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1. 发明专利

JP2005151915A Method for producing lysozyme 审中-公开
标题翻译：生产LYSOZYME的方法
公开(公告)号：JP2005151915A
公开(公告)日：2005-06-16
申请号：JP2003397881
申请日：2003-11-27
申请人： Li Min-Shiung , 敏雄李
发明人： LI MINXIONG
IPC分类号： C12N9/24
摘要： PROBLEM TO BE SOLVED: To provide a method for producing useful lysozyme.
SOLUTION: The method for the production of lysozyme contains a step to use diatomaceous earth, china clay, zeolite or their mixture as an adsorbent and mix the adsorbent with albumen liquid or its diluted solution to adsorb the lysozyme and a step to elute the lysozyme from the adsorbent with a solution of a salt. The lysozyme is effectively and selectively adsorbed by the diatomaceous earth, china clay and zeolite and easily eluted with the salt solution. Lysozyme is produced by the method with a simple process in high recovery at a low cost. The unadsorbed albumen liquid is free from contamination with foreign material and safely usable as a food processing material.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供生产有用的溶菌酶的方法。解决方案：生产溶菌酶的方法包括使用硅藻土，瓷土，沸石或其混合物作为吸附剂的步骤，并将吸附剂与蛋清液或其稀释溶液混合以吸附溶菌酶并洗脱一步来自吸附剂的溶菌酶与盐溶液。溶菌酶被硅藻土，瓷土和沸石有效且有选择地吸附，并易溶于盐溶液。通过该方法以低成本高回收率的简单方法生产溶菌酶。未吸收的白蛋白液体不含异物污染物，可安全用作食品加工材料。版权所有（C）2005，JPO＆NCIPI

2. 发明公开

EP3466961A1 PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF 有权转让
公开(公告)号：EP3466961A1
公开(公告)日：2019-04-10
申请号：EP18208270.1
申请日：2011-11-04
申请人： Li, Min
发明人： Li, Min , Shan, Hanbin , Huang, Yu , Yuan, Zhedong , Yu, Xiong
IPC分类号： C07K5/078 , A61K38/04 , A61K31/401 , A61P7/02
摘要： Provided are two N-protected D-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide compounds, pharmaceutically acceptable salts thereof, preparation methods and these compounds for use in inhibiting thrombin, and for use in the treatment and prevention of thrombin-mediated and thrombin-related diseases.

3. 发明公开

EP3151785A4 DEVICES AND METHODS FOR RESHAPING BLOOD VESSELS 有权转让
公开(公告)号：EP3151785A4
公开(公告)日：2017-12-20
申请号：EP15805768
申请日：2015-06-08
申请人： KONSTANTINO EITAN , BINYAMIN GARY , WIESNER STEVEN , KOH LI MIN
发明人： KONSTANTINO EITAN , BINYAMIN GARY , WIESNER STEVEN , KOH LI MIN
IPC分类号： A61B17/064 , A61B17/12
CPC分类号： A61B17/12109 , A61B17/0644 , A61B17/068 , A61B17/12 , A61B17/12036 , A61B17/12145 , A61B2017/00778 , A61B2017/00867 , A61B2017/0406 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0443 , A61B2017/0464 , A61B2017/06052 , A61B2017/06171 , A61B2017/0649 , A61F2/2442 , A61F2/2475 , A61F2/26 , A61F5/41 , A61F2002/068 , A61F2220/0008
摘要： Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction.

4. 发明公开

EP1637152A4 A NOTOGINSENG SAPONIN INTRAVENOUS INJECTION AND THE METHOD FOR PREPARING THIS INJECTION 失效转让
标题翻译：静脉注射三七皂苷注射液和方法制备本注射液
公开(公告)号：EP1637152A4
公开(公告)日：2006-03-22
申请号：EP04729596
申请日：2004-04-27
申请人： LI MIN PHARMACEUTICAL FACTORY
发明人： XIE WEIHONG , LIU XUEHUA , CHEN MAORU
IPC分类号： A61K31/704 , A61K36/258 , A61P9/10
CPC分类号： A61K36/258 , A61K2300/00
摘要： The present invention discloses a notoginseng saponin large capacity intravenous injection and the method for preparing this injection. The injection of the present invention consists of notoginseng saponin, isoosmotic agent, PH regulator; the solvent of the injection is injection distilled water. A refined injection is prepared through dissolving isoosmotic agent by injection distilled water; adding acticarbon, filtering; adding notoginseng saponin in the filtertes, agitating to dissolution; adding PH regulator, filtering to clarification, asepticizing, packing, then notoginseng saponin large capacity intravenous injection is prepared.

