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1. 发明申请

WO2005067582A3 METHODS AND APPARATUS FOR ENHANCED SAMPLE IDENTIFICATION BASED ON COMBINED ANALYTICAL TECHNIQUES 审中-公开
标题翻译：基于组合分析技术的增强样本识别方法与装置
公开(公告)号：WO2005067582A3
公开(公告)日：2006-11-23
申请号：PCT/US2005001867
申请日：2005-01-13
申请人： SIONEX CORP , MILLER RAANAN A , KAUFMAN LAWRENCE A , NAZAROV ERKINJON G , KRYLOV EVGENY , EICEMAN GARY A
发明人： MILLER RAANAN A , KAUFMAN LAWRENCE A , NAZAROV ERKINJON G , KRYLOV EVGENY , EICEMAN GARY A
IPC分类号： H01J49/00
CPC分类号： G01N27/624
摘要： The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using multiple detection and analytical techniques in combination.
摘要翻译：本发明一般涉及基于离子迁移的系统，用于分析样品的方法和装置，更具体地，涉及使用多个检测和分析技术组合的样品检测。

2. 发明申请

WO2006015305A3 SYSTEMS AND METHODS FOR ION MOBILITY CONTROL 审中-公开
标题翻译：用于离子运动控制的系统和方法
公开(公告)号：WO2006015305A3
公开(公告)日：2006-04-06
申请号：PCT/US2005027224
申请日：2005-07-29
申请人： SIONEX CORP , MILLER RAANAN A , MORRIS C JAMES , CAMERON DOUGLAS B , NAZAROV ERKINJON G , WRIGHT JOHN A
发明人： MILLER RAANAN A , MORRIS C JAMES , CAMERON DOUGLAS B , NAZAROV ERKINJON G , WRIGHT JOHN A
IPC分类号： B01D59/44 , H01J49/28
CPC分类号： H01J49/42 , G01N27/622
摘要： The invention provides, in various embodiments, systems and methods relating to controlling ion behavior in an ion-based analysis system.
摘要翻译：在各种实施例中，本发明提供了与基于离子的分析系统中的离子行为控制有关的系统和方法。

3. 发明申请

WO2005106450A1 SYSTEM AND METHOD FOR ION SPECIES ANALYSIS WITH ENHANCED CONDITION CONTROL AND DATA INTERPRETATION USING DIFFERENTIAL MOBILITY SPECTROMETERS 审中-公开
标题翻译：具有增强条件控制的物种分析系统和方法和使用差分移动光谱仪的数据解释
公开(公告)号：WO2005106450A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/014681
申请日：2005-04-28
申请人： SIONEX CORPORATION , MILLER, Raanan, A. , NAZAROV, Erkinjon, G. , CAMERON, Douglas, B. , WHEELER, David, B. , KRYLOV, Evgeny , COY, Stephen , SHI, Quan
发明人： MILLER, Raanan, A. , NAZAROV, Erkinjon, G. , CAMERON, Douglas, B. , WHEELER, David, B. , KRYLOV, Evgeny , COY, Stephen , SHI, Quan
IPC分类号： G01N27/64
CPC分类号： G01N27/624
摘要： System and method for identifying one or more ion species of a sample, comprising a first for filtering the ion species of the sample over a range of applied asymmetric fields and compensation fileds, a detector for measuring the ion intensities of the filtered ion species over the range of applied asymmetric fields and compensation fields, a processor for generating an image showing the ion intensities over the range of the asymmetric fields and compensation fields and processing windowed portions of the image to identify one or more ion species of the sample.
摘要翻译：用于鉴定样品的一种或多种离子种类的系统和方法，包括用于在所施加的不对称场和补偿膜的范围上过滤样品的离子种类的第一种，用于测量过滤离子种类的离子强度的检测器，施加的不对称场和补偿场的范围的处理器，用于产生在不对称场和补偿场的范围内的离子强度的图像的处理器，以及图像的处理窗口部分，以识别样品的一个或多个离子种类。

4. 发明申请

WO2005074584A3 COMPACT SAMPLE ANALYSIS SYSTEMS AND RELATED METHODS USING COMBINED CHROMATOGRAPHY AND MOBILITY SPECTROMETRY TECHNIQUES 审中-公开
公开(公告)号：WO2005074584A3
公开(公告)日：2005-08-18
申请号：PCT/US2005/002975
申请日：2005-02-02
申请人： SIONEX CORPORATION , CAMERON, Douglas, B. , WHEELER, David, B. , SHI, Quan , MILLER, Raanan, A. , NAZAROV, Erkinjon, G. , WRIGHT, John, A.
发明人： CAMERON, Douglas, B. , WHEELER, David, B. , SHI, Quan , MILLER, Raanan, A. , NAZAROV, Erkinjon, G. , WRIGHT, John, A.
IPC分类号： B01D59/44 , H01J49/00
摘要： The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems (138) and methods, and the techniques for correcting nonlinear characteristics in an ion mobility based analyzer. The system uses a compact rectangular spiral/counter-spiral GC column (140) along with a DMS analyzer (142) to aid in analyzing the constituents.

