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1. 发明申请

WO2009008988A1 IMMUNOSTIMULATING POLYPHOSPHAZENE COMPOUNDS FOR INTRADERMAL IMMUNIZATION 审中-公开
标题翻译：免疫抑制多形态化合物用于肠内免疫
公开(公告)号：WO2009008988A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/008230
申请日：2008-07-03
申请人： APOGEE TECHNOLOGY, INC. , ANDRIANOV, Alexander, K. , MARIN, Alexander , DECOLLIBUS, Daniel, P. , KHA, Henry, Hy , GILLIS, Helice, A.
发明人： ANDRIANOV, Alexander, K. , MARIN, Alexander , DECOLLIBUS, Daniel, P. , KHA, Henry, Hy , GILLIS, Helice, A.
IPC分类号： A61M36/14 , A61K51/00 , A61K31/74
CPC分类号： A61K47/26 , A61B17/205 , A61K9/0021 , A61K31/74 , A61K39/00 , A61K47/34 , A61K47/38 , A61M37/0015 , A61K2300/00
摘要： Disclosed are intradermal^ administered products and methods for producing an immune response in a human or in an animal comprising an antigen and a polyphosphazene polyelectrolyte adjuvant in an amount effective to elicit an immune response in the human or in the animal against said antigen.
摘要翻译：公开了用于在人或动物中产生免疫应答的产品和方法，所述方法包括抗原和聚磷腈聚电解质佐剂，其量有效地引发人或动物中针对所述抗原的免疫应答。

2. 发明申请

WO2003102050A1 SULFONATED POLYPHOSPHAZENES, USES THEREOF, AND METHODS FOR PREPARING SAME 审中-公开
标题翻译：硫化多磷酸酯，其用途及其制备方法
公开(公告)号：WO2003102050A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/017616
申请日：2003-05-30
申请人： PARALLEL SOLUTIONS, INC. , ANDRIANOV, Alexander, Ph., D. , CHEN, Jiangping , SARGENT, Jonathan, Ph., D. , MARIN, Alexander, Ph., D.
发明人： ANDRIANOV, Alexander, Ph., D. , CHEN, Jiangping , SARGENT, Jonathan, Ph., D. , MARIN, Alexander, Ph., D.
IPC分类号： C08G75/24
CPC分类号： C08G79/025 , C08G2650/02 , C08L85/02
摘要： Polyphosphazene polymers having at least one sulfonated pendent group, and no more than five different sulfonated pendent groups, repeated along the polymer chain, wherein at least one the repeated sulfonated pendent groups links at least one S0 3 - group to the polymer chain through a nitrogen-free linkage containing at least three carbon atoms, are disclosed, along with methods of making same, and uses therefor.
摘要翻译：具有至少一个磺化侧基的聚磷腈聚合物和不超过五个不同的磺化侧基，沿着聚合物链重复，其中至少一个重复的磺化侧基通过一个至少一个SO 3 - 基团与至少一个SO 3 - 公开了含有至少三个碳原子的无氮键连同其制备方法及其用途。

