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1. 发明专利

AU2013359273B2 Pyridone derivatives and uses thereof in the treatment of tuberculosis 未知
公开(公告)号：AU2013359273B2
公开(公告)日：2016-04-14
申请号：AU2013359273
申请日：2013-12-12
申请人： KONDREDDI RAVINDER REDDY , MA NGAI LING , NOVARTIS AG , PEUKERT STEFAN , RAO SRINIVASA P S , UJJINI MANJUNATHA H
发明人： KONDREDDI RAVINDER REDDY , MANJUNATHA UJJINI H , MA NGAI LING , PEUKERT STEFAN , RAO SRINIVASA P S
IPC分类号： C07D401/06 , A61K31/4412 , A61P31/06 , C07D213/64 , C07D405/06
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of mycolic acid biosynthesis through inhibition of M. tuberculosis EnoyI Acyl Carrier Protein Reductase enzyme (InhA): wherein R

2. 发明申请

WO2014037900A1 INDOLE CARBOXAMIDE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：包含羧酰胺衍生物及其用途
公开(公告)号：WO2014037900A1
公开(公告)日：2014-03-13
申请号：PCT/IB2013/058318
申请日：2013-09-05
申请人： NOVARTIS AG , JIRICEK, Jan , KONDREDDI, Ravinder Reddy , SMITH, Paul William
发明人： JIRICEK, Jan , KONDREDDI, Ravinder Reddy , SMITH, Paul William
IPC分类号： C07D209/42 , A61K31/403 , A61P31/06
CPC分类号： C07D209/42 , A61K31/404 , A61K31/4045 , A61K31/407 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D491/056
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein.
摘要翻译：提供了式（I）化合物，其已被证明可用于治疗通过在mmpL3途径中运输必需分子介导的疾病，病症或综合征：（I）其中R1，R2，R3，R4， R5和R6如本文所定义。

3. 发明申请

WO2010015643A1 NEW ANTIVIRAL MODIFIED NUCLEOSIDES 审中-公开
标题翻译：新的抗病毒修饰的核苷酸
公开(公告)号：WO2010015643A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060125
申请日：2009-08-04
申请人： NOVARTIS AG , CHEN, Yen Liang , DURAISWAMY, Jeyaraj , HALLER, Sarah , KEIM, Matthias , KONDREDDI, Ravinder Reddy , YIN, Zheng
发明人： CHEN, Yen Liang , DURAISWAMY, Jeyaraj , HALLER, Sarah , KEIM, Matthias , KONDREDDI, Ravinder Reddy , YIN, Zheng
IPC分类号： C07H19/23 , A61K31/7052
CPC分类号： C07H19/23
摘要： This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections. wherein: X is CH or CR 6 ; R 1 is halogen, NR 7 R 8 or OR 9 ; R 2 is H, halogen, or NR 7 R 8 ; R 3 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, each of which is optionally substituted with one or more substituents; R 4 is H, acyl or an amino acid ester; R 5 is H, acyl or an amino acid ester; R 6 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, halogen, cyano, nitro, hydroxy, alkoxy, alkylthio, amino, alkylamino, carboxy, carboxamide or alkyloxycarbonyl, each of which is optionally substituted with one or more substituents; R 7 and R 8 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, amino, alkylamino, arylamino, hydroxy, alkoxy, arylcarbonyl and alkylcarbonyl, each of which is optionally substituted with one or more substituents; and R 3 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkylcarbonyl or arylcarbonyl, each of which is optionally substituted with one or more substituents;
摘要翻译：本发明涉及具有各种药用应用的新化合物，例如用于治疗和/或预防病毒感染。其中：X为CH或CR 6; R1是卤素，NR7R8或OR9; R2是H，卤素或NR7R8; R3是H，烷基，烯基，炔基，芳基，环烷基，杂环烷基或杂芳基，它们各自任选被一个或多个取代基取代; R4是H，酰基或氨基酸酯; R5是H，酰基或氨基酸酯; R6是烷基，烯基，炔基，芳基，环烷基，杂环烷基，杂芳基，卤素，氰基，硝基，羟基，烷氧基，烷硫基，氨基，烷基氨基，羧基，羧酰胺或烷氧基羰基，其各自任选被一个或多个取代基取代; R 7和R 8独立地选自H，烷基，烯基，炔基，芳基，环烷基，杂环烷基，杂芳基，氨基，烷基氨基，芳基氨基，羟基，烷氧基，芳基羰基和烷基羰基，其各自任选被一个或更多的取代基; R 3为H，烷基，烯基，炔基，芳基，环烷基，杂环烷基，杂芳基，烷基羰基或芳基羰基，其各自任选被一个或多个取代基取代;

