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1. 发明专利

JP2010151677A Uterine cancer diagnosis method and uterine cancer diagnosis kit 审中-公开
标题翻译：子宫癌诊断方法和子宫癌诊断包
公开(公告)号：JP2010151677A
公开(公告)日：2010-07-08
申请号：JP2008331273
申请日：2008-12-25
申请人： National Cancer Center-Japan , Olympus Corp , オリンパス株式会社 , 国立がんセンター総長
发明人： KOBAYASHI TAMIYO , MURASE YUMI , MATSUMURA YASUHIRO , KOGA NOBUKATSU , YASUNAGA MASAHIRO
IPC分类号： G01N33/574 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide an uterine cancer diagnosis method, which is a cell base screening method for directly measuring and analyzing cervical cancer and body cancer cells, non-invasive, decreasing test load, and obtaining diagnosis result with high reliability, and a kit used in the diagnosis method.
SOLUTION: According to this uterine cancer diagnosis method, an uterine cancer is diagnosed according to whether an uterine cancer cell is contained in a living body sample. The method includes: (a1) a process of dyeing cells in the living body sample after being fixed in a cell observation container; and (b1) a process of acquiring a microscopic image of the cell dyed in the process (a1), and analyzing the image to detect an uterine cancer cell. The living body sample derives from a womb. A uterine cancer diagnosis kit is also provided which is used in the diagnosis method for the uterine cancer.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种子宫癌诊断方法，其是用于直接测量和分析子宫颈癌和体癌细胞的非侵入性，降低的测试负荷并获得具有高可靠性的诊断结果的细胞基础筛选方法，以及用于诊断方法的试剂盒。解决方案：根据该子宫癌诊断方法，根据子宫癌细胞是否含有活体样本来诊断子宫癌。该方法包括：（a1）固定在细胞观察容器中后，将活体样品中的细胞染色的工序; 和（b1）获得在步骤（a1）中染色的细胞的显微图像并分析该图像以检测子宫癌细胞的过程。活体样本来源于子宫。还提供了用于子宫癌诊断方法的子宫癌诊断试剂盒。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2010107306A Prognostic prediction method of esophagus cancer 有权
标题翻译：卵巢癌的预后预测方法
公开(公告)号：JP2010107306A
公开(公告)日：2010-05-13
申请号：JP2008278554
申请日：2008-10-29
申请人： Infocom Corp , National Cancer Center-Japan , インフォコム株式会社 , 国立がんセンター総長
发明人： KONDO ITARU , UEMURA NORIHISA , SAITO HIDE , HIROHASHI AKIO
IPC分类号： G01N33/574 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting a prognosis of an esophagus cancer patient, a method for providing information on a selection of a medical treatment, and a reagent for a prognostic prediction of the esophagus cancer patient.
SOLUTION: The invention detects an expression of a biomarker within a sample obtained from the esophagus cancer patient and predicts the prognosis of an esophagus cancer from an excess or a decrease in the expression of the biomarker. The biomarker is preferably transglutaminase 3.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种预测食道癌患者的预后的方法，提供关于医疗的选择的信息的方法以及用于预测食管癌患者的试剂。解决方案：本发明检测从食管癌患者获得的样品内的生物标志物的表达，并从生物标志物的表达的过量或降低预测食管癌的预后。生物标志物优选为转谷氨酰胺酶3.版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009148269A Method for detecting minute amount of gastric cancer cell 有权
标题翻译：检测胃癌细胞数量的方法
公开(公告)号：JP2009148269A
公开(公告)日：2009-07-09
申请号：JP2009000223
申请日：2009-01-05
申请人： Canon Inc , National Cancer Center-Japan , キヤノン株式会社 , 国立がんセンター総長
发明人： SUZUKI TOMOHIRO , YAMAMOTO NOBUKO , SASAKI HIROMI , MORI KAZUHIKO
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09 , G01N33/48 , G01N33/53 , G01N33/574 , G01N37/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/16
摘要： PROBLEM TO BE SOLVED: To provide a combination of genes useful for information usable for predicting postoperative recurrence of gastric cancer and acquisition of the information, a probe detecting these genes and a primer set for PCR, a method for detecting these genes using the probe and the primer set, a method for obtaining the information usable for the prediction of recurrence and the like. SOLUTION: The information useful for the prediction of postoperative recurrence can be obtained by determining the presence or absence of gastric cancer cells showing a possibility of postoperative recurrence in a sample such as an peritoneal wash collected from a patient by detecting a particular gene specific to gastric cancer cells or a gene product thereof. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供可用于预测胃癌术后复发和获取信息的信息的基因组合，检测这些基因的探针和用于PCR的引物组，使用以下方法检测这些基因的方法：探针和引物组，用于获得可用于预测复发的信息的方法等。
解决方案：通过确定胃癌细胞的存在或不存在，可以通过确定样品中是否存在患者术后复发的可能性，例如通过检测特定基因从患者收集的腹膜洗液来获得对术后复发的预测信息特异于胃癌细胞或其基因产物。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2008306976A Method for screening gene to be used in cancer examination, and gene set 有权
标题翻译：用于筛选在癌症检查和基因组中使用的基因的方法
公开(公告)号：JP2008306976A
公开(公告)日：2008-12-25
申请号：JP2007157478
申请日：2007-06-14
申请人： Canon Inc , National Cancer Center-Japan , キヤノン株式会社 , 国立がんセンター総長
发明人： ISHII MIE , YAMAMOTO NOBUKO , OKABE TETSUO , KAWAGUCHI MASAHIRO , SASAKI HIROMI , YAJIMA SATOSHI , MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI
IPC分类号： C12Q1/06 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for early diagnosis of cancer, enabling cancer patients to be detected with higher accuracy, as compared with conventional methods.
