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1. 发明申请

WO2006035243A1 TOY PLAY SET 审中-公开
标题翻译：玩具集
公开(公告)号：WO2006035243A1
公开(公告)日：2006-04-06
申请号：PCT/GB2005/003784
申请日：2005-09-30
申请人： CARTERBENCH PRODUCT DEVELOPMENT, LTD. , COLLINS, Gary , LAU, Stephen , KAY, Robert , NEEDHAM, Andrew
发明人： COLLINS, Gary , LAU, Stephen , KAY, Robert , NEEDHAM, Andrew
IPC分类号： A63F1/00 , A63F1/06
CPC分类号： A63F1/02 , A63F1/06 , A63F1/062 , A63F2001/025
摘要： A toy play set (10, 110) contains a set of playing cards (50) used to play at least one predetermined card game. The toy play set includes a generally elongated body (11, 111) having a closed configuration in which ends (1lb, 11c, 111b, 111c) and a side wall (11d, 111d) generally surround a hollow interior (11a, 111a) and an open configuration in which the hollow interior is at least partially accessible. The cards are identically shaped and sized and sufficiently small to be completely stored within the body in its closed configuration. The body includes an internal spindle (34, 134), and each of the cards has an opening (52) allowing it to be mounted on the spindle.
摘要翻译：玩具玩具集（10,110）包含一组用于播放至少一个预定纸牌游戏的扑克牌（50）。玩具游戏机包括具有闭合构型的大致细长的主体（11,111），其中端部（11b，11c，111b，111c）和侧壁（11d，111d）通常围绕中空的内部（11a，111a）和其中中空内部至少部分可接近的打开构造。这些卡具有相同的形状和尺寸并且足够小以在其闭合构型中完全储存在身体内。主体包括内部主轴（34,134），并且每个卡具有允许其安装在主轴上的开口（52）。

2. 发明申请

WO2006047455A3 TOY PLAY SET 审中-公开
公开(公告)号：WO2006047455A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/038262
申请日：2005-10-21
申请人： MATTEL, INC. , COLLINS, Gary , LAU, Stephen
发明人： COLLINS, Gary , LAU, Stephen
IPC分类号： A63H33/08
摘要： A toy play set (10) for use in a vehicle having a beverage cup holder (80) includes a body (11) having first and second opposing ends (11a, 11b) and a side wall (11c) extending therebetween defining an at least partially hollow cavity (11d) within the body. The body has in a closed configuration (16) at least the first end sized and shaped to fit at least partially into the cup holder sufficiently for the cup holder to support the body in a first generally upright orientation (20) with the second end forming a top end of the body. The body has an open configuration (18) in which the hollow cavity is at least partially accessible. A tank (30) with a pump (33) is disposed within the body and is capable of being at least partially filled with a fluid (50) in order to play at least one predetermined game.

3. 发明申请

WO2006047309A2 TOY PLAY SET 审中-公开
标题翻译：玩具集
公开(公告)号：WO2006047309A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/037947
申请日：2005-10-20
申请人： MATTEL, INC. , COLLINS, Gary , LAU, Stephen , O'BRYAN, Alan
发明人： COLLINS, Gary , LAU, Stephen , O'BRYAN, Alan
IPC分类号： A63H33/04
CPC分类号： A63H18/02
摘要： A toy play set (10, 110, 210) for use in a vehicle having a beverage cup holder (80) includes a body (11, 111, 211) having first and second opposing ends (11a, 11b) and a side wall (11c) therebetween, which define and generally surround an at least partially hollow cavity (11d, 111d, 211d) within the body in a closed configuration (17) of the body. In the closed configuration, at least the first end is sized and shaped to fit at least partially into the cup holder sufficiently for the cup holder to support the body in a generally upright orientation (15). The body has an open configuration (18, 118, 218) in which the hollow cavity is at least partially accessible. A track (20, 120, 220) is sized and configured for storage within the cavity of the body in the closed configuration. The track is engaged with the body for play in the open configuration.
摘要翻译：一种用于具有饮料杯架（80）的车辆中的玩具组（10,110,210）包括具有第一和第二相对端（11a，11b）和侧壁（11,111,211）的主体（11,111,211） 11c），其限定并且大致围绕主体的封闭构造（17）内的至少部分中空的空腔（11d，111d，211d）。在封闭构造中，至少第一端的尺寸和形状至少部分地装配到杯架中，以使杯保持器以大致直立的方向（15）支撑身体。主体具有打开构型（18,118,218），其中中空腔至少部分可接近。轨道（20,120,220）的尺寸和构造适于在关闭构型中存储在身体的空腔内。轨道与身体接合，以打开配置进行播放。

