专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

IL220616D0 NOVEL 3 - HYDROXY - 5 - ARYLISOTHIAZOLE DERIVATIVE 未知
公开(公告)号：IL220616D0
公开(公告)日：2012-08-30
申请号：IL22061612
申请日：2012-06-24
申请人： MOCHIDA PHARM CO LTD , AKIHIRO OKANA , NAOTO KOSUGA , MUNETAKA OHKOUCHI , DAIDO HOTTA , MUNEYOSHI MAKABE
IPC分类号： C07D20060101
摘要： [Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, -NR 7 -; and R 1 to R 7 are specific groups), a salt of the compound, or a solvate of the salt or the compound.

2. 发明授权

US09072758B2 Cyclic amide derivative 有权
标题翻译：环状酰胺衍生物
公开(公告)号：US09072758B2
公开(公告)日：2015-07-07
申请号：US14114017
申请日：2012-04-11
申请人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
发明人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
IPC分类号： C07D279/02 , C07D285/10 , C07D285/16 , C07D417/12 , C07D417/14 , A61K31/69 , A61K31/425 , A61K31/4439 , A61K31/54 , A61K31/541 , A61K31/549 , A61K45/06 , C07D275/03 , C07F5/04 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48
CPC分类号： C07D275/03 , A61K9/145 , A61K9/1652 , A61K9/2018 , A61K9/485 , A61K31/425 , A61K31/4439 , A61K31/4985 , A61K31/54 , A61K31/541 , A61K31/549 , A61K31/69 , A61K45/06 , C07D279/02 , C07D285/10 , C07D285/16 , C07D417/12 , C07D417/14 , C07F5/04
摘要： [Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or the like.[Means of solving the problem]A compound of Formula (III): (where f is 0 to 2; g is 1 to 4; j is 0 to 3; k is 0 to 2; n is 0 to 2; p is 0 to 4; h is 0 to 3; q1 id 0 to 3; q2 is 0 or 1; r1 is 0 to 2 (with the proviso that q1+q2+r1 is 0 to 5); J1a is —CR11a—, N; J2 is —CR12aR12b—, —CR12c—; T is —CH2—, O, —S(O)i— (i is an integer of 0 to 2) or —NR7—; X is O, S, or —NR7—; ring A′″ is a benzene ring, a pyridine ring; ring B′ is a benzene ring, a pyridine ring, a pyrimidine ring; and R1 to R14 are specific groups), a salt of the compound, or a solvate of the salt or the compound.
摘要翻译：本发明提供具有GPR40激动剂作用的新化合物，化合物的盐，盐或化合物等的溶剂合物作为有效成分的GPR40活化剂，特别是胰岛素促分泌素和糖尿病，肥胖症等的预防和/或治疗剂。 [解决问题的方法]式（III）的化合物：其中f为0〜2，g为1〜4，j为0〜3，k为0〜2，n为0〜2，p为0 至4; h为0至3; q1为0至3; q2为0或1; r1为0至2（条件是q1 + q2 + r1为0至5）; J1a为-CR11a，N; J2是-CR12aR12b-，-CR12c-; T是-CH2-，O，-S（O）i-（i是0-2的整数）或-NR7-; X是O，S或-NR7- 环A'“为苯环，吡啶环，环B'为苯环，吡啶环，嘧啶环，R1〜R14为特定基团），化合物的盐或其溶剂合物盐或化合物。

