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1. 发明申请

WO2005049851A3 METHODS, ARTICLES, AND COMPOSITIONS FOR IDENTIFYING OLIGONUCLEOTIDES 审中-公开
公开(公告)号：WO2005049851A3
公开(公告)日：2005-06-02
申请号：PCT/US2004/038092
申请日：2004-11-15
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , GESTELAND, Raymond, F. , ATKINS, John, F. , MATEEVA, Olga, V. , SHABALINA, Svetlana, A.
发明人： GESTELAND, Raymond, F. , ATKINS, John, F. , MATEEVA, Olga, V. , SHABALINA, Svetlana, A.
IPC分类号： C12Q1/68
摘要： There are many situations where oligonucleotides that efficiently bind a target DNA or RNA are desired. These oligonucleotides can be used for a variety of purposes, including antisense, diagnostics, and array generation. While researchers have worked for many years to identify algorithms and methods for predicting the oligonucleotides that will bind the target with the highest efficiency, better prediction methods are needed. Disclosed are methods, articles, machines, and compositions that aid in identifying oligonucleotides and sets of oligonucleotides that will efficiently bind a target nucleic acid molecule. Also disclosed are optimized sets of oligonucleotides that bind HIV-1 genomic RNA or DNA,, such as the GAG RNA, and methods of using them.

2. 发明申请

WO2011159803A3 LOOK-AHEAD SEISMIC WHILE DRILLING 审中-公开
标题翻译：在钻井时看到前方地震
公开(公告)号：WO2011159803A3
公开(公告)日：2012-04-19
申请号：PCT/US2011040531
申请日：2011-06-15
申请人： SHELL OIL CO , SHELL INT RESEARCH , MATEEVA ALBENA ALEXANDROVA , MEHTA KURANG JVALANT , TATANOVA MARIA
发明人： MATEEVA ALBENA ALEXANDROVA , MEHTA KURANG JVALANT , TATANOVA MARIA
IPC分类号： G01V1/48 , E21B47/00
CPC分类号： G01V1/48 , E21B49/006
摘要： A method of evaluating a formation of interest, comprises collecting a data set comprising signals received at a plurality of receivers signals from a source on a bottom- hole assembly at a position in a borehole, processing the data set so as to create a virtual trace received at a virtual receiver located at the source position, and using the virtual trace to generate an image or measurement containing information about the formation of interest. The source may or may not be a drill bit and the data can be collected at several different source positions.
摘要翻译：一种评估感兴趣的形成的方法，包括：收集包括在多个接收器处接收的信号的数据集，所述信号来自井眼位置处的底部钻具组合上的源，处理所述数据集以创建虚拟迹线在位于源位置的虚拟接收器处接收，并且使用虚拟轨迹来生成包含关于兴趣形成的信息的图像或测量。源可能是或可能不是钻头，数据可以在几个不同的源位置收集。

3. 发明授权

US07508735B2 Method of analyzing vertical seismic profile data, method of producing a hydrocarbon fluid, and a computer readable medium 有权
标题翻译：分析垂直地震剖面数据的方法，生产烃流体的方法和计算机可读介质
公开(公告)号：US07508735B2
公开(公告)日：2009-03-24
申请号：US11614564
申请日：2006-12-21
申请人： Vladimir Grechka , Albena Alexandrova Mateeva
发明人： Vladimir Grechka , Albena Alexandrova Mateeva
IPC分类号： G01V1/30
CPC分类号： G01V1/42
摘要： A P-wave slowness-polarization data set resolving P-wave slowness against P-wave polarization angle is extracted from a multi-offset vertical seismic profiling data set. A function relating P-wave polarization angle to P-wave slowness, and being dependent on at least three free parameters, wherein in at least two of these free parameters information of shear wave velocity is absorbed together with one or more anisotropy parameters that characterize formation anisotropy is selected, and regression values found for the at least three free parameters by fitting the selected function to the P-wave slowness-polarization data set. The regression values may be utilized in a method of producing a mineral hydrocarbon fluid from an earth formation.
摘要翻译：从多偏移垂直地震剖面数据集中提取出P波偏振数据集解析P波慢波对P波偏振角。涉及P波偏振角与P波慢度并且取决于至少三个自由参数的函数，其中在这些自由参数中的至少两个中，剪切波速度的信息与表征形成的一个或多个各向异性参数一起被吸收选择各向异性，通过将所选择的函数拟合到P波慢度偏振数据集中，找到用于至少三个自由参数的回归值。回归值可以用于从地层生产矿物烃流体的方法中。

