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1. 发明授权

US07884984B2 Multicolor holographic replication by masking 有权
标题翻译：通过掩蔽进行多色全息复制
公开(公告)号：US07884984B2
公开(公告)日：2011-02-08
申请号：US12080620
申请日：2008-04-04
申请人： Brett Ronald Nelson , Michael G. Fickes
发明人： Brett Ronald Nelson , Michael G. Fickes
IPC分类号： G03H1/20 , G03H1/26 , G02B5/32
CPC分类号： G03H1/202 , G03H2001/2263 , G03H2001/2271 , G03H2001/2655 , G03H2222/13 , G03H2222/18 , G03H2223/12 , Y10S359/90
摘要： A multicolor hologram (e.g., a two-color hologram) is replicated (copied) into a photosensitive layer by masking to produce a copy (replicate) of the hologram in a manner such that the copy is an accurate and true replication of the hologram (e.g., master hologram), and the copy is characterized to possess a high brightness level and color fidelity comparable to that of the multicolor hologram that was replicated. Both flood and scan modes can be employed in the replication.
摘要翻译：通过掩蔽将多色全息图（例如，双色全息图）复制（复制）到感光层中，以产生全息图的复制（复制），使得该拷贝是全息图的精确和真实的复制（例如，主全息图），并且复印件的特征在于具有与复制的多色全息图相当的高亮度水平和色彩保真度。冗余和扫描模式都可以在复制中使用。

2. 发明授权

US5188863A Direct effect master/stamper for optical recording 失效
标题翻译：直接效应主/压模用于光学记录
公开(公告)号：US5188863A
公开(公告)日：1993-02-23
申请号：US628889
申请日：1990-12-18
申请人： Martinus J. M. de Graaf , Michael G. Fickes , George H. Johnson , Howard E. Simmons, III
发明人： Martinus J. M. de Graaf , Michael G. Fickes , George H. Johnson , Howard E. Simmons, III
IPC分类号： B29C59/02 , B29D17/00 , G11B7/26
CPC分类号： B29D17/005 , G11B7/263 , B29C59/02
摘要： A method for making optical recording media in which the optically readable information is embossed therein by means of an information master recording which is directly usable as a stamper.
摘要翻译：一种制造光学记录介质的方法，其中通过可直接用作压模的信息主记录将光学可读信息压印在其中。

3. 发明授权

US4215193A Dry toner process with improved toning uniformity for color developing an imaged tacky and nontacky surface 失效
标题翻译：干调色剂工艺具有改进的调色均匀性，用于彩色显影成像的粘性和非粘性表面
公开(公告)号：US4215193A
公开(公告)日：1980-07-29
申请号：US963083
申请日：1978-11-22
申请人： Charles W. Manger , Michael G. Fickes , John W. Long
发明人： Charles W. Manger , Michael G. Fickes , John W. Long
IPC分类号： G03G9/08 , G03F7/28 , G03G9/087 , G03G9/09 , G03G15/01 , G03C5/24
CPC分类号： G03F7/28
摘要： Toner particles of an intimate mixture of 25 to 75% by weight of substantially colorless, inert, nonelectroscopic spheroidal-shape polymer particles of size distribution in the range of greater than 5 to less than 60 .mu.m, not more than 15% of the polymer particles being less than 10 .mu.m or greater than 50 .mu.m equivalent spherical diameter, and 75 to 25% by weight of colorant particles having a size distribution within the range of 0.2 to 30 .mu.m and not more than 50% of the colorant particles being less than 1 .mu.m particle size. Ionic copolymer spheroidal particles are preferred. The toner particles are useful for color development of tacky areas by depositing and distributing the toner particles by means of a pad, including an applicator apparatus comprising a housing for toner, a free moving weight in the housing for agitating the toner, means to release toner from the housing, and at least two hinged pads mounted on the housing.
摘要翻译： 25至75重量％的基本上无色，惰性的非电光球形聚合物颗粒的均匀混合物的调色剂颗粒，其尺寸分布在大于5至小于60μm的范围内，不超过15％的聚合物颗粒小于10微米或大于50μm的当量球形直径，和75至25重量％的着色剂颗粒，其尺寸分布在0.2至30微米范围内且不超过50％的着色剂颗粒粒径小于1μm。离子共聚物球形颗粒是优选的。调色剂颗粒可用于通过用垫沉积和分配调色剂颗粒来显色粘性区域，包括涂布装置，包括用于调色剂的壳体，用于搅拌调色剂的壳体中的自由移动重量，用于释放调色剂的装置以及至少两个安装在壳体上的铰接垫。