3. 发明申请

US20100016285A1 HETEROCYCLIDENE-N-(ARYL) ACETAMIDE DERIVATIVE 审中-公开
标题翻译：异氰尿酸-N-（ARYL）乙酰胺衍生物
公开(公告)号：US20100016285A1
公开(公告)日：2010-01-21
申请号：US12507861
申请日：2009-07-23
申请人： Hideharu UCHIDA , Shinichi OGAWA , Muneyoshi MAKABE , Yoshitaka MAEDA
发明人： Hideharu UCHIDA , Shinichi OGAWA , Muneyoshi MAKABE , Yoshitaka MAEDA
IPC分类号： A61K31/553 , A61K31/5415 , A61K31/536 , A61K31/517 , C07D267/10 , C07D279/16 , C07D265/36 , C07D405/12
CPC分类号： C07D405/12 , A61K31/517 , A61K31/536 , A61K31/5415 , A61K31/553 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/10 , C07D493/10
摘要： The blow-described formula (I) [Ch. 1] a compound represented by formula (I) (wherein k, m, n, and p each represent 0 to 2; j and q represents 0 or 1; R1 represents a halogen atom, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, NH2, OH, a carboxyl group, an alkanoyl group, CN, NO2, or the like; R2 represents a halogen atom, an amino group, a hydrocarbon group, an aromatic heterocyclic group, an oxo group, or the like; represents an oxygen atom, —NR3—, or —S(O)r- (wherein r is an integer of 0 to 2); X2 represents a methylene group, an oxygen atom, —NR3— (wherein R3 is a hydrogen atom, a hydrocarbon group, or the like), or S(O)r- (wherein r is an integer of 0 to 2); W represents a methylene group, a carbonyl group, or a sulfonyl group; R7 represents a hydrogen atom, a hydrocarbon group, a heterocyclic group, or the like; R8 represents a hydrogen atom, a halogen atom, a hydrocarbon group, a heterocyclic group, the broken line in the ring containing X1 and X2 represents a condensation of two rings; cycle moiety represents a five- or six-membered aryl ring or heteroaryl ring; and the solid line and the broken line between L1 and L2 are a single bond or double bond, and the wavy line represents an E-isomer or a Z-isomer), a salt thereof, or solvates thereof, and a pharmaceutical composition containing the compound as an active ingredient.
摘要翻译：吹风描述的公式（I）[Ch。 1]由式（I）表示的化合物（其中k，m，n和p各自表示0〜2; j和q表示0或1; R1表示卤素原子，烃基，杂环基，烷氧基基团，烷氧基羰基，NH 2，OH，羧基，烷酰基，CN，NO 2等; R 2表示卤素原子，氨基，烃基，芳香族杂环基，氧代基或代表氧原子，-NR 3 - 或-S（O）r - （其中r为0-2的整数）; X 2表示亚甲基，氧原子，-NR 3 - （其中R 3为氢原子，烃基等）或S（O）r-（其中r为0〜2的整数）; W表示亚甲基，羰基或磺酰基; R7表示氢原子，烃基，杂环基等; R8表示氢原子，卤素原子，烃基，杂环基，含有X1和X2的环中的虚线表示缩合两环环状部分表示五或六元芳基环或杂芳基环; L1和L2之间的实线和虚线是单键或双键，波浪线表示E-异构体或Z-异构体），其盐或其溶剂合物，以及含有化合物作为活性成分。

4. 发明授权

US08476287B2 3-hydroxy-5-arylisothiazole derivative 有权
标题翻译： 3-羟基-5-芳基异噻唑衍生物
公开(公告)号：US08476287B2
公开(公告)日：2013-07-02
申请号：US13392350
申请日：2010-12-24
申请人： Akihiro Okano , Naoto Kosuga , Munetaka Ohkouchi , Daido Hotta , Muneyoshi Makabe
发明人： Akihiro Okano , Naoto Kosuga , Munetaka Ohkouchi , Daido Hotta , Muneyoshi Makabe
IPC分类号： A61K31/506 , A61K31/425 , A61K31/4436 , A61K31/4535 , C07D239/24 , C07D275/02 , C07D417/02
CPC分类号： C07D275/03 , A61K9/1623 , A61K9/2018 , A61K9/4858 , C07D417/12 , C07D417/14
摘要： [Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases.[Means of solving the problem]A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, —NR7—; and R1 to R7 are specific groups),a salt of the compound, or a solvate of the salt or the compound.
摘要翻译： [问题]提供具有GPR40激动剂作用的新化合物，化合物的盐，盐或化合物等的溶剂合物作为活性成分的GPR40活化剂，特别是胰岛素促分泌素和用于预防和/或治疗糖尿病，肥胖或其它疾病的药物。解决问题的方法式（I）的化合物：（其中n为0〜2; p为0〜4; j为0〜3; k为0〜2，环A为任选被L取代或被L取代的杂环基;环B是苯环，吡啶环或嘧啶环; X是O，S，-NR7-，R1至R7是特定基团），化合物的盐或盐或化合物的溶剂合物。