4. 发明申请

US20070195643A1 METHOD OF DETERMINING A SEISMIC VELOCITY PROFILE 有权
标题翻译：确定地震速度剖面的方法
公开(公告)号：US20070195643A1
公开(公告)日：2007-08-23
申请号：US11671310
申请日：2007-02-05
申请人： Andrey Bakulin , Rodney Calvert , Albena Mateeva
发明人： Andrey Bakulin , Rodney Calvert , Albena Mateeva
IPC分类号： G01V1/28
CPC分类号： G01V1/303
摘要： A seismic velocity profile in a region of interest in a subsurface formation is determined using at least the following steps. (a) Activating a seismic source at a location n, thereby exciting a wave in the subsurface formation. (b) Recording a wave signal trace unm(t) against time t, at a seismic receiver m. (c) Recording a wave signal trace unk(t) against time t at a seismic receiver k. (d) Cross correlating the wave signal traces unm(t) and unk(t) to obtain uconvnmnk(t). (e) Repeating these steps, for different locations n; (f) Summing uconvnmnk(t) over all locations n, to obtain a signal trace uvsmk(t) which corresponds to the signal received by the seismic receiver k from the virtual source at the position of seismic receiver m; (g) Deriving the seismic velocity based on the time of first arrival of the wave in uvsmk(t) and the predetermined distance between the seismic receiver m and the seismic receiver k.
摘要翻译：使用至少以下步骤确定地下地层中感兴趣区域中的地震速度分布。（a）在位置n处激活地震源，从而激发地下地层中的波。（b）在地震接收机m处对时间t记录波信号迹线u nm（t）。（c）在地震接收机k处对时间t记录波信号迹线u N k（t）。（d）将波信号迹线u NA（t）和u nk（t）交叉相关，以获得u nmnk（t）（t）。（e）对不同地点重复这些步骤; （f）在所有位置n上求和u＆lt; SUP＆gt;＆gt; nmnk（t），以获得信号跟踪 mk

5. 发明授权

US07706211B2 Method of determining a seismic velocity profile 有权
标题翻译：确定地震速度剖面的方法
公开(公告)号：US07706211B2
公开(公告)日：2010-04-27
申请号：US11671310
申请日：2007-02-05
申请人： Andrey Victorovich Bakulin , Rodney William Calvert , Albena Alexandrova Mateeva
发明人： Andrey Victorovich Bakulin , Rodney William Calvert , Albena Alexandrova Mateeva
IPC分类号： G01V1/00
CPC分类号： G01V1/303
摘要： A seismic velocity profile in a region of interest in a subsurface formation is determined using at least the following steps. (a) Activating a seismic source at a location n, thereby exciting a wave in the subsurface formation. (b) Recording a wave signal trace unm(t) against time t, at a seismic receiver m. (c) Recording a wave signal trace unk(t) against time t at a seismic receiver k. (d) Cross correlating the wave signal traces unm(t) and unk(t) to obtain uconvnmnk(t). (e) Repeating these steps, for different locations n; (f) Summing uconvnmnk(t) over all locations n, to obtain a signal trace uvsmk(t) which corresponds to the signal received by the seismic receiver k from the virtual source at the position of seismic receiver m; (g) Deriving the seismic velocity based on the time of first arrival of the wave in uvsmk(t) and the predetermined distance between the seismic receiver m and the seismic receiver k.
摘要翻译：使用至少以下步骤确定地下地层中感兴趣区域中的地震速度分布。（a）在位置n处激活地震源，从而激发地下地层中的波。（b）在地震接收机m处对时间t记录波信号迹线unm（t）。（c）在地震接收机k处对时间t记录波信号迹线unk（t）。（d）将波信号迹线unm（t）和unk（t）相互相关以获得uconvnmnk（t）。（e）对不同地点重复这些步骤; （f）在所有位置n上求和uconvnmnk（t），以获得对应于由地震接收机k从地震接收机m的位置处的虚拟源接收的信号的信号迹线uvsmk（t）; （g）基于波在uvsmk（t）中的首次到达时间和地震接收机m与地震接收机k之间的预定距离得出地震速度。