3. 发明申请

WO2008024141A3 NANOFIBER STRUCTURES ON ASPERITIES FOR SEQUESTERING, CARRYING AND TRANSFERRING SUBSTANCES 审中-公开
标题翻译：用于测序，携带和转运物质的纳米比亚结构
公开(公告)号：WO2008024141A3
公开(公告)日：2008-04-24
申请号：PCT/US2007011228
申请日：2007-05-09
申请人： APOGEE TECHNOLOGY INC , UNIV AKRON , RENEKER DARRELL H , SMITH DANIEL J , MEYERS DAVID BARRETT , GOLUBOVIC-LIAKOPOULOS NEVENKA , MARIN ALEXANDER , ANDRIANOV ALEXANDER K , CARROLL PETER G , SIMON SANFORD R , HAN TAO
发明人： RENEKER DARRELL H , SMITH DANIEL J , MEYERS DAVID BARRETT , GOLUBOVIC-LIAKOPOULOS NEVENKA , MARIN ALEXANDER , ANDRIANOV ALEXANDER K , CARROLL PETER G , SIMON SANFORD R , HAN TAO
IPC分类号： A61M5/00 , A61M5/162 , A61M5/31
CPC分类号： A61K9/70 , A61K9/0021 , A61K38/29 , A61K38/465 , A61K39/07 , A61K2039/54
摘要： A device which comprises a substrate which includes a plurality of asperities, such as microneedles, extending from the surface of the substrate, and an electrospun material in contact with the substrate. The electrospun material may comprise a plurality of nanofibers which carry at least one biologically active agent. Such devices are useful as transdermal delivery devices for delivering pharmaceuticals and other biologically active agents.
摘要翻译：一种包括基板的装置，其包括从基板的表面延伸的多个凹凸，例如微针，以及与基板接触的电纺材料。电纺丝材料可以包含携带至少一种生物活性剂的多个纳米纤维。这样的装置可用作递送药物和其它生物活性剂的透皮递送装置。

4. 发明申请

WO2006089161A2 IMMUNOSTIMULATING POLYPHOSPHAZENE COMPOUNDS 审中-公开
标题翻译：免疫多磷酸化合物
公开(公告)号：WO2006089161A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005736
申请日：2006-02-17
申请人： PARALLEL SOLUTIONS, INC. , ANDRIANOV, Alexander, K. , MARIN, Alexander
发明人： ANDRIANOV, Alexander, K. , MARIN, Alexander
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K31/74 , A61K31/80 , A61K39/00 , A61K39/292 , A61K39/35 , A61K2039/55511 , A61K2039/55555 , C08G79/025 , C12N7/00 , C12N2730/10134 , Y02A50/464 , A61K2300/00
摘要： Polyphosphazene polymers having immunomodulating activity, and the biomedical use of such polyphosphazene polymers, in conjunction with an antigen or an immunogen are disclosed.
摘要翻译：公开了具有免疫调节活性的聚磷腈聚合物，以及这种聚磷腈聚合物与抗原或免疫原的生物医学应用。

5. 发明申请

WO2009008951A3 METHODS AND SYSTEMS FOR COATING A MICRONEEDLE WITH A DOSAGE OF A BIOLOGICALLY ACTIVE COMPOUND 审中-公开
公开(公告)号：WO2009008951A3
公开(公告)日：2009-01-15
申请号：PCT/US2008/007200
申请日：2008-06-09
申请人： APOGEE TECHNOLOGY, INC. , ANDRIANOV, Alexander, K. , MARIN, Alexander
发明人： ANDRIANOV, Alexander, K. , MARIN, Alexander
IPC分类号： A61K9/00 , A61M37/00 , A61L31/10 , A61L31/16
摘要： Methodologies and systems are disclosed for coating one or more microneedles, particularly in a microneedle array, for administering a predetermined dosage of biologically active compound through the skin to a recipient. The microneedles of the array are each immersed into at least one reservoir of a fluid liquid formulation of the biologically active compound wherein the at least one reservoir receives a metered predetermined amount of the formulation that corresponds to the dosage to be coated on each microneedle. The microneedles are immersed into the at least one reservoir one or more times to consume the entire amount of formulation in the at least one reservoir such the consumed amount forms the coating comprising one or more layers comprising the predetermined dose on each microneedle. Various embodiments are disclosed for immersing the microneedles one needle at a time, one or more times into the reservoir, or in an array into corresponding reservoirs in one or more repetitive immersions. The reservoirs may be repetitively filled to the predetermined amount to produce the desired single dosage on a microneedle.

