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1. 发明授权

US08647337B2 Devices and methods for dispensing a cryogenic fluid 有权
标题翻译：用于分配低温流体的装置和方法
公开(公告)号：US08647337B2
公开(公告)日：2014-02-11
申请号：US12489875
申请日：2009-06-23
申请人： R. Sam Niedbala , Lincoln C. Young , Peng Zhou
发明人： R. Sam Niedbala , Lincoln C. Young , Peng Zhou
IPC分类号： A61B18/18 , F17C7/02 , F17C13/00
CPC分类号： A61B18/0218 , A61B2018/0275
摘要： A dispensing head for dispensing a cryogenic fluid may comprise a flow passage configured to be placed in flow communication with a reservoir containing a cryogenic fluid, the flow passage defining a flow passage inlet opening configured to receive the cryogenic fluid from the reservoir, and a flow passage outlet opening opposite the flow passage inlet opening. The dispensing head may further comprise a dispensing member configured to dispense the cryogenic fluid, the dispensing member defining a lumen having a lumen inlet opening and a lumen outlet opening; and at least one porous member disposed in the flow passage, the at least one porous member being configured as a primary flow regulation mechanism to limit a flow rate of the cryogenic fluid as it flows from the reservoir to the lumen outlet opening.
摘要翻译：用于分配低温流体的分配头可以包括流动通道，其构造成与包含低温流体的储存器流动连通，流动通道限定被构造成从储存器接收低温流体的流动通道入口开口，通道出口与流路入口相对。分配头还可以包括配置成分配低温流体的分配构件，分配构件限定具有管腔入口和管腔出口的内腔; 以及至少一个多孔构件，其设置在所述流动通道中，所述至少一个多孔构件被构造为主流量调节机构，以限制所述低温流体从储存器流到管腔出口开口的流量。

2. 发明授权

US08383039B2 Self-contained biological assay apparatus, methods, and applications 有权
公开(公告)号：US08383039B2
公开(公告)日：2013-02-26
申请号：US13033165
申请日：2011-02-23
申请人： Peng Zhou , Lincoln C. Young , Benjamin Thomas , Zongyuan Chen , Greg Mouchka , Todd Roswech , Gwendolyn Spizz , Rubina Yasmin
发明人： Peng Zhou , Lincoln C. Young , Benjamin Thomas , Zongyuan Chen , Greg Mouchka , Todd Roswech , Gwendolyn Spizz , Rubina Yasmin
IPC分类号： G01N21/00 , B01L3/02
CPC分类号： C12Q1/6806 , B01L3/022 , B01L3/5027 , B01L3/502753 , B01L7/52 , B01L2200/0647 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2300/044 , B01L2300/0681 , B01L2300/0829 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2400/043 , B01L2400/0481 , B01L2400/0666 , C12Q1/6846 , C12Q1/686 , C12Q1/6883 , C12Q1/708 , G01N35/1002 , C12Q2565/629
摘要： A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.

3. 发明申请

US20120279638A1 MICROFLUIDIC PUMP AND VALVE STRUCTURES AND FABRICATION METHODS 有权
标题翻译：微流体泵和阀结构与制造方法
公开(公告)号：US20120279638A1
公开(公告)日：2012-11-08
申请号：US13555506
申请日：2012-07-23
申请人： Peng Zhou , Lincoln C. Young
发明人： Peng Zhou , Lincoln C. Young
IPC分类号： B32B37/02 , B32B37/10 , B32B37/12
CPC分类号： B32B37/0038 , B01F5/0683 , B01F5/0688 , B01F11/0071 , B01F13/0059 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B01L2400/084 , B29C65/4895 , B29C66/1122 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/83411 , B29C66/8362 , B29L2031/756 , F04B43/043 , F04B43/06 , F16K99/0001 , F16K99/0015 , F16K99/0021 , F16K99/0034 , F16K99/0055 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0094 , Y10T156/1002 , B29K2069/00 , B29K2033/08 , B29K2025/06
摘要： Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.
摘要翻译：塑料微流体结构具有基本上刚性的膜片，其在松弛状态之间起作用，其中隔膜抵靠衬底的表面，以及致动状态，其中隔膜移动离开衬底。从以下描述可以看出，用这种隔膜形成的微流体结构提供易于制造和坚固的系统，以及易于制造的部件，例如阀和泵。