SOLUTION: The method is constituted of processes which include using a gene set selected from among a group of genes whose expressions are confirmed in living normal cells and living cancer cells but are not confirmed in necrosed cells, a gene expression in cells retrieved from a relevant patient's feces is analyzed, thereby cancer cells are detected, without setting screening from normal cells.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：与传统方法相比，提供一种癌症早期诊断方法，能够更高精度地检测癌症患者。解决方案：该方法包括使用选自表达在活的正常细胞中表达的基因组和活细胞癌细胞中但在坏死细胞中未证实的基因组的过程，检索到的细胞中的基因表达从相关患者的粪便中分析，从而检测癌细胞，而不设定来自正常细胞的筛选。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2008253638A Gripping forceps 有权
标题翻译：传送力
公开(公告)号：JP2008253638A
公开(公告)日：2008-10-23
申请号：JP2007101274
申请日：2007-04-09
申请人： Hoya Corp , Hoya株式会社 , National Cancer Center-Japan , 国立がんセンター総長
发明人： KAKIZOE TADAO , KOBAYASHI HISAMITSU , IKEDA KUNITOSHI , KANDA HIROYUKI , SANO HIROSHI
IPC分类号： A61B17/28
摘要： PROBLEM TO BE SOLVED: To provide gripping forceps, surely gripping in-vivo tissue without causing damage such as contused wound. SOLUTION: The gripping forceps includes a pair of forceps members respectively having pivoted parts pivoted to relatively rotate by a common rotating shaft and arm parts extending from the pivoted parts toward the tip, and performing opening and closing operation to make pawl parts provided on the tip parts of the arm parts approach and separate each other around the pivoted parts, wherein a lightening part is formed in each of opposite surface parts of the arm parts so that when the paired forceps members are closed, the space between the whole opposite surfaces of the arm parts is uniformly spread wider than the space between the base parts of the pawl parts. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供夹钳，确保抓住体内组织而不引起伤口等伤害。解决方案：夹钳包括一对镊子构件，它们分别具有枢转部分，枢转部分由共同的旋转轴和从枢转部分朝向尖端延伸的臂部分枢转，并且执行打开和关闭操作以使得提供棘爪部分在臂部的尖端部分接近并且绕枢转部分彼此分离，其中在臂部件的相对表面部分中的每一个中形成减轻部分，使得当成对的钳子部件关闭时，整个相对的空间臂部分的表面均匀地扩展得比棘爪部分的基部之间的空间宽。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2008173297A Charged particle beam irradiation device 有权
标题翻译：充电颗粒光束辐射装置
公开(公告)号：JP2008173297A
公开(公告)日：2008-07-31
申请号：JP2007009524
申请日：2007-01-18
申请人： National Cancer Center-Japan , Sumitomo Heavy Ind Ltd , 住友重機械工業株式会社 , 国立がんセンター総長
发明人： NISHIO TEIJI , OGINO TAKASHI , NOMURA KAZUHIRO , TACHIKAWA TOSHIKI
IPC分类号： A61N5/10 , A61B6/00 , A61N5/01 , G01T1/161 , G21K5/00 , G21K5/04
摘要： PROBLEM TO BE SOLVED: To provide a charged particle beam irradiation device permitting confirmation of an irradiation position in a desired region. SOLUTION: The charged particle beam irradiation device has an irradiation chamber 103 with a charged particle beam irradiation part 1 which is rotatable around an object 51 to be irradiated. A detection part 30 for detecting annihilation gamma rays generated in the object 51 to be irradiated is movable in the direction in which the axis X of rotation of the charged particle beam irradiation part 1. Accordingly, by moving the detection part 30 in the direction of the axis X, the detection part 30 can be prevented from preventing rotation of the charged particle beam irradiation part 1. Further, the detection part 30 will not be an obstacle in carrying the object to be irradiated into/out of the irradiation chamber 103, and the position of the desired region can be confirmed. Since the detection part 30 can be moved in the direction of the axis X according to the size of the object to be irradiated, the range of detection by the detection part 30 can be expanded. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供允许在期望区域中确认照射位置的带电粒子束照射装置。解决方案：带电粒子束照射装置具有照射室103，其具有能够围绕物体51旋转以照射的带电粒子束照射部分1。用于检测在被照射物体51中产生的湮灭伽马射线的检测部30能够沿着带电粒子束照射部1的旋转轴线X的方向移动。因此，通过使检测部30沿着可以防止轴线X，检测部件30阻止带电粒子束照射部分1的旋转。此外，检测部件30将不会妨碍将被照射入/离开照射室103的物体，并且可以确认所需区域的位置。由于检测部30能够根据被照射物的尺寸沿轴线X的方向移动，所以能够扩大检测部30的检测范围。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2008118915A Utilization to diagnosis of gastric cancer, and drug discovery by identification of high gastric cancer-expressing gene 审中-公开
