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1. 发明授权

EP2935215B1 RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION 有权
公开(公告)号：EP2935215B1
公开(公告)日：2019-11-13
申请号：EP13865418.1
申请日：2013-12-20
申请人： Lu, Qing-Bin
发明人： Lu, Qing-Bin
IPC分类号： A61K31/136 , A61K31/44 , A61K31/4965 , A61P35/00 , C07C211/52 , C07D241/20 , C07D213/73

2. 发明公开

EP2935215A1 RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION 有权
标题翻译：放射免疫学家VERBINDUNGEN ZUR VERWENDUNG在KOMBINATION MIT EINER BESTRAHLUNG
公开(公告)号：EP2935215A1
公开(公告)日：2015-10-28
申请号：EP13865418.1
申请日：2013-12-20
申请人： Lu, Qing-Bin
发明人： Lu, Qing-Bin
IPC分类号： C07D213/73 , A61K31/135 , A61K31/44 , A61K31/4965 , A61P35/00 , C07C211/52 , C07D241/20
摘要： Disclosed herein are radiosensitizer compounds useful in combination with radiation therapy, e.g., a synergistic combination therapy for the treatment of cancer and other disorders. The radiosensitizer compounds have the general formula I: wherein A represents an aromatic core; at least one of Ra and Rb is an electron transfer promoter as defined herein, e.g., NH2; and at least one of Rc is a leaving group as defined herein, e.g., halogen; and the remainder of the molecule is as defined herein. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the radiosensitizer compounds are also disclosed.
摘要翻译：本文公开了与放射治疗组合使用的放射增敏剂化合物，例如用于治疗癌症和其它病症的协同组合疗法。放射增敏剂化合物具有通式I：其中A表示芳族核; Ra和Rb中的至少一个是如本文所定义的电子转移促进剂，例如NH 2; 并且R c中的至少一个是如本文所定义的离去基团，例如卤素; 并且分子的其余部分如本文所定义。还公开了包含放射增敏剂化合物的药物组合物，方法，用途，试剂盒和商业包装。

3. 发明公开

EP2935215A4 RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION 有权
标题翻译：放射增敏剂化合物，其用结合辐射
公开(公告)号：EP2935215A4
公开(公告)日：2016-10-26
申请号：EP13865418
申请日：2013-12-20
申请人： LU QING-BIN
发明人： LU QING-BIN
IPC分类号： C07D213/73 , A61K31/136 , A61K31/44 , A61K31/4965 , A61P35/00 , C07C211/52 , C07D241/20
CPC分类号： A61K41/0038 , A61K31/136 , A61K31/44 , A61K31/4965 , A61N2005/1098 , C07C211/52 , C07D213/73 , C07D241/20
摘要： Disclosed herein are radiosensitizer compounds useful in combination with radiation therapy, e.g., a synergistic combination therapy for the treatment of cancer and other disorders. The radiosensitizer compounds have the general formula I: wherein A represents an aromatic core; at least one of Ra and Rb is an electron transfer promoter as defined herein, e.g., NH2; and at least one of Rc is a leaving group as defined herein, e.g., halogen; and the remainder of the molecule is as defined herein. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the radiosensitizer compounds are also disclosed.

4. 发明公开

EP3578176A1 NON-PLATINUM-BASED ANTI-CANCER COMPOUNDS FOR USE IN TARGETED CHEMOTHERAPY 审中-公开
公开(公告)号：EP3578176A1
公开(公告)日：2019-12-11
申请号：EP19188591.2
申请日：2014-10-08
申请人： Lu, Qing-Bin
发明人： Lu, Qing-Bin
IPC分类号： A61K31/136 , A61K31/44 , A61K31/495 , A61K31/4965 , C07D213/73 , C07C211/52 , C07D241/20 , A61P35/00 , A61P1/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P37/06
摘要： Disclosed herein are non-platinum-based (NPB) anti-cancer compounds useful for targeted chemotherapy, e.g., to generate anti-cancer effects for the treatment of cancer and other disorders while having no or minimal toxicity. The compounds have the general formula III:

Wherein X and Y are independently C-R 3 or N; R 1 is a halogen selected from the group of CI, Br, I or F;one of R 2 and R 3 is H, OH, halogen, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl, or heteroaryl, and the other of R 2 and R 3 is H or halogen; wherein each of the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl and heteroaryl moieties is optionally substituted by one or more functional groups selected from the list consisting of hydroxyl, amino, amido, cyano, nitro, carboxyl, ester, ether, ketone, aldehyde, or a combination thereof;or a pharmaceutically acceptable salt thereof.

