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1. 发明申请

WO2004084935A3 FRANCISELLA STRAIN FOR LIVE VACCINE 审中-公开
公开(公告)号：WO2004084935A3
公开(公告)日：2004-10-07
申请号：PCT/GB2004/001264
申请日：2004-03-24
申请人： THE SECRETARY OF STATE FOR DEFENCE , MICHELL, Stephen, Lloyd , OYSTON, Petra, Claire, Farquhar , QUARRY, Janine, Elizabeth , TITBALL, Richard, William
发明人： MICHELL, Stephen, Lloyd , OYSTON, Petra, Claire, Farquhar , QUARRY, Janine, Elizabeth , TITBALL, Richard, William
IPC分类号： A61K39/02
摘要： A strain of Francisella species wherein a gene which encodes an enzyme in the purine pathway has been inactivated, and which is able to produce a protective immune response in an animal, for use as a live prophylactic or therapeutic vaccine against infection by said Francisella species. Suitable genes for inactivation include the purF gene. Pharmaceutical compositions and methods which utilise these strains are also described and claimed.

2. 发明申请

WO2005117334A1 STATE BASED SECURE TRANSMISSION FOR A WIRELESS SYSTEM 审中-公开
标题翻译：无线系统基于状态的安全传输
公开(公告)号：WO2005117334A1
公开(公告)日：2005-12-08
申请号：PCT/CA2005/000817
申请日：2005-05-31
申请人： NATIONAL RESEARCH COUNCIL OF CANADA , SRINIVASAN, Kannan , MICHELL, Stephen
发明人： SRINIVASAN, Kannan , MICHELL, Stephen
IPC分类号： H04L9/18
CPC分类号： H04L9/065 , H04L9/12 , H04L2209/80
摘要： Methods, devices, and systems for ensuring state synchronization between two communicating nodes which use a state based stream cipher. Two nodes in a communications network set up two one way links between them, one from a first node to a second node and one from the second node to the first node. Each link has its own resources at each node and each link has its own counter at each node. When communicating, the transmitting node encrypts data using a state based stream cipher and a key shared by both nodes along with an encryption state. The transmitting node transmits the encrypted data to the receiving node along with a counter value corresponding to the link used for the transmission. The receiving node, after receiving the encrypted data, confirms the received counter value with its own counter for that link. After confirmation, the receiving link decrypts the encrypted data using the state based stream cipher, the shared key, and the encryption state. The two nodes are state synchronized such that each node, when using the state based stream cipher and the same key, produce the same cipher stream. In the event synchronization is lost, on possible resynchronization procedure involving a 4 part handshaking process between the two nodes and which involves an exchange of nonces (also referred to as markers) may be used.
摘要翻译：用于确保使用基于状态的流密码的两个通信节点之间的状态同步的方法，设备和系统。通信网络中的两个节点在它们之间建立两个单向链路，一个从第一节点到第二节点，一个从第二节点到第一节点。每个链路在每个节点都有自己的资源，每个链路在每个节点都有自己的计数器。当通信时，发送节点使用基于状态的流密码和由两个节点共享的密钥以及加密状态来加密数据。发送节点将加密数据与对应于用于发送的链路的计数器值一起发送到接收节点。接收节点在接收到加密数据后，用自己的该连接计数器确认接收到的计数器值。在确认之后，接收链路使用基于状态的流密码，共享密钥和加密状态解密加密数据。两个节点是状态同步的，使得每个节点在使用基于状态的流密码和相同密钥时产生相同的密码流。在同步丢失的情况下，可以使用涉及在两个节点之间的4次握手处理并涉及随机交换（也称为标记）的可能的重新同步过程。