标题翻译：通过识别高钾基因表达基因，利用胃癌诊断和药物发现
公开(公告)号：JP2008118915A
公开(公告)日：2008-05-29
申请号：JP2006306057
申请日：2006-11-10
申请人： Tokuzo Arao , National Cancer Center-Japan , Kazuto Nishio , 国立がんセンター総長 , 徳三荒尾 , 和人西尾
发明人： NISHIO KAZUTO , ARAO TOKUZO , YAMADA YASUHIDE
IPC分类号： C12Q1/68 , A61K31/7088 , A61K39/395 , A61K48/00 , A61P35/00 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/574 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a kit for detecting or determining the gastric cancer marker gene, which includes a gastric cancer marker gene effective for determining gastric cancer, a gastric cancer marker polypeptide being an expression product thereof, or a molecule that specifically binds to the gastric cancer marker gene, to provide a kit for detecting or determining a gastric cancer polypeptide, which includes a molecule that specifically binds to the gastric cancer marker gene, and to provide a gastric cancer-treating drug including a double strand RNA, or the like including an antisense RNA and a sense RNA for one or more kinds of genes selected from among the gastric cancer marker genes, as an active ingredient. SOLUTION: The gastric cancer is determined by detecting or determining the quantity of a gastric marker gene which more markedly promotes expression in gastric cancer tissue than in a non-gastric cancer tissue or a gastric cancer marker polypeptide being an expression product thereof. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于检测或确定胃癌标志物基因的试剂盒，其包括有效确定胃癌的胃癌标记基因，作为其表达产物的胃癌标志物多肽或分子，特异性结合胃癌标记基因，提供用于检测或确定胃癌多肽的试剂盒，其包括特异性结合胃癌标记基因的分子，以及提供包含双链RNA的胃癌治疗药物等，包括反义RNA和选自胃癌标记基因的一种或多种基因的有义RNA作为活性成分。解决方案：通过检测或确定胃癌组织中更显着促进胃癌组织中胃癌组织的表达量的胃癌组织或胃癌标志物多肽来测定胃癌。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2007265331A Image recognition device 有权
标题翻译：图像识别装置
公开(公告)号：JP2007265331A
公开(公告)日：2007-10-11
申请号：JP2006092949
申请日：2006-03-30
申请人： Hitachi Medical Corp , National Cancer Center-Japan , 国立がんセンター総長 , 株式会社日立メディコ
发明人： ABE NOBUTAKA , TANIGUCHI HIROKI , KAKIZOE TADAO , KOBAYASHI HISAMITSU
IPC分类号： G06T7/60 , A61B5/00 , A61B5/055 , G06T1/00
摘要： PROBLEM TO BE SOLVED: To provide an image recognition device for extracting an object image with high accuracy. SOLUTION: The image recognition device sets a closed curve 3 when extracting the outline of the object image 1. The image recognition device sets a band region 29 having a predetermined width including the closed curve 3, computes a threshold value 45 maximum in separation based on the pixel value distribution of the band region 29, and compares the threshold value with the pixel value of each sample point 31 on the closed curve 3 to compute the moving direction and moving amount of each sample point 31. Each sample point 31, i.e., the closed curve 3 is dynamically moved to eventually converge the closed curve 3 on the outline of the object region 1 and to extract the outline of the object region 1. To determine the movement of each sample point 31, a statistic based on the pixel value of an internal region 33 inside the band region 29 is compared with a statistic based on the pixel value on the closed curve or in the band region 29, to use a threshold value computed from the pixel value distribution of the band region 29. The outline of the object region 1 can thereby be extracted with high accuracy after reflecting information on the internal region 33 inside the band region 29. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于以高精度提取对象图像的图像识别装置。解决方案：当提取对象图像1的轮廓时，图像识别装置设置闭合曲线3.图像识别装置设置具有包括闭合曲线3的预定宽度的带区域29，计算最大值的阈值45 基于带区域29的像素值分布进行分离，并将阈值与闭合曲线3上的各采样点31的像素值进行比较，计算各采样点31的移动方向和移动量。各采样点31 即闭合曲线3被动态地移动以最终收敛在对象区域1的轮廓上的闭合曲线3并提取对象区域1的轮廓。为了确定每个采样点31的移动，基于将带区域29内的内部区域33的像素值与基于闭合曲线或带区域29中的像素值的统计量进行比较，以使用从像素计算出的阈值带区域29的值分布。因此，可以在反映关于区域29内的内部区域33的信息之后，高精度地提取对象区域1的轮廓。（C）2008，JPO和INPIT

9. 发明专利

JP2007202589A Electronic endoscope apparatus 审中-公开
标题翻译：电子内窥镜装置
公开(公告)号：JP2007202589A
公开(公告)日：2007-08-16
申请号：JP2006021345
申请日：2006-01-30
申请人： National Cancer Center-Japan , Pentax Corp , ペンタックス株式会社 , 国立がんセンター総長
发明人： KAKIZOE TADAO , KOBAYASHI HISAMITSU , MATSUI TAKESHI , IKETANI KOHEI
IPC分类号： A61B1/04 , A61B1/06 , G02B23/24 , H04N7/18
摘要： PROBLEM TO BE SOLVED: To provide an electronic endoscope apparatus allowing easy understanding of the whole image of an observation surface and providing a clear image of a microstructure of the observation surface in an intended depth. SOLUTION: This electronic endoscope apparatus is provided with a light source, a rotating filter emitting the emission light from the light source by sequentially changing over between a wide band light having a wide wavelength band and a narrow band light having a narrow wavelength band, a first image memory section recording a first image signal obtained when irradiated with the wide band light, a second image memory section recording a second image signal obtained when irradiated with the narrow band light, and image signal composition section composing the first image signal and the second image signal. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种允许容易地理解观察表面的整个图像并且以预期深度提供观察表面的微结构的清晰图像的电子内窥镜装置。解决方案：该电子内窥镜装置设置有光源，旋转滤光器，其通过在具有宽波长带的宽带光和具有窄波长的窄带光之间顺序地转换来发射来自光源的发射光记录当用宽带光照射时获得的第一图像信号的第一图像存储部分，记录用窄带光照射时获得的第二图像信号的第二图像存储部分，以及构成第一图像信号的图像信号合成部分和第二图像信号。版权所有（C）2007，JPO＆INPIT

10. 发明专利

JP2007173580A Magnetic field generator and its controlling method 有权
标题翻译：磁场发生器及其控制方法
公开(公告)号：JP2007173580A
公开(公告)日：2007-07-05
申请号：JP2005370063
申请日：2005-12-22
申请人： National Cancer Center-Japan , Pentax Corp , Tamakawa Co Ltd , ペンタックス株式会社 , 国立がんセンター総長 , 株式会社玉川製作所
发明人： KAKIZOE TADAO , KOBAYASHI HISAMITSU , TAMAGAWA KATSUNORI , IKEDA KUNITOSHI , OHARA KENICHI
IPC分类号： H01F7/20 , A61B19/00
摘要： PROBLEM TO BE SOLVED: To provide a magnetic field generator capable of performing a magnetic induction of an induced object more safely and high precisely, and to provide a method of controlling the magnetic field generator. SOLUTION: There are arranged a plurality of magnetic field generating basic structures 71, each of which is self-standing by a simple substance and is provided with two coils 11, 12 which are arranged up and down magnetic poles 711, 712 which are threaded through the coils 11, 12, respectively, yokes 721, 723 which are linked with the magnetic poles 711, 712, a yoke 722 which links and supports these two yokes 721, 723, and a base 725 which supports the yoke 722. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够更精确地更安全和更高地执行感应物体的磁感应的磁场发生器，并且提供一种控制磁场发生器的方法。解决方案：布置有多个磁场产生基础结构71，每个磁场产生基本结构71由简单物质自立，并且设置有两个线圈11,12，上部和下部磁极711,712设置线圈11,12分别穿过与磁极711,712连接的磁轭721,723，连接并支撑这两个磁轭721,723的磁轭722和支撑磁轭722的基座725。版权所有（C）2007，JPO＆INPIT

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