4. 发明授权

US08399468B2 Octahydro-pyrrolo[3,4-B]pyrrole derivatives 有权
标题翻译：八氢吡咯并[3,4-B]吡咯衍生物
公开(公告)号：US08399468B2
公开(公告)日：2013-03-19
申请号：US12715660
申请日：2010-03-02
申请人： Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G. Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
发明人： Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G. Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
IPC分类号： A61K31/501 , C07D403/10
CPC分类号： C07D487/04
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译：八氢吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体预防或改善的病症或病症。八氢吡咯并[3,4-b]吡咯化合物，使用这些化合物的方法，制备它们的组合物和制备这些化合物的方法在本文中公开。

5. 发明授权

US08045245B2 Multicolor holgraphic replication by masking 有权
标题翻译：通过掩蔽进行多色全复制
公开(公告)号：US08045245B2
公开(公告)日：2011-10-25
申请号：US13021885
申请日：2011-02-07
申请人： Brett Ronald Nelson , Michael G. Fickes
发明人： Brett Ronald Nelson , Michael G. Fickes
IPC分类号： G03H1/20 , G03H1/26 , G02B5/32
CPC分类号： G03H1/202 , G03H2001/2263 , G03H2001/2271 , G03H2001/2655 , G03H2222/13 , G03H2222/18 , G03H2223/12 , Y10S359/90
摘要： A multicolor hologram (e.g., a two-color hologram) is replicated (copied) into a photosensitive layer by masking to produce a copy (replicate) of the hologram in a manner such that the copy is an accurate and true replication of the hologram (e.g., master hologram) and the copy is characterized to possess a high brightness level and color fidelity comparable to that of the multicolor hologram that was replicated. Both flood and scan modes can be employed in the replication.
摘要翻译：通过掩蔽将多色全息图（例如，双色全息图）复制（复制）到感光层中，以产生全息图的复制（复制），使得该拷贝是全息图的精确和真实的复制（例如，主全息图），并且复印件的特征在于具有与复制的多色全息图相当的高亮度水平和色彩保真度。冗余和扫描模式都可以在复制中使用。

6. 发明申请

US20110122375A1 MULTICOLOR HOLGRAPHIC REPLICATION BY MASKING 有权
标题翻译：多媒体通过屏蔽复制
公开(公告)号：US20110122375A1
公开(公告)日：2011-05-26
申请号：US13021885
申请日：2011-02-07
申请人： BRETT RONALD NELSON , MICHAEL G. FICKES
发明人： BRETT RONALD NELSON , MICHAEL G. FICKES
IPC分类号： G03B27/00
CPC分类号： G03H1/202 , G03H2001/2263 , G03H2001/2271 , G03H2001/2655 , G03H2222/13 , G03H2222/18 , G03H2223/12 , Y10S359/90
摘要： A multicolor hologram (e.g., a two-color hologram) is replicated (copied) into a photosensitive layer by masking to produce a copy (replicate) of the hologram in a manner such that the copy is an accurate and true replication of the hologram (e.g., master hologram) and the copy is characterized to possess a high brightness level and color fidelity comparable to that of the multicolor hologram that was replicated. Both flood and scan modes can be employed in the replication.
摘要翻译：通过掩蔽将多色全息图（例如，双色全息图）复制（复制）到感光层中，以产生全息图的复制（复制），使得该拷贝是全息图的精确和真实的复制（例如，主全息图），并且复印件的特征在于具有与复制的多色全息图相当的高亮度水平和色彩保真度。冗余和扫描模式都可以在复制中使用。