3. 发明申请

WO2004084935A2 LIVE VACCINE STRAIN 审中-公开
标题翻译：活生物体系
公开(公告)号：WO2004084935A2
公开(公告)日：2004-10-07
申请号：PCT/GB2004001264
申请日：2004-03-24
申请人： SECR DEFENCE , MICHELL STEPHEN LLOYD , OYSTON PETRA CLAIRE FARQUHAR , QUARRY JANINE ELIZABETH , TITBALL RICHARD WILLIAM
发明人： MICHELL STEPHEN LLOYD , OYSTON PETRA CLAIRE FARQUHAR , QUARRY JANINE ELIZABETH , TITBALL RICHARD WILLIAM
IPC分类号： A61K39/02 , A61P31/04
CPC分类号： A61K39/0208 , A61K2039/522
摘要： A strain of Francisella species wherein a gene which encodes an enzyme in the purine pathway has been inactivated, and which is able to produce a protective immune response in an animal, for use as a live prophylactic or therapeutic vaccine against infection by said Francisella species. Suitable genes for inactivation include the purF gene. Pharmaceutical compositions and methods which utilise these strains are also described and claimed.
摘要翻译：一种弗朗西斯氏菌属菌种，其中编码嘌呤途径中的酶的基因已经被灭活，并且能够在动物中产生保护性免疫应答，以用作针对所述弗朗西斯菌属感染的活的预防性或治疗性疫苗。合适的灭活基因包括purF基因。还描述和要求保护利用这些菌株的药物组合物和方法。

4. 发明申请

WO2008075075A1 FRANCISELLA STRAIN FOR LIVE VACCINE 审中-公开
标题翻译： FRANCISELLA菌株为活体疫苗
公开(公告)号：WO2008075075A1
公开(公告)日：2008-06-26
申请号：PCT/GB2007/004930
申请日：2007-12-21
申请人： THE SECRETARY OF STATE FOR DEFENCE , MICHELL, Stephen, Lloyd , OYSTON, Petra, Claire, Farquar , RICHARDS, Mark, Ivor , TITBALL, Richard, William
发明人： MICHELL, Stephen, Lloyd , OYSTON, Petra, Claire, Farquar , RICHARDS, Mark, Ivor , TITBALL, Richard, William
IPC分类号： A61K39/02 , C12N1/36
CPC分类号： A61K39/0208 , A61K2039/521 , A61K2039/522 , C12N1/36 , Y02A50/405
摘要： A strain of Francisella species in which gene FTT1564, or homologue thereof, has been inactivated, and which is able to produce a protective immune response in an animal, for use as live prophylactic or therapeutic vaccine against infection by said Francisella species. Other embodiments of the invention describe strains which comprise a further genetic mutation wherein additional genes are also inactivated. Pharmaceutical compositions comprising said strains, together with methods of preventing and treating tularemia infection, which utilise such strains, are also described and claimed.
摘要翻译：其中基因FTT1564或其同源物已经被灭活并且能够在动物中产生保护性免疫应答的弗朗西斯氏菌属菌株用作针对所述弗朗西斯菌属感染的活的预防性或治疗性疫苗。本发明的其它实施方案描述了包含进一步遗传突变的菌株，其中其它基因也被灭活。还描述和要求保护包含所述菌株的药物组合物，以及利用这种菌株的预防和治疗土耳其木霉感染的方法。

5. 发明申请

WO2006131752A1 LIVE AND SUBUNIT VACCINES 审中-公开
标题翻译：生物和亚类疫苗
公开(公告)号：WO2006131752A1
公开(公告)日：2006-12-14
申请号：PCT/GB2006/002120
申请日：2006-06-08
申请人： THE SECRETARY OF STATE FOR DEFENCE , TITBALL, Richard, William , MICHELL, Stephen, Lloyd , OYSTON, Petra, Claire, Farquhar , FORSLUND, Anna-Lena , KUOPPA, Kerstin , SVENSSON, Kerstin , SALOMONSSON, Emelie , JOHANSSON, Anders , NOPPA, Laila , BYSTROM, Mona , FRITHZ-LINDSTEN, Elisabet , FORSMAN, Mats , FORSBERG, Ake
发明人： TITBALL, Richard, William , MICHELL, Stephen, Lloyd , OYSTON, Petra, Claire, Farquhar , FORSLUND, Anna-Lena , KUOPPA, Kerstin , SVENSSON, Kerstin , SALOMONSSON, Emelie , JOHANSSON, Anders , NOPPA, Laila , BYSTROM, Mona , FRITHZ-LINDSTEN, Elisabet , FORSMAN, Mats , FORSBERG, Ake
IPC分类号： A61K39/00 , A61K39/02
CPC分类号： A61K39/107 , A61K39/0208 , C07K16/1228 , Y02A50/405 , Y02A50/472
摘要： The present invention relates to new immunogenic compositions based on certain Francisella components or live strains of the Francisella species, and their use in preventing or treating disease.
摘要翻译：本发明涉及基于某些弗朗西斯组分或弗朗西斯氏菌属的活菌株的新型免疫原性组合物及其在预防或治疗疾病中的用途。

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