5. 发明申请

US20140057871A1 CYCLIC AMIDE DERIVATIVE 有权
标题翻译：循环酰胺衍生物
公开(公告)号：US20140057871A1
公开(公告)日：2014-02-27
申请号：US14114017
申请日：2012-04-11
申请人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
发明人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
IPC分类号： A61K31/69 , A61K31/4439 , C07D275/03 , A61K31/425 , C07D285/16 , A61K45/06 , C07D279/02 , A61K31/54 , A61K31/541 , C07D285/10 , C07D417/14 , C07F5/04 , C07D417/12 , A61K31/549
CPC分类号： C07D275/03 , A61K9/145 , A61K9/1652 , A61K9/2018 , A61K9/485 , A61K31/425 , A61K31/4439 , A61K31/4985 , A61K31/54 , A61K31/541 , A61K31/549 , A61K31/69 , A61K45/06 , C07D279/02 , C07D285/10 , C07D285/16 , C07D417/12 , C07D417/14 , C07F5/04
摘要： [Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or the like.[Means of solving the problem]A compound of Formula (III): (where f is 0 to 2; g is 1 to 4; j is 0 to 3; k is 0 to 2; n is 0 to 2; p is 0 to 4; h is 0 to 3; q1 id 0 to 3; q2 is 0 or 1; r1 is 0 to 2 (with the proviso that q1+q2+r1 is 0 to 5); J1a is —CR11a—, N; J2 is —CR12aR12b—, —CR12c—; T is —CH2—, O, —S(O)i— (i is an integer of 0 to 2) or —NR7—; X is O, S, or —NR7—; ring A′″ is a benzene ring, a pyridine ring; ring B′ is a benzene ring, a pyridine ring, a pyrimidine ring; and R1 to R14 are specific groups), a salt of the compound, or a solvate of the salt or the compound.
摘要翻译：本发明提供具有GPR40激动剂作用的新化合物，化合物的盐，盐或化合物等的溶剂合物作为活性成分的GPR40活化剂，特别是胰岛素促分泌素和糖尿病，肥胖症等的预防和/或治疗剂。 [解决问题的方法]式（III）的化合物：其中f为0〜2，g为1〜4，j为0〜3，k为0〜2，n为0〜2，p为0 至4; h为0至3; q1为0至3; q2为0或1; r1为0至2（条件是q1 + q2 + r1为0至5）; J1a为-CR11a，N; J2是-CR12aR12b-，-CR12c-; T是-CH2-，O，-S（O）i-（i是0-2的整数）或-NR7-; X是O，S或-NR7- 环A“为苯环，吡啶环，环B'为苯环，吡啶环，嘧啶环，R1〜R14为特定基团），化合物的盐或溶剂化物盐或化合物。

6. 发明授权

US09040525B2 Cyclic amide derivative 有权
标题翻译：环状酰胺衍生物
公开(公告)号：US09040525B2
公开(公告)日：2015-05-26
申请号：US13877626
申请日：2011-10-11
申请人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
发明人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
IPC分类号： C07D279/02 , A61K31/541 , C07D277/04 , C07D275/02 , C07D285/10 , C07D285/16 , C07D417/12 , A61K31/425 , A61K31/433 , A61K31/4439 , A61K31/549 , A61K45/06 , C07D285/34 , C07D417/14
CPC分类号： C07D417/12 , A61K31/4152 , A61K31/425 , A61K31/433 , A61K31/4439 , A61K31/54 , A61K31/541 , A61K31/549 , A61K45/06 , C07D275/02 , C07D275/03 , C07D277/04 , C07D279/02 , C07D285/10 , C07D285/16 , C07D285/34 , C07D417/14
摘要： [Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases.[Means of Solving the Problem]A compound of Formula (1): (where n is 0 to 2; p is 0 to 4; h is 0 to 3; j is 0 to 3; k is 0 to 2; a ring B is an aryl group or a heteroaryl group; X is O, S, or —NR7—; J1 is —CR11aR11b— or —NR11c—; J2 is —CR12aR12b— or —NR12c—; and R1 to R12c are specific groups), a salt of the compound, or a solvate of the salt or the compound.
摘要翻译：本发明提供具有GPR40激动剂作用的新化合物，化合物的盐，盐或化合物等的溶剂合物作为活性成分的GPR40活化剂，特别是胰岛素促分泌素和用于预防和/或治疗糖尿病，肥胖或其它疾病的药物。解决问题的方法式（1）的化合物：（其中n为0〜2; p为0〜4; h为0〜3; j为0〜3; k为0〜2;环B 是芳基或杂芳基; X是O，S或-NR7-; J1是-CR11aR11b-或-NR11c-; J2是-CR12aR12b-或-NR12c-，R1至R12c是特定基团），a 化合物的盐或盐或化合物的溶剂化物。

