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1. 发明授权

US06329157B1 Antigen cocktails and uses thereof 失效
标题翻译：抗原鸡尾酒及其用途
公开(公告)号：US06329157B1
公开(公告)日：2001-12-11
申请号：US09086503
申请日：1998-05-28
申请人： Gregory T. Maine , Jeffrey C. Hunt , Susan Brojanac , Michael Jyh-Tsing Sheu , Linda E. Chovan , Joan D. Tyner , Lawrence V. Howard
发明人： Gregory T. Maine , Jeffrey C. Hunt , Susan Brojanac , Michael Jyh-Tsing Sheu , Linda E. Chovan , Joan D. Tyner , Lawrence V. Howard
IPC分类号： G01N3353
CPC分类号： G01N33/56905 , Y02A50/57 , Y02A50/58
摘要： The present invention relates to combinations or mixtures of antigens which may be used in the detection of IgM and/or IgG antibodies to Toxoplasma gondii. Furthermore, the present invention also relates to methods of using these combinations of antigens, antibodies raised against these combinations of antigens or against the novel P29 antigen thereof, as well as kits and vaccines containing the antigens present in the combinations.
摘要翻译：本发明涉及可用于检测弓形虫的IgM和/或IgG抗体的抗原的组合或混合物。此外，本发明还涉及使用这些抗原组合，针对这些抗原组合产生的抗体或其新型P29抗原以及含有组合中存在的抗原的试剂盒和疫苗的方法。

2. 发明授权

US06221619B1 Method of using P35 antigen of toxoplasma gondii in distinguishing acute from chronic toxoplasmosis 有权
标题翻译：使用弓形虫弓形虫的P35抗原鉴别急性与慢性弓形虫病的方法
公开(公告)号：US06221619B1
公开(公告)日：2001-04-24
申请号：US09303064
申请日：1999-04-30
申请人： Gregory T. Maine , Jeffrey C. Hunt , Susan Brojanac , Michael Jyh-Tsing Sheu , Linda E. Chovan , Joan D. Tyner , Lawrence V. Howard , Stephen F. Parmley , Jack S. Remington , Fausto Araujo , Yashuhiro Suzuki , Shuli Li
发明人： Gregory T. Maine , Jeffrey C. Hunt , Susan Brojanac , Michael Jyh-Tsing Sheu , Linda E. Chovan , Joan D. Tyner , Lawrence V. Howard , Stephen F. Parmley , Jack S. Remington , Fausto Araujo , Yashuhiro Suzuki , Shuli Li
IPC分类号： G01N3353
CPC分类号： G01N33/56905 , Y02A50/57 , Y02A50/58
摘要： The present invention relates to combinations or mixtures of antigens which may be used in the detection of IgM and/or IgG antibodies to Toxoplasma gondii as well as to the P35 antigen which may be used to distinguish acute from chronic toxoplasmosis. Furthermore, the present invention also relates to methods of using these combinations of antigens, antibodies raised against these combinations of antigens or against the novel P29 antigen thereof, as well as kits and vaccines containing the antigens present in the combinations.
摘要翻译：本发明涉及可用于检测弓形体的IgM和/或IgG抗体以及可用于区分急性和慢性弓形虫病的P35抗原的抗原的组合或混合物。此外，本发明还涉及使用这些抗原组合，针对这些抗原组合产生的抗体或其新型P29抗原以及含有组合中存在的抗原的试剂盒和疫苗的方法。

3. 发明申请

US20050277178A1 EMBEDDED EXPRESSION OF HETEROLOGOUS PROTEINS 失效
标题翻译：杂交蛋白的嵌入表达
公开(公告)号：US20050277178A1
公开(公告)日：2005-12-15
申请号：US08742619
申请日：1996-11-01
申请人： GREGORY T. MAINE , LINDA E. CHOVAN
发明人： GREGORY T. MAINE , LINDA E. CHOVAN
IPC分类号： C12N15/09 , C12N15/62 , C12N15/70
CPC分类号： C12N15/70 , C12N15/62
摘要： A method for expressing a heterologous protein in a prokaryotic host cell, comprising the steps of: (a) providing a DNA vector having: (1) a control region operatively linked to a first genetic element encoding a carrier protein capable of expression in the host cell, and (2) a second genetic element encoding the heterologous protein, the second element being embedded within the first element such that the first and second elements are contiguous and in the same reading frame; (b) transforming the host cell with the DNA vector; and (c) expressing a fusion protein of the heterologous protein and the carrier protein, wherein the heterologous protein is joined at its N-terminus to a first domain of the carrier protein and at its C-terminus to a second domain of the carrier protein, and also a method for confirming intact expression of heterologous proteins, as well as fusion proteins, DNA constructs, plasmid vectors and transformed host cells relating to the above methods.
摘要翻译：一种用于在原核宿主细胞中表达异源蛋白质的方法，包括以下步骤：（a）提供DNA载体，所述DNA载体具有：（1）与编码能够在宿主中表达的载体蛋白的第一遗传元件可操作地连接的对照区细胞，和（2）编码异源蛋白质的第二遗传元件，第二元素嵌入在第一元素内，使得第一和第二元素连续并且位于相同的阅读框中; （b）用DNA载体转化宿主细胞; 和（c）表达异源蛋白质和载体蛋白质的融合蛋白，其中所述异源蛋白质在其N末端连接至载体蛋白质的第一结构域，并且其C末端连接至载体蛋白质的第二结构域，以及用于确认异源蛋白质的完整表达以及与上述方法相关的融合蛋白，DNA构建体，质粒载体和转化的宿主细胞的方法。

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