5. 发明申请

WO2005067582A2 METHODS AND APPARATUS FOR ENHANCED SAMPLE IDENTIFICATION BASED ON COMBINED ANALYTICAL TECHNIQUES 审中-公开
标题翻译：基于组合分析技术的增强样本识别方法与设备
公开(公告)号：WO2005067582A2
公开(公告)日：2005-07-28
申请号：PCT/US2005/001867
申请日：2005-01-13
申请人： SIONEX CORPORATION , MILLER, Raanan, A. , KAUFMAN, Lawrence, A. , NAZAROV, Erkinjon, G. , KRYLOV, Evgeny , EICEMAN, Gary, A.
发明人： MILLER, Raanan, A. , KAUFMAN, Lawrence, A. , NAZAROV, Erkinjon, G. , KRYLOV, Evgeny , EICEMAN, Gary, A.
IPC分类号： H01J49/00
CPC分类号： G01N27/624
摘要： The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using multiple detection and analytical techniques in combination.
摘要翻译：本发明一般涉及基于离子迁移的系统，用于分析样品的方法和装置，更具体地涉及使用多个检测和分析技术组合的样品检测。

6. 发明申请

WO2005052546A2 MOBILITY BASED APPARATUS AND METHODS USING DISPERSION CHARACTERISTICS, SAMPLE FRAGMENTATION, AND/OR PRESSURE CONTROL TO IMPROVE ANALYSIS OF A SAMPLE 审中-公开
标题翻译：基于移动性的装置和使用分散特性，样品分解和/或压力控制的方法来改进样品的分析
公开(公告)号：WO2005052546A2
公开(公告)日：2005-06-09
申请号：PCT/US2004039590
申请日：2004-11-24
申请人： SIONEX CORP , MILLER RAANAN A , NAZAROV ERKINJON G , KAUFMAN LAWRENCE A , CAMERON DOUGLAS B
发明人： MILLER RAANAN A , NAZAROV ERKINJON G , KAUFMAN LAWRENCE A , CAMERON DOUGLAS B
IPC分类号： B01D59/44 , G01N20060101 , H01J49/00 , G01N
CPC分类号： G01N27/624
摘要： The invention relates generally to ion mobility-based systems, methods and devices for analyzing samples.
摘要翻译：本发明一般涉及基于离子迁移率的系统，用于分析样品的方法和装置。

7. 发明申请

WO2005028973A2 SOLID-STATE FLOW GENERATOR AND RELATED SYSTEMS, APPLICATIONS, AND METHODS 审中-公开
标题翻译：固态流量发生器及相关系统，应用和方法
公开(公告)号：WO2005028973A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/030446
申请日：2004-09-17
申请人： SIONEX CORPORATION , MILLER, Raanan, A. , WRIGHT, John, A.
发明人： MILLER, Raanan, A. , WRIGHT, John, A.
IPC分类号： F25D
CPC分类号： H01J49/105 , H01J49/40
摘要： The invention, in various embodiments, is directed to a solid-state flow generator and related systems, methods and applications.
摘要翻译：在各种实施例中，本发明涉及固态流量发生器及相关系统，方法和应用。

8. 发明申请

WO2004090534A1 NON-INVASIVE BREATH ANALYSIS USING FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY 审中-公开
标题翻译：使用场非对称离子电离分光光度法进行非侵入式呼吸分析
公开(公告)号：WO2004090534A1
公开(公告)日：2004-10-21
申请号：PCT/US2004/010288
申请日：2004-04-01
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , DAVIS, Cristina, E. , BORENSTEIN, Jeffrey, T. , ZAPATA, Angela, M. , GELFAND, Jeffrey, A. , CALLAHAN, Michael, V. , STAIR, Thomas, O. , MILLER, Raanan, A.
发明人： DAVIS, Cristina, E. , BORENSTEIN, Jeffrey, T. , ZAPATA, Angela, M. , GELFAND, Jeffrey, A. , CALLAHAN, Michael, V. , STAIR, Thomas, O. , MILLER, Raanan, A.
IPC分类号： G01N33/497
CPC分类号： G01N27/624 , A61B5/08 , A61B5/082 , A61B5/097 , A61B5/413 , G01N33/497
摘要： An asymmetric field ion mobility spectrometer for breath analysis and a system for analysis of a sample of breath taken from a patient.
摘要翻译：用于呼吸分析的不对称场离子迁移谱仪和用于分析从患者取得的呼吸样本的系统。