6. 发明授权

US06458534B1 Gene associated with Nijmegen breakage syndrome, it's gene product and methods for their use 失效
标题翻译：与奈梅康破裂综合征相关的基因，是其使用的基因产物和方法
公开(公告)号：US06458534B1
公开(公告)日：2002-10-01
申请号：US09300008
申请日：1999-04-27
申请人： Patrick J. Concannon , Christine S. Vissinga , Karen M. Cerosaletti , Raymonda Varon-Mateeva , Karl Sperling , André Wiesmann da Silva Reis
发明人： Patrick J. Concannon , Christine S. Vissinga , Karen M. Cerosaletti , Raymonda Varon-Mateeva , Karl Sperling , André Wiesmann da Silva Reis
IPC分类号： C12Q168
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to a novel gene, NBS1, and its gene product, nibrin. In addition, it relates to methods for detecting mutations or polymorphisms of the gene that are associated with Nijmegen breakage syndrome in patients. Such mutations may be used to diagnose a predisposition to the development of certain pathological conditions in these patients.
摘要翻译：本发明涉及一种新型基因NBS1及其基因产物奈布林。另外，它涉及用于检测与奈梅因破裂综合征相关的基因的突变或多态性的方法。这些突变可用于诊断这些患者某些病理状况发展的倾向。

7. 发明授权

US08314143B2 Synthetic flavonoids and pharmaceutical compositions and therapeutic methods of treatment of HIV infection and other pathologies 有权
标题翻译：合成类黄酮及其药物组合物及治疗方法治疗艾滋病毒感染等病理
公开(公告)号：US08314143B2
公开(公告)日：2012-11-20
申请号：US11968146
申请日：2007-12-31
申请人： Kinfe Redda , Chavonda Janeebra Mills , Nelly Mateeva
发明人： Kinfe Redda , Chavonda Janeebra Mills , Nelly Mateeva
IPC分类号： A61K31/35 , A61K31/12
CPC分类号： C07D311/30 , C07C49/84 , C07C205/45
摘要： A compound, pharmaceutical composition and method for the treatment of mammals wherein the active therapeutic agent is a compound having the structure: wherein: R1 is an electronegative substituent, R2 is R1 or alkyl, R3 is H or O-alkyl, R4 and R5 are the same or different and are alkyl and R6 is H or OH.
摘要翻译：用于治疗哺乳动物的化合物，药物组合物和方法，其中所述活性治疗剂是具有以下结构的化合物：其中：R1是电负性取代基，R2是R1或烷基，R3是H或O-烷基，R4和R5是相同或不同，为烷基，R6为H或OH。