7. 发明申请

US20100297194A1 FORMULATION FOR ORAL ADMINISTRATION OF APOPTOSIS PROMOTER 审中-公开
标题翻译：制剂推荐药物的口服制剂
公开(公告)号：US20100297194A1
公开(公告)日：2010-11-25
申请号：US12770299
申请日：2010-04-29
申请人： Nathaniel Catron , Michael G. Fickes , Cristina M. Fischer , Rajeev Gokhale , Anthony R. Haight , Katherine Heemstra , David Hill , Martin Knobloch , Drazen Kostelac , Justin S. Lafountaine , Yanxia Li , Bernd Liepold , Kennan Marsh , Jonathan M. Miller , Claudia Packhaeuser , Yeshwant D. Sanzgiri , Eric A. Schmitt , Yi Shi , Norbert Steiger , Ping Tong , Huailiang Wu , Geoff G.Z. Zhang , Deliang Zhou
发明人： Nathaniel Catron , Michael G. Fickes , Cristina M. Fischer , Rajeev Gokhale , Anthony R. Haight , Katherine Heemstra , David Hill , Martin Knobloch , Drazen Kostelac , Justin S. Lafountaine , Yanxia Li , Bernd Liepold , Kennan Marsh , Jonathan M. Miller , Claudia Packhaeuser , Yeshwant D. Sanzgiri , Eric A. Schmitt , Yi Shi , Norbert Steiger , Ping Tong , Huailiang Wu , Geoff G.Z. Zhang , Deliang Zhou
IPC分类号： A61K31/5377 , A61K33/04 , A61K9/14 , A61P35/00
CPC分类号： A61K31/5377 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/2054 , A61K9/2077 , A61K9/4858 , A61K9/4866
摘要： An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
摘要翻译：可口服递送的药物组合物包含作为唯一或第一活性成分的本文定义的式I化合物或其药学上可接受的盐，例如ABT-263游离碱或ABT-263双-HCl盐，以游离碱当量至少约2.5重量％的组合物，在药学上可接受的载体中; 其中所述活性成分是固态形式和/或所述组合物还包含以有效抑制活性成分在其硫醚键的氧化的量分散在载体中的药学上可接受的较重硫族元素抗氧化剂。该组合物适合于有需要的受试者的口服给药，用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

8. 发明申请

US20100280031A1 LIPID FORMULATION OF APOPTOSIS PROMOTER 审中-公开
标题翻译：脂肪制剂的配方
公开(公告)号：US20100280031A1
公开(公告)日：2010-11-04
申请号：US12770122
申请日：2010-04-29
申请人： Paul David , Michael G. Fickes , Cristina M. Fischer , Anthony R. Haight , Katherine Heemstra , Kennan Marsh , Peter Mayer , Vitaly Rubin , Yeshwant D. Sanzgiri , Eric A. Schmitt , Ping Tong , Deliang Zhou
发明人： Paul David , Michael G. Fickes , Cristina M. Fischer , Anthony R. Haight , Katherine Heemstra , Kennan Marsh , Peter Mayer , Vitaly Rubin , Yeshwant D. Sanzgiri , Eric A. Schmitt , Ping Tong , Deliang Zhou
IPC分类号： A61K31/5377 , A61K31/4965 , A61P35/00 , A61P35/02
CPC分类号： A61K31/4965 , A61K9/4858 , A61K31/5377 , A61K47/14 , A61K47/24
摘要： An orally deliverable pharmaceutical composition comprises a drug-carrier system having a Bcl-2 family protein inhibitory compound, e.g., ABT-263, in solution in a substantially non-aqueous carrier that comprises at least one phospholipid and a pharmaceutically acceptable solubilizing agent. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
摘要翻译：可口服递送的药物组合物包含在包含至少一种磷脂和药学上可接受的增溶剂的基本上非水性载体中的溶液中具有Bcl-2家族蛋白质抑制化合物例如ABT-263的药物 - 载体体系。该组合物适合于有需要的受试者的口服给药，用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