6. 发明申请

WO2009008951A2 METHODS AND SYSTEMS FOR COATING A MICRONEEDLE WITH A DOSAGE OF A BIOLOGICALLY ACTIVE COMPOUND 审中-公开
标题翻译：用生物活性化合物给药一种麦芽糖的方法和系统
公开(公告)号：WO2009008951A2
公开(公告)日：2009-01-15
申请号：PCT/US2008007200
申请日：2008-06-09
申请人： APOGEE TECHNOLOGY INC , ANDRIANOV ALEXANDER K , MARIN ALEXANDER
发明人： ANDRIANOV ALEXANDER K , MARIN ALEXANDER
IPC分类号： A61L31/16 , A61L31/10
CPC分类号： A61K9/0021 , A61M37/0015
摘要： Methodologies and systems are disclosed for coating one or more microneedles, particularly in a microneedle array, for administering a predetermined dosage of biologically active compound through the skin to a recipient. The microneedles of the array are each immersed into at least one reservoir of a fluid liquid formulation of the biologically active compound wherein the at least one reservoir receives a metered predetermined amount of the formulation that corresponds to the dosage to be coated on each microneedle. The microneedles are immersed into the at least one reservoir one or more times to consume the entire amount of formulation in the at least one reservoir such the consumed amount forms the coating comprising one or more layers comprising the predetermined dose on each microneedle. Various embodiments are disclosed for immersing the microneedles one needle at a time, one or more times into the reservoir, or in an array into corresponding reservoirs in one or more repetitive immersions. The reservoirs may be repetitively filled to the predetermined amount to produce the desired single dosage on a microneedle.
摘要翻译：公开了用于涂覆一个或多个微针的方法和系统，特别是在微针阵列中，用于通过皮肤向接受者施用预定剂量的生物活性化合物。阵列的微针各自浸入生物活性化合物的流体液体制剂的至少一个储存器中，其中至少一个储存器接收与计量的预定量的制剂相当于要涂覆在每个微针上的剂量。将微针浸入至少一个储存器中一次或多次以消耗至少一个储存器中的整个量的制剂，从而消耗量形成包含一个或多个包含每个微针上的预定剂量的层的涂层。公开了各种实施例，用于将一根针一次或多次的一只针浸入储存器中，或者以一次或多次重复浸渍将其放入相应的储存器中。储存器可以重复地填充到预定量，以在微针上产生所需的单一剂量。

7. 发明申请

WO2006036203A3 POLYPHOSPHAZENES INCLUDING IONIC OR IONIZABLE MOIETIES AND FLUORINE-CONTAINING MOIETIES 审中-公开
标题翻译：多晶硅包括离子或可离子电荷和含氟化合物
公开(公告)号：WO2006036203A3
公开(公告)日：2006-10-26
申请号：PCT/US2005012161
申请日：2005-04-11
申请人： PARALLEL SOLUTIONS INC , ANDRIANOV ALEXANDER K , MARIN ALEXANDER
发明人： ANDRIANOV ALEXANDER K , MARIN ALEXANDER
IPC分类号： C08G79/02 , A61K39/39
CPC分类号： C08G79/025 , A61K8/84 , A61K9/0024 , A61K2800/91 , A61Q19/08 , C08J5/2256 , C08J2385/02 , C08L85/02 , H01M8/103 , H01M8/1034 , H01M2300/0082 , H01M2300/0094
摘要： A polyphosphazene polymer which includes both (i) ionic or ionizable moieties; and (ii) fluorine-containing moieties. Such polymers may be used as matrices for pharmaceuticals, as multilayer coatings for fuel cell membranes, as dopants for electrically conductive polymers, or as multilayer coatings for biomedical devices.
摘要翻译：一种聚磷腈聚合物，其包括（i）离子或可离子化部分; 和（ii）含氟部分。这种聚合物可以用作药物的基质，作为燃料电池膜的多层涂层，用作导电聚合物的掺杂剂，或用作生物医学装置的多层涂层。

