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1. 发明申请

US20100314051A1 METHODS AND DEVICES FOR CRYSTALLIZATION BY CONTROLLED EVAPORATION 有权
标题翻译：通过控制蒸发进行结晶的方法和装置
公开(公告)号：US20100314051A1
公开(公告)日：2010-12-16
申请号：US12483787
申请日：2009-06-12
申请人： Jack Barger , James Sinclair , Michael P. Emery
发明人： Jack Barger , James Sinclair , Michael P. Emery
IPC分类号： B01D1/12 , B01D1/00
CPC分类号： B01D3/346 , B01D1/14 , B01L3/06 , B01L3/50853 , B01L2200/0678 , B01L2300/048 , B01L2300/049 , B01L2300/0829 , G01N2001/4027
摘要： Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, the device can control evaporation of different solutions comprising solvents of dissimilar volatilities simultaneously. In another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the pressure at an inlet port and an exhaust port of the device. In yet another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the size of a disk flow control orifice positioned between the wells and a vapor removal outlet of the device. In still another embodiment, control over the flow of solvent vapor out of the device is provided by the opening and closing of the vapor removal outlet of the device. In yet a further embodiment, the rate of evaporation of solvent is controlled by controlling the temperature of the solution. The flow rate control mechanisms can be used alone or in any combination to control evaporation of one or more solvents from solutions.
摘要翻译：提供了从溶液中控制溶剂蒸发的方法和装置。在一个实施方案中，该装置可以同时控制包含不同挥发性溶剂的不同溶液的蒸发。在另一个实施例中，通过选择装置的入口和排气口处的压力来提供通过装置流出的溶剂蒸气的控制。在另一个实施方案中，通过选择位于孔之间的盘流量控制孔和装置的蒸汽除去出口的尺寸来提供从装置出来的溶剂蒸气流的控制。在另一个实施方案中，通过打开和关闭装置的蒸汽除去出口来提供从装置出来的溶剂蒸气流的控制。在又一个实施方案中，通过控制溶液的温度来控制溶剂的蒸发速率。流量控制机构可以单独使用或以任何组合使用以控制溶液中的一种或多种溶剂的蒸发。

2. 发明授权

US08337754B2 Automated developer for immuno-stained biological samples 有权
标题翻译：免疫染色生物样品的自动显影剂
公开(公告)号：US08337754B2
公开(公告)日：2012-12-25
申请号：US12644839
申请日：2009-12-22
申请人： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
发明人： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
IPC分类号： G01N21/00
CPC分类号： G01N1/31 , B01L3/0217 , B01L2200/147 , B01L2200/16 , B01L2300/1822 , B01L2400/0487 , G01N1/30 , G01N27/44721 , G01N33/54366 , G01N35/00029 , G01N35/10 , G01N2035/00425 , Y10T436/2575
摘要： Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.
摘要翻译：本文公开了用于开发免疫染色的生物样品的系统和方法。本文公开的系统是自动化的并且被配置为控制开发过程的一个或多个步骤。可以使用自动注射器分注添加试剂。试剂温度，试剂搅拌和洗涤程序是可编程的，可以单独控制，同时进行单独的免疫染色程序。

3. 发明授权

US07219545B2 Sensor for levels of conductive liquids 有权
标题翻译：传感器用于导电液体
公开(公告)号：US07219545B2
公开(公告)日：2007-05-22
申请号：US10900996
申请日：2004-07-28
申请人： Philip E. Salzmann , Alec T. Harootunian , Michael P. Emery , Javier H. Flores , Todd N. Bennett , Minh Vuong
发明人： Philip E. Salzmann , Alec T. Harootunian , Michael P. Emery , Javier H. Flores , Todd N. Bennett , Minh Vuong
IPC分类号： G01F23/00 , G01F23/24 , G01F23/26
CPC分类号： G01F23/243 , G01F23/242
摘要： A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.
摘要翻译：液位传感器包括以相对于容器填充轨迹限定的关系布置的多个电极，耦合到所述多个电极中的一个或多个的信号发生器，耦合到多个电极中的一个或多个的信号接收器，以及耦合到信号发生器和信号接收器中的至少一个的感测电路。感测电路被配置为产生指示至少一对多个电极之间的电阻的输出。感测电路可以与信号接收器和/或信号发生器相关联。