9. 发明授权

US4451553A Halogen finishing of flexographic printing plates containing butadiene/acrylonitrile copolymers 失效
标题翻译：包含丁二烯/丙烯腈共聚物的柔版印刷版的卤素整理
公开(公告)号：US4451553A
公开(公告)日：1984-05-29
申请号：US472103
申请日：1983-03-04
申请人： Michael G. Fickes , Bohdan Rakoczy
发明人： Michael G. Fickes , Bohdan Rakoczy
IPC分类号： G03F7/40 , G03C5/00
CPC分类号： G03F7/405
摘要： Process for providing improved solvent resistant surfaces of relief flexographic printing plates prepared by imagewise exposure and liquid development of the unexposed areas of a layer of photosensitive elastomeric composition comprising a high molecular weight butadiene/acrylonitrile copolymer and a monomeric compound wherein, optionally after drying, the developed surface is, in either order, (1) postexposed to actinic radiation, and (2) contacted with two successive aqueous halogen solutions, first, 0.01 to 3.5% by weight aqueous bromine solution for about 15 seconds to 20 minutes or 0.2 to 10% by weight aqueous iodine solution for about 1.0 to 10 minutes, followed by chlorine solution equivalent to that supplied by an aqueous solution, 0.01 to 1.0 molar in NaOCl and 0.012 to 1.2 molar in HCl, for about 15 seconds to 5 minutes.
摘要翻译：通过图像曝光和感光性弹性体组合物的未曝光区域的液体显影制备的消除柔性版印刷板的改进的抗溶剂表面的方法，所述光敏弹性体组合物包含高分子量丁二烯/丙烯腈共聚物和单体化合物，其中任选地干燥后显影的表面按照任何顺序，（1）经过光固化辐射，和（2）与两个连续的含水卤素溶液接触，首先，0.01至3.5重量％的溴水溶液约15秒至20分钟或0.2至10 碘化钾水溶液约1.0-10分钟，然后加入与水溶液相同的氯溶液，NaOCl为0.01至1.0摩尔，HCl为0.012至1.2摩尔，时间为约15秒至5分钟。

10. 发明授权

US4397941A Dry nonelectroscopic toners for toning tacky image surfaces 失效
标题翻译：用于调色粘性图像表面的干燥非光学调色剂
公开(公告)号：US4397941A
公开(公告)日：1983-08-09
申请号：US335509
申请日：1981-12-29
申请人： Michael G. Fickes
发明人： Michael G. Fickes
IPC分类号： G03F7/28 , G03C5/04
CPC分类号： G03F7/28 , Y10S430/166
摘要： Dry nonelectroscopic toners comprising pigmented organic resin particles having a size distribution of 0.2 to 30 micrometers, not more than 50 percent of the particles being less than 1 micrometer surface treated with a combination of at least 1% by weight of an antistatic agent and at least 0.5% of a slip agent as described. The preparation of the toners is described. The toners are useful in color developing positive and negative-working photosensitive elements particularly in an automatic toning machine. Improved clean-up and low stain propensity are achieved.
摘要翻译：干性非光学调色剂包括尺寸分布为0.2至30微米的颜料有机树脂颗粒，不超过表面积小于1微米的颗粒的50％，用至少1重量％的抗静电剂和至少1重量％的组合如所述的0.5％的滑爽剂。描述了调色剂的制备。调色剂可用于彩色显影正性和负性感光元件，特别是在自动调色机中。实现了清洁和低污染倾向的改善。

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