5. 发明专利

MX2015008010A COMPUESTOS RADIOSENSABILIZADORES PARA USARSE EN COMBINACION CON RADIACION. 未知
公开(公告)号：MX2015008010A
公开(公告)日：2016-04-26
申请号：MX2015008010
申请日：2013-12-20
申请人： LU QING-BIN
发明人： LU QING-BIN
IPC分类号： C07D213/73 , A61K31/135 , A61K31/44 , A61K31/4965 , A61P35/00 , C07C211/52 , C07D241/20
摘要： Se describen aquí compuestos radiosensibilizadores útiles en combinación con la terapia de radiación, por ejemplo una terapia de combinación sinérgica para el tratamiento del cáncer y otros trastornos. Los compuestos radiosensibilizadores tienen la fórmula general I: donde A representa un núcleo aromático; al menos uno de Ra y Rb es una promotor de la transferencia de electrones como se define aquí, por ejemplo, NH2 y al menos un de Rc es un grupo saliente como se define aquí, por ejemplo halógeno; y el resto de la molécula es como se define aquí. También se describen composiciones farmacéuticas, métodos, usos, equipos y paquetes comerciales que comprenden los compuestos radiosensibilizadores.

6. 发明专利

AU2014334461B2 Non-platimun-based anti-cancer compounds for use in targeted chemotherapy 未知
公开(公告)号：AU2014334461B2
公开(公告)日：2019-06-13
申请号：AU2014334461
申请日：2014-10-08
申请人： LU QING BIN
发明人： LU QING-BIN
IPC分类号： C07D213/73 , A61K31/136 , A61K31/44 , A61K31/495 , A61P35/00 , C07C211/52 , C07D241/20
摘要： Disclosed herein are non-platinum-based (NPB) anti-cancer compounds useful for targeted chemotherapy, e.g., to generate anti-cancer effects for the treatment of cancer and other disorders while having no or minimal toxicity. The compounds have the general formula I: (I) wherein A represents an aromatic core; at least one of R

7. 发明专利

CA2895526A1 RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION 未知
公开(公告)号：CA2895526A1
公开(公告)日：2014-06-26
申请号：CA2895526
申请日：2013-12-20
申请人： LU QING-BIN
发明人： LU QING-BIN
IPC分类号： C07D213/73 , A61K31/135 , A61K31/44 , A61K31/4965 , A61P35/00 , C07C211/52 , C07D241/20
摘要： Disclosed herein are radiosensitizer compounds useful in combination with radiation therapy, e.g., a synergistic combination therapy for the treatment of cancer and other disorders. The radiosensitizer compounds have the general formula I: wherein A represents an aromatic core; at least one of Ra and Rb is an electron transfer promoter as defined herein, e.g., NH2; and at least one of Rc is a leaving group as defined herein, e.g., halogen; and the remainder of the molecule is as defined herein. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the radiosensitizer compounds are also disclosed.

8. 发明专利

CA2895526C RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION 未知
公开(公告)号：CA2895526C
公开(公告)日：2021-08-24
申请号：CA2895526
申请日：2013-12-20
申请人： LU QING BIN
发明人： LU QING-BIN
IPC分类号： A61K31/44 , A61K31/136 , A61K31/4965 , A61P35/00
摘要： Disclosed herein are radiosensitizer compounds useful in combination with radiation therapy, e.g., a synergistic combination therapy for the treatment of cancer and other disorders. The radiosensitizer compounds have the general formula: wherein X and Y are independently C-R3 or N; R3 is H, OH, halogen, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl, or heteroaryl; Rl and R2 are, independently, H, OH, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl, heteroaryl, or a leaving group; wherein at least one of Rl and R2 is a leaving group; wherein each of the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl and heteroaryl moieties is optionally substituted; or a pharmaceutically acceptable salt thereof Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the radiosensitizer compounds are disclosed.

9. 发明专利

AU2014334461A1 Non-platimun-based anti-cancer compounds for use in targeted chemotherapy 未知
公开(公告)号：AU2014334461A1
公开(公告)日：2016-04-28
申请号：AU2014334461
申请日：2014-10-08
申请人： LU QING-BIN
发明人： LU QING-BIN
IPC分类号： C07D213/73 , A61K31/136 , A61K31/44 , A61K31/495 , A61P35/00 , C07C211/52 , C07D241/20
摘要： Disclosed herein are non-platinum-based (NPB) anti-cancer compounds useful for targeted chemotherapy, e.g., to generate anti-cancer effects for the treatment of cancer and other disorders while having no or minimal toxicity. The compounds have the general formula I: (I) wherein A represents an aromatic core; at least one of R

10. 发明专利

CA2926571C NON-PLATINUM-BASED ANTI-CANCER COMPOUNDS FOR USE IN TARGETED CHEMOTHERAPY 未知
公开(公告)号：CA2926571C
公开(公告)日：2022-05-17
申请号：CA2926571
申请日：2014-10-08
申请人： LU QING BIN
发明人： LU QING-BIN
IPC分类号： A61K31/136 , A61K31/44 , A61K31/495 , A61P35/00
摘要： Disclosed herein are non-platinum-based (NPB) compounds useful for chemotherapy, for the treatment of cancer while having no or minimal toxicity. The compounds have the general formula: (see above formula) wherein: X and Y are independently C-R3 or N; R1 is a halogen selected from the group of CI, Br, I or F; one of R2 and R3 is H, OH, halogen, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl, or heteroaryl, and the other of R2 and R3 is H or halogen; wherein each of the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl and heteroaryl moieties is optionally substituted by one or more functional groups selected from the list consisting of hydroxyl, amino, amido, cyano, nitro, carboxyl, ester, ether, ketone, aldehyde, or a combination thereof; or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the NPB compounds are disclosed.

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