8. 发明申请

US20090312407A1 Synthetic Flavonoids and Pharmaceutical Compositions and Therapeutic Methods of Treatment of Cancer and other Pathologies 审中-公开
标题翻译：合成类黄酮和药物组合物和治疗癌症和其他病理学的治疗方法
公开(公告)号：US20090312407A1
公开(公告)日：2009-12-17
申请号：US11957462
申请日：2007-12-16
申请人： Kinfe Redda , Chavonda Janeebra Mills , Nelly Mateeva
发明人： Kinfe Redda , Chavonda Janeebra Mills , Nelly Mateeva
IPC分类号： A61K31/352 , C07D311/26 , C07C49/84 , A61K31/12 , A61P35/00
CPC分类号： C07C49/84 , C07D311/26
摘要： A compound, pharmaceutical composition and method for the treatment of mammals wherein the active therapeutic agent is a compound having the structure: wherein: R1 is an electronegative substituent, R2 is R1 or alkyl, R3 is H or O-alkyl, R4 and R5 are the same or different and are alkyl and R6 is H or OH.
摘要翻译：用于治疗哺乳动物的化合物，药物组合物和方法，其中所述活性治疗剂是具有以下结构的化合物：其中：R1是电负性取代基，R2是R1或烷基，R3是H或O-烷基，R4和R5是相同或不同，为烷基，R6为H或OH。

9. 发明申请

US20130094325A1 LOOK-AHEAD SEISMIC WHILE DRILLING 审中-公开
标题翻译：钻探时的前瞻性地震
公开(公告)号：US20130094325A1
公开(公告)日：2013-04-18
申请号：US13704304
申请日：2011-06-15
申请人： Albena Alexandrova Mateeva , Kurang Jvalant Mehta , Maria Tatanova
发明人： Albena Alexandrova Mateeva , Kurang Jvalant Mehta , Maria Tatanova
IPC分类号： G01V1/48 , E21B49/00
CPC分类号： G01V1/48 , E21B49/006
摘要： A method of evaluating a formation of interest, comprises collecting a data set comprising signals received at a plurality of receivers signals from a source on a bottom-hole assembly at a position in a borehole, processing the data set so as to create a virtual trace received at a virtual receiver located at the source position, and using the virtual trace to generate an image or measurement containing information about the formation of interest. The source may or may not be a drill bit and the data can be collected at several different source positions.
摘要翻译：一种评估感兴趣的形成的方法，包括：收集包括在多个接收器处接收到的信号的数据集合，该信号从位于钻孔中的位置处的井底组件上的源起处理数据集，以便产生虚拟迹线在位于源位置处的虚拟接收器处接收，并且使用虚拟轨迹来生成包含关于感兴趣的形成的信息的图像或测量。源可以是或可以不是钻头，并且可以在几个不同的源位置收集数据。

10. 发明申请

US20070115755A1 METHOD OF ANALYZING VERTICAL SEISMIC PROFILE DATA, METHOD OF PRODUCING A HYDROCARBON FLUID, AND A COMPUTER READABLE MEDIUM 有权
标题翻译：分析垂直地震剖面数据的方法，生产烃油的方法和计算机可读介质
公开(公告)号：US20070115755A1
公开(公告)日：2007-05-24
申请号：US11614564
申请日：2006-12-21
申请人： Vladimir GRECHKA , Albena Mateeva
发明人： Vladimir GRECHKA , Albena Mateeva
IPC分类号： G01V1/00
CPC分类号： G01V1/42
摘要： A P-wave slowness-polarization data set resolving P-wave slowness against P-wave polarization angle is extracted from a multi-offset vertical seismic profiling data set. A function relating P-wave polarization angle to P-wave slowness, and being dependent on at least three free parameters, wherein in at least two of these free parameters information of shear wave velocity is absorbed together with one or more anisotropy parameters that characterize formation anisotropy is selected, and regression values found for the at least three free parameters by fitting the selected function to the P-wave slowness-polarization data set, The regression values may be utilized in a method of producing a mineral hydrocarbon fluid from an earth formation.
摘要翻译：从多偏移垂直地震剖面数据集中提取出P波偏振数据集解析P波慢波对P波偏振角。涉及P波偏振角与P波慢度并且取决于至少三个自由参数的函数，其中在这些自由参数中的至少两个中，剪切波速度的信息与表征形成的一个或多个各向异性参数一起被吸收选择各向异性，并通过将所选择的函数拟合到P波慢极化数据集中来找到用于至少三个自由参数的回归值。回归值可以用于从地层中生产矿物烃流体的方法。

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