4. 发明申请

WO2010011584A3 PROCESS FOR MAKING A RENIN INHIBITOR AND RELATED INTERMEDIATES 审中-公开
标题翻译：制备瑞宁抑制剂及相关中间体的方法
公开(公告)号：WO2010011584A3
公开(公告)日：2010-07-29
申请号：PCT/US2009051101
申请日：2009-07-20
申请人： MERCK SHARP & DOHME , MERCK FROSST CANADA LTD , ANGELAUD REMY , DAVIES IAN , MAGUIRE COURTNEY , LAU STEPHEN , O'SHEA PAUL , SHULTZ SCOTT
发明人： ANGELAUD REMY , DAVIES IAN , MAGUIRE COURTNEY , LAU STEPHEN , O'SHEA PAUL , SHULTZ SCOTT
IPC分类号： C07D213/643
CPC分类号： C07D213/643
摘要： A salt of the compound (3'R,4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide selected from the group consisting of monoacetate salt and bis-D-tartrate salt. In one embodiment of the invention, the salt is (3',4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide monoacetate. In one embodiment of the invention, the salt is (3'R, 4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide bis-D-tartrate. The invention also describes a asymmetric synthesis of (3'R, 4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide as a monoacetate salt or as a bis-D-tartrate salt.
摘要翻译：化合物（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4'，5' 6'-六氢 - [3,4']联吡啶基-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基酰胺，其选自单乙酸盐和双 - D-酒石酸盐。在本发明的一个实施方案中，盐是（3'，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4' ，5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺单乙酸酯。在本发明的一个实施方案中，盐是（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4 '，5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺双-D-酒石酸盐。本发明还描述了（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4' 5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺，为单乙酸盐或二 -D-酒石酸盐。

5. 发明申请

WO2008088690A3 A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS 审中-公开
公开(公告)号：WO2008088690A3
公开(公告)日：2008-07-24
申请号：PCT/US2008/000224
申请日：2008-01-08
申请人： MERCK & CO., INC. , MERCK FROSST CANADA LTD. , GAUVREAU, Danny , HUFFMAN, Mark, A. , HUGHES, Greg , ITOH, Tetsuji , YIN, Jingjun , LAU, Stephen , O'SHEA, Paul
发明人： GAUVREAU, Danny , HUFFMAN, Mark, A. , HUGHES, Greg , ITOH, Tetsuji , YIN, Jingjun , LAU, Stephen , O'SHEA, Paul
IPC分类号： C07D471/08 , C07C237/20
摘要： The invention is a process for preparing a diazabicyclo compound of formula (I) process for preparing a diazabicyclo compound of formula (I):where X is selected from the group consisting of hydrogen, C 1 -C 6 alkoxycarbonyl, and carbobenzyloxy; R 6 is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and benzyl; and R 9 , R 10 , and R 11 are independently selected from the group consisting of hydrogen, halogen, and C 1 -C 6 alkyl. wherein the process involves cyclizing I-I, formula (II).

