤的方法
公开(公告)号：US07842292B2
公开(公告)日：2010-11-30
申请号：US11502134
申请日：2006-08-09
申请人： Herve Broly , Arnaud Ythier , Eric Sievers , Sharon J. Busby , Jan Öhrström , Ivan Nestorov , Stephen M. Ansell
发明人： Herve Broly , Arnaud Ythier , Eric Sievers , Sharon J. Busby , Jan Öhrström , Ivan Nestorov , Stephen M. Ansell
IPC分类号： A61K39/395
CPC分类号： A61K49/0008 , A61K38/177 , A61K47/6835 , C07K2319/30
摘要： The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.
摘要翻译：本发明提供了用于治疗B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法和组合物，其包括向需要治疗的患者施用足以抑制BlyS和APRIL增殖诱导功能的TACI-Ig融合分子。

6. 发明申请

US20070274984A1 METHODS FOR TREATING AUTOIMMUNE DISEASES USING A TACI-IG FUSION MOLECULE 失效
标题翻译：使用TACI-IG融合分子治疗自身免疫疾病的方法
公开(公告)号：US20070274984A1
公开(公告)日：2007-11-29
申请号：US11748978
申请日：2007-05-15
申请人： Herve Broly , Jennifer Visich , Ivan Nestorov , Sharon Busby , Jane Gross
发明人： Herve Broly , Jennifer Visich , Ivan Nestorov , Sharon Busby , Jane Gross
IPC分类号： A61K39/395
CPC分类号： A61K33/24 , A61K31/198 , A61K31/42 , A61K31/4706 , A61K31/519 , A61K31/52 , A61K31/65 , A61K38/177 , A61K45/06 , C07K2319/30 , A61K2300/00
摘要： In various embodiments, the present invention provides methods and compositions for treatment of autoimmune diseases, including rheumatoid arthritis, for example comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BlyS and APRIL.
摘要翻译：在各种实施方案中，本发明提供了用于治疗自身免疫疾病（包括类风湿性关节炎）的方法和组合物，例如包括向需要这种治疗的患者施用TACI-Ig融合分子。在一个实施方案中，TACI-Ig融合分子以足以减缓，抑制或抑制BlyS和APRIL的增殖诱导功能的量施用。

7. 发明申请

US20070071760A1 Methods for treating B-cell malignancies using a TACI-Ig fusion molecule 有权
标题翻译：使用TACI-Ig融合分子治疗B细胞恶性肿瘤的方法
公开(公告)号：US20070071760A1
公开(公告)日：2007-03-29
申请号：US11502134
申请日：2006-08-09
申请人： Herve Broly , Arnaud Ythier , Eric Sievers , Sharon Busby , Jan Ohrstrom , Ivan Nestorov , Stephen Ansell
发明人： Herve Broly , Arnaud Ythier , Eric Sievers , Sharon Busby , Jan Ohrstrom , Ivan Nestorov , Stephen Ansell
IPC分类号： A61K39/395
CPC分类号： A61K49/0008 , A61K38/177 , A61K47/6835 , C07K2319/30
摘要： The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.
摘要翻译：本发明提供了用于治疗B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法和组合物，其包括向需要治疗的患者施用足以抑制BlyS和APRIL增殖诱导功能的TACI-Ig融合分子。