9. 发明申请

WO2011020034A1 COUPLING ION DIFFERENTIAL MOBILITY BASED AMBIENT PRESSURE ION PRE-FILTERING AND ION FOCUSING FOR A PORTABLE MASS SPECTROMETER 审中-公开
标题翻译：联合差分移动性基于环境压力离子预过滤和离子聚焦用于便携式质谱仪
公开(公告)号：WO2011020034A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045492
申请日：2010-08-13
申请人： SIONEX CORPORATION , MILLER, Raanan, A. , NAZAROV, Erkinjon, G. , MORRIS, C., James , COY, Stephen , KRYLOV, Evgeny , DAVIS, D., Westervelt
发明人： MILLER, Raanan, A. , NAZAROV, Erkinjon, G. , MORRIS, C., James , COY, Stephen , KRYLOV, Evgeny , DAVIS, D., Westervelt
IPC分类号： G01N27/64 , B01D59/44 , H01J49/00
CPC分类号： G01N27/624
摘要： Method and apparatus for analysing ions comprising a pre-filter operating at ambient pressure, based on the mobility of the ions and an ion focusing assembly which directs the ion stream into an ion detector, such as an mass spectrometer (MS). The mobility-based filter can be: a cylindrical field asymmetric waveform ion mobility spectrometer (FAIMS), a planar or aspiration differential mobility spectrometer (DMS) or an ion mobility spectrometer (IMS). The ion focusing assembly comprises: two grids with an opening through which the ions flow, two DC voltage sources and a time varying voltage source to generate an electric field between the grids.
摘要翻译：用于分析离子的方法和装置，其包括在环境压力下操作的预过滤器，基于离子的迁移率和将离子流引导到诸如质谱仪（MS）的离子检测器中的离子聚焦组件。基于迁移率的滤波器可以是：圆柱场非对称波形离子迁移谱仪（FAIMS），平面或抽吸差分迁移谱仪（DMS）或离子迁移谱仪（IMS）。离子聚焦组件包括：具有离子流过的开口的两个栅极，两个DC电压源和时变电压源，以在栅格之间产生电场。

10. 发明申请

WO2004079334A3 BIOMARKER DETECTION BASED ON ASPECTS OF ION MOBILITY 审中-公开
标题翻译：基于离子移动性的生物标记检测
公开(公告)号：WO2004079334A3
公开(公告)日：2009-04-09
申请号：PCT/US2004004132
申请日：2004-02-12
申请人： SIONEX CORP , MILLER RAANAN A , NAZAROV ERKINJON G , BASHALL ANTHONY D , KAUFMAN LAWRENCE A
发明人： MILLER RAANAN A , NAZAROV ERKINJON G , BASHALL ANTHONY D , KAUFMAN LAWRENCE A
IPC分类号： C12Q1/68 , A61K38/00 , C07H21/02 , G01N20060101 , G01N33/53 , G01N33/58
CPC分类号： G01N33/58 , C12Q1/6823 , C12Q2563/137 , C12Q2565/627
摘要： A method of identifying biological or chemical target. A tagged complex is formed between a target and one or more ionizable tags. The identity of the ionizable tags corresponds to the identity of the target. At least one tag is optionally cleaved off the tagged complex, thereby forming a cleaved tag. A tag-target complex or at least one cleaved tag is directed into an ion mobility detection device to obtain a mobility-based signature of the cleaved tag. The mobility-based signature correlates with the tag. A method for detecting the binding of a probe to a target. At least one probe is combined with a sample that includes a chemical or a biological target under conditions and for a time sufficient to permit binding of at least one probe to a target, thereby forming a probe-target complex. Optionally, the probe-target complex is separating from unbound probes and targets. The probe-target complex is directed into an ion mobility detection device, to obtain a mobility-based signature of th probe-target complex. The mobility-based signature correlates with the probe-target complex.
摘要翻译：识别生物或化学靶标的方法。在靶和一个或多个可电离标签之间形成标记的复合体。可电离标签的身份对应于目标的身份。至少一个标签任选地从标记的复合物上切下，从而形成切割的标签。将标签 - 靶复合体或至少一个切割的标签导入离子迁移率检测装置，以获得切割标签的基于移动性的签名。基于移动性的签名与标签相关。用于检测探针与靶标的结合的方法。在足以允许至少一个探针与靶标结合的条件下和至少一段时间内将至少一个探针与包含化学物质或生物靶标的样品组合，由此形成探针 - 目标复合物。任选地，探针 - 目标复合物与未结合的探针和靶标分离。探针 - 目标复合物被引导到离子迁移率检测装置中，以获得探针 - 目标复合物的基于移动性的签名。基于移动性的签名与探针 - 目标复合体相关。

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