4. 发明授权

US08206659B2 Devices for crystallization by controlled evaporation 有权
标题翻译：通过控制蒸发结晶的装置
公开(公告)号：US08206659B2
公开(公告)日：2012-06-26
申请号：US12483787
申请日：2009-06-12
申请人： Jack Barger , James Sinclair , Michael P. Emery
发明人： Jack Barger , James Sinclair , Michael P. Emery
IPC分类号： B01D9/00
CPC分类号： B01D3/346 , B01D1/14 , B01L3/06 , B01L3/50853 , B01L2200/0678 , B01L2300/048 , B01L2300/049 , B01L2300/0829 , G01N2001/4027
摘要： Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, the device can control evaporation of different solutions comprising solvents of dissimilar volatilities simultaneously. In another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the pressure at an inlet port and an exhaust port of the device. In yet another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the size of a disk flow control orifice positioned between the wells and a vapor removal outlet of the device. In still another embodiment, control over the flow of solvent vapor out of the device is provided by the opening and closing of the vapor removal outlet of the device. In yet a further embodiment, the rate of evaporation of solvent is controlled by controlling the temperature of the solution. The flow rate control mechanisms can be used alone or in any combination to control evaporation of one or more solvents from solutions.
摘要翻译：提供了从溶液中控制溶剂蒸发的方法和装置。在一个实施方案中，该装置可以同时控制包含不同挥发性溶剂的不同溶液的蒸发。在另一个实施例中，通过选择装置的入口和排气口处的压力来提供通过装置流出的溶剂蒸气的控制。在另一个实施方案中，通过选择位于孔之间的盘流量控制孔和装置的蒸汽除去出口的尺寸来提供从装置出来的溶剂蒸气流的控制。在另一个实施方案中，通过打开和关闭装置的蒸汽除去出口来提供从装置出来的溶剂蒸气流的控制。在又一个实施方案中，通过控制溶液的温度来控制溶剂的蒸发速率。流量控制机构可以单独使用或以任何组合使用以控制溶液中的一种或多种溶剂的蒸发。

5. 发明申请

US20110151482A1 AUTOMATED DEVELOPER FOR IMMUNO-STAINED BIOLOGICAL SAMPLES 有权
标题翻译：用于免疫染色生物样品的自动化开发
公开(公告)号：US20110151482A1
公开(公告)日：2011-06-23
申请号：US12644839
申请日：2009-12-22
申请人： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
发明人： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
IPC分类号： G01N33/53 , C12M1/38
CPC分类号： G01N1/31 , B01L3/0217 , B01L2200/147 , B01L2200/16 , B01L2300/1822 , B01L2400/0487 , G01N1/30 , G01N27/44721 , G01N33/54366 , G01N35/00029 , G01N35/10 , G01N2035/00425 , Y10T436/2575
摘要： Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.
摘要翻译：本文公开了用于开发免疫染色的生物样品的系统和方法。本文公开的系统是自动化的并且被配置为控制开发过程的一个或多个步骤。可以使用自动注射器分注添加试剂。试剂温度，试剂搅拌和洗涤程序是可编程的，可以单独控制，同时进行单独的免疫染色程序。

6. 发明授权

US07919047B2 Air displacement pipetter 有权
标题翻译：排气移液器
公开(公告)号：US07919047B2
公开(公告)日：2011-04-05
申请号：US11446821
申请日：2006-06-05
申请人： James E. Sinclair , Michael P. Emery , Minh Vuong
发明人： James E. Sinclair , Michael P. Emery , Minh Vuong
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01L9/52 , B01L2200/0689
摘要： An air displacement pipetter comprises a guidance sleeve positioned within a hole in a cylinder block and a piston within a portion of the guidance sleeve a piston penetrating the cylinder block, a spring energized seal disposed within the cylinder block, a seal capture plate contacting the spring energized seal, a carrier plate, a pipette tip attached to the carrier plate, and a manifold plate between said carrier plate and said cylinder block.
摘要翻译：排气移液器包括定位在气缸体的孔内的引导套筒和引导套筒的一部分内的活塞，穿过气缸体的活塞，设置在气缸体内的弹簧加压密封件，与弹簧接触的密封件捕获板通电密封件，承载板，附接到承载板的移液管末端，以及在所述承载板和所述气缸体之间的歧管板。