4. 发明申请

US20100319360A1 DEVICES AND METHODS FOR DISPENSING A CRYOGENIC FLUID 有权
标题翻译：用于分配低温流体的装置和方法
公开(公告)号：US20100319360A1
公开(公告)日：2010-12-23
申请号：US12489875
申请日：2009-06-23
申请人： R. Sam NIEDBALA , Lincoln C. Young , Peng Zhou
发明人： R. Sam NIEDBALA , Lincoln C. Young , Peng Zhou
IPC分类号： F17C7/02
CPC分类号： A61B18/0218 , A61B2018/0275
摘要： A dispensing head for dispensing a cryogenic fluid may comprise a flow passage configured to be placed in flow communication with a reservoir containing a cryogenic fluid, the flow passage defining a flow passage inlet opening configured to receive the cryogenic fluid from the reservoir, and a flow passage outlet opening opposite the flow passage inlet opening. The dispensing head may further comprise a dispensing member configured to dispense the cryogenic fluid, the dispensing member defining a lumen having a lumen inlet opening and a lumen outlet opening; and at least one porous member disposed in the flow passage, the at least one porous member being configured as a primary flow regulation mechanism to limit a flow rate of the cryogenic fluid as it flows from the reservoir to the lumen outlet opening.
摘要翻译：用于分配低温流体的分配头可以包括流动通道，其构造成与包含低温流体的储存器流动连通，流动通道限定被构造成从储存器接收低温流体的流动通道入口开口，通道出口与流路入口相对。分配头还可以包括配置成分配低温流体的分配构件，分配构件限定具有管腔入口和管腔出口的内腔; 以及至少一个多孔构件，其设置在所述流动通道中，所述至少一个多孔构件被构造为主流量调节机构，以限制所述低温流体从储存器流到管腔出口开口的流量。

5. 发明申请

US20090056822A1 Microfluidic Pump and Valve Structures and Fabrication Methods 有权
公开(公告)号：US20090056822A1
公开(公告)日：2009-03-05
申请号：US12248496
申请日：2008-10-09
申请人： Lincoln C. Young , Peng Zhou
发明人： Lincoln C. Young , Peng Zhou
IPC分类号： F15C3/04
CPC分类号： F16K7/12 , B01F5/0683 , B01F5/0688 , B01F11/0071 , B01F13/0059 , B01F2215/0034 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , B01L2400/084 , B29C65/4895 , B29C66/004 , B29C66/54 , B29C66/5412 , B29C66/71 , B29K2025/00 , B29K2025/04 , B29K2033/08 , B29K2069/00 , B29K2101/12 , B29L2031/7496 , B29L2031/7506 , B29L2031/756 , B81B3/0021 , B81B2201/036 , B81B2201/054 , B81B2203/0127 , B81C1/00103 , B81C1/00158 , F04B43/028 , F04B43/043 , F04B43/06 , F15C1/08 , F16K99/0001 , F16K99/0015 , F16K99/0021 , F16K99/0034 , F16K99/0055 , F16K99/0057 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T29/49405 , Y10T137/212 , Y10T137/2202 , Y10T137/2218 , Y10T137/8593 , Y10T137/85978 , Y10T156/1002 , Y10T156/1043 , B29K2033/12 , B29K2025/06
摘要： Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

6. 发明授权

US08715447B2 Laminated microfluidic structures and method for making 有权
标题翻译：层压微流体结构及其制造方法
公开(公告)号：US08715447B2
公开(公告)日：2014-05-06
申请号：US13185619
申请日：2011-07-19
申请人： Peng Zhou , Lincoln C. Young
发明人： Peng Zhou , Lincoln C. Young
IPC分类号： B32B38/04
CPC分类号： B32B37/0038 , B01F5/0683 , B01F5/0688 , B01F11/0071 , B01F13/0059 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B01L2400/084 , B29C65/4895 , B29C66/1122 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/83411 , B29C66/8362 , B29L2031/756 , F04B43/043 , F04B43/06 , F16K99/0001 , F16K99/0015 , F16K99/0021 , F16K99/0034 , F16K99/0055 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0094 , Y10T156/1002 , B29K2069/00 , B29K2033/08 , B29K2025/06
摘要： A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.
摘要翻译：一种制备聚合微流体结构的方法，其中微流体结构的两个或多个组分（层）用弱溶剂粘合剂，特别是乙腈或乙腈和醇的混合物固定粘合或层压。在一个方面，乙腈可以用作弱溶剂粘合剂以包围在非弹性聚合物如聚苯乙烯，聚碳酸酯，丙烯酸或其它线性聚合物中或其上制造的微结构，以形成三维微流体网络。该方法包括以下步骤：在给定的较低温度范围内用弱溶剂粘合剂润湿聚合物基材组分的至少一个相对表面，相邻接触相对表面，并在比在一定时间内较低的温度范围。接触的聚合物基材还可以在热活化之前对准，并在热活化期间被压缩。还公开了层压聚合物微流体结构。