8. 发明申请

WO2015117207A1 TIGHTENING JOINTS FOR VERSATILE MODULAR SYSTEMS FOR OSTEOSYNTHESIS 审中-公开
标题翻译：用于骨质疏松的各种模块化系统的紧密接合
公开(公告)号：WO2015117207A1
公开(公告)日：2015-08-13
申请号：PCT/BG2014/000006
申请日：2014-02-06
申请人： NESTOROV, Stanislav Georgiev
发明人： NESTOROV, Stanislav Georgiev
IPC分类号： A61B17/64 , A61B17/68 , A61B17/70 , A61B17/86
CPC分类号： A61B17/686 , A61B17/6466 , A61B17/8004 , A61B17/8066 , A61B17/8863 , A61B2017/681 , A61B2017/867
摘要： The invention provides improved tightening joints for elements of versatile modular systems for osteosynthesis designed for orthopedics and traumatology as well their application. The tightening joints of the invention are three as the second and third are embodiments of the first joint. In the first tightening joint (Fig. 4) a rotational wedge-shaped body called clamp is moved along the hole in the other body and pressed against a rod inserted in a cross hole, which intersects the first hole. In the second tightening joint, the clamp is formed as a hemispherical nut in which is screwed the threaded shank of the bone screw, previously screwed in a bone fragment (Fig. 6). In the third tightening joint, the clamp is formed as a sphere having slots (Fig. 7). The versatile modular system for internal osteosynthesis includes bone screws, rods and plates which can be mounted on the rods. The versatile modular system for external osteosynthesis includes bone screws (pins), rods, screwholders and connection modules.
摘要翻译：本发明为骨科和创伤学以及其应用设计的用于骨接合术的通用模块化系统的元件提供改进的紧固接头。本发明的紧固接头是三个，第二和第三是第一接头的实施例。在第一紧固接头（图4）中，称为夹具的旋转楔形体沿着另一体的孔移动并且压靠在插入与第一孔相交的十字孔中的杆上。在第二紧固接头中，夹具形成为半球形螺母，其中螺纹拧入骨螺钉的螺纹柄，预先拧入骨片中（图6）。在第三紧固接头中，夹具形成为具有槽的球（图7）。用于内部骨接合术的多用途模块化系统包括可以安装在杆上的骨螺钉，杆和板。用于外部骨接合术的多功能模块化系统包括骨螺钉（销钉），杆，螺丝刀和连接模块。

9. 发明申请

WO2007019575A3 METHODS FOR TREATING B-CELL MALIGNANCIES USING TACI-IG FUSION MOLECULE 审中-公开
标题翻译：使用TACI-IG融合分子治疗B细胞恶性肿瘤的方法
公开(公告)号：WO2007019575A3
公开(公告)日：2007-06-21
申请号：PCT/US2006031277
申请日：2006-08-09
申请人： ZYMOGENETICS INC , ARES TRADING SA , MAYO FOUNDATION , BROLY HERVE , SIEVERS ERIC , YTHIER ARNAUD , BUSBY SHARON J , ANSELL STEPHEN M , OEHRSTROEM JAN , NESTOROV IVAN
发明人： BROLY HERVE , SIEVERS ERIC , YTHIER ARNAUD , BUSBY SHARON J , ANSELL STEPHEN M , OEHRSTROEM JAN , NESTOROV IVAN
IPC分类号： A61K38/17 , A61P35/00 , C07K14/705
CPC分类号： A61K49/0008 , A61K38/177 , A61K47/6835 , C07K2319/30
摘要： The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BIyS and APRIL.
摘要翻译：本发明提供了用于治疗B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法和组合物，其包括向需要治疗的患者施用足以抑制BIyS和APRIL增殖诱导功能的TACI-Ig融合分子。

10. 发明申请

WO1994027514A1 EXTERNAL OSTEOSYNTHESIS FIXATOR 审中-公开
标题翻译：外部骨质疏松固定器
公开(公告)号：WO1994027514A1
公开(公告)日：1994-12-08
申请号：PCT/BG1993000008
申请日：1993-06-02
申请人： NESTOROV, Stanislav Georgiev
IPC分类号： A61B17/60
CPC分类号： A61B17/60
摘要： The stabilizer is designed for orthopaedics and traumatic surgery and is applied in treatment of long tubular bones. Its design is a compact one and has been simplified to the highest degree, allowing quick immobilization of moving bone fragments. The stabilizer comprises a carrier, shaped as a thin-wall tube (1) with radial holes (3) containing a compact tubular body (2) with diametrical holes (10); bone bolts (17) are fixed in the holes (3, 10) by threading means (9, 12).
摘要翻译：稳定器设计用于骨科和外伤手术，并用于长管状骨的治疗。它的设计是一个紧凑的设计，并被简化到最高程度，允许快速固定移动的骨碎片。稳定器包括形成为具有径向孔（3）的薄壁管（1）的载体，所述径向孔包含具有直径孔（10）的紧凑型管状体（2）。骨螺栓（17）通过螺纹装置（9,12）固定在孔（3,10）中。

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