7. 发明授权

US08353969B2 Methods for crystallization by controlled evaporation 有权
标题翻译：通过控制蒸发结晶的方法
公开(公告)号：US08353969B2
公开(公告)日：2013-01-15
申请号：US13480747
申请日：2012-05-25
申请人： Jack Barger , James Sinclair , Michael P. Emery
发明人： Jack Barger , James Sinclair , Michael P. Emery
IPC分类号： B01D9/00
CPC分类号： B01D3/346 , B01D1/14 , B01L3/06 , B01L3/50853 , B01L2200/0678 , B01L2300/048 , B01L2300/049 , B01L2300/0829 , G01N2001/4027
摘要： Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.
摘要翻译：提供了从溶液中控制溶剂蒸发的方法和装置。在一个实施方案中，用于从至少一种溶液控制蒸发溶剂的方法包括用包含至少一种第一溶剂的第一溶液填充多孔板中选定的第一组孔。该方法还包括将入口歧管连接到板上，入口歧管包括连接到所选择的第一组井中的每个井中并仅与其中的每个井连通并且仅在其中流体连通的入口歧管。所述方法还包括将排气歧管连接到所述板上，所述排气歧管包括与所选择的第一组井中的每个孔连接并且仅与所述第一组井中的每个井相连通的排气口。该方法还包括将气体引入入口并从所选择的第一组孔中除去溶剂蒸气。

8. 发明申请

US20120241100A1 METHODS AND DEVICES FOR CRYSTALLIZATION BY CONTROLLED EVAPORATION 有权
标题翻译：通过控制蒸发进行结晶的方法和装置
公开(公告)号：US20120241100A1
公开(公告)日：2012-09-27
申请号：US13480747
申请日：2012-05-25
申请人： Jack Barger , James Sinclair , Michael P. Emery
发明人： Jack Barger , James Sinclair , Michael P. Emery
IPC分类号： B01D1/14
CPC分类号： B01D3/346 , B01D1/14 , B01L3/06 , B01L3/50853 , B01L2200/0678 , B01L2300/048 , B01L2300/049 , B01L2300/0829 , G01N2001/4027
摘要： Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.
摘要翻译：提供了从溶液中控制溶剂蒸发的方法和装置。在一个实施方案中，用于从至少一种溶液控制蒸发溶剂的方法包括用包含至少一种第一溶剂的第一溶液填充多孔板中选定的第一组孔。该方法还包括将入口歧管连接到板上，入口歧管包括连接到所选择的第一组井中的每个井中并仅与其中的每个井连通并且仅在其中流体连通的入口歧管。所述方法还包括将排气歧管连接到所述板上，所述排气歧管包括与所选择的第一组井中的每个孔连接并且仅与所述第一组井中的每个井相连通的排气口。该方法还包括将气体引入入口并从所选择的第一组孔中除去溶剂蒸气。

9. 发明授权

US07490513B2 Method for sensing levels of conductive liquids 有权
标题翻译：感应导电液体水平的方法
公开(公告)号：US07490513B2
公开(公告)日：2009-02-17
申请号：US11747142
申请日：2007-05-10
申请人： Philip E. Salzmann , Alec T. Harootunian , Michael P. Emery , Javier H. Flores , Todd N. Bennett , Minh Vuong
发明人： Philip E. Salzmann , Alec T. Harootunian , Michael P. Emery , Javier H. Flores , Todd N. Bennett , Minh Vuong
IPC分类号： G01F23/00
CPC分类号： G01F23/243 , G01F23/242
摘要： A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.
摘要翻译：液位传感器包括以相对于容器填充轨迹限定的关系布置的多个电极，耦合到多个电极中的一个或多个的信号发生器，耦合到所述多个电极中的一个或多个的信号接收器，以及耦合到信号发生器和信号接收器中的至少一个的感测电路。感测电路被配置为产生指示至少一对多个电极之间的电阻的输出。感测电路可以与信号接收器和/或信号发生器相关联。

10. 发明申请

US20070207062A1 Air displacement pipetter 有权
标题翻译：排气移液器
公开(公告)号：US20070207062A1
公开(公告)日：2007-09-06
申请号：US11446821
申请日：2006-06-05
申请人： James E. Sinclair , Michael P. Emery , Minh Vuong
发明人： James E. Sinclair , Michael P. Emery , Minh Vuong
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01L9/52 , B01L2200/0689
摘要： An air displacement pipetter comprises a guidance sleeve positioned within a hole in a cylinder block and a piston within a portion of the guidance sleeve a piston penetrating the cylinder block, a spring energized seal disposed within the cylinder block, a seal capture plate contacting the spring energized seal, a carrier plate, a pipette tip attached to the carrier plate, and a manifold plate between said carrier plate and said cylinder block.
摘要翻译：排气移液器包括定位在气缸体的孔内的引导套筒和引导套筒的一部分内的活塞，穿过气缸体的活塞，设置在气缸体内的弹簧加压密封件，与弹簧接触的密封件捕获板通电密封件，承载板，附接到承载板的移液管末端，以及在所述承载板和所述气缸体之间的歧管板。

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