8. 发明申请

WO2008024141A8 NANOFIBER STRUCTURES ON ASPERITIES FOR SEQUESTERING, CARRYING AND TRANSFERRING SUBSTANCES 审中-公开
标题翻译：用于测序，携带和转运物质的纳米比亚结构
公开(公告)号：WO2008024141A8
公开(公告)日：2009-07-09
申请号：PCT/US2007011228
申请日：2007-05-09
申请人： APOGEE TECHNOLOGY INC , UNIV AKRON , RENEKER DARRELL H , SMITH DANIEL J , MEYERS DAVID BARRETT , GOLUBOVIC-LIAKOPOULOS NEVENKA , MARIN ALEXANDER , ANDRIANOV ALEXANDER K , CARROLL PETER G , SIMON SANFORD R , HAN TAO
发明人： RENEKER DARRELL H , SMITH DANIEL J , MEYERS DAVID BARRETT , GOLUBOVIC-LIAKOPOULOS NEVENKA , MARIN ALEXANDER , ANDRIANOV ALEXANDER K , CARROLL PETER G , SIMON SANFORD R , HAN TAO
IPC分类号： A61M5/00 , A61M5/162 , A61M5/31
CPC分类号： A61K9/70 , A61K9/0021 , A61K38/29 , A61K38/465 , A61K39/07 , A61K2039/54
摘要： A device which comprises a substrate which includes a plurality of asperities, such as microneedles, extending from the surface of the substrate, and an electrospun material in contact with the substrate. The electrospun material may comprise a plurality of nanofibers which carry at least one biologically active agent. Such devices are useful as transdermal delivery devices for delivering pharmaceuticals and other biologically active agents.
摘要翻译：一种包括基板的装置，其包括从基板的表面延伸的多个凹凸，例如微针，以及与基板接触的电纺材料。电纺丝材料可以包含携带至少一种生物活性剂的多个纳米纤维。这样的装置可用作递送药物和其它生物活性剂的透皮递送装置。

9. 发明申请

WO2006113274A1 BIODEGRADABLE POLYPHOSPHAZENES CONTAINING PYRROLIDONE SIDE GROUPS 审中-公开
标题翻译：含有吡咯烷酮基团的生物可降解聚磷酸酯
公开(公告)号：WO2006113274A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/013661
申请日：2006-04-11
申请人： PARALLEL SOLUTIONS, INC. , ANDRIANOV, Alexander, K. , MARIN, Alexander
发明人： ANDRIANOV, Alexander, K. , MARIN, Alexander
IPC分类号： C07D207/36 , A61K31/4015
CPC分类号： C08G79/025 , A61L27/18 , A61L27/34 , A61L29/06 , A61L29/085 , A61L31/06 , A61L31/10 , C07F9/5721 , C08L85/02
摘要： Biodegradable polyphosphazene polymers containing pyrrolidone side groups, and the biomedical use of such polyphosphazene polymers are disclosed.
摘要翻译：公开了含有吡咯烷酮侧基的可生物降解的聚磷腈聚合物，以及这种聚磷腈聚合物的生物医学应用。

10. 发明申请

WO2009009004A1 COATING FORMULATIONS INCLUDING POLYPHOSPHAZENE POLYELECTROLYTES AND BIOLOGICALLY ACTIVE AGENTS AND ASPERITIES COATED WITH SUCH FORMULATIONS 审中-公开
标题翻译：涂层配方包括聚磷酸酯聚电解质和生物活性剂及其配方与此配方
公开(公告)号：WO2009009004A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/008265
申请日：2008-07-03
申请人： APOGEE TECHNOLOGY, INC. , ANDRIANOV, Alexander, K. , MARIN, Alexander
发明人： ANDRIANOV, Alexander, K. , MARIN, Alexander
IPC分类号： A61K45/00
CPC分类号： A61K9/0021 , A61B17/205 , A61B2017/00526 , A61K47/34 , A61M37/0015 , A61M2037/0053
摘要： A formulation for coating asperities, such as microprojections or microneedles, which comprises at least one polyphosphazene polyelectrolyte and at least one biologically active agent. Such formulation provides for improved loading and improved homogeneity of the at least one biologically active agent on the microprojections or microneedles.
摘要翻译：用于涂布粗糙度的制剂，例如微注射剂或微针，其包含至少一种聚磷腈聚电解质和至少一种生物活性剂。这样的制剂提供了在微突出物或微针上的至少一种生物活性剂的改进的负载和改善的均匀性。

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