7. 发明申请

US20130203739A1 CYCLIC AMIDE DERIVATIVE 有权
标题翻译：循环酰胺衍生物
公开(公告)号：US20130203739A1
公开(公告)日：2013-08-08
申请号：US13877626
申请日：2011-10-11
申请人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
发明人： Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
IPC分类号： C07D277/04 , A61K31/549 , A61K31/4439 , A61K31/433 , A61K45/06 , C07D285/34 , C07D279/02 , C07D417/14 , C07D417/12 , A61K31/541 , A61K31/425
CPC分类号： C07D417/12 , A61K31/4152 , A61K31/425 , A61K31/433 , A61K31/4439 , A61K31/54 , A61K31/541 , A61K31/549 , A61K45/06 , C07D275/02 , C07D275/03 , C07D277/04 , C07D279/02 , C07D285/10 , C07D285/16 , C07D285/34 , C07D417/14
摘要： [Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases.[Means of solving the problem]A compound of Formula (1): (where n is 0 to 2; p is 0 to 4; h is 0 to 3; j is 0 to 3; k is 0 to 2; a ring B is an aryl group or a heteroaryl group; X is O, S, or —NR7—; J1 is —CR11aR11b— or —NR11c—; J2 is —CR12aR12b— or —NR12c—; and R1 to R12c are specific groups), a salt of the compound, or a solvate of the salt or the compound.
摘要翻译：本发明提供具有GPR40激动剂作用的新化合物，化合物的盐，盐或化合物等的溶剂合物作为活性成分的GPR40活化剂，特别是胰岛素促分泌素和用于预防和/或治疗糖尿病，肥胖或其它疾病的药物。 [解决问题的方法]式（1）的化合物：（其中n为0〜2; p为0〜4; h为0〜3; j为0〜3; k为0〜2;环B 是芳基或杂芳基; X是O，S或-NR7-; J1是-CR11aR11b-或-NR11c-; J2是-CR12aR12b-或-NR12c-，R1至R12c是特定基团），a 化合物的盐或盐或化合物的溶剂化物。

8. 发明申请

US20120157459A1 NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE 有权
标题翻译：新型3-羟基-5-亚氨基噻唑衍生物
公开(公告)号：US20120157459A1
公开(公告)日：2012-06-21
申请号：US13392350
申请日：2010-12-24
申请人： Akihiro Okano , Naoto Kosuga , Munetaka Ohkouchi , Daido Hotta , Muneyoshi Makabe
发明人： Akihiro Okano , Naoto Kosuga , Munetaka Ohkouchi , Daido Hotta , Muneyoshi Makabe
IPC分类号： A61K31/4985 , A61K31/425 , C07D417/12 , A61K31/4439 , A61K31/506 , A61K31/427 , C07D417/14 , A61K31/454 , A61K31/4545 , A61K31/40 , A61K31/403 , A61K31/522 , A61K31/496 , A61P3/10 , C07D275/03
CPC分类号： C07D275/03 , A61K9/1623 , A61K9/2018 , A61K9/4858 , C07D417/12 , C07D417/14
摘要： [Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases.[Means of solving the problem]A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, —NR7—; and R1 to R7 are specific groups),a salt of the compound, or a solvate of the salt or the compound.
摘要翻译： [问题]提供具有GPR40激动剂作用的新化合物，化合物的盐，盐或化合物等的溶剂合物作为活性成分的GPR40活化剂，特别是胰岛素促分泌素和用于预防和/或治疗糖尿病，肥胖或其它疾病的药物。解决问题的方法式（I）的化合物：（其中n为0〜2; p为0〜4; j为0〜3; k为0〜2，环A为任选被L取代或被L取代的杂环基;环B是苯环，吡啶环或嘧啶环; X是O，S，-NR7-，R1至R7是特定基团），化合物的盐或盐或化合物的溶剂合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式