6. 发明申请

WO2006047197B1 TRAVEL GAME 审中-公开
标题翻译：旅行游戏
公开(公告)号：WO2006047197B1
公开(公告)日：2006-08-17
申请号：PCT/US2005037683
申请日：2005-10-18
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN
发明人： COLLINS GARY , LAU STEPHEN
IPC分类号： A63F3/00
CPC分类号： A63F3/0023 , A63F2003/00233 , A63F2003/00255 , A63F2003/00293 , A63F2003/00949 , A63F2250/602
摘要： A toy set (10, 110) for containing at least one predetermined board game includes a generally elongated body (11, 111) having a hollow interior (11a, 111a), first and second opposing longitudinal ends (11b, 11c, 111b, 111c), and a generally curved side wall (11d, 111d) extending around the hollow interior between the first and second ends. The first and second ends and side wall generally surround the hollow interior in a closed configuration (30, 130) of the body. The body has an open configuration (32, 132) in which the hollow interior is at least partially accessible. A playing surface (20, 120) is operably engaged with the body and is configured to play the predetermined board game. The playing surface is shaped and sized to enable the playing surface to be completely stored within the hollow interior of the body with the body in the closed configuration. The playing surface is accessible at least with the body in the open configuration to play the predetermined board game.
摘要翻译：一种用于容纳至少一个预定棋盘游戏的玩具装置（10,110），包括具有中空内部（11a，111a）的大致细长主体（11,111），第一和第二相对纵向端部（11b，11c，111b，111c ）以及围绕第一端和第二端之间的中空内部延伸的大致弯曲的侧壁（11d，111d）。第一和第二端以及侧壁通常围绕主体的闭合构造（30,130）的中空内部。本体具有开放构型（32,132），其中中空内部至少部分可接近。游戏表面（20,120）可操作地与主体接合并且被配置为玩预定的棋盘游戏。游戏表面的形状和尺寸被确定为使得游戏表面能够在主体处于关闭配置的情况下被完全存储在主体的中空内部中。至少在打开配置中的身体可以进入比赛场地以进行预定的棋盘游戏。

7. 发明申请

WO2008088690A2 A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS 审中-公开
标题翻译：制备DIAZABICYCLO [3.3.1] NONANE化合物的方法
公开(公告)号：WO2008088690A2
公开(公告)日：2008-07-24
申请号：PCT/US2008000224
申请日：2008-01-08
申请人： MERCK & CO INC , MERCK FROSST CANADA LTD , GAUVREAU DANNY , HUFFMAN MARK A , HUGHES GREG , ITOH TETSUJI , YIN JINGJUN , LAU STEPHEN , O'SHEA PAUL
发明人： GAUVREAU DANNY , HUFFMAN MARK A , HUGHES GREG , ITOH TETSUJI , YIN JINGJUN , LAU STEPHEN , O'SHEA PAUL
IPC分类号： C07D471/08 , C07C237/20
CPC分类号： C07C237/20 , C07D471/08
摘要： The invention is a process for preparing a diazabicyclo compound of formula (I) process for preparing a diazabicyclo compound of formula (I):where X is selected from the group consisting of hydrogen, C 1 -C 6 alkoxycarbonyl, and carbobenzyloxy; R 6 is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and benzyl; and R 9 , R 10 , and R 11 are independently selected from the group consisting of hydrogen, halogen, and C 1 -C 6 alkyl. wherein the process involves cyclizing I-I, formula (II).
摘要翻译：本发明是制备式（I）的二氮杂双环化合物的方法，用于制备式（I）的二氮杂双环化合物：其中X选自氢，C 1 -C 3烷基，烷氧基羰基和苄氧羰基; R 6选自C 1 -C 6 -C 6烷基，C 2 -C 6亚烷基，C 2 -C 6亚烷基 > 6 链烯基和苄基; R 9，R 10和R 11独立地选自氢，卤素和C 1〜 / C 1 -C 6烷基。其中该方法涉及使I-I，式（II）环化。

8. 发明申请

WO2006047455B1 TOY PLAY SET 审中-公开
标题翻译：玩具集
公开(公告)号：WO2006047455B1
公开(公告)日：2006-11-02
申请号：PCT/US2005038262
申请日：2005-10-21
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN
发明人： COLLINS GARY , LAU STEPHEN
IPC分类号： A63H33/08
CPC分类号： G09F19/08 , A63F7/045 , A63F2009/0012 , A63F2009/0033 , A63F2250/0414 , A63H23/16 , A63H33/00
摘要： A toy play set (10) for use in a vehicle having a beverage cup holder (80) includes a body (11) having first and second opposing ends (11a, 11b) and a side wall (11c) extending therebetween defining an at least partially hollow cavity (11d) within the body. The body has in a closed configuration (16) at least the first end sized and shaped to fit at least partially into the cup holder sufficiently for the cup holder to support the body in a first generally upright orientation (20) with the second end forming a top end of the body. The body has an open configuration (18) in which the hollow cavity is at least partially accessible. A tank (30) with a pump (33) is disposed within the body and is capable of being at least partially filled with a fluid (50) in order to play at least one predetermined game.
摘要翻译：一种用于具有饮料杯架（80）的车辆中的玩具玩具组（10）包括具有第一和第二相对端（11a，11b）的主体（11）和在其间延伸的侧壁（11c），至少限定了至少在体内部分中空的空腔（11d）。主体具有封闭构造（16），至少第一端的尺寸和形状至少部分地装配到杯架中，以使杯架能够以第一大致直立的方向（20）支撑身体，第二端形成身体的顶端。主体具有打开构造（18），其中中空腔至少部分可接近。具有泵（33）的罐（30）设置在主体内并且能够至少部分地填充有流体（50）以便发挥至少一个预定游戏。