5. 发明公开

EP1532884A3 An illuminant imitation plant and a method making same 有权
标题翻译：明亮的人工植物和方法，它们的制备方法
公开(公告)号：EP1532884A3
公开(公告)日：2006-01-11
申请号：EP04257138.0
申请日：2004-11-17
申请人： Liu, Li Min
发明人： Liu, Li Min
IPC分类号： A41G1/00
CPC分类号： A41G1/005 , Y10S362/805
摘要： An illuminating imitation plant, comprising a stem, twigs and leaves. Said stem is made as the pattern of a real plant stem and stem light circles and light bands are arranged outside or inside the stem at intervals; the elastic supporting rod is installed in the middle of said stem and interposes pin said stem; meanwhile, the illuminant bodies are installed inside twigs on which multiple leaves are distributed; said leaves imitate the natural leaves and colors and show natural flexible patterns and are also inserted with elastic strips and with distributed light bands made of illuminant bodies and photo conducting materials. The twigs and leaves are ideally elastic and flexible especially can wobble vividly when it is breezy. They also glow more evenly and dimly and the effects of night illuming and decorating are excellent.

6. 发明公开

EP3151785A1 DEVICES AND METHODS FOR RESHAPING BLOOD VESSELS 有权转让
标题翻译：用于重新放置血管的装置和方法
公开(公告)号：EP3151785A1
公开(公告)日：2017-04-12
申请号：EP15805768.7
申请日：2015-06-08
申请人： Konstantino, Eitan , Binyamin, Gary , Wiesner, Steven , Koh, Li Min
发明人： Konstantino, Eitan , Binyamin, Gary , Wiesner, Steven , Koh, Li Min
IPC分类号： A61F2/24
摘要： Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction.
摘要翻译：静脉和其他血管可以通过利用定位在壁的相对侧上的锚定器通过血管壁引入植入物来重新成形。锚具通常包括具有形成于其中的线圈或其他锚定件的细长主体。植入物可以使用能够在外部或内部保持锚的套管经皮输送。该方法和装置可用于治疗背静脉以减少勃起功能障碍患者的血流量。

7. 发明公开

EP3142711A1 ANTIMICROBIAL DEVICES FOR USE WITH MEDICAL DEVICES AND RELATED ASSEMBLIES AND METHODS 审中-公开
标题翻译：抗菌设备对于医疗器械及相关安排和程序使用
公开(公告)号：EP3142711A1
公开(公告)日：2017-03-22
申请号：EP14891838.6
申请日：2014-05-14
申请人： Health Line International Corp. , She, Li Min , Faulkner, Joel K. , Jie, Zhao , Faulkner, Aaron Garcia
发明人： SHE, Li Min , FAULKNER, Joel, K. , JIE, Zhao , FAULKNER, Aaron, Garcia
IPC分类号： A61L2/16 , A61J1/05 , A61M35/00
CPC分类号： A61M25/00 , A61M5/001 , A61M39/162 , A61M39/20 , A61M2025/0019 , A61M2209/10
摘要： Antimicrobial devices for use with at least a portion of a medical device include at least one flexible portion configured to secure the antimicrobial device to the at least a portion of the medical device. Medical device assemblies include an access port configured to at least one of sample fluid from a subject and deliver fluid to a subject and an antimicrobial device adapted to disinfect at least a portion of the access port. Methods of disinfecting a portion of a device include deforming a housing of the antimicrobial device to couple the antimicrobial device to the portion of the device.
摘要翻译：用于与医疗装置的至少一部分使用抗菌装置包括配置成将所述抗微生物装置固定到医疗装置的至少一个部分的至少一个柔性部分。医疗装置组件包括在来自受试者配置成样品流体中的至少一个进入端口和将流体输送到对象，并抗微生物装置angepasst消毒至少所述接入端口的一部分。消毒装置的一部分的方法包括变形抗菌装置的外壳以耦接该抗微生物装置到所述装置的一部分。