4. 发明申请

WO2010015637A1 NEW ANTIVIRAL MODIFIED NUCLEOSIDES 审中-公开
标题翻译：新的抗病毒修饰的核苷酸
公开(公告)号：WO2010015637A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060114
申请日：2009-08-04
申请人： NOVARTIS AG , CHEN, Yen-Liang , DURAISWAMY, Jeyaraj , KONDREDDI, Ravinder Reddy , YIN, Zheng
发明人： CHEN, Yen-Liang , DURAISWAMY, Jeyaraj , KONDREDDI, Ravinder Reddy , YIN, Zheng
IPC分类号： C07H19/04 , A61K31/7052
CPC分类号： C07H19/04
摘要： This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections.
摘要翻译：本发明涉及具有各种药用应用的新化合物，例如用于治疗和/或预防病毒感染。

5. 发明申请

WO2014093606A1 PYRIDONE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF TUBERCULOSIS 审中-公开
标题翻译：吡格列酮衍生物及其在治疗结肠癌中的应用
公开(公告)号：WO2014093606A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/074632
申请日：2013-12-12
申请人： NOVARTIS AG , KONDREDDI, Ravinder Reddy , MANJUNATHA, Ujjini H. , NGAI, Ling Ma , PEUKERT, Stefan , RAO, Srinivasa P S
发明人： KONDREDDI, Ravinder Reddy , MANJUNATHA, Ujjini H. , NGAI, Ling Ma , PEUKERT, Stefan , RAO, Srinivasa P S
IPC分类号： C07D401/06 , C07D405/06 , C07D213/64 , A61K31/4412 , A61P31/06
CPC分类号： C07D213/69 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/675 , A61K45/06 , C07D213/64 , C07D401/04 , C07D401/06 , C07D405/06 , C07F9/581
摘要： A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of mycolic acid biosynthesis through inhibition of M. tuberculosis EnoyI Acyl Carrier Protein Reductase enzyme (InhA): wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein.
摘要翻译：提供式（I）化合物，其已被证明可用于治疗通过抑制结核分枝杆菌EnoI酰基载体蛋白还原酶（InhA）而抑制霉菌酸生物合成介导的疾病，病症或综合征：其中R1，R2，R3，R4和R5如本文所定义。

6. 发明申请

WO2014078802A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES 审中-公开
标题翻译：用于治疗寄生虫病的化合物和组合物
公开(公告)号：WO2014078802A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/070601
申请日：2013-11-18
申请人： IRM LLC , NOVARTIS AG , CHATTERJEE, Arnab Kumar , NAGLE, Advait Suresh , PARASELLI, Prasuna , KONDREDDI, Ravinder Reddy , LEONG, Seh Yong , MISHRA, Pranab Kumar , MOREAU, Robert Joseph , ROLAND, Jason Thomas , SIM, Wei Lin Sandra , SIMON, Oliver , TAN, Liying Jocelyn , YEUNG, Bryan KS , ZOU, Bin , BOLLU, Venkatataiah
发明人： CHATTERJEE, Arnab Kumar , NAGLE, Advait Suresh , PARASELLI, Prasuna , KONDREDDI, Ravinder Reddy , LEONG, Seh Yong , MISHRA, Pranab Kumar , MOREAU, Robert Joseph , ROLAND, Jason Thomas , SIM, Wei Lin Sandra , SIMON, Oliver , TAN, Liying Jocelyn , YEUNG, Bryan KS , ZOU, Bin , BOLLU, Venkatataiah
IPC分类号： C07D471/04 , A61K31/437 , A61P33/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/538 , A61K45/06 , C07D519/00
摘要： The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
摘要翻译：本发明提供了式I化合物：[其中的[INSERT FORMULA]或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。

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