9. 发明申请

WO2006047309A3 TOY PLAY SET 审中-公开
标题翻译：玩具套装
公开(公告)号：WO2006047309A3
公开(公告)日：2006-07-27
申请号：PCT/US2005037947
申请日：2005-10-20
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN , O'BRYAN ALAN
发明人： COLLINS GARY , LAU STEPHEN , O'BRYAN ALAN
IPC分类号： A63H18/00
CPC分类号： A63H18/02
摘要： A toy play set (10, 110, 210) for use in a vehicle having a beverage cup holder (80) includes a body (11, 111, 211) having first and second opposing ends (11a, 11b) and a side wall (11c) therebetween, which define and generally surround an at least partially hollow cavity (11d, 111d, 211d) within the body in a closed configuration (17) of the body. In the closed configuration, at least the first end is sized and shaped to fit at least partially into the cup holder sufficiently for the cup holder to support the body in a generally upright orientation (15). The body has an open configuration (18, 118, 218) in which the hollow cavity is at least partially accessible. A track (20, 120, 220) is sized and configured for storage within the cavity of the body in the closed configuration. The track is engaged with the body for play in the open configuration.
摘要翻译：一种用于具有饮料杯保持器（80）的车辆中的玩具游戏装置（10,110,210），包括具有第一和第二相对端部（11a，11b）和侧壁（11a，11b）的主体（11,111,211） 11c），其在主体的闭合构造（17）中限定并且大致围绕在主体内的至少部分中空的空腔（11d，111d，211d）。在关闭构造中，至少第一端的尺寸和形状被设计为至少部分地适合杯托，以使杯托以大致直立方向（15）支撑主体。该主体具有开放构型（18,118,218），其中空腔至少部分可进入其中。轨道（20,120,220）的尺寸和构造被设置为在闭合构造中存储在身体的腔内。轨道在开放配置下与身体接合以便玩耍。

10. 发明申请

WO2010011584A2 PROCESS FOR MAKING A RENIN INHIBITOR 审中-公开
标题翻译：制备阮宁抑制剂的方法
公开(公告)号：WO2010011584A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051101
申请日：2009-07-20
申请人： MERCK & CO., INC. , MERCK FROSST CANADA LTD. , ANGELAUD, Remy , DAVIES, Ian , MAGUIRE, Courtney , LAU, Stephen , O'SHEA, Paul , SHULTZ, Scott
发明人： ANGELAUD, Remy , DAVIES, Ian , MAGUIRE, Courtney , LAU, Stephen , O'SHEA, Paul , SHULTZ, Scott
IPC分类号： C07D213/643
CPC分类号： C07D213/643
摘要： A salt of the compound (3 'R ,4 'S )-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide selected from the group consisting of monoacetate salt and bis-D-tartrate salt. In one embodiment of the invention, the salt is (3 ', 4' S )-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide monoacetate. In one embodiment of the invention, the salt is (3 'R , 4 'S )-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide bis-D-tartrate. The invention also describes a asymmetric synthesis of (3'R, 4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide as a monoacetate salt or as a bis-D-tartrate salt.
摘要翻译：化合物（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4'，5' 6'-六氢 - [3,4']联吡啶基-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基酰胺，其选自单乙酸盐和双 - D-酒石酸盐。在本发明的一个实施方案中，盐是（3'，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4' ，5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺单乙酸酯。在本发明的一个实施方案中，盐是（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4 '，5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺双-D-酒石酸盐。本发明还描述了（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4' 5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺，为单乙酸盐或二 -D-酒石酸盐。

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