7. 发明授权

US08715446B2 Latent solvent-based microfluidic apparatus, methods, and applications 有权
标题翻译：潜在的溶剂型微流体装置，方法和应用
公开(公告)号：US08715446B2
公开(公告)日：2014-05-06
申请号：US13010014
申请日：2011-01-20
申请人： Todd Roswech , Peng Zhou , Lincoln C. Young
发明人： Todd Roswech , Peng Zhou , Lincoln C. Young
IPC分类号： B32B38/04
CPC分类号： F16K99/0021 , B01F5/0688 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B01L2400/084 , B29C65/4895 , B29C66/1122 , B29C66/54 , B29C66/5412 , B29C66/71 , B29C66/73161 , B29C66/953 , B29L2031/756 , F04B43/043 , F04B43/06 , F16K99/0001 , F16K99/0015 , F16K99/0034 , F16K99/0055 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0094 , Y10T156/1002 , B29K2023/38
摘要： A latent solvent-based microfluidic apparatus and method involves laminate bonding of two non-elastomeric, cyclic olefin copolymer (COC) components having opposing surfaces to be bonded, wherein in a contacted state there is at least one interstitial space between the contacted surfaces, applying an organic latent solvent to at least one of the opposing surfaces, wherein the latent solvent is in an inactive state, contacting the two opposing surfaces together, actively removing the latent solvent from the at least one interstitial space; and adjusting a latent solvency parameter to activate the latent solvent, wherein the opposing contacted surfaces become bonded.
摘要翻译：潜在的溶剂型微流体装置和方法涉及两种具有相互接合表面的非弹性环状烯烃共聚物（COC）组分的层压结合，其中在接触状态下，在接触表面之间存在至少一个间隙空间，一种有机潜溶剂，其中所述潜在溶剂处于非活性状态，使所述两个相对的表面接触在一起，从所述至少一个间隙空间主动去除所述潜在溶剂; 以及调整潜在溶解度参数以激活所述潜在溶剂，其中所述相对的接触表面变粘合。

8. 发明授权

US08609039B2 Microfluidic systems and control methods 有权
标题翻译：微流体系统和控制方法
公开(公告)号：US08609039B2
公开(公告)日：2013-12-17
申请号：US13331211
申请日：2011-12-20
申请人： Peng Zhou , Lincoln C. Young
发明人： Peng Zhou , Lincoln C. Young
IPC分类号： B01L3/00 , F04B19/00 , G01N1/10
CPC分类号： F04B43/043 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0655 , B01L2400/0666 , B01L2400/084 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , F16K2099/0094 , G01N21/5907
摘要： The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.
摘要翻译：本文公开的系统和方法包括微流体系统，其包括具有多个孔的气动歧管和具有设置在其中的通道的芯片歧管，用于将来自相应孔的气动信号路由到微流体芯片中的多个阀，其中通道根据微流体芯片中的多个阀的结构来传送气动信号。

9. 发明授权

US08372355B2 Microfluidic chips and assay systems 有权
公开(公告)号：US08372355B2
公开(公告)日：2013-02-12
申请号：US13111137
申请日：2011-05-19
申请人： Peng Zhou , Lincoln C. Young
发明人： Peng Zhou , Lincoln C. Young
IPC分类号： B01L3/00
CPC分类号： G01N1/28 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0655 , B01L2400/0666 , B01L2400/084 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T436/117497 , Y10T436/2575
摘要： The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.

10. 发明授权

US08323586B2 Microfluidic chips and assay systems 有权
标题翻译：微流控芯片和测定系统
公开(公告)号：US08323586B2
公开(公告)日：2012-12-04
申请号：US13189787
申请日：2011-07-25
申请人： Peng Zhou , Lincoln C. Young
发明人： Peng Zhou , Lincoln C. Young
IPC分类号： B01L3/00
CPC分类号： G01N1/28 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0655 , B01L2400/0666 , B01L2400/084 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T436/117497 , Y10T436/2575
摘要： The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.
摘要翻译：本文所述的系统和方法包括具有互连以提供用于处理至少一种试剂的可配置流体输送系统的多个微特征的微流体芯片。提供插入件可移除地与芯片的一个或多个微特征相配合，其中插入物包括与试剂相互作用的位点。从以下描述可以看出，微流体芯片和插入物提供用于进行平行测定的有效和准确的方法。

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