8. 发明公开

EP2916130A1 METHOD FOR ESTABLISHING SHENQI FUZHENG INJECTION FINGERPRINT SPECTRUM 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES深圳市福田兴业有限公司 - FINGERABDRUCKSPEKTRUMS
公开(公告)号：EP2916130A1
公开(公告)日：2015-09-09
申请号：EP13851081.3
申请日：2013-11-01
申请人： Li Min Pharmaceutical Factory of Livzon Pharmceutical Group
发明人： SONG, Yangang , LIU, Xuehua , HUANG, Wenhua , LIU, Donglai
IPC分类号： G01N30/02 , G01N30/72 , G01N33/15
CPC分类号： G01N30/8686 , G01N30/7233 , G01N33/15 , G01N2030/8813
摘要： A method for establishing a Shenqi Fuzheng injection fingerprint spectrum, comprising: employing an ultra-high voltage liquid chromatography mass spectrometer to test the Shenqi Fuzheng injection, the chromatography conditions including: chromatographic column: Agilent Zorbax Eclipse Plus C18, 2.1 mm x 100 mm, 1.8 µm; mobile phase: mobile phase A is 0.1 % formic acid aqueous solution, and mobile phase B is 0.1% formic acid acetonitrile solution; employing gradient elution procedure as follows: 0-0.5 min, 95% of mobile phase A, and 5% of mobile phase B; 0.5-10 min, 95%-75% of mobile phase A, and 5%-25% of mobile phase B; 10-15 min, 75%-45% of mobile phase A, and 25%-55% of mobile phase B; 15-18 min, 45%-0% of mobile phase A, and 55%-100% of mobile phase B; and 18-20 min, 0% of mobile phase A, and 100% of mobile phase B.
摘要翻译：一种建立神奇福正注射指纹谱的方法，包括：采用超高压液相色谱质谱仪对沉奇福正注射液进行检测，色谱条件为：色谱柱：Agilent Zorbax Eclipse Plus C18,2.1mm×100mm， 1.8μm; 流动相：流动相A为0.1％甲酸水溶液，流动相B为0.1％甲酸乙腈溶液; 采用梯度洗脱程序如下：0-0.5分钟，95％流动相A和5％流动相B; 0.5-10分钟，95％-75％流动相A和5％-25％流动相B; 10-15分钟，75％-45％流动相A和25％-55％流动相B; 15-18分钟，流动相A为45％-0％，流动相B为55％-100％; 和18-20分钟，流动相A为0％，流动相B为100％。

9. 发明公开

EP2824097A1 Prolinamide derivative as thrombin inhibitor, preparation method and application thereof 审中-公开
标题翻译： Prolinamidderivat als Thrombinhemmer，Herstellungsverfahren und Anwendung davon
公开(公告)号：EP2824097A1
公开(公告)日：2015-01-14
申请号：EP14183844.1
申请日：2011-11-04
申请人： Shanghai Institute of Pharmaceutical Industry , Li, Min
发明人： Li, Min , Shan, Hanbin , Huang, Yu , Yuan, Zhedong , Yu, Xiong
IPC分类号： C07D207/16 , C07D295/104 , C07D401/12 , A61K31/397 , A61K31/401 , A61P7/02
CPC分类号： C07K5/0215 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61K38/06 , A61K47/12 , A61K47/38 , C07D205/04 , C07D207/16 , C07D211/60
摘要： Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.
摘要翻译：提供式（I）的化合物，其药学上可接受的盐，其用于抑制凝血酶的制备方法和应用，以及在治疗和预防凝血酶介导的凝血酶相关疾病中的应用。

10. 发明授权

EP1637152B1 A NOTOGINSENG SAPONIN INTRAVENOUS INJECTION AND THE METHOD FOR PREPARING THIS INJECTION 失效转让
标题翻译：静脉注射三七皂苷注射液和方法制备本注射液
公开(公告)号：EP1637152B1
公开(公告)日：2011-08-10
申请号：EP04729596.9
申请日：2004-04-27
申请人： Li Min Pharmaceutical Factory of Livzon Pharmceutical Group
发明人： XIE, Weihong , LIU, Xuehua , CHEN, Maoru
IPC分类号： A61K36/258
CPC分类号： A61K36/258 , A61K2300/00
摘要： The present invention discloses a notoginseng saponin large capacity intravenous injection and the method for preparing this injection. The injection of the present invention consists of notoginseng saponin, isoosmotic agent, PH regulator; the solvent of the injection is injection distilled water. A refined injection is prepared through dissolving isoosmotic agent by injection distilled water; adding acticarbon, filtering; adding notoginseng saponin in the filtertes, agitating to dissolution; adding PH regulator, filtering to clarification, asepticizing, packing, then notoginseng saponin large capacity intravenous injection is prepared.

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