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    • 2. 发明申请
    • PLANT LIPID COMPOSITION FOR MODULATING FUNCTIONS OF KERATINOUS MATERIALS, METHOD FOR MODULATING SAID FUNCTIONS AND USE OF SAID PLANT LIPIDS
    • 用于调节KERATINOUS材料功能的植物脂肪组合物,调节功能的方法和使用植物脂肪
    • WO2014053038A3
    • 2014-10-30
    • PCT/BR2013000388
    • 2013-10-01
    • NATURA COSMÉTICOS S A
    • FERRARI CINTIA ROSAZIMBARDI DANIELAPLACONA DINIZ GABRIELA PLACONÁDE ASSIS SANTOS ÍCAROLORENCINI MARCIODA LUZ MOREIRA PATRÍCIA
    • A61K8/97
    • A61K8/922A61K2800/75A61Q17/00A61Q19/08
    • The present invention is directed to cosmetic and/or pharmaceutical compositions comprising at least one plant lipid, having as its main application the treatment of keratinous materials, particularly skin, hair, scalp, nails and eyelashes, by modulating the expression of genes responsible for ROS metabolism, lipid metabolism, skin integrity, cell renewal, cell differentiation, strengthening the skin barrier, calcium metabolism, cell proliferation, tissue healing and/or repair, cell adhesion, carbohydrate metabolism, hydration, skin homeostasis/maintenance, skin defense and/or protection, remodeling and/or extracellular matrix synthesis, skin peeling, tissue maintenance, cell signaling, normal development of the epidermis, epidermal barrier function, development of the skin, dermis-epidermis junction, anti-inflammatory or antioxidant action in keratinous materials, through the modulation of the expression of the genes involved in said functions. The present invention also teaches methods of modulating the expression of genes responsible for such functions of keratinous materials and the use of said plant lipids in the preparation of said compositions.
    • 本发明涉及包含至少一种植物脂质的化妆品和/或药物组合物,其主要应用是通过调节负责ROS的基因的表达来治疗角质材料,特别是皮肤,毛发,头皮,指甲和睫毛 代谢,脂质代谢,皮肤完整性,细胞更新,细胞分化,增强皮肤屏障,钙代谢,细胞增殖,组织愈合和/或修复,细胞粘附,碳水化合物代谢,水合,皮肤稳态/维持,皮肤防御和/或 保护,重塑和/或细胞外基质合成,皮肤剥离,组织维持,细胞信号传导,表皮正常发育,表皮屏障功能,皮肤发育,真皮表皮交界处,角质素材料中的抗炎或抗氧化作用,通过 涉及所述功能的基因表达的调节。 本发明还教导了调节负责角质化材料功能的基因表达的方法以及所述植物脂质在制备所述组合物中的用途。