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    • 5. 发明申请
    • Methods for improving glycemic control in humans
    • 改善人体血糖控制的方法
    • US20090076111A1
    • 2009-03-19
    • US11975192
    • 2007-10-18
    • Steve S. LeeRichard B. HynsonKe-Qin ZhangWu-Zhou LiJing Shi Zhou
    • Steve S. LeeRichard B. HynsonKe-Qin ZhangWu-Zhou LiJing Shi Zhou
    • A61K31/197A61P3/00A61K31/4172
    • A61K31/198A61K31/401A61K31/4745A61K36/48A61K2300/00
    • The present invention is directed to methods for improving glycemic control in humans and animals comprising the step of administering a composition comprising an amino acid content including 4-hydroxyisoleucine in an amount between about 60% and about 70% of a total weight of the amino acid content, together with one or more amino acids selected from the group consisting of glutamate, aspartate, arginine, cysteine, threonine, serine, glycine, alanine, valine, methionine, isoleucine, and histidine (inclusive of any chemical salts, anhydrides, or isomers of any of the foregoing), in addition to, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Fasting blood glucose and glucose tolerance were studied in normal human subjects, in human subjects diagnosed with Metabolic Syndrome X, and in diabetic rats by means of dosing the subjects with compositions comprising 4-hydroxyisoleucine in an amount between about 20% and about 30% of the total weight of the composition, wherein improving glycemic control in standard glucose tolerance tests.
    • 本发明涉及用于改善人和动物血糖控制的方法,包括以下步骤:施用含有包含4-羟基异亮氨酸的氨基酸含量的组合物,其量为氨基酸总重量的约60%至约70% 含有一种或多种选自谷氨酸,天冬氨酸,精氨酸,半胱氨酸,苏氨酸,丝氨酸,甘氨酸,丙氨酸,缬氨酸,甲硫氨酸,异亮氨酸和组氨酸的氨基酸(包括任何化学盐,酸酐或异构体 除了生物碱,糖苷,挥发性油,皂角苷,皂甙元,甘露聚糖,类黄酮,脂肪酸,维生素和维生素,矿物质和碳水化合物之外。 在正常人受试者,诊断为代谢综合征X的人类受试者中以及在糖尿病大鼠中通过给受试者给予包含4-羟基异亮氨酸的组合物的空腹血糖和葡萄糖耐量在约20%至约30%之间的量 组合物的总重量,其中改善标准葡萄糖耐量试验中的血糖控制。
    • 6. 发明申请
    • Methods for supporting metabolism and transportation of glucose and carbohydrates into muscle
    • 支持葡萄糖和碳水化合物进入肌肉的代谢和运输的方法
    • US20050053679A1
    • 2005-03-10
    • US10902219
    • 2004-07-29
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • A61K35/78
    • A61K36/48
    • Methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells are taught. Preferably, the methods include the step of administering a composition of bio-active compounds further including 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate. In one presently preferred embodiment of the present invention, the bio-active compounds are extracted from fenugreek seeds. The methods of the present invention preferably include a composition of bio-active compounds with between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids. In presently preferred embodiments of the present invention, methods may work independently of or synergistically with insulin to stimulate the activity of glucose transport receptors located in muscle. More particularly, methods of the present invention may stimulate the activity of glucose transport receptor type 4.
    • 教导促进和支持葡萄糖和碳水化合物进入肌肉细胞的代谢和转运的方法。 优选地,所述方法包括施用进一步包含4-羟基异亮氨酸和一种或多种选自精氨酸,天冬氨酸,苏氨酸,丝氨酸,谷氨酸,脯氨酸,甘氨酸,丙氨酸,半胱氨酸的氨基酸的生物活性化合物组合物的步骤 ,缬氨酸,甲硫氨酸,异亮氨酸,亮氨酸,色氨酸,苯丙氨酸,鸟氨酸,赖氨酸,组氨酸和γ-氨基丁酸酯。 在本发明的一个目前优选的实施方案中,从葫芦巴种子中提取生物活性化合物。 本发明的方法优选包括具有约10%至70%的4-羟基异亮氨酸和约20%至40%的氨基酸的生物活性化合物的组合物。 在本发明目前优选的实施方案中,方法可以与胰岛素独立地或协同地起作用以刺激位于肌肉中的葡萄糖转运受体的活性。 更具体地,本发明的方法可以刺激4型葡萄糖转运受体的活性。
    • 7. 发明授权
    • Method and apparatus for conducting an interactive design conference over the internet
    • 通过互联网进行交互式设计会议的方法和装置
    • US06809749B1
    • 2004-10-26
    • US09563658
    • 2000-05-02
    • Tsung-Yen ChenKe-Qin GuChing-Chih HanKuo-Chun Lee
    • Tsung-Yen ChenKe-Qin GuChing-Chih HanKuo-Chun Lee
    • G06F1300
    • H04L12/1813H04L67/02H04L67/142H04L69/329
    • A method of conducting an interactive design conference over the Internet, comprises: selectively admitting clients communicating through web browsers over the Internet to an interactive design conference; receiving a graphics file indicative of a design from one of the clients; and transmitting the graphics file to the other clients so as to be viewable as a graphics image through graphics file readers in the client web browsers. The graphics file is generated by a snapshot program previously transmitted to a client initiating the design conference and controlling the design database. Java applets are transmitted to each of the design conference participants to facilitate communicating annotations of the graphics image and messages between clients through their web browsers.
    • 一种通过因特网进行交互式设计会议的方法,包括:通过互联网选​​择性地将通过网络浏览器进行通信的客户端接入交互式设计会议; 从一个客户端接收指示设计的图形文件; 并将图形文件传输到其他客户端,以便通过客户端Web浏览器中的图形文件读取器可视为图形图像。 图形文件由先前发送到客户端的快照程序生成,启动设计会议并控制设计数据库。 将Java小程序传送到每个设计会议参与者,以便于通过其Web浏览器在客户端之间传递图形图像的注释和消息。
    • 9. 发明申请
    • Methods for deriving, isolating, and/or extracting amino acid compositions from Fenugreek seed
    • 从葫芦巴种子得到,分离和/或提取氨基酸组合物的方法
    • US20050238738A1
    • 2005-10-27
    • US11069747
    • 2005-03-01
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • A61K36/286A61K36/48A61K36/55A61K36/88A61K36/8962A61K36/9066A61K35/78
    • A61K36/48A61K36/286A61K36/55A61K36/88A61K36/8962A61K36/9066A61K2300/00
    • The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
    • 本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸,生物碱,糖苷,挥发性油,皂角苷,皂甙元,甘露聚糖,类黄酮,脂肪酸,维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物, 维生素,矿物质和碳水化合物。 优选地,生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸,天冬氨酸,苏氨酸,丝氨酸,谷氨酸,脯氨酸,甘氨酸,丙氨酸,半胱氨酸,缬氨酸,甲硫氨酸,异亮氨酸, 亮氨酸,色氨酸,苯丙氨酸,鸟氨酸,脯氨酸,赖氨酸,组氨酸和γ-氨基丁酸。 生物活性化合物的组合物优选包括约10%至约70%的4-羟基异亮氨酸和约20%至约40%的其它氨基酸。 本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生,分离和/或提取。 从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤:(1)提供多种葫芦巴种子; (2)准备葫芦巴种子; (3)从葫芦巴种子中提取生物活性化合物的新组合物,其中包括初步提取步骤和二次提取步骤。 已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡,帮助体重管理工作,以及通过协助身体更有效地利用现有的(例如, ,内源性)胰岛素。
    • 10. 发明申请
    • Methods for enhancing the transport of glucose for balancing blood sugar levels
    • 用于增强血糖运输以平衡血糖水平的方法
    • US20050233013A1
    • 2005-10-20
    • US11068734
    • 2005-03-01
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • Steve LeeRichard HynsonKe-Qin ZhangWu-Zhou LiJing Zhou
    • A61K31/198A61K31/401A61K31/405A61K31/4172A61K35/78
    • A61K31/401A61K31/202A61K31/40A61K31/404A61K31/405A61K31/4172A61K31/436A61K31/44A61K31/4425A61K31/445A61K31/495A61K36/48A61K45/06A61K2236/39A61K31/198A61K2300/00
    • The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.
    • 本发明涉及包含4-羟基异亮氨酸和一种或多种选自氨基酸,生物碱,糖苷,挥发性油,皂角苷,皂甙元,甘露聚糖,类黄酮,脂肪酸,维生素和/或其中的一种或多种化合物的生物活性化合物的新组合物, 维生素,矿物质和碳水化合物。 优选地,生物活性化合物的新组合物包括4-羟基异亮氨酸和一种或多种选自精氨酸,天冬氨酸,苏氨酸,丝氨酸,谷氨酸,脯氨酸,甘氨酸,丙氨酸,半胱氨酸,缬氨酸,甲硫氨酸,异亮氨酸, 亮氨酸,色氨酸,苯丙氨酸,鸟氨酸,脯氨酸,赖氨酸,组氨酸和γ-氨基丁酸。 生物活性化合物的组成优选包括约10%至约70%的4-羟基异亮氨酸和约20%至约40%的其它氨基酸。 本发明的新型组合物的生物活性化合物可以从胡芦巴种子中衍生,分离和/或提取。 从葫芦巴种子提取生物活性化合物的优选方法包括以下步骤:(1)提供多种葫芦巴种子; (2)准备葫芦巴种子; (3)从葫芦巴种子中提取生物活性化合物的新组合物,其中包括初步提取步骤和二次提取步骤。 已经发现生物活性化合物的组合有助于恢复人和动物中的健康能量平衡,帮助体重管理工作,以及通过协助身体更有效地利用现有的(例